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1. 发明申请

WO2012052752A3 FLUID DISCRIMINATION APPARATUS AND METHOD 审中-公开
标题翻译：流体识别装置和方法
公开(公告)号：WO2012052752A3
公开(公告)日：2012-06-07
申请号：PCT/GB2011052014
申请日：2011-10-18
申请人： BERRY & CO PIPE FITTING SUPPLIES LTD D , WILLIAMS JACQUE , ANDERSON KEITH
发明人： WILLIAMS JACQUE , ANDERSON KEITH
IPC分类号： G01N33/28 , B67D7/34 , G01N21/41
CPC分类号： G01N21/4133 , G01N21/85 , G01N33/2829 , G01N2021/1774
摘要： In an aspect of the invention there is provided fluid discrimination apparatus comprising fluid inspection means, the fluid inspection means comprising a light source (111), a detector (113) and an optical element (121), the inspection means being operable to direct a beam of light from the source (111) through the optical element (121) to an inspection surface (125) of the optical element (121) and to detect by means of the detector (113) light scattered back through the optical element (121), the apparatus being operable to determine whether a fluid (135) in contact with the inspection surface (125) corresponds to a fluid having a prescribed refractive index characteristic responsive to light detected by the detector (113). The apparatus may be useful in applications in which liquid fuels are handled, and may be used for detecting a misfuelling event.
摘要翻译：在本发明的一个方面，提供了一种流体鉴别装置，包括流体检查装置，流体检查装置包括光源（111），检测器（113）和光学元件（121），检查装置可操作以引导光源（111）通过光学元件（121）到光学元件（121）的检查表面（125）的光束，并通过检测器（113）检测通过光学元件（121）散射的光），该装置可操作以确定与检查表面（125）接触的流体（135）是否对应于响应于由检测器（113）检测到的光的具有规定折射率特性的流体。该装置可用于处理液体燃料的应用中，并且可用于检测误食事件。

2. 发明申请

WO2012048043A1 METHODS OF MAKING L-ORNITHINE PHENYL ACETATE 审中-公开
标题翻译：制备L-对硝基苯甲酸酯的方法
公开(公告)号：WO2012048043A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054983
申请日：2011-10-05
申请人： OCERA THERAPEUTICS, INC. , ANDERSON, Keith, H. , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
发明人： ANDERSON, Keith, H. , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： C07C227/18 , C07C229/26 , C07C57/46 , A61K31/198 , A61K31/192 , A61P1/16
CPC分类号： C07C227/18 , A61K31/192 , A61K31/198 , C07C51/412 , C07C229/26 , C07C57/32
摘要： Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, intermixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ . The present application also relates to various compositions obtained from these processes, including crystalline forms.
摘要翻译：本文公开了制备L-鸟氨酸苯乙酸酯的方法。该方法可以包括例如将L-鸟氨酸的卤化物盐与醋酸苯酯混合。该方法还可以包括原位形成乙酸苯酯盐。本申请还涉及从这些方法获得的各种组合物，包括结晶形式。

3. 发明申请

WO2010115055A1 L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THEREOF 审中-公开
标题翻译： L-乙酸乙酯及其制备方法
公开(公告)号：WO2010115055A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029708
申请日：2010-04-01
申请人： OCERA THERAPEUTICS, INC. , ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
摘要翻译：本文公开了L-鸟氨酸苯乙酸酯的结晶形式及其制备方法。在一些实施方案中，结晶形式可以是I，II，III和V型，或其混合物。结晶形式可以配制用于治疗具有肝病的受试者，例如肝性脑病。因此，一些实施方案包括施用L-鸟氨酸苯基乙酸酯的制剂和方法。

