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1. 发明申请

WO2009027707A3 METHODS FOR PREPARING PEPTIDES, ESPECIALLY RADIO-LABELLED PEPTIDES 审中-公开
标题翻译：制备肽，特别是无线标记肽的方法
公开(公告)号：WO2009027707A3
公开(公告)日：2009-04-16
申请号：PCT/GB2008002951
申请日：2008-08-29
申请人： UNIV KENT CANTERBURY , BIAGINI STEFANO CARLO GIORGIO , BLOWER PHILLIP JOHN , PARRY ALISON , SMITH GARETH E
发明人： BIAGINI STEFANO CARLO GIORGIO , BLOWER PHILLIP JOHN , PARRY ALISON , SMITH GARETH E
IPC分类号： A61K51/08 , C07F5/02 , C07K1/04 , C07K1/13 , C07K7/06
CPC分类号： C07K1/13 , A61K51/08 , C07B59/008 , C07F5/025 , C07K5/0827 , C07K14/595
摘要： The invention provides a substituted amino acid comprising an optionally protected primary or secondary amino group, a carboxylic acid group and a group capable of binding a fluoride ion; a peptide comprising the substituted amino acid; a method for the preparation of the peptide and its use in diagnosis. The substituted amino acid according to the invention permits a synthetic approach with greater flexibility and control of the site of labelling than conventional methods.
摘要翻译：本发明提供包含任选保护的伯或仲氨基，羧酸基团和能够结合氟离子的基团的取代的氨基酸; 包含取代的氨基酸的肽; 肽的制备方法及其在诊断中的应用。根据本发明的取代的氨基酸允许具有比常规方法更大的灵活性和对标记位点的控制的合成方法。

2. 发明申请

WO2006008649A1 ANTI-SENSE POLYNUCLEOTIDE THERAPY FOR GASTRIN-PROMOTED TUMORS 审中-公开
标题翻译：用于胃肠促进肿瘤的抗感染多核苷酸治疗
公开(公告)号：WO2006008649A1
公开(公告)日：2006-01-26
申请号：PCT/IB2005/002222
申请日：2005-07-14
申请人： APHTON CORPORATION , WATSON, Susan, A. , GRABOWSKA, Anna , McWILLIAMS, Daniel, F.
发明人： WATSON, Susan, A. , GRABOWSKA, Anna , McWILLIAMS, Daniel, F.
IPC分类号： C12N15/11 , C07K14/595 , C12N15/16 , A61K48/00 , A61K31/7088 , A61P35/00
CPC分类号： C12N15/1136 , C07K14/595 , C12N2310/11 , C12N2310/111
摘要： A therapeutic method for the treatment of patients suffering from a gastrin-promoted tumor; a tumor comprising cells bearing a gastrin receptor; or a tumor of the gastrointestinal (GI) tract, a pancreatic tumor, a medullary thyroid carcinoma (MTC), a tumor of the lung, a glioblastoma, an ovarian tumor, or a tumor of neuroendocrine origin is provided. The method includes administering to a patient a DNA molecule comprising a gastrin anti-sense sequence operatively linked to a regulatory sequence that expresses gastrin anti-sense RNA to the patient, and also administering a chemotherapeutic agent. The method is especially useful for the treatment of patients with advanced stage disease, and for patients having undergone prior surgery, radiotherapy or chemotherapy treatment.
摘要翻译：治疗胃泌素促进肿瘤患者的治疗方法; 包含具有胃泌素受体的细胞的肿瘤; 或胃肠道（GI）的肿瘤，胰腺肿瘤，甲状腺髓样癌（MTC），肺肿瘤，成胶质细胞瘤，卵巢肿瘤或神经内分泌源的肿瘤。该方法包括向患者施用包含与向患者表达胃泌素反义RNA的调节序列有效连接的胃泌素反义序列的DNA分子，以及施用化学治疗剂。该方法对于治疗晚期阶段性疾病的患者以及经过先前手术，放射治疗或化疗治疗的患者特别有用。

