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1. 发明申请

WO02072540A3 IMPROVED METHODS OF ORTHO ALKYLATION 审中-公开
标题翻译：改进的正交烷化方法
公开(公告)号：WO02072540A3
公开(公告)日：2002-12-27
申请号：PCT/US0207880
申请日：2002-03-14
申请人： DU PONT , ANNIS GARY DAVID , BROWN RICHARD JAMES , CASALNUOVO ALBERT LOREN , JACOBSON STEPHEN ERNEST , MOSS PHILIP OSBORNE
发明人： ANNIS GARY DAVID , BROWN RICHARD JAMES , CASALNUOVO ALBERT LOREN , JACOBSON STEPHEN ERNEST , MOSS PHILIP OSBORNE
IPC分类号： C07C231/02 , C07B61/00 , C07C67/297 , C07C68/06 , C07C209/68 , C07C211/52 , C07C213/08 , C07C227/16 , C07C231/12 , C07C231/14 , C07C233/15 , C07C233/25 , C07C317/28 , C07C319/14 , C07C323/29 , C07C381/10 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/76 , C07C217/90
CPC分类号： C07D213/73 , C07C67/297 , C07C68/06 , C07C209/68 , C07C211/52 , C07C213/08 , C07C227/16 , C07C231/12 , C07C231/14 , C07C233/25 , C07C317/28 , C07C319/14 , C07C323/29 , C07C381/10 , C07D213/64 , C07D213/68 , C07D213/75 , C07D213/76 , C07C69/017 , C07C69/24 , C07C69/96 , C07C233/15 , C07C69/63 , C07C69/157 , C07C69/16
摘要： The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system wherein each ring or ring system is optionally substituted; R is H, C1 to C4 alkyl or CO2R ; R is H or C1 to C4 alkyl; and R is C1 to C4 alkyl; comprising hydrogenating a compound of Formula (II), wherein n is 0, 1 or 2 in the presence of a catalyst comprising palladium to form the compound of Formula (I). This invention further pertains to methods for preparing compounds of Formula (II) useful for preparing compounds of Formula (I). This invention also pertains to compounds used in these methods.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中A是O或N-L; 每个L独立地为H或酰基; K与两个连续的连接碳原子一起形成苯环，5-或6-元杂芳族环或芳族8-，9-或10-元稠合的碳双环或杂二环环系，其中每个环或环系为任选取代的; R 1是H，C 1 -C 4烷基或CO 2 R 3; R 2是H或C 1 -C 4烷基; 并且R 3是C 1至C 4烷基; 包括在包含钯的催化剂存在下氢化其中n为0,1或2的式（II）化合物以形成式（I）化合物。本发明还涉及制备可用于制备式（I）化合物的式（II）化合物的方法。本发明还涉及这些方法中使用的化合物。

2. 发明申请

WO2011120076A1 PREVENTION AND TREATMENT OF CUTANEOUS LUPUS ERYTHEMATOSUS 审中-公开
标题翻译：预防和治疗溃疡性红斑狼疮
公开(公告)号：WO2011120076A1
公开(公告)日：2011-10-06
申请号：PCT/AU2011/000346
申请日：2011-03-25
申请人： CBIO LIMITED , ANDERS, Hans- Joachim , NAYLOR, Dean Jason , BROWN, Richard James , VAN HEUMEN, Walter Rene Antonius
发明人： ANDERS, Hans- Joachim , NAYLOR, Dean Jason , BROWN, Richard James , VAN HEUMEN, Walter Rene Antonius
IPC分类号： A61K38/16 , A61P37/00
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The present invention relates to a method for preventing or treating cutaneous lupus erythematosus in a subject, the method comprising administering a therapeutically effective amount of a chaperonin 10 (Cpn10) polypeptide to the subject.
摘要翻译：本发明涉及一种用于预防或治疗受试者的皮肤红斑狼疮的方法，所述方法包括向受试者施用治疗有效量的伴侣蛋白10（Cpn10）多肽。

