专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997023508A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1997023508A1
公开(公告)日：1997-07-03
申请号：PCT/DK1996000529
申请日：1996-12-16
申请人： NOVO NORDISK A/S , HANSEN, Thomas, Kruse , PESCHKE, Bernd , LAU, Jesper , LUNDT, Behrend, Friedrich , ANKERSEN, Michael , WATSON, Brett , MADSEN, Kjeld
发明人： NOVO NORDISK A/S
IPC分类号： C07K14/60
CPC分类号： C07D271/06 , A61K38/00 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Compounds of peptide mimetic nature having general formula (I), wherein a and b are independently 1 or 2, R and R are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups, are growth hormone secretagogous with improved bioavailability.
摘要翻译：具有通式（I）的肽模拟性质的化合物，其中a和b独立地为1或2，R 1和R 2独立地为H或C 1-6烷基，G和J独立地为芳族， D和E独立地是几个不同的组，是具有改善的生物利用度的具有促分泌素的生长激素。

2. 发明申请

WO2005049019A1 N-HETEROARYL INDOLE CARBOXAMIDES AND ANALOGUES THEREOF, FOR USE AS GLUCOKINASE ACTIVATORS IN THE TREATMENT OF DIABETES 审中-公开
标题翻译： N-羟基吲哚类化合物及其类似物，用作治疗糖尿病的糖尿病激活剂
公开(公告)号：WO2005049019A1
公开(公告)日：2005-06-02
申请号：PCT/DK2004/000814
申请日：2004-11-24
申请人： NOVO NORDISK A/S? , LAU, Jesper F? , VEDSØ, Per? , KODRA, János Tibor? , MURRAY, Anthony? , JEPPESEN, Lone? , ANKERSEN, Michael? , SUBRAMANIAN, Govindan? , MJALLI, Adnan M. M.? , ANDREWS, Robert Carl? , POLISETTI, Dharma Rao? , CHRISTEN, Daniel Peter?
发明人： LAU, Jesper F? , VEDSØ, Per? , KODRA, János Tibor? , MURRAY, Anthony? , JEPPESEN, Lone? , ANKERSEN, Michael? , SUBRAMANIAN, Govindan? , MJALLI, Adnan M. M.? , ANDREWS, Robert Carl? , POLISETTI, Dharma Rao? , CHRISTEN, Daniel Peter?
IPC分类号： A61K31/427
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要： This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial, such as diabetes. The compounds are of the general formula (I) wherein B is (X) and A is heteroaryl as defined in the claims.
摘要翻译：本发明涉及作为葡萄糖激酶活化剂的化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的，例如糖尿病。化合物具有通式（I），其中B是（X），A是权利要求中所定义的杂芳基。

3. 发明申请

WO2004002481A1 ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗剂的ARYL CARBONYL衍生物
公开(公告)号：WO2004002481A1
公开(公告)日：2004-01-08
申请号：PCT/DK2003/000449
申请日：2003-06-27
申请人： NOVO NORDISK A/S , POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LÓPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSØ, Per , MURRAY, Anthony , JEPPESEN, Lone
发明人： POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LÓPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSØ, Per , MURRAY, Anthony , JEPPESEN, Lone
IPC分类号： A61K31/433
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives of the general formula (I), which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.(Formul 1).
摘要翻译：本发明涉及通式（I）的芳基羰基衍生物，其是可用于治疗，治疗，控制或辅助治疗疾病的葡萄糖激酶的活化剂，其中葡萄糖激酶活性增加是有益的（Formul 1）。

