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1. 发明申请

WO2013003625A2 ANTIBODIES 审中-公开
标题翻译：抗体
公开(公告)号：WO2013003625A2
公开(公告)日：2013-01-03
申请号：PCT/US2012044703
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
发明人： ROHLFF CHRISTIAN , TERRETT JONATHAN ALEXANDER
IPC分类号： C07K16/28
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/30 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
摘要翻译：本发明提供了结合ADP-核糖基环化酶2的抗体。还提供了编码抗体的核酸分子，表达载体，宿主细胞和用于表达抗体的方法。抗体可用于治疗人类癌症，包括急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌和胰腺癌，以及人类炎症性疾病，包括哮喘，痛风，克罗恩病，狼疮，多发性硬化，类风湿性关节炎，牛皮癣，糖尿病和动脉粥样硬化。

2. 发明申请

WO2009150513A3 EPHRIN TYPE-A RECEPTOR 7 PROTEIN 审中-公开
标题翻译： EPHRIN型A受体7蛋白
公开(公告)号：WO2009150513A3
公开(公告)日：2010-07-08
申请号：PCT/IB2009005884
申请日：2009-06-09
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2333/9121
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, for monitoring the effectiveness of treatment of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, and for drug development.
摘要翻译：本发明提供了膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌等的治疗，筛选，诊断和预后的方法和组合物。甲状腺癌或子宫癌，包括转移性癌症，用于监测膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌的治疗效果，甲状腺癌或子宫癌，包括转移性癌症和药物开发。

3. 发明申请

WO2010026473A3 PTA072 PROTEIN 审中-公开
标题翻译： PTA072蛋白
公开(公告)号：WO2010026473A3
公开(公告)日：2010-05-27
申请号：PCT/IB2009006747
申请日：2009-09-03
申请人： OXFORD BIOTHERAPEUTICS LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： C07K16/30 , C07K14/47 , G01N33/574
CPC分类号： C07K16/30 , C07K14/4748 , C07K2317/56
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer, for monitoring the effectiveness of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer treatment, and for drug development.
摘要翻译：本发明提供了用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，肾癌，胰腺癌或前列腺癌的治疗，筛选，诊断和预后的方法和组合物，用于监测B细胞非霍奇金淋巴瘤淋巴瘤，乳腺癌，结肠直肠癌，肾癌，胰腺癌或前列腺癌治疗，以及药物开发。

4. 发明申请

WO2010026473A2 PTA072 PROTEIN 审中-公开
标题翻译： PTA072蛋白质
公开(公告)号：WO2010026473A2
公开(公告)日：2010-03-11
申请号：PCT/IB2009/006747
申请日：2009-09-03
申请人： OXFORD BIOTHERAPEUTICS LTD. , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： C07K16/30 , C07K14/47 , G01N33/574
CPC分类号： C07K16/30 , C07K14/4748 , C07K2317/56
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer, for monitoring the effectiveness of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, kidney cancer, pancreatic cancer or prostate cancer treatment, and for drug development.
摘要翻译：本发明提供用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结直肠癌，肾癌，胰腺癌或前列腺癌的治疗，筛选，诊断和预后的方法和组合物 B细胞非霍奇金淋巴瘤，乳腺癌，结直肠癌，肾癌，胰腺癌或前列腺癌治疗的有效性，以及用于药物开发。

5. 发明申请

WO2009150513A2 PROTEIN 审中-公开
标题翻译：蛋白
公开(公告)号：WO2009150513A2
公开(公告)日：2009-12-17
申请号：PCT/IB2009/005884
申请日：2009-06-09
申请人： OXFORD BIOTHERAPEUTICS LTD. , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2333/9121
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, for monitoring the effectiveness of treatment of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer, kidney cancer, lung cancer, osteosarcoma, pancreatic cancer, prostate cancer, skin cancer, thyroid cancer or uterine cancer, including metastatic cancer, and for drug development.
摘要翻译：本发明提供了膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌等的治疗，筛选，诊断和预后的方法和组合物。甲状腺癌或子宫癌，包括转移性癌症，用于监测膀胱癌，乳腺癌，结肠直肠癌，胃癌，头颈癌，肾癌，肺癌，骨肉瘤，胰腺癌，前列腺癌，皮肤癌的治疗效果，甲状腺癌或子宫癌，包括转移性癌症和药物开发。