3. 发明申请

WO9805652A3 Arthropodical and fungicidal cyclic amides 审中-公开
标题翻译：节肢动物和杀真菌环酰胺
公开(公告)号：WO9805652A3
公开(公告)日：1998-06-11
申请号：PCT/US9712809
申请日：1997-07-24
申请人： E I DE POUNT DE NEMOURS AND CO , BROWN RICHARD JAMES , CHAN DOMINIC MING-TAK , CLARK DAVID ALAN , DRUMM JOSEPH EUGENE III , KOETHER GERARD MICHAEL , MCCANN STEPHEN FREDERICK , RORER MORRIS PADGETT , SELBY THOMAS PAUL , WALKER MICHAEL PAUL
发明人： BROWN RICHARD JAMES , CHAN DOMINIC MING-TAK , CLARK DAVID ALAN , DRUMM JOSEPH EUGENE III , KOETHER GERARD MICHAEL , MCCANN STEPHEN FREDERICK , RORER MORRIS PADGETT , SELBY THOMAS PAUL , WALKER MICHAEL PAUL
IPC分类号： A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , A01N43/836 , A01N43/84 , C07D249/12 , C07D261/12 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07F7/08 , C07F7/18 , C07F7/30 , A01N43/74 , C07D413/10
CPC分类号： C07D401/04 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , C07D249/12 , C07D261/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07F7/0812 , C07F7/1856
摘要： Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides and arthropodicides, wherein A is O; S; N; NR ; or CR ; G is C or N; provided that when G is C, then A is O, S or NR and the floating double bond is attached to G; and when G is N, then A is N or CR and the floating double bond is attached to A; W is O; S; NH; N(C1-C6alkyl); or NO(C1-C6alkyl); X is OR ; S(O)mR ; or halogen; R is C1-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; or C2-C4alkoxycarbonyl; R is H; C1-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; C2-C4alkoxycarbonyl; hydroxy; C1-C2alkoxy; or acetyloxy; m is 0, 1 or 2; and E, R , Y, Z and R are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula (I). Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling arthropods which involves contacting the arthropods or their environment with an effective amount of a compound of formula (I).

4. 发明申请

WO1998005652A2 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES 审中-公开
标题翻译：抗坏血酸和杀真菌循环系统
公开(公告)号：WO1998005652A2
公开(公告)日：1998-02-12
申请号：PCT/US1997012809
申请日：1997-07-24
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BROWN, Richard, James , CHAN, Dominic, Ming-Tak , CLARK, David, Alan , DRUMM, Joseph, Eugene, III , KOETHER, Gerard, Michael , McCANN, Stephen, Frederick , RORER, Morris, Padgett , SELBY, Thomas, Paul , WALKER, Michael, Paul
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D249/12
CPC分类号： C07D401/04 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/82 , C07D249/12 , C07D261/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07F7/0812 , C07F7/1804
摘要： Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides and arthropodicides, wherein A is O; S; N; NR ; or CR ; G is C or N; provided that when G is C, then A is O, S or NR and the floating double bond is attached to G; and when G is N, then A is N or CR and the floating double bond is attached to A; W is O; S; NH; N(C1-C6alkyl); or NO(C1-C6alkyl); X is OR ; S(O)mR ; or halogen; R is C1-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; or C2-C4alkoxycarbonyl; R is H; C1-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; C2-C4alkoxycarbonyl; hydroxy; C1-C2alkoxy; or acetyloxy; m is 0, 1 or 2; and E, R , Y, Z and R are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula (I). Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling arthropods which involves contacting the arthropods or their environment with an effective amount of a compound of formula (I).
摘要翻译：公开了式（I）化合物及其N-氧化物和农业上合适的盐，其可用作杀真菌剂和杀节肢动物剂，其中A为O; S; N; NR <5>; 或CR <14>; G为C或N; 条件是当G为C时，A为O，S或NR 5，浮动双键连接至G; 当G为N时，A为N或CR 14，浮选双键连接至A; W是O; S; NH; N（C1-C6烷基）; 或NO（C 1 -C 6烷基）; X为OR 1; S（O）MR <1>; 或卤素; R 1是C 1 -C 6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6haloalkenyl; C2-C6炔基; C2-6卤代炔基; C3-C6环烷基; C2-C4alkylcarbonyl; 或C 2 -C 4烷氧基羰基; R 2是H; C1-C6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6haloalkenyl; C2-C6炔基; C2-6卤代炔基; C3-C6环烷基; C2-C4alkylcarbonyl; C2-C4烷氧基; 羟基; C1-C2烷氧基; 或乙酰氧基; m为0,1或2; 并且E，R 5，Y，Z和R 14如本公开所定义。还公开了含有式（I）化合物和控制由真菌植物病原体引起的植物病害的方法的组合物，其涉及施用有效量的式（I）的化合物。还公开了含有式（I）化合物和控制节肢动物的方法的组合物，其包括将节肢动物或其环境与有效量的式（I）化合物接触。

