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1. 发明申请

WO2009126668A2 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES 审中-公开
标题翻译：制备3-三氟甲基吡咯烷酮的方法
公开(公告)号：WO2009126668A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/039832
申请日：2009-04-08
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , ANNIS, Gary, David
发明人： ANNIS, Gary, David
IPC分类号： C07C45/68 , C07D261/04 , C07C45/74 , C07C49/80 , C07C25/13
CPC分类号： C07D261/04 , C07C17/35 , C07C25/13 , C07C45/455 , C07C45/70 , C07C49/80 , C07C49/813 , C07C67/343 , C07C205/45 , C07C209/74 , C07C231/12 , C07C231/14 , C07C235/84 , C07D213/40 , C07D231/12 , C07D231/14 , C07D231/16 , C07D249/08 , C07D249/10 , C07D277/28 , C07C69/94 , C07C69/76 , C07C211/56
摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M 1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR 11 or NR 12 R 13 , and R 11 , R 12 and R 13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
摘要翻译：公开了一种制备式1化合物的方法，其中Q和Z如本公开中所定义，包括从包含式2化合物，式3化合物，包含至少一种选自由式4的碱土金属氢氧化物组成的组，其中M是Ca，Sr或Ba，式4a的碱金属碳酸盐，其中M1是Li，Na或K，1,5-二氮杂双环[4.3.0]壬-5-烯和 1,8-二氮杂双环[5.4.0]十一碳-7-烯，以及能够与水形成低沸点共沸物的非质子传递溶剂。还公开了制备式2化合物的方法，其包括（1）形成反应混合物，该反应混合物包含衍生自在存在下使式5的化合物（其中X为Cl，Br或I）与镁金属或烷基卤化镁接触的格利雅试剂的醚溶剂，然后（2）使反应混合物与式6化合物（其中Y是OR 11或NR 12 R 13）和R 11，R 12和R 13如本公开中所定义。进一步公开的是制备式7化合物的方法，其中Q和Z如本公开内容所定义，使用式1化合物，其特征在于通过上述方法制备式1化合物或使用制备的式1化合物通过上述方法。

2. 发明申请

WO1998022448A1 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OXAZOLINE DERIVATIVES 审中-公开
标题翻译：用于制备氧杂环丁烷衍生物的方法和中间体
公开(公告)号：WO1998022448A1
公开(公告)日：1998-05-28
申请号：PCT/US1997020798
申请日：1997-11-13
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , ANNIS, Gary, David , SHAPIRO, Rafael
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D263/10
CPC分类号： C07D263/10 , C07C317/32 , C07C323/22 , C07C323/32 , C07C323/42
摘要： Arthropodicidal oxazoline derivatives and processes and intermediates for the preparation thereof are disclosed. The intermediates are racemic or enantiomerically enriched compounds having formula (I), wherein R and n are disclosed in the specification.
摘要翻译：公开了节肢动物杀虫恶唑啉衍生物及其制备方法和中间体。中间体是具有式（I）的外消旋或对映异构体富集的化合物，其中R和n在说明书中公开。

3. 发明申请

WO2004011453A2 METHOD FOR PREPARING 3-HALO-4,5-DIHYDRO-1H-PYRAZOLES 审中-公开
标题翻译：制备3-卤代-4,5-二氢-1H-吡唑的方法
公开(公告)号：WO2004011453A2
公开(公告)日：2004-02-05
申请号：PCT/US0323820
申请日：2003-07-29
申请人： DU PONT , ANNIS GARY DAVID
发明人： ANNIS GARY DAVID
IPC分类号： C07D231/06 , C07D231/08 , C07D401/04
CPC分类号： C07D231/08 , C07D231/06 , C07D401/04
摘要： This invention relates to a method for preparing 3-halo-4,5-dihydro-1H-pyrazole compound of Formula (I), comprising contacting with HX a different 4,5-dihydro-1H-pyrazole compound of Formula (II), wherein X is halogen and L, R, k and X are as defined in the disclosure. This invention also discloses preparation of compounds of Formula (III) wherein X , R , R , R , R , R , and n are as defined in the disclosure.
摘要翻译：本发明涉及制备式（I）的3-卤代-4,5-二氢-1H-吡唑化合物的方法，该方法包括使式（I）的不同的4,5-二氢-1H-吡唑化合物与HX 1接触， II）的化合物，其中X 1是卤素并且L，R 1，k和X 2如在本公开中所定义。本发明还公开了其中X 1，R 3，R 6，R 7，R 8a，R 8b和n如上文定义的式（III）披露。

