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1. 发明申请

WO2011109106A2 IMMUNOGENIC COMPOSITIONS AGAINST HUMAN PROGASTRIN PEPTIDES 审中-公开
标题翻译：免疫组织化学反应人类孕激素
公开(公告)号：WO2011109106A2
公开(公告)日：2011-09-09
申请号：PCT/US2011000413
申请日：2011-03-03
申请人： ONKOLOGIX LTD , ASCIONE RICHARD , QI SHENGMEI , WANG BIN
发明人： ASCIONE RICHARD , QI SHENGMEI , WANG BIN
CPC分类号： A61K39/0005 , A61K47/646 , A61K47/65 , C07K14/595
摘要： Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.
摘要翻译：针对人类延伸的前胃泌素物种的免疫原包含（A）模仿肽，其包含（i）泌乳素或N-和/或C-末端加工物种的泌乳素的氨基酸序列，连接到（ii）与（B）免疫原性载体偶联的酸性间隔基。示例性的模拟肽/间隔物组合是21个氨基酸的肽（SEQ ID NO：1）和其它相关多肽（SEQ ID NO：2-5）。含有这种免疫原的药物组合物显示出改善的免疫学性质，包括在施用免疫原的初始过程之后不久诱导有效的抗体水平。因此引发的抗体水平保持升高几个月，并且通过单次注射免疫原随后升高时容易升高至较高水平。

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