5. 发明申请

WO1997000612A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES 审中-公开
标题翻译：抗坏血酸和杀真菌循环系统
公开(公告)号：WO1997000612A1
公开(公告)日：1997-01-09
申请号：PCT/US1996010326
申请日：1996-06-13
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BROWN, Richard, James , CHAN, Dominic, Ming-Tak , HOWARD, Michael, Henry, Jr. , DANIEL, Dilon, Jancey , CLARK, David, Alan , SELBY, Thomas, Paul
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： A01N43/00
CPC分类号： C07D403/10 , A01N43/653 , A01N43/74 , A01N43/80 , A01N43/82 , A01N43/90 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： Uses of compounds of Formula (I), and their N-oxides and agriculturally suitable salts, as arthropodicides are disclosed, wherein E is an optionally substituted 1,2-phenylene, and optionally substituted naphthalene ring, or a ring system selected from certain 5 to 12-membered monocyclic and fused bicyclic aromatic heterocyclic ring systems as defined in the disclosure; A is O; S; N; NR ; or CR ; G is C or N; provided that when G is C, then A is O, S or NR and the floating double bond is attached to G; and when G is N, then A is N or CR and the floating double bond is attached to A; W is O; S; NH; N(C1-C6 alkyl); or NO(C1-C6 alkyl); X is H; OR ; S(O)mR ; halogen; C1-C6 alkyl; C1-C6 haloalkyl; C3-C6 cycloalkyl; cyano; NH2; NHR ; N(C1-C6 alkyl)R ; NH(C1-C6 alkoxy); or N(C1-C6 alkoxy)R ; R is H; C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 haloalkenyl; C2-C6 alkynyl; C2-C6 haloalkynyl; C3-C6 cycloalkyl; C2-C4 alkylcarbonyl; C2-C4 alkoxycarbonyl; hydroxy; C1-C2 alkoxy; or acetyloxy; R , R , Y, Z, R and m are as defined in the disclosure. Also diclosed are compounds and compositions of Formula (IA) as defined in the disclosure and their use as arthropodicides and fungicides, and compounds and compositions of Formula (IB) as defined in the disclosure and their use as arthropodicides and fungicides. Also disclosed are compounds of Formula (II) as defined in the disclosure which are useful as intermediates for the preparation of the fungicides and arthropodicides of this invention where Y is oxygen and E is 1,2-phenylene.
摘要翻译：公开了式（I）化合物及其N-氧化物和农业上合适的盐作为杀虫剂的用途，其中E是任选取代的1,2-亚苯基和任选取代的萘环，或选自某些5 至本文公开中定义的12元单环和稠合双环芳族杂环体系; A是O S; N; NR <5>; 或CR <14>; G为C或N; 条件是当G为C时，A为O，S或NR 5，浮动双键连接至G; 当G为N时，A为N或CR 14，浮选双键连接至A; W是O; S; NH; N（C 1 -C 6烷基）; 或NO（C 1 -C 6烷基）; X是H; OR <1>; S（O）MR <1>; 卤素; C1-C6烷基; C1-C6卤代烷基; C3-C6环烷基; 氰基; NH2; NHR <1>; N（C 1 -C 6烷基）R 1; NH（C 1 -C 6烷氧基）; 或N（C 1 -C 6烷氧基）R 1; R 2是H; C1-C6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6卤代烯基; C2-C6炔基; C 2 -C 6卤代炔基; C3-C6环烷基; C 2 -C 4烷基羰基; C 2 -C 4烷氧基羰基; 羟基; C1-C2烷氧基; 或乙酰氧基; R 1，R 5，Y，Z，R 14和m如本公开所定义。还包括的是本公开中定义的式（IA）化合物和组合物及其作为杀虫剂和杀真菌剂的用途，以及本公开中所定义的式（IB）的化合物和组合物及其作为杀节肢动物杀真菌剂的用途。还公开了本公开中定义的式（II）化合物，其可用作制备本发明的杀真菌剂和节肢动物剂的中间体，其中Y是氧，E是1,2-亚苯基。