4. 发明申请

WO2003016282A2 NOVEL SUBSTITUTED 1H-DIHYDROPYRAZOLES, THEIR PREPARATION AND USE 审中-公开
标题翻译：新型取代的1H-二氢吡咯烷酮，其制备和使用
公开(公告)号：WO2003016282A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/025612
申请日：2002-08-13
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , ANNIS, Gary, David , LAHM, George, Philip , SELBY, Thomas, Paul , STEVENSON, Thomas, Martin
发明人： ANNIS, Gary, David , LAHM, George, Philip , SELBY, Thomas, Paul , STEVENSON, Thomas, Martin
IPC分类号： C07D231/00
CPC分类号： C07D213/77 , A01N43/56 , C07C251/76 , C07C255/66 , C07D231/08 , C07D231/14 , C07D231/16 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14
摘要： This invention provides compounds of Formula (I), methods for their preparation and use for preparing compounds of Formula (II) wherein R 1 , R 2 , R 3 , R 5 , R 6 , X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula (III) wherein R 1 , R 2 , R 7 , R 8 , R 9 and n are as defined in the disclosure. This invention also pertains to certain compounds of Formula 4 and 6 used to prepare compounds of Formula (I), wherein R 1 , R 2 , R 5 , X and n are as defined in the disclosure.
摘要翻译：本发明提供式I化合物，其制备方法和用于制备式II化合物的方法，其中R 1，R 2，R 3，R 5，R 6，X和n是如本公开中所定义的。本发明还公开了式III化合物的制备，其中R 1，R 2，R 7，R 8，R 9，和n如本公开中所定义。本发明还涉及用于制备式I化合物的式4和6的某些化合物，其中R 1，R 2，R 5，X和n如本公开所定义。

5. 发明申请

WO1993019045A1 ARTHROPODICIDAL AMIDES 审中-公开
标题翻译：抗抑郁药
公开(公告)号：WO1993019045A1
公开(公告)日：1993-09-30
申请号：PCT/US1993002434
申请日：1993-03-18
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , AMOO, Victor, Ekow , ANNIS, Gary, David , MARCH, Robert, William, Jr.
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D207/20
CPC分类号： C07D273/04 , A01N43/52 , A01N47/38 , C07D207/20 , C07D235/02 , C07D253/10
摘要： Substituted amides, agricultural compositions containing them and a method to control arthropods in agronomic and nonagronomic environments, the amides having formula (I) wherein X is oxygen or sulfur and Q, G and Y are as defined in the text.
摘要翻译：取代的酰胺，含有它们的农业组合物和在农学和非农业环境中控制节肢动物的方法，具有式（I）的酰胺，其中X是氧或硫，Q，G和Y如文中所定义。