4. 发明申请

WO2005066145A1 HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： HETEROARYL-UREAS及其作为GLUCOKINASE激活剂的用途
公开(公告)号：WO2005066145A1
公开(公告)日：2005-07-21
申请号：PCT/DK2005/000002
申请日：2005-01-06
申请人： NOVO NORDISK A/S , MURRAY, Anthony , LAU, Jesper , JEPPESEN, Lone , VEDSØ, Per , ANKERSEN, Michael , LUNDBECK, Jane, Marie , KRISTIANSEN, Marit , VALCARCE-LOPEZ, Maria Carmen , POLISETTI, Dharma, Rao , SUBRAMANIAN, Govindan , ANDREWS, Robert, Carl , CHRISTEN, Daniel, P. , COOPER, Jeremy, T. , SANTHOSH, Kalpathy, Chidambareswaran
发明人： MURRAY, Anthony , LAU, Jesper , JEPPESEN, Lone , VEDSØ, Per , ANKERSEN, Michael , LUNDBECK, Jane, Marie , KRISTIANSEN, Marit , VALCARCE-LOPEZ, Maria Carmen , POLISETTI, Dharma, Rao , SUBRAMANIAN, Govindan , ANDREWS, Robert, Carl , CHRISTEN, Daniel, P. , COOPER, Jeremy, T. , SANTHOSH, Kalpathy, Chidambareswaran
IPC分类号： C07D277/48
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/427 , A61K31/433 , C07D213/75 , C07D233/88 , C07D241/20 , C07D261/14 , C07D271/08 , C07D277/48 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R 1 and R 2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial .
摘要翻译：本发明涉及式（I）化合物，其中A是杂芳基，R 1和R 2都是环状残基，其是葡糖激酶的活化剂，因此可用于治疗，治疗，对照或疾病的辅助治疗，其中增加葡萄糖激酶活性是有益的。

5. 发明申请

WO1996024587A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1996024587A1
公开(公告)日：1996-08-15
申请号：PCT/DK1996000059
申请日：1996-02-06
申请人： NOVO NORDISK A/S , ANKERSEN, Michael
发明人： NOVO NORDISK A/S
IPC分类号： C07D215/08
CPC分类号： C07D215/08
摘要： There are disclosed novel compounds of general formula (I) which compounds of formula (I) promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the status of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such compounds of formula (I) as the active ingredient thereof, methods of stimulating the release of growth hormone as well as use of such compounds of formula (I) are also disclosed.
摘要翻译：公开了通式（I）的新化合物，式（I）化合物促进人和动物中生长激素的释放。该物质可用于促进食用动物的生长，使食用肉制品的生产更有效率，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身体状况。还公开了含有式（I）化合物作为其活性成分的生长促进组合物，刺激生长激素释放的方法以及使用式（I）化合物。

6. 发明申请

WO1996024580A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1996024580A1
公开(公告)日：1996-08-15
申请号：PCT/DK1996000058
申请日：1996-02-06
申请人： NOVO NORDISK A/S , ANKERSEN, Michael
发明人： NOVO NORDISK A/S
IPC分类号： C07C335/12
CPC分类号： C07D213/75 , C07C335/16 , C07D215/38 , C07D257/04 , C07D285/06
摘要： There are disclosed novel compounds of general formula (I) which compounds of formula (I) promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the status of those afflicted with a lack of a normal secretion of natural gowth hormone. Growth promoting compositions containing such compounds of formula (I) as the active ingredient thereof, methods of stimulating the release of growth hormone as well as use of such compounds of formula (I) are also disclosed.
摘要翻译：公开了通式（I）的新化合物，式（I）化合物促进人和动物中生长激素的释放。该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受天然高粱激素缺乏正常分泌感染的人的身体状况。还公开了含有式（I）化合物作为其活性成分的生长促进组合物，刺激生长激素释放的方法以及使用式（I）化合物。

7. 发明申请

WO1998003473A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1998003473A1
公开(公告)日：1998-01-29
申请号：PCT/DK1997000314
申请日：1997-07-17
申请人： NOVO NORDISK A/S , PESCHKE, Bernd , ANKERSEN, Michael , HANSEN, Thomas, Kruse , THOGERSEN, Henning
发明人： NOVO NORDISK A/S
IPC分类号： C07C237/16
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要： The present invention relates to novel compounds of general formula (I), pharmaceutical compositions containing them, a method of stimulating the release of growth hormone from the pituitary, a method for increasing the rate and extent of growth of animals to increase their milk and wool production, or for the treatment of ailments, and to use of the compounds for the preparation of medicaments.
摘要翻译：本发明涉及通式（I）的新化合物，含有它们的药物组合物，刺激生长激素从垂体释放的方法，增加动物生长速度和程度以增加其牛奶和羊毛的方法生产或治疗疾病，以及使用化合物制备药物。