3. 发明申请

WO2005074967A3 PROGASTRIN DERIVED PEPTIDES 审中-公开
标题翻译： PROGASTRIN衍生肽
公开(公告)号：WO2005074967A3
公开(公告)日：2005-09-29
申请号：PCT/DK2005000080
申请日：2005-02-04
申请人： RIGSHOSPITALET , REHFELD JENS FREDERIK , GOETZE JENS PETER , BUNDGAARD JENS RENE , UNIV COPENHAGEN
发明人： REHFELD JENS FREDERIK , GOETZE JENS PETER , BUNDGAARD JENS RENE
IPC分类号： A61K38/00 , A61K38/22 , C07K14/595 , A61P1/00
CPC分类号： C07K14/595 , A61K38/2207 , A61K2300/00
摘要： The present invention describes the use of an isolated polypeptide sequence comprising the N-terminal SWKPR motif of progastrin for the generation of a medicament for the treatment of a dyspepsia in a mammal. Also pseudopeptides of polypeptides of the invention are disclosed. The pseudopeptide is of the formula I, (R )(R ) N-S-Y -W-Y -K-Y P-Y -R-C(=O)O-R , wherein each Y is an amide bond, pseudo-amide bond or amide bond derivative; and each of S, W, K, P, R represents their the CH-R side chain moiety of their respective amino acids, or known derivatives thereof. Pharmaceutical preparations comprising at one or more peptides and/or pseudopeptides of the invention are also provided.
摘要翻译：本发明描述了分离的多肽序列在哺乳动物中用于产生用于治疗消化不良的药物的分离的多肽序列的用途，所述序列包含前导肽的N-末端SWKPR基序。还公开了本发明的多肽的伪肽。假肽具有式I，（R A'）（R A2）NSY 1 -WY 2 -KY 3 PY 4 -RC（= O）OR B，其中每个Y是酰胺键，假酰胺键或酰胺键衍生物; S，W，K，P，R各自表示它们各自氨基酸的CH-R侧链部分或其已知衍生物。还提供了包含本发明的一种或多种肽和/或假肽的药物制剂。

4. 发明申请

WO2004097406A2 Nε AND/OR Nα DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]+ BY FAC COORDINATION 审中-公开
标题翻译：用于通过FAC协调与[M（OH）3（CO）3] +的高效标记相结合的生物分子的Nε和/或Nα衍生的金属和有机保护的L-酪氨酸
公开(公告)号：WO2004097406A2
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004683
申请日：2004-04-29
申请人： UNIVERSITÄT ZÜRICH , ALBERTO, Roger , PAK, Jaw, Kyoung
发明人： ALBERTO, Roger , PAK, Jaw, Kyoung
IPC分类号： G01N33/48
CPC分类号： G01N33/6842 , C07D233/64 , C07D487/04 , C07K5/06139 , C07K7/083 , C07K7/086 , C07K14/5421 , C07K14/595 , C07K14/655 , C07K14/685 , G01N33/68
摘要： The present invention relates to novel histidine derivatives that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is derivatized at the N ε and at least protected at the N α and optionally at the N δ ; or derivatized at the N α and at least protected at the N α and optionally at the N δ ; or derivatized at the N ε and N α and at least protected at the N α and optionally at the N δ ; or derivatized at the N ε ; or derivatized at the N α ; or derivatized at the N ε and N α ; or at least protected at the N α and optionally at the N .δ .
摘要翻译：本发明涉及可用于用放射性金属三羰基标记生物分子的新型组氨酸衍生物。新衍生物具有在Nε处衍生的组氨酸，并且至少在Nα和任选在N 5处被保护; 或者在Nα处衍生并且至少在N和任选地在N'处被保护; 或者在Nε和Nα下衍生，并至少在N和任选地在N 5处被保护; 或在Nε衍生化; 或在Nα衍生化; 或在Nε和Nα衍生化; 或者至少在N'和任选地在N'保护。

5. 发明申请

WO2004027067A3 METHODS FOR INCREASING THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE FROM A HOST CELL 审中-公开
标题翻译：从主体细胞增加重组多肽的方法
公开(公告)号：WO2004027067A3
公开(公告)日：2004-08-19
申请号：PCT/DK0300609
申请日：2003-09-19
申请人： CYM1P AS , JOENSON LARS , REHFELD JENS F , JOHNSEN ANDERS H
发明人： JOENSON LARS , REHFELD JENS F , JOHNSEN ANDERS H
IPC分类号： C12N15/09 , C07K14/58 , C07K14/595 , C07K14/605 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/60 , C12N15/57 , C12P21/02
CPC分类号： C12N9/60 , C07K14/58 , C07K14/595 , C07K14/605 , C12P21/02
摘要： The present invention provides a host cell comprising a nucleic acid sequence encoding a recombinant polypeptide in which the production of a naturally occurring metalloprotease comprising the sequenc HXXEH has been reduced or inhibited by genetic manipulation. The present invention also relates to methods for enhancing the production of a polypeptide from a cell by disrupting the synthesis or activity of the metalloprotease. In particular, the present invention relates to methods for enhancing the secretion of recombinant polypeptides from host cells such as, but not limited to, yeast and bacterial cells. The metalloprotease is a member of the pitrilysin subfamily of proteases, characterized by comprising the sequence HXXEH, where X is any amino acid.
摘要翻译：本发明提供了一种宿主细胞，其包含编码重组多肽的核酸序列，其中通过遗传操作已经减少或抑制了包含序列HXXEH的天然存在的金属蛋白酶的产生。本发明还涉及通过破坏金属蛋白酶的合成或活性来增强细胞产生多肽的方法。特别地，本发明涉及用于增强重组多肽从宿主细胞分泌的方法，例如但不限于酵母和细菌细胞。金属蛋白酶是蛋白酶的丝氨蛋白亚家族的成员，其特征在于包含序列HXXEH，其中X是任何氨基酸。