6. 发明申请

WO2009126668A3 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES 审中-公开
标题翻译：制备3-三氟甲基吡咯烷酮的方法
公开(公告)号：WO2009126668A3
公开(公告)日：2010-04-08
申请号：PCT/US2009039832
申请日：2009-04-08
申请人： DU PONT , ANNIS GARY DAVID
发明人： ANNIS GARY DAVID
IPC分类号： C07C45/68 , C07C25/13 , C07C45/74 , C07C49/80 , C07D261/04
CPC分类号： C07D261/04 , C07C17/35 , C07C25/13 , C07C45/455 , C07C45/70 , C07C49/80 , C07C49/813 , C07C67/343 , C07C205/45 , C07C209/74 , C07C231/12 , C07C231/14 , C07D213/40 , C07D231/12 , C07D231/14 , C07D231/16 , C07D249/08 , C07D249/10 , C07D277/28 , C07C69/94 , C07C69/76 , C07C235/84 , C07C211/56
摘要： Disclosed is a method for preparing a compound of Formula (1) wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula (2), a compound of Formula (3), a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula (4) wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula (4a) wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula (2) comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula (5) wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula (6) wherein Y is OR11 or NR12 R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula (7) wherein Q and Z are as defined in the disclosure, using a compound of Formula (1) characterized by preparing the compound of Formula (1) by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
摘要翻译：公开了制备式（1）化合物的方法，其中Q和Z如本公开所定义，包括从包含式（2）的化合物，式（3）的化合物，包含至少一种选自式（4）的碱土金属氢氧化物，其中M是Ca，Sr或Ba的式（4a）的碱金属碳酸盐，其中M1是Li，Na或K，1,5-二氮杂双环[ 4.3.0]壬-5-烯和1,8-二氮杂双环[5.4.0]十一碳-7-烯，以及能够与水形成低沸点共沸物的非质子溶剂。还公开了制备式（2）化合物的方法，其包括：（1）形成反应混合物，该反应混合物包含衍生自与其中X为Cl，Br或I的式（5）的化合物与镁金属或烷基镁卤化物，然后（2）使反应混合物与式（6）的化合物（其中Y是OR 11或NR 12 R 13）和R 11，R 12和R 13如本公开中所定义。进一步公开的是制备式（7）化合物的方法，其中Q和Z如本发明所定义，使用式（1）化合物，其特征在于通过上述方法制备式（1）化合物或使用通过上述方法制备的式1的化合物。

7. 发明申请

WO2009025983A4 METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES 审中-公开
标题翻译：制备5-羟基甲基-4,5-二氢异恶唑衍生物的方法
公开(公告)号：WO2009025983A4
公开(公告)日：2009-06-25
申请号：PCT/US2008072074
申请日：2008-08-04
申请人： DU PONT , ANNIS GARY DAVID , SMITH BRENTON TODD
发明人： ANNIS GARY DAVID , SMITH BRENTON TODD
IPC分类号： C07D261/04 , C07C49/235 , C07D413/10 , C07D413/12 , C07D417/12
CPC分类号： C07D261/04 , C07C45/65 , C07C45/68 , C07C45/72 , C07C49/813 , C07C49/83 , C07C49/835 , C07C49/84 , C07C65/38 , C07C69/007 , C07C201/12 , C07C205/45 , C07D413/10 , C07D413/12 , C07D417/12
摘要： Disclosed is a method for preparing a compound of Formula: (1); wherein R1 is CHX2, CX3, CX2CHX2 or CX2CX3; each X is independently Cl or F; Z is optionally substituted phenyl; and Q is phenyl or 1-naphthalenyl, each optionally substituted as defined in the disclosure; comprising contacting a compound of Formula: (2).
摘要翻译：公开了一种制备式（1）化合物的方法：其中R1是CHX2，CX3，CX2CHX2或CX2CX3; 每个X独立地为Cl或F; Z是任选取代的苯基; 且Q为苯基或1-萘基，各自如本公开所定义; 包括使式（2）的化合物接触。