4. 发明申请

WO2010144498A2 TREATMENT OF PORTAL HYPERTENSION AND RESTORATION OF LIVER FUNCTION USING L-ORNITHINE PHENYLACETATE 审中-公开
标题翻译：使用L-邻苯二甲酸酯处理门静脉高压和恢复肝功能
公开(公告)号：WO2010144498A2
公开(公告)日：2010-12-16
申请号：PCT/US2010037838
申请日：2010-06-08
申请人： UCL BUSINESS PLC , OCERA THERAPEUTICS INC , JALAN RAJIV , ANDERSON KEITH
发明人： JALAN RAJIV , ANDERSON KEITH
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P1/16 , A61P9/12
CPC分类号： A61K31/19 , A61K31/192 , A61K31/195
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate.
摘要翻译：本文公开了使用L-鸟氨酸苯乙酸酯治疗和/或预防门静脉高压和/或恢复肝功能的方法。

5. 发明申请

WO2007143519A1 SEPARATION AND/OR RECOVERY OF PROPYL BROMIDE 审中-公开
标题翻译：丙烯酰胺的分离和/或回收
公开(公告)号：WO2007143519A1
公开(公告)日：2007-12-13
申请号：PCT/US2007/070168
申请日：2007-06-01
申请人： ALBEMARLE CORPORATION , HARKINS, Alvin, E. , TORRES, James, E. , ANDERSON, Keith, G.
发明人： HARKINS, Alvin, E. , TORRES, James, E. , ANDERSON, Keith, G.
IPC分类号： C07C17/38
CPC分类号： C07C17/38 , C07C17/08 , C07C17/383 , C07C19/075
摘要： Described is a process for separating an organic phase comprising mainly propyl bromide from a crude reaction mixture formed by free-radical catalyzed hydrobromination of propylene with hydrogen bromide. The process comprises (A) feeding cold water into an upper or mid- portion of a packed column; (B) concurrently feeding the crude reaction mixture into an upper portion and/or mid-portion of the column so that the water contacts the crude reaction mixture; to form a mixture of (i) an acidic aqueous phase comprising aqueous hydrogen bromide and (ii) an organic phase comprising propyl bromide; (C) withdrawing the resultant phases from said column, at a rate comparable to the feeds being made into the column; and (D) separating the phases to form an upper acidic aqueous phase comprising aqueous hydrogen bromide superposed on a lower liquid organic phase comprising propyl bromide, and separating these upper and lower phases from each other.
摘要翻译：描述了从由丙烯与溴化氢的自由基催化氢溴酸形成的粗反应混合物中分离主要包含丙基溴的有机相的方法。该方法包括（A）将冷水送入填充塔的上部或中部; （B）同时将粗反应混合物进料到塔的上部和/或中间部分，使得水接触粗反应混合物; 以形成（i）包含溴化氢水溶液的酸性水相和（ii）包含丙基溴的有机相的混合物; （C）以与进料塔进料相当的速率从所述塔中取出所得相; 和（D）分离相以形成上层酸性水相，其包含叠加在包含丙基溴的下部液体有机相上的溴化氢水溶液，并将这些上部和下部相分离。

6. 发明申请

WO2007073526A3 UNIT DOSE FLEXIBLE CONTAINER 审中-公开
公开(公告)号：WO2007073526A3
公开(公告)日：2007-06-28
申请号：PCT/US2006/061157
申请日：2006-11-21
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , BACKES, Larry, P. , ANDERSON, Keith, M.
发明人： BACKES, Larry, P. , ANDERSON, Keith, M.
IPC分类号： B65D75/58 , B65D81/32
摘要： A pliable single use liquid container and dispensing device for delivery of liquids across a broad range of viscosities is provided with the container being formed of opposed pliable sheets (3, 5), a first seal (7) joining the first and second sheets (3, 5) and partially defining a liquid-containing chamber (9), a second seal (13) joining the first and second sheets and partially defining a pressure relieving chamber (15) adjacent to the liquid-containing chamber (9), a boundary seal (17) joining the first and second sheets (3, 5) between the liquid containing chamber (9) and the pressure relieving chamber (15), the boundary seal (17) being lighter than the first and second seals (7, 13) so that upon application of pressure to the liquid in the liquid-containing chamber (9) the fluid transfer region seal opens to permit the liquid to flow from the liquid-containing chamber into the pressure relieving chamber (15), a sealed outlet (27) adapted for fluid communication with the pressure relieving chamber for flow of the liquid from the pressure relieving chamber (15), the outlet seal (33) being adapted to open upon application of fluid pressure from the pressure relieving chamber (15) for dispensing the liquid from liquid container and prevent spilling and splashing of the liquid prior to delivery.

