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1. 发明申请

WO2015042120A1 SURGICAL NAVIGATION SYSTEM AND METHOD 审中-公开
标题翻译：手术导航系统及方法
公开(公告)号：WO2015042120A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056039
申请日：2014-09-17
申请人： AWDEH, Richard
发明人： AWDEH, Richard
IPC分类号： A61F9/00
CPC分类号： G06F3/012 , A61B3/005 , A61B3/0058 , A61B3/14 , A61B34/20 , A61B34/25 , A61B90/20 , A61B2034/2061 , A61B2034/252 , A61B2090/365 , A61B2090/371 , A61B2090/372 , A61B2090/3735 , A61B2090/502 , A61F9/00 , A61F9/007 , G06F3/011 , G06T11/00
摘要： A surgical guidance system and method for assisting a surgeon in a surgical procedure performed on a patient is disclosed. The system comprises an image acquisition device configured to generate substantially real-time digital video data representing patient images of an eye of the patient. The system further comprises a processor coupled to the image acquisition device and configured to receive the digital video data from the image acquisition device, receive external data from an external data source, and generate composite digital image data based on the digital video data and the external data. The system further comprises a display device coupled to the processor, the display device being configured to display, to the surgeon from the composite digital image data, overlaid images including procedural prompts according to the patient images and the external data.
摘要翻译：公开了一种用于辅助外科医生进行对患者的外科手术的手术引导系统和方法。该系统包括被配置为生成表示患者眼睛的患者图像的基本上实时的数字视频数据的图像采集装置。该系统还包括处理器，其耦合到图像采集设备并且被配置为从图像采集设备接收数字视频数据，从外部数据源接收外部数据，并基于数字视频数据和外部数据生成复合数字图像数据数据。所述系统还包括耦合到所述处理器的显示装置，所述显示装置被配置为根据所述患者图像和所述外部数据，从所述复合数字图像数据向所述外科医生显示包括程序提示的重叠图像。

2. 发明申请

WO2015138994A2 METHODS AND SYSTEMS FOR REGISTRATION USING A MICROSCOPE INSERT 审中-公开
标题翻译：使用MICROSCOPE插件注册的方法和系统
公开(公告)号：WO2015138994A2
公开(公告)日：2015-09-17
申请号：PCT/US2015/020595
申请日：2015-03-13
申请人： AWDEH, Richard
发明人： AWDEH, Richard
IPC分类号： H04N5/225
CPC分类号： A61B3/132 , A61B3/0025 , A61B3/0058 , A61B3/113 , A61B3/14 , A61B34/20 , A61B90/20 , A61B90/37 , A61B2017/00119 , A61B2017/00973 , A61B2034/2065 , A61B2090/3612 , A61B2090/363 , A61B2090/364 , A61B2090/365 , A61B2090/371 , G02B21/0012 , G02B21/22 , G02B21/244 , G02B21/365 , G02B21/368
摘要： A microscope insert includes a camera, a display device, a beam splitter, and a processing unit. The camera is configured to receive a first portion of first light through a microscope from an object and generate a signal representing an image of the object. The display device is configured to generate a graphical representation of information relevant to the object and project second light representing the graphical representation. The beam splitter is configured to direct a second portion of the first light from the object and a first portion of the second light to a viewing device for simultaneously viewing the object and the information by a user. The processing unit is configured to track motions of the object based on the image of the object and control the display device to adjust the graphical representation according to the motions of the object.
摘要翻译：显微镜插入件包括照相机，显示装置，分束器和处理单元。相机被配置为通过来自对象的显微镜接收第一光的第一部分并且生成表示对象的图像的信号。显示设备被配置为生成与对象相关的信息的图形表示和表示图形表示的项目第二光。分束器被配置为将来自物体的第一光的第二部分和第二光的第一部分引导到观察装置，以便用户同时观察物体和信息。处理单元被配置为基于对象的图像跟踪对象的运动，并且控制显示设备以根据对象的运动来调整图形表示。