6. 发明申请

WO1996036633A1 FUNGICIDAL CYCLIC AMIDES 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO1996036633A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006533
申请日：1996-05-08
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BROWN, Richard, James , DANIEL, Dilon, Jancey , FRASIER, Deborah, Ann , HOWARD, Michael, Henry, Jr. , KOETHER, Gerard, Michael , RORER, Morris, Padgett
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D405/04
CPC分类号： C07D401/04 , A01N43/653 , A01N43/82 , A01N55/00 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07F7/0812
摘要： Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides. In said formula, E is a ring system selected from certain 5- to 12-membered monocyclic and fused bicyclic aromatic heterocyclic ring systems, or an optionally substituted naphthalene ring as defined in the disclosure; A is O; S; N; NR ; or CR ; G is C or N; provided that when G is C, then A is O, S or NR and the floating double bond is attached to G; and when G is N, then A is N or CR and the floating double bond is attached to A; W is O; S; NH; N(C1-C6 alkyl); or NO(C1-C6 alkyl); X is OR ; S(O)mR ; or halogen; R is C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 haloalkenyl; C2-C6 alkynyl; C2-C6 haloalkynyl; C3-C6 cycloalkyl; C2-C4 alkylcarbonyl; or C2-C4 alkoxycarbonyl; R is H; C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 haloalkenyl; C2-C6 alkynyl; C2-C6 haloalkynyl; C3-C6 cycloalkyl; C2-C4 alkylcarbonyl; C2-C4 alkoxycarbonyl; hydroxy; C1-C2 alkoxy; or acetyloxy; R is H; C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 haloalkenyl; C2-C6 alkynyl; C2-C6 haloalkynyl; C3-C6 cycloalkyl; C2-C4 alkylcarbonyl; or C2-C4 alkoxycarbonyl; and Y, Z, R and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula (I).
摘要翻译：公开了式（I）化合物及其N-氧化物和农业上合适的盐，其可用作杀真菌剂。在所述式中，E是选自某些5-至12-元单环和稠合双环芳族杂环系统或本公开中所定义的任选取代的萘环的环系; A是O S; N; NR <5>; 或CR <14>; G为C或N; 条件是当G为C时，A为O，S或NR 5，浮动双键连接至G; 当G为N时，A为N或CR 14，浮选双键连接至A; W是O; S; NH; N（C 1 -C 6烷基）; 或NO（C 1 -C 6烷基）; X为OR 1; S（O）MR <1>; 或卤素; R 1是C 1 -C 6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6卤代烯基; C2-C6炔基; C 2 -C 6卤代炔基; C3-C6环烷基; C 2 -C 4烷基羰基; 或C 2 -C 4烷氧基羰基; R 2是H; C1-C6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6卤代烯基; C2-C6炔基; C 2 -C 6卤代炔基; C3-C6环烷基; C 2 -C 4烷基羰基; C 2 -C 4烷氧基羰基; 羟基; C1-C2烷氧基; 或乙酰氧基; R 5为H; C1-C6烷基; C1-C6卤代烷基; C2-C6烯基; C2-C6卤代烯基; C2-C6炔基; C 2 -C 6卤代炔基; C3-C6环烷基; C 2 -C 4烷基羰基; 或C 2 -C 4烷氧基羰基; 和Y，Z，R 14和m如本公开所定义。还公开了含有式（I）化合物的组合物和控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式（I）的化合物。

7. 发明申请

WO1996036229A1 FUNGICIDAL CYCLIC AMIDES 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO1996036229A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006507
申请日：1996-05-08
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , ANDREA, Tariq, Arthur , BROWN, Richard, James , COATS, Reed, Aaron , DANIEL, Dilon, Jancey , FRASIER, Deborah, Ann , HOWARD, Michael, Henry, Jr. , KOETHER, Gerard, Michael , RORER, Morris, Padgett , WALKER, Michael, Paul , XU, Simon, Lingqi , SELBY, Thomas, Paul
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： A01N43/653
CPC分类号： C07D257/04 , A01N43/56 , A01N43/653 , A01N43/713 , A01N47/24 , A01N55/00 , A01N55/02 , C07D231/32 , C07D249/12 , C07D249/14 , C07F7/081 , C07F7/0812 , C07F7/30 , A01N43/84 , A01N43/54 , A01N43/40 , A01N2300/00
摘要： Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides, wherein G is selected from the group (G-1), (G-2), (G-3), (G-4), and (G-5). A is N or CR ; B is O; S; or NR ; each W is independently O; S; NH; N(C1-C6 alkyl); or NO(C1-C6alkyl); X is H; C1-C6alkyl; C1-C6haloalkyl; C3-C6cycloalkyl; cyano; NH2; NHR ; N(C1-C6alkyl)R ; NH(C1-C6alkoxy); or N(C1-C6alkoxy)R ; and E, X , R , R , R , R , Y, and Z are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula (I).
摘要翻译：公开了式（I）化合物及其N-氧化物和农业上合适的盐，其可用作杀真菌剂，其中G选自（G-1），（G-2），（G-3），（G-4）和（G-5）。 A为N或CR 14; B是O S; 或NR 5; 每个W独立地为O; S; NH; N（C 1 -C 6烷基）; 或NO（C 1 -C 6烷基）; X为H; C1-C6烷基; C1-C6卤代烷基; C3-C6环烷基; 氰基; NH2; NHR <1>; N（C1-C6烷基）R <1>; NH（C1-C6烷氧基）; 或N（C 1 -C 6烷氧基）R 1; 并且E，X 1，R 1，R 2，R 5，R 14，Y和Z如本公开所定义。还公开了含有式（I）化合物和控制由真菌植物病原体引起的植物病害的方法的组合物，其涉及施用有效量的式（I）的化合物。