7. 发明申请

WO2005112346A2 NETWORK TOPOLOGY DISCOVERY 审中-公开
标题翻译：网络拓扑发现
公开(公告)号：WO2005112346A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/013818
申请日：2005-04-21
申请人： RAPISTAN SYSTEMS ADVERTISING CORP. , ANDERSON, Keith W. , WEICHHOLD, Peter , SIMON, Christopher S.
发明人： ANDERSON, Keith W. , WEICHHOLD, Peter , SIMON, Christopher S.
IPC分类号： H04L12/24
CPC分类号： H04L29/12952 , H04L29/12009 , H04L29/12783 , H04L41/0213 , H04L41/12 , H04L61/35 , H04L61/6077
摘要： A method of assigning device identification in a switched network, and the resulting switched network, includes designing a network having a design topology made up of network devices, constructing a network from the designed network and discovering the actual topology of the constructed network. The discovered topology is compared with the design topology to assign identifications to network devices of the constructed network.
摘要翻译：一种在交换网络中分配设备识别的方法，以及所形成的交换网络，包括设计具有由网络设备构成的设计拓扑的网络，从所设计的网络构建网络并发现所构建的网络的实际拓扑。将发现的拓扑与设计拓扑进行比较，为构建的网络的网络设备分配标识。

8. 发明申请

WO2016099709A1 POWERED LAVAGE HANDLE AND ASSOCIATED USE THEREFORE 审中-公开
标题翻译：动力拖车手柄及相关用途
公开(公告)号：WO2016099709A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/059780
申请日：2015-11-09
申请人： DOERR, Daniel Glenn , STRELITZKI, Roland , BARAKAT, Mohammed Ali , ANDERSON, Keith , HABERLAND, Gary Wayne , FARNELLA, John A. , ROGER, Kenneth M.
发明人： DOERR, Daniel Glenn , STRELITZKI, Roland , BARAKAT, Mohammed Ali , ANDERSON, Keith , HABERLAND, Gary Wayne , FARNELLA, John A. , ROGER, Kenneth M.
IPC分类号： A61M1/00 , A61M3/02
CPC分类号： A61M1/0064 , A61M1/0035 , A61M3/0283
摘要： A lavage handle for facilitating at least one of an irrigation function and a suctioning function at a target zone preferably includes a portable body, a power-operated fluid-displacing mechanism in communication with said body wherein said fluid-displacing mechanism has one of a first operating mode for inducing outward irrigation of fluid towards the target zone and a second operating mode for inducing inward suction of fluid from the target zone. An actuation mechanism is located at said body and operable communicated with said fluid-displacing mechanism such that said fluid-displacing mechanism is selectively operated in at least one of said first operating mode and said second operating mode. The actuation mechanism may include an irrigation-inducing mechanism and/or a suction-inducing mechanism.
摘要翻译：用于促进目标区域的冲洗功能和抽吸功能中的至少一个的冲洗手柄优选地包括便携式主体，与所述主体连通的动力操作的流体移动机构，其中所述流体移位机构具有第一用于诱导流体朝向目标区域的向外冲洗的操作模式和用于引导来自目标区域的流体的向内抽吸的第二操作模式。致动机构位于所述主体处，并与所述流体移动机构可操作地连通，使得所述流体移动机构选择性地以所述第一操作模式和所述第二操作模式中的至少一个操作。致动机构可以包括冲洗诱导机构和/或吸引诱导机构。

