会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • IMIDAZO[1,2-C]PYRIMIDINYLACETIC ACID DERIVATIVES
    • 咪唑并[1,2-C]嘧啶基乙酸衍生物
    • WO2005073234A3
    • 2005-10-06
    • PCT/EP2005000475
    • 2005-01-19
    • BAYER HEALTHCARE AGLY TAI-WEIYOSHINO TAKASHITAKEKAWA YUKISHINTANI TAKUYASUGIMOTO HIROMIBACON KEVIN BURBAHNS KLAUS
    • LY TAI-WEIYOSHINO TAKASHITAKEKAWA YUKISHINTANI TAKUYASUGIMOTO HIROMIBACON KEVIN BURBAHNS KLAUS
    • A61K31/519C07D487/04
    • C07D487/04
    • The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
    • 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优良的CRTH2(在Th2细胞上表达的G蛋白偶联化学引诱物受体)拮抗活性,可用于预防和治疗与CRTH2活性有关的疾病 特别是用于治疗过敏性疾病,如哮喘,过敏性鼻炎,特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病,如Churg-Strauss综合征和鼻窦炎; 嗜碱性粒细胞相关疾病,如嗜碱性白血病,人类和其他哺乳动物中的慢性荨麻疹和嗜碱性白细胞增多症; 和以T淋巴细胞和大量白细胞浸润为特征的炎性疾病,例如牛皮癣,湿疹,炎性肠病,溃疡性结肠炎,克罗恩病,COPD(慢性阻塞性肺病)和关节炎。
    • 6. 发明申请
    • IMIDAZO[1,2-C]PYRIMIDINYLACETIC ACID DERIVATIVES
    • 咪唑并[1,2-C]吡啶-2-基酸衍生物
    • WO2005073234A2
    • 2005-08-11
    • PCT/EP2005/000475
    • 2005-01-19
    • BAYER HEALTHCARE AGLY, Tai-weiYOSHINO, TakashiTAKEKAWA, YukiSHINTANI, TakuyaSUGIMOTO, HiromiBACON, Kevin B.URBAHNS, Klaus
    • LY, Tai-weiYOSHINO, TakashiTAKEKAWA, YukiSHINTANI, TakuyaSUGIMOTO, HiromiBACON, Kevin B.URBAHNS, Klaus
    • C07D487/00
    • C07D487/04
    • The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
    • 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2(G蛋白偶联的化学引诱物受体,在Th2细胞上表达)拮抗活性,可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘,过敏性鼻炎,特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病,如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病,如嗜碱性白血病,慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病,湿疹,炎性肠病,溃疡性结肠炎,克罗恩病,COPD(慢性阻塞性肺病)和关节炎等。