6. 发明申请

WO2007015113A2 NEW PROTEIN ISOFORMS AND USES THEREOF 审中-公开
标题翻译：新蛋白质的身份及其用途
公开(公告)号：WO2007015113A2
公开(公告)日：2007-02-08
申请号：PCT/GB2006/050232
申请日：2006-08-04
申请人： OXFORD GENOME SCIENCES (UK) LTD , ROHLFF, Christian
发明人： ROHLFF, Christian
CPC分类号： G01N33/6896
摘要： A method for screening for or diagnosis or prognosis of a neurological disorder associated with de-regulated glutamate signalling in a subject, for determining the stage or severity of such a neurological disorder in a subject, for identifying a subject at risk of developing such a neurological disorder, or for monitoring the effect of therapy administered to a subject having such a neurological disorder, said method comprising: (a) analyzing a test sample of body fluid or tissue from the subject said sample comprising at least one Protein Isoform selected from the following Protein Isoform Families: PIF-1, PIF-2, and PIF-3 in a detectable amount; and (b) comparing the abundance of said Protein Isoform(s) in the test sample or the abundance of said Protein Isoform(s) relative to another Protein Isoform with the abundance or relative abundance of said Protein Isoform(s) in a test sample from one or more persons free from neurological disorder, or with a previously determined reference range for that Protein Isoform in subjects free from neurological disorder, wherein a diagnosis of or a positive result in screening for or a prognosis of a more advanced condition of said neurological disorder is indicated by (i) decreased abundance or relative abundance of PIF-1 and/or (ii) increased abundance or relative abundance of PIF-2 and/or (iii) decreased abundance or relative abundance of PIF-3.
摘要翻译：用于筛选或诊断或预测与受试者中去调节的谷氨酸信号传导相关的神经障碍的方法，用于确定受试者中这种神经障碍的阶段或严重程度，用于鉴定患有发展这种神经系统的风险的受试者或用于监测施用于具有这种神经障碍的受试者的治疗效果，所述方法包括：（a）分析来自受试者的体液或组织的测试样品，所述样品包含至少一种选自以下的蛋白质异构体蛋白质异构体家族：可检测量的PIF-1，PIF-2和PIF-3; 和（b）比较测试样品中所述蛋白质异构体的丰度或相对于另一种蛋白质异构体的所述蛋白质同种型的丰度与测试样品中所述蛋白质同种型的丰度或相对丰度来自一个或多个没有神经障碍的人，或者在没有神经障碍的受试者中与该蛋白质同种型的预先确定的参考范围，其中诊断或阳性导致所述神经系统的更晚期状态的筛选或预后（i）PIF-1的丰度或相对丰度降低和/或（ii）增加的PIF-2的丰度或相对丰度和/或（iii）减少的PIF-3的丰度或相对丰度。

7. 发明申请

WO2004084800A2 A3 RECEPTOR-MEDIATED CARDIOPROTECTIVE PROTEINS AND THERAPEUTIC AND DIAGNOSTIC METHODS OF USE 审中-公开
标题翻译： A3受体介导的保护性蛋白质和治疗与诊断方法
公开(公告)号：WO2004084800A2
公开(公告)日：2004-10-07
申请号：PCT/US2003/027373
申请日：2003-08-29
申请人： PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , THOMPSON, John, F. , POTTER, David, M. , KNIGHT, Delvin, R., Jr. , GUALBERTO, Antonio , LANDSCHULZ, Katherine, T. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , ROHLFF, Christian
发明人： THOMPSON, John, F. , POTTER, David, M. , KNIGHT, Delvin, R., Jr. , GUALBERTO, Antonio , LANDSCHULZ, Katherine, T. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , ROHLFF, Christian
IPC分类号： A61K
CPC分类号： C07K14/47 , A61K38/00 , G01N33/6893 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A 3 agonist infusion. These proteins are termed A 3 receptor-mediated cardioprotective proteins (A 3 Ps) and protein isoforms (A 3 PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A 3 P and/or A 3 PI.
摘要翻译：鉴定出响应于A3激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。这些蛋白质被称为A3受体介导的心脏保护性蛋白质（A3P）和蛋白质同种型（A3PI），并且可用作鉴定能够调节一种或多种A3P和/或A3PI的表达的试剂的筛选方法中的药物和靶标。