8. 发明申请

WO02072540A3 IMPROVED METHODS OF ORTHO ALKYLATION 审中-公开
标题翻译：改进的正交烷化方法
公开(公告)号：WO02072540A3
公开(公告)日：2002-12-27
申请号：PCT/US0207880
申请日：2002-03-14
申请人： DU PONT , ANNIS GARY DAVID , BROWN RICHARD JAMES , CASALNUOVO ALBERT LOREN , JACOBSON STEPHEN ERNEST , MOSS PHILIP OSBORNE
发明人： ANNIS GARY DAVID , BROWN RICHARD JAMES , CASALNUOVO ALBERT LOREN , JACOBSON STEPHEN ERNEST , MOSS PHILIP OSBORNE
IPC分类号： C07C231/02 , C07B61/00 , C07C67/297 , C07C68/06 , C07C209/68 , C07C211/52 , C07C213/08 , C07C227/16 , C07C231/12 , C07C231/14 , C07C233/15 , C07C233/25 , C07C317/28 , C07C319/14 , C07C323/29 , C07C381/10 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/76 , C07C217/90
CPC分类号： C07D213/73 , C07C67/297 , C07C68/06 , C07C209/68 , C07C211/52 , C07C213/08 , C07C227/16 , C07C231/12 , C07C231/14 , C07C233/25 , C07C317/28 , C07C319/14 , C07C323/29 , C07C381/10 , C07D213/64 , C07D213/68 , C07D213/75 , C07D213/76 , C07C69/017 , C07C69/24 , C07C69/96 , C07C233/15 , C07C69/63 , C07C69/157 , C07C69/16
摘要： The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system wherein each ring or ring system is optionally substituted; R is H, C1 to C4 alkyl or CO2R ; R is H or C1 to C4 alkyl; and R is C1 to C4 alkyl; comprising hydrogenating a compound of Formula (II), wherein n is 0, 1 or 2 in the presence of a catalyst comprising palladium to form the compound of Formula (I). This invention further pertains to methods for preparing compounds of Formula (II) useful for preparing compounds of Formula (I). This invention also pertains to compounds used in these methods.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中A是O或N-L; 每个L独立地为H或酰基; K与两个连续的连接碳原子一起形成苯环，5-或6-元杂芳族环或芳族8-，9-或10-元稠合的碳双环或杂二环环系，其中每个环或环系为任选取代的; R 1是H，C 1 -C 4烷基或CO 2 R 3; R 2是H或C 1 -C 4烷基; 并且R 3是C 1至C 4烷基; 包括在包含钯的催化剂存在下氢化其中n为0,1或2的式（II）化合物以形成式（I）化合物。本发明还涉及制备可用于制备式（I）化合物的式（II）化合物的方法。本发明还涉及这些方法中使用的化合物。

9. 发明申请

WO2009025983A2 METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES 审中-公开
标题翻译：制备5-卤代烷基-4,5-二氢异恶唑衍生物的方法
公开(公告)号：WO2009025983A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/072074
申请日：2008-08-04
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , ANNIS, Gary, David , SMITH, Brenton, Todd
发明人： ANNIS, Gary, David , SMITH, Brenton, Todd
IPC分类号： C07D261/04 , C07D413/10
CPC分类号： C07D261/04 , C07C45/65 , C07C45/68 , C07C45/72 , C07C49/813 , C07C49/83 , C07C49/835 , C07C49/84 , C07C65/38 , C07C69/007 , C07C201/12 , C07C205/45 , C07D413/10 , C07D413/12 , C07D417/12
摘要： Disclosed is a method for preparing a compound of Formula: (1); wherein R 1 is CHX 2 , CX 3 , CX 2 CHX 2 or CX 2 CX 3 ; each X is independently Cl or F; Z is optionally substituted phenyl; and Q is phenyl or 1-naphthalenyl, each optionally substituted as defined in the disclosure; comprising contacting a compound of Formula: (2).
摘要翻译：公开了用于制备式（1）化合物的方法：其中R 1为CHX 2，CX 3，CX 2 CHX 2或 CX <子> 2 CX <子> 3 ; 每个X独立地为Cl或F; Z是任选取代的苯基; 并且Q是苯基或1-萘基，各自如本公开中所定义被任选取代; 包括使式（2）的化合物接触。

10. 发明申请

WO2009006061A3 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES 审中-公开
公开(公告)号：WO2009006061A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/067826
申请日：2008-06-23
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , ANNIS, Gary, David
发明人： ANNIS, Gary, David
IPC分类号： C07D231/14 , C07D401/04 , C07C253/14 , C07C255/58 , C07F15/04
摘要： Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula (4); wherein R 1 is NHR 3 or OR 4 ; R 2 is CH 3 or Cl; R 3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R 4 is H or C 1 -C 4 alkyl; and X is Br, Cl or I. Also disclosed is a method for preparing a compound of Formula (4 )comprising contacting a mixture of (i) at least one compound of Formula (9 )and (ii) at least one metal reducing agent with (iii) dichlorobis(triphenylphosphine)nickel, and further disclosed is a method for removing nickel impurities from a mixture thereof with compounds of Formula (1 )comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution, and additionally disclosed is a method for preparing a compound of Formula (5); wherein R 5, R 6, R 7 and Z are as defined in the disclosure, using a compound of Formula (1,) characterized by preparing the compound of Formula (1) by the method disclosed above.

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