6. 发明申请

WO00044400A1 TREATMENT FOR DIABETES 审中-公开
标题翻译：治疗糖尿病
公开(公告)号：WO00044400A1
公开(公告)日：2000-08-03
申请号：PCT/US1999/025463
申请日：1999-10-27
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61K48/00 , A61P3/10 , A61P5/48 , A61P43/00 , C07K14/495 , C07K14/595 , C12N5/02 , A61K35/39
CPC分类号： C07K14/495 , A61K38/2207 , A61K48/00 , C07K14/595 , Y10S514/866 , A61K38/1808 , A61K38/1841 , A61K2300/00
摘要： Methods and compositions for treating diabetes mellitus in a patient in need thereof are provided. The methods include administering to a patient a composition providing a gastrin/CCK receptor ligand, e.g., a gastrin, and/or an epidermal growth factor (EGF) receptor ligand, e.g., TGF- alpha , in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The composition can be administered systemically or expressed in situ by cells transgenically supplemented with one or both of a gastrin/CCK receptor ligand gene, e.g., a preprogastrin peptide precursor gene and an EGF receptor ligand gene, e.g., a TGF- alpha gene. The methods also include transplanting into a patient cultured pancreatic islets in which mature insulin-secreting beta cells are proliferated by exposure to a gastrin/CCK receptor ligand and an EGF receptor ligand.
摘要翻译：提供了在有需要的患者中治疗糖尿病的方法和组合物。所述方法包括向患者施用足以实现胰腺分化的量的组合物，其提供胃泌素/ CCK受体配体，例如胃泌素和/或表皮生长因子（EGF）受体配体，例如TGF-α 胰岛前体细胞成熟胰岛素分泌细胞。组合物可以全身施用或通过转基因补充胃泌素/ CCK受体配体基因例如前胃泌素肽前体基因和EGF受体配体基因例如TGF-α基因中的一个或两者的细胞原位表达。所述方法还包括移植到培养的胰岛中，其中成熟的胰岛素分泌型β细胞通过暴露于胃泌素/ CCK受体配体和EGF受体配体而增殖。

7. 发明申请

WO99065513A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HELICOBACTER PYLORI-ASSOCIATED DISORDERS 审中-公开
标题翻译：用于治疗幽门螺杆菌相关疾病的药物组合物
公开(公告)号：WO99065513A2
公开(公告)日：1999-12-23
申请号：PCT/IL1999/000335
申请日：1999-06-17
IPC分类号： A61K45/00 , A61K38/00 , A61K38/07 , A61K38/22 , A61K47/48 , A61P1/04 , A61P31/04 , A61P43/00 , C07K14/595
CPC分类号： B82Y5/00 , A61K38/07 , A61K38/2207 , A61K47/6898 , C07K14/595
摘要： The invention relates to pharmaceutical compositions and methods for treating and/or preventing Helicobacter pylori-associated disorders, particularly disorders of the gastrointestinal tract. The pharmaceutical compositions comprise as active ingredient a therapeutically effective amount of a compound which inhibits the growth-enhancing effect of gastrin on H. pylori. The active ingredient may specifically be a compound which is capable of inhibiting gastrin uptake by H. pylori, and/or which is an antagonist of the human or H. pylori gastrin receptor.
摘要翻译：本发明涉及用于治疗和/或预防幽门螺杆菌相关病症，特别是胃肠道疾病的药物组合物和方法。药物组合物包含治疗有效量的抑制胃泌素对幽门螺杆菌生长增强作用的化合物作为活性成分。活性成分可以具体地是能够抑制幽门螺杆菌胃泌素摄取的化合物和/或其是人或幽门螺杆菌胃泌素受体的拮抗剂。