8. 发明申请

WO1997043278A1 SOMATOSTATIN AGONISTS AND ANTAGONISTS 审中-公开
标题翻译： SOMATOSTATIN激素和拮抗剂
公开(公告)号：WO1997043278A1
公开(公告)日：1997-11-20
申请号：PCT/DK1997000222
申请日：1997-05-14
申请人： NOVO NORDISK A/S , ANKERSEN, Michael , STIDSEN, Carsten, Enggaard , ANDERSEN, Henrik, Sune
发明人： NOVO NORDISK A/S
IPC分类号： C07D401/12
CPC分类号： C07D213/74 , A61K31/4439 , A61K31/4709 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/12
摘要： The present invention relates to somatostatin ligands (Ia) or (Ib) which are useful for treating medical disorders related to binding to human somatostatin receptor subtypes, wherein X is =S, =O, =NH, =NCOPh or =N(CN), A is aryl optionally substituted with halogen, amino, hydroxy, nitro, C1-6-alkyl, C1-6-alkoxy or aryl, B is aryl optionally substituted with halogen, amino, hydroxy, C1-6-alkyl, C1-6-alkoxy or aryl, D is aryl, amino, optionally substituted with halogen, amino, hydroxy, C1-6-alkyl, C1-6-alkoxy or aryl, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及生长抑素配体（Ia）或（Ib），其可用于治疗与结合人生长抑素受体亚型相关的医学病症，其中X = S，= O，= NH，= NCOPh或= N（CN） A为任选被卤素，氨基，羟基，硝基，C 1-6 - 烷基，C 1-6 - 烷氧基或芳基取代的芳基，B为任选被卤素取代的芳基，氨基，羟基，C 1-6 - 烷基，C 1-6 - 烷氧基或芳基，D是芳基，任选被卤素，氨基，羟基，C 1-6 - 烷基，C 1-6 - 烷氧基或芳基取代的氨基或其药学上可接受的盐。

9. 发明申请

WO1996022997A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1996022997A1
公开(公告)日：1996-08-01
申请号：PCT/DK1996000045
申请日：1996-01-26
申请人： NOVO NORDISK A/S , LAU, Jesper , PESCHKE, Bernd , HANSEN, Thomas, Kruse , JOHANSEN, Nils, Langeland , ANKERSEN, Michael
发明人： NOVO NORDISK A/S
IPC分类号： C07K05/02
CPC分类号： C07D271/06 , A61K38/00 , C07C233/38 , C07C237/22 , C07C237/32 , C07C237/36 , C07D211/62 , C07D271/10 , C07D277/56 , C07D401/12 , C07D413/12 , C07D417/12 , C07K14/60
摘要： There are disclosed novel synthetic peptides of general formula (I), where the abbreviations A, B, D, E, F, G, J and m, n, p are further defined in the description. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient thereof, methods of stimulating the release of growth hormone as well as use of such compounds of formula (I) are also disclosed.
摘要翻译：公开了通式（I）的新型合成肽，其中缩写A，B，D，E，F，G，J和m，n，p在说明书中进一步定义。式（I）化合物促进人和动物中生长激素的释放。还公开了含有式（I）化合物作为其活性成分的生长促进组合物，刺激生长激素释放的方法以及使用式（I）化合物。

10. 发明申请

WO2005114180A3 FUNCTIONAL GHS-R ANTAGONISTS 审中-公开
标题翻译：功能性GHS-R拮抗剂
公开(公告)号：WO2005114180A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005052222
申请日：2005-05-13
申请人： NOVO NORDISK AS , ANDERSEN BIRGITTE , ANKERSEN MICHAEL , RAUN KIRSTEN
发明人： ANDERSEN BIRGITTE , ANKERSEN MICHAEL , RAUN KIRSTEN
IPC分类号： G01N33/50 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/4245 , G01N33/68 , G01N33/74
CPC分类号： C07D271/06 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/4245
摘要： Described herein is a new class of biologically active molecules which may be characterized as functional ghrelin receptor antagonists. These molecules are associated with an initial increase in ghrelin receptor-associated calcium release followed by a significantly attenuated amount of calcium release over a prolonged period (e.g., as compared to ghrelin), and may be associated with an ability to inhibit ghrelin-induced GHS-R-associated sustained calcium release. Methods of identifying such molecules, methods of using such molecules, and various other features and aspects also are provided.
摘要翻译：本文描述的是一类新的生物活性分子，其可以表征为功能性生长素释放肽受体拮抗剂。这些分子与生长素释放肽受体相关的钙释放的初始增加相关，随后在长时间内显着减少钙释放量（例如，与生长素释放肽相比），并且可能与抑制生长素释放肽诱导的GHS的能力有关 -R相关持续钙释放。还提供了鉴定这种分子的方法，使用这种分子的方法，以及各种其他特征和方面。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式