8. 发明申请

WO1992003050A1 FUNGICIDAL SULFONEOXIME ESTERS 审中-公开
标题翻译：杀真菌抗氧化剂
公开(公告)号：WO1992003050A1
公开(公告)日：1992-03-05
申请号：PCT/US1991005508
申请日：1991-08-08
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BROWN, Richard, James
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： A01N41/10
CPC分类号： A01N43/10 , A01N41/10 , A01N47/06 , A01N47/24 , A01N51/00 , C07C327/58 , C07C381/00 , C07D333/34 , C07D333/70
摘要： Fungicidally effective compounds of formula (I) are disclosed.
摘要翻译：公开了具有杀真菌效果的式（I）化合物。

9. 发明申请

WO2009124353A1 MODIFIED CPN10 AND PRR SIGNALLING 审中-公开
标题翻译：修改CPN10和PRR信号
公开(公告)号：WO2009124353A1
公开(公告)日：2009-10-15
申请号：PCT/AU2009/000444
申请日：2009-04-09
申请人： CBIO LIMITED , NAYLOR, Dean, Jason , BROWN, Richard, James , HOWARD, Christopher Bruce , DE BAKKER, Christopher John , WARD, Linda, Alisson , STOK, Jeanette, Elizabeth , JAMES, Andrew, Leigh , LAMBERT, Daniel, Scott , RALSTON, Keylie, Jane , VAN HEUMEN, Walter, Rene, Antonius
发明人： NAYLOR, Dean, Jason , BROWN, Richard, James , HOWARD, Christopher Bruce , DE BAKKER, Christopher John , WARD, Linda, Alisson , STOK, Jeanette, Elizabeth , JAMES, Andrew, Leigh , LAMBERT, Daniel, Scott , RALSTON, Keylie, Jane , VAN HEUMEN, Walter, Rene, Antonius
IPC分类号： C07K14/47 , A61K38/17 , A61P37/02
CPC分类号： C07K14/4715 , A61K38/00
摘要： The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
摘要翻译：本发明涉及与Ala Cpn10多肽相比具有增加的对PRR配体的亲和性的分离的Cpn10多肽。在另一个实施方案中，本发明还涉及修饰的伴侣蛋白10多肽，以及编码其的核酸以及包含这种多肽的组合物及其用途。

10. 发明申请

WO1996036615A1 FUNGICIDAL CYCLIC AMIDES 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO1996036615A1
公开(公告)日：1996-11-21
申请号：PCT/US1995005847
申请日：1995-05-16
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BROWN, Richard, James , SUN, King-Mo , FRASIER, Deborah, Ann
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C07D249/12
CPC分类号： C07D401/12 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/90 , C07D249/12 , C07D261/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Cyclic amides of formula (I) which are useful as fungicides, wherein: A is O; S; N; NR ; or CR ; G is C or N; W is O or S; X is OR , S(O)mR or halogen; R , R , and R are independently, in part, C1-C6 alkyl; Y is, in part, -O-; -S(O)n-; -CHR O-; -OCHR -; or -CHR O-N=C(R )-; Z is, in part, optionally substituted cycloalkyl, phenyl, pyridinyl, pyrimidinyl, or naphthyl; and R , R , R , R , R , m, and n are defined in the disclosure, are disclosed.
摘要翻译：可用作杀真菌剂的式（I）的环状酰胺，其中：A为O; S; N; NR <5>; 或CR <14>; G为C或N; W为O或S; X是OR 1，S（O）m R 1或卤素; R 1，R 2和R 5部分独立地为C 1 -C 6烷基; Y部分为-O-; -儿子-; -CHR <6> O-; -OCHR <6> - ; 或-CHR 6 O-N = C（R 7） - ; Z部分是任选取代的环烷基，苯基，吡啶基，嘧啶基或萘基; 在本公开中公开了R 3，R 4，R 6，R 7，R 14，m和n定义。

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