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1. 发明申请

WO2021216560A2 VACCINE COMPOSITIONS FOR SARS-RELATED CORONAVIRUSES AND METHODS OF USE 审中-公开
公开(公告)号：WO2021216560A2
公开(公告)日：2021-10-28
申请号：PCT/US2021/028172
申请日：2021-04-20
申请人： ASCIONE, Richard , QI, Shengmei , HODGE, David
发明人： ASCIONE, Richard , QI, Shengmei , HODGE, David
IPC分类号： A61K39/05 , A61K39/215
摘要： The invention provides a pan-Severe Acute Respiratory Syndrome (SARS) vaccine compositions (i.e., vaccine compositions useful against multiple SARS viruses such as MERS, SARS-CoV-2, etc.), a vaccination regimen for immunization against such coronavirus diseases, and its use in medicine and in augmenting immune responses to various antigens present in such viruses and to methods of preparation of such compositions. In particular, the invention relates to polyvalent multi-targeting immunogenic compositions comprising SARS-coronaviral antigens or antigen preparations thereof from multiple strains associated with human pandemic outbreaks in combination with accessory delivery vehicle(s) and adjuvants.

2. 发明申请

WO2011109106A3 IMMUNOGENIC COMPOSITIONS AGAINST HUMAN PROGASTRIN PEPTIDES 审中-公开
公开(公告)号：WO2011109106A3
公开(公告)日：2011-09-09
申请号：PCT/US2011/000413
申请日：2011-03-03
申请人： ONKOLOGIX LTD , ASCIONE, Richard , QI, Shengmei , WANG, Bin
发明人： ASCIONE, Richard , QI, Shengmei , WANG, Bin
IPC分类号： A61K38/22 , A61K38/16 , A61K47/42 , A61K9/113 , C07K19/00 , C07K14/575 , C07K17/02 , A61P37/00
摘要： Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.

3. 发明申请

WO2022032274A1 VACCINE COMPOSITIONS FOR INFLUENZA VIRUSES AND METHODS OF USE 审中-公开
公开(公告)号：WO2022032274A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/071080
申请日：2021-07-30
申请人： ASCIONE, Richard , QI, Shengmei
发明人： ASCIONE, Richard , QI, Shengmei
IPC分类号： A61K39/12 , A61K39/145 , A61K39/39 , C07K14/005
摘要： The invention provides pan-influenza vaccine compositions (i.e., vaccine compositions useful against multiple influenza viruses such as H1N1, H2N2, H5N2, etc.), a vaccination regimen for immunization against such influenza diseases, and its use in medicine and in augmenting immune responses to various antigens present in such viruses and to methods of preparation of such compositions. In particular, the invention relates to polyvalent multi-targeting immunogenic compositions comprising influenza viral antigens or antigen preparations thereof from multiple strains associated with human pandemic outbreaks in combination with accessory delivery vehicle(s) and adjuvants.

4. 发明申请

WO2011109106A2 IMMUNOGENIC COMPOSITIONS AGAINST HUMAN PROGASTRIN PEPTIDES 审中-公开
标题翻译：免疫组织化学反应人类孕激素
公开(公告)号：WO2011109106A2
公开(公告)日：2011-09-09
申请号：PCT/US2011000413
申请日：2011-03-03
申请人： ONKOLOGIX LTD , ASCIONE RICHARD , QI SHENGMEI , WANG BIN
发明人： ASCIONE RICHARD , QI SHENGMEI , WANG BIN
CPC分类号： A61K39/0005 , A61K47/646 , A61K47/65 , C07K14/595
摘要： Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.
摘要翻译：针对人类延伸的前胃泌素物种的免疫原包含（A）模仿肽，其包含（i）泌乳素或N-和/或C-末端加工物种的泌乳素的氨基酸序列，连接到（ii）与（B）免疫原性载体偶联的酸性间隔基。示例性的模拟肽/间隔物组合是21个氨基酸的肽（SEQ ID NO：1）和其它相关多肽（SEQ ID NO：2-5）。含有这种免疫原的药物组合物显示出改善的免疫学性质，包括在施用免疫原的初始过程之后不久诱导有效的抗体水平。因此引发的抗体水平保持升高几个月，并且通过单次注射免疫原随后升高时容易升高至较高水平。

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