8. 发明申请

WO0175454A3 DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：诊断和治疗阿尔茨海默病
公开(公告)号：WO0175454A3
公开(公告)日：2003-05-08
申请号：PCT/US0110908
申请日：2001-04-03
申请人： OXFORD GLYCOSCIENCES UK LTD , PFIZER , DURHAM KATHRYN L , FRIEDMAN DAVID L , HERATH HERATH MUDIYANSELAGE AT , KIMMEL LIDA H , PAREKH RAJESH BHIKHU , POTTER DAVID M , ROHLFF CHRISTIAN , SILBER B MICHAEL , STIGER THOMAS R , SUNDERLAND P TREY , TOWNSEND ROBERT REID , WHITE FROST , WILLIAMS STEPHEN A
发明人： DURHAM KATHRYN L , FRIEDMAN DAVID L , HERATH HERATH MUDIYANSELAGE AT , KIMMEL LIDA H , PAREKH RAJESH BHIKHU , POTTER DAVID M , ROHLFF CHRISTIAN , SILBER B MICHAEL , STIGER THOMAS R , SUNDERLAND P TREY , TOWNSEND ROBERT REID , WHITE FROST , WILLIAMS STEPHEN A
IPC分类号： G01N27/62 , A61K31/7088 , A61K39/395 , A61K48/00 , A61P25/28 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/68 , G01N37/00 , C07K14/47 , G01N33/561
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

9. 发明申请

WO2003028543A2 NUCLEIC ACID MOLECULES, POLYPEPTIDES AND USES THEREFOR, INCLUDING DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：核酸分子，多肽及其用途，包括诊断和治疗阿尔茨海默病
公开(公告)号：WO2003028543A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031642
申请日：2002-10-03
申请人： PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
发明人： DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
IPC分类号： A61B
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2500/00 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
摘要翻译：本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默病相关特征（AF）。本发明进一步提供在脑脊液，血清或血浆中可检测的阿尔茨海默病相关蛋白质异构体（API），包含针对API免疫特异性的分离的API抗体的制剂，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。

10. 发明申请

WO02059604A8 PROTEINS, GENES AND THEIR USE FOR DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
标题翻译：蛋白质，基因及其用于诊断和治疗多发性硬化症的用途
公开(公告)号：WO02059604A8
公开(公告)日：2002-11-21
申请号：PCT/GB0200330
申请日：2002-01-25
申请人： OXFORD GLYCOSCIENCES UK LTD , HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
发明人： HERATH HERATH MUDIYANSELAGE AT , PAREKH RAJESH BHIKHU , ROHLFF CHRISTIAN
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/566 , G01N33/68 , G01N33/564 , A61K39/00
CPC分类号： C07K14/4713 , A61K38/00 , C07K2319/00 , G01N33/6803 , G01N33/6896 , G01N2800/285 , G01N2800/52
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Multiple Sclerosis, for monitoring the effectiveness of Multiple Sclerosis treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Multiple Sclerosis-Associated Features (MSFs), detectable by two-dimensional electrophoresis of body fluid e.g. cerebrospinal fluid are described. The invention further provides Multiple Sclerosis-Associated Protein Isoforms (MSPIs) detectable in body fluid e.g. cerebrospinal fluid, preparations comprising isolated MSPIs, antibodies immunospecific for MSPIs, and kits comprising the aforesaid.
摘要翻译：本发明提供用于多发性硬化症的筛选，诊断和预后的方法和组合物，用于监测多发性硬化症治疗的有效性，鉴定最可能对特定治疗和药物开发作出反应的患者。多发性硬化相关特征（MSF）可通过体液的二维电泳检测。描述脑脊液。本发明进一步提供在体液中可检测的多发性硬化症相关蛋白质异构体（MSPI），例如。脑脊液，包含分离的MSPI的制剂，针对MSPI的免疫特异性抗体，以及包含上述的试剂盒。

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