8. 发明申请

WO1992001707A1 PURIFICATION DIRECTED CLONING OF PEPTIDES 审中-公开
标题翻译：纯化方向的克隆
公开(公告)号：WO1992001707A1
公开(公告)日：1992-02-06
申请号：PCT/US1991004511
申请日：1991-06-24
申请人： BIONEBRASKA, INC.
发明人： BIONEBRASKA, INC. , COOLIDGE, Thomas, R. , WAGNER, Fred , VAN HEEKE, Gino , SCHUSTER, Sheldon, M. , STOUT, Jay , WYLIE, Dwane, E.
IPC分类号： C07K03/28
CPC分类号： C12N9/14 , C07K7/14 , C07K14/245 , C07K14/47 , C07K14/585 , C07K14/595 , C07K2319/00 , C07K2319/50 , C07K2319/75 , C12N9/88 , C12N15/62
摘要： The present invention is directed to microbial and higher organism methods for expression and ligand immobilized affinity purification of a product peptide. The biological compositions of the invention which are produced by these methods include or are designed to express, a protein purification construct having three tandem, coupled segments composed of a binding protein, an interconnecting peptide and a variable fused polypeptide which incorporates the product peptide in one or more copies. According to the method of the invention, the following steps will allow production of the product peptide: (a) host cell or host organism expression regulated by the recombinant expression vector carrying the recombinant gene coding for the protein purification construct; (b) purification of the protein purification construct by a ligand immobilized affinity separation technique; and (c) enzymatic or chemical cleavage of the protein purification construct to produce the product peptide.
摘要翻译：本发明涉及用于产物肽的表达和配体固定化亲和纯化的微生物和更高有机体方法。通过这些方法产生的本发明的生物组合物包括或被设计为表达具有三个串联耦合区段的蛋白质纯化构建体，其由结合蛋白，互连肽和可变融合多肽组成，所述多肽与产物肽结合在一起或更多副本。根据本发明的方法，以下步骤将允许产生产物肽：（a）由携带编码蛋白纯化构建体的重组基因的重组表达载体调节的宿主细胞或宿主生物体表达; （b）通过配体固定化亲和分离技术纯化蛋白质纯化构建体; 和（c）蛋白质纯化构建体的酶促或化学切割以产生产物肽。

9. 发明申请

WO1991008225A1 HEXAPEPTIDES WITH SULPHATE ESTER GROUPS 审中-公开
标题翻译：具有硫酸钙组的下一步
公开(公告)号：WO1991008225A1
公开(公告)日：1991-06-13
申请号：PCT/US1990006739
申请日：1990-11-16
申请人： FISONS CORPORATION , ROSAMOND, James, Donald
发明人： FISONS CORPORATION
IPC分类号： C07K07/06
CPC分类号： C07K14/595 , A61K38/00 , C07K14/5955
摘要： Compounds of formula (I), wherein M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; G is Gly, DAla, Pro, Ala, beta Ala or Sar; W is Trp, MeTrp, Ala or Nal; X is Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys; J is Asp, DAsp, MeAsp, Ala or Asn; F is (S)-NH, (R)-NH, (S)-R N or (R)-R N; F is H, Cl, I, Br, F, NO2, NH2, R or OR ; Z is NH2, NHR or NR R ; R , R , R , R and R are C1 to 6 alkyl; and R is H or C1 to 6 alkyl, and pharmaceutically acceptable salts thereof, are new and useful as pharmaceuticals. In particular they are useful for the treatment of obesity and for stimulating contraction of the gall bladder.
摘要翻译：式（I）化合物，其中M为Met，DMet，MeMet，MetO，Ahx，DAhx，MeAhx，Leu，MeLeu，Pro，Ile，MeIle，Ala或Lys; G为Gly，DAla，Pro，Ala，βAla或Sar; W是Trp，MeTrp，Ala或Nal; X是Met，MeMet，MetO，Ahx，MeAhx，Leu，MeLeu，Pro，Ile，MeIle，Ala或Lys; J为Asp，DAsp，MeAsp，Ala或Asn; F 1是（S）-NH，（R）-NH，（S）-R 1 N或（R）-R 2 N; F 2是H，Cl，I，Br，F，NO 2，NH 2，R 3或OR 4; Z是NH 2，NHR 5或NR 5 R 6; R 1，R 2，R 3，R 5和R 6是C 1-6烷基; 和R 4是H或C 1-6烷基，及其药学上可接受的盐作为药物是新的和有用的。特别是它们可用于治疗肥胖症和刺激胆囊的收缩。

10. 发明申请

WO1990006937A1 DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS 审中-公开
标题翻译：作为CCK激素的衍生物的衍生物
公开(公告)号：WO1990006937A1
公开(公告)日：1990-06-28
申请号：PCT/US1989005673
申请日：1989-12-18
申请人： ABBOTT LABORATORIES , SHIOSAKI, Kazumi , NADZAN, Alex, M. , KOPECKA, Hana , SHUE, Youe-Kong
发明人： ABBOTT LABORATORIES
IPC分类号： C07K05/00
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0207 , C07K5/0215 , C07K5/0815 , C07K5/1016 , C07K5/1024 , C07K14/595
摘要： Tetrapeptide analogs are disclosed which possess CCK agonist activity.
摘要翻译：公开了具有CCK激动剂活性的四肽类似物。

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