3. 发明申请

WO2010148298A1 SYSTEM AND METHOD FOR MOLECULAR IN VIVO IMAGING AND THERANOSTICS 审中-公开
标题翻译：用于体细胞成像和神经元分子的系统和方法
公开(公告)号：WO2010148298A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/039159
申请日：2010-06-18
申请人： UNIVERSITY OF MIAMI , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , AWDEH, Richard, M. , PEREZ, Victor, L. , DE LA ZERDA, Adam , GAMBHIR, Sanjiv
发明人： AWDEH, Richard, M. , PEREZ, Victor, L. , DE LA ZERDA, Adam , GAMBHIR, Sanjiv
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： B82Y5/00 , A61B3/102 , A61B5/0066 , A61B2562/0285 , A61K49/00
摘要： Systems and methods of characterizing biological tissues are provided. Tn the systems and methods, a first optical coherence tomography ( OCT) image of a selected portion of biological tissues combined with a plurality of nanoparticϊεs is obtained, where the plurality of nanoparticlεs are configured to bind to one or more types of biological molecules in the biological tissues and to produce contrast during OCT imaging. The systems and methods also include estimating a first distribution of the plurality of nanoparticles in the selected portion based on the first OCT image and characterizing the selected portion with respect to the types of biological molecules based on the distribution.
摘要翻译：提供了表征生物组织的系统和方法。在系统和方法中，获得与多个纳米颗粒结合的生物组织的选定部分的第一光学相干断层摄影（OCT）图像，其中多个纳米颗粒被配置为结合一种或多种类型的生物分子在生物组织中并在OCT成像期间产生对比度。系统和方法还包括基于第一OCT图像估计所选择的部分中的多个纳米颗粒的第一分布，并基于分布来表征相对于生物分子类型的所选择的部分。

4. 发明申请

WO2015138988A1 A MICROSCOPE INSERT 审中-公开
标题翻译： MICROSCOPE插件
公开(公告)号：WO2015138988A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020584
申请日：2015-03-13
申请人： AWDEH, Richard
发明人： AWDEH, Richard
IPC分类号： G02B21/22 , G02B27/14 , G02B27/22
CPC分类号： G02B21/365 , A61B3/0025 , A61B3/0041 , A61B3/13 , A61B3/14 , G02B21/0012 , G02B21/18 , G02B21/22 , G02B21/361 , G02B21/362 , G02B21/368 , G02B27/0101 , G02B27/283 , G02B27/286 , G02B2027/0141
摘要： A microscope insert includes a beam splitter, a camera, a processing unit, a display device, and a polarizer element. The beam splitter is configured to direct a first portion of first Iight from an object in a first direction and a second portion of the first Iight in a second direction. The display device is configured to generate a graphical representation of information relevant to the object and transmit second Iight corresponding to the graphical representation. The polarizer element is configured to modify a polarization of the second light from the display device. The beam splitter directs a first portion of the modified second Iight in the first direction to a viewing device. The first portion of the modified second Iight and the first portion of the first Iight from the object are combined for simultaneous viewing of the graphical representation and the object by the user.
摘要翻译：显微镜插入件包括分束器，相机，处理单元，显示装置和偏振器元件。分束器被配置成在第一方向上将物体的第一部分的第一部分引导到第一方向的第一部分和第一方向上的第二部分。显示设备被配置为生成与对象相关的信息的图形表示，并且发送与图形表示相对应的第二视点。偏振器元件被配置为修改来自显示装置的第二光的偏振。分束器将修改后的第二光阑的第一部分沿第一方向引导到观察装置。修改的第二个Iight的第一部分和来自对象的第一个Iight的第一部分被组合，以便用户同时观看图形表示和对象。

5. 发明申请

WO2013049525A1 PACKAGING OR OTHER MATERIALS COMPRISING A BIOSENSOR AND METHODS OF THEIR USE 审中-公开
标题翻译：包装或包含生物传感器的其他材料及其使用方法
公开(公告)号：WO2013049525A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057851
申请日：2012-09-28
申请人： CIRLE , AWDEH, Richard
发明人： AWDEH, Richard
IPC分类号： G01N33/52 , C12Q1/04
CPC分类号： C12Q1/10 , C12Q1/04 , C12Q1/14 , G01N33/56911 , G01N33/586
摘要： Provided herein is a composition for detection of a microbial product in a sample comprising a polydiacetylene (PDA) and a packaging polymer, wherein the sample contacts the PDA and a change of PDA color indicates detection. Also provided herein are methods of making a packaging material comprising a PDA and methods of using the composition for detection of a microbial product in a sample.
摘要翻译：本文提供了用于检测包含聚二乙炔（PDA）和包装聚合物的样品中的微生物产物的组合物，其中样品接触PDA并且PDA颜色的改变指示检测。本文还提供制备包含PDA的包装材料的方法以及使用该组合物检测样品中微生物产物的方法。

6. 发明申请

WO2016149155A1 METHODS AND SYSTEMS FOR REGITRATION USING A MICROSCOPE INSERT 审中-公开
标题翻译：使用MICROSCOPE插件进行注册的方法和系统
公开(公告)号：WO2016149155A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022236
申请日：2016-03-13
申请人： AWDEH, Richard
发明人： AWDEH, Richard
IPC分类号： A61B6/00 , G02B21/22 , G06K9/00
CPC分类号： A61B90/20 , A61B3/13 , A61B6/00 , A61B2034/2046 , A61B2034/2065 , A61B2090/363 , G02B21/22 , G02B21/365 , G02B27/0093
摘要： A microscope insert includes a camera, a display device, a beam splitter, and a processing unit. The camera is configured to receive a first portion of first light through a microscope from an object and generate a signal representing an image of the object. The display device is configured to generate a graphical representation of information relevant to the object and project second light representing the graphical representation. The beam splitter is configured to direct a second portion of the first light from the object and a first portion of the second light to a viewing device for simultaneously viewing the object and the information by a user. The processing unit is configured to track motions of the object based on the image of the object and control the display device to adjust the graphical representation according to the motions of the object.
摘要翻译：显微镜插入件包括照相机，显示装置，分束器和处理单元。相机被配置为通过来自对象的显微镜接收第一光的第一部分并且生成表示对象的图像的信号。显示设备被配置为生成与对象相关的信息的图形表示和表示图形表示的项目第二光。分束器被配置为将来自物体的第一光的第二部分和第二光的第一部分引导到观察装置，以便用户同时观察物体和信息。处理单元被配置为基于对象的图像跟踪对象的运动，并且控制显示设备以根据对象的运动来调整图形表示。

7. 发明申请

WO2015138994A3 REGISTRATION USING A MICROSCOPE INSERT 审中-公开
标题翻译：使用MICROSCOPE插件注册
公开(公告)号：WO2015138994A3
公开(公告)日：2015-12-10
申请号：PCT/US2015020595
申请日：2015-03-13
申请人： AWDEH RICHARD
发明人： AWDEH RICHARD
IPC分类号： G02B21/22 , G02B27/14 , G02B27/22
CPC分类号： A61B3/132 , A61B3/0025 , A61B3/0058 , A61B3/113 , A61B3/14 , A61B34/20 , A61B90/20 , A61B90/37 , A61B2017/00119 , A61B2017/00973 , A61B2034/2065 , A61B2090/3612 , A61B2090/363 , A61B2090/364 , A61B2090/365 , A61B2090/371 , G02B21/0012 , G02B21/22 , G02B21/244 , G02B21/365 , G02B21/368 , G02B27/283
摘要： A microscope insert includes a camera, a display device, a beam splitter, and a processing unit. The camera is configured to receive a first portion of first light through a microscope from an object and generate a signal representing an image of the object. The display device is configured to generate a graphical representation of information relevant to the object and project second light representing the graphical representation. The beam splitter is configured to direct a second portion of the first light from the object and a first portion of the second light to a viewing device for simultaneously viewing the object and the information by a user. The processing unit is configured to track motions of the object based on the image of the object and control the display device to adjust the graphical representation according to the motions of the object.
摘要翻译：显微镜插入件包括照相机，显示装置，分束器和处理单元。相机被配置为通过来自对象的显微镜接收第一光的第一部分并且生成表示对象的图像的信号。显示设备被配置为生成与对象相关的信息的图形表示和表示图形表示的项目第二光。分束器被配置为将来自物体的第一光的第二部分和第二光的第一部分引导到观察装置，以便用户同时观察物体和信息。处理单元被配置为基于对象的图像跟踪对象的运动，并且控制显示设备以根据对象的运动来调整图形表示。

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