9. 发明申请

WO2010008568A1 TM4SF4 AND MODULATORS THEREOF AND METHODS FOR THEIR USE 审中-公开
标题翻译： TM4SF4及其调制器及其使用方法
公开(公告)号：WO2010008568A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/004121
申请日：2009-07-15
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , SUSSEL, Lori , ANDERSON, Keith, Robert
发明人： SUSSEL, Lori , ANDERSON, Keith, Robert
IPC分类号： A61K48/00 , C12N5/00
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/3233
摘要： The present invention relates to methods for modulating a β-cell population using a TM4SF4 modulator or a modulator of a TM4SF4 homolog. More particularly, the invention relates, inter alia, to methods and compositions for generating, expanding, and maintaining a β-cell population and treatment of diseases associated with the loss of β-cells using a TM4SF4 modulator or a modulator of a TM4SF4 homolog.
摘要翻译：本发明涉及使用TM4SF4调节剂或TM4SF4同源物的调节剂调节β细胞群体的方法。更具体地，本发明特别涉及用于产生，扩增和维持β细胞群体并使用TM4SF4调节剂或TM4SF4同源物的调节剂治疗与β细胞丧失相关的疾病的方法和组合物。

10. 发明申请

WO2007073526A2 UNIT DOSE FLEXIBLE CONTAINER 审中-公开
标题翻译：单位软管灵活容器
公开(公告)号：WO2007073526A2
公开(公告)日：2007-06-28
申请号：PCT/US2006061157
申请日：2006-11-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA , BACKES LARRY P , ANDERSON KEITH M
发明人： BACKES LARRY P , ANDERSON KEITH M
IPC分类号： B65D75/58 , B65D81/32
CPC分类号： B65D75/30 , B65D1/095 , B65D75/58 , B65D75/5855 , B65D75/5866 , B65D81/3266
摘要： A pliable single use liquid container and dispensing device for delivery of a precise amount of orally administered liquids across a broad range of viscosities is provide with the container being formed of generally opposed pliable sheets, a first seal joining the first and second pliable sheets and partially defining a liquid-containing chamber, a second seal joining the first and second pliable sheets and partially defining a pressure relieving chamber adjacent to the liquid-containing chamber, a boundary seal joining the first and second pliable sheets between the liquid containing chamber and the pressure relieving chamber, a precisely measured single dose volume of fluent liquid disposed within the liquid containing chamber, the boundary seal being lighter than the first and second seals so that upon application of pressure to the liquid in the liquid-containing chamber the fluid transfer region seal opens to permit the liquid to flow from the liquid- containing chamber into the pressure relieving chamber, a sealed outlet adapted for fluid communication with the pressure relieving chamber for flow of the liquid from the pressure relieving chamber out of the liquid container and sized based on the viscosity of the liquid and the geometry of the dispensing device, the outlet seal adapted to open upon application of fluid pressure from liquid in the pressure relieving chamber for dispensing the liquid from the liquid container and prevent spilling and splashing of the liquid prior to delivery, control the delivery rate of the liquid to the recipient, and provide tactile force flow rate information feedback to the administrator.
摘要翻译：提供一种用于在宽范围的粘度下递送精确量的经口施用的液体的柔韧的一次性液体容器和分配装置，其中容器由大致相对的柔韧片形成，第一密封接合第一和第二柔韧片，限定液体容纳室，第二密封件，其接合所述第一和第二柔性片材并且部分地限定邻近所述液体容纳室的减压室;边界密封件，其将所述第一和第二柔性片材在所述液体容纳室和所述压力容器泄放室，设置在液体容纳室内的精确测量的单剂量体积的流体液体，边界密封件比第一和第二密封件轻，使得当对液体容纳室中的液体施加压力时，流体传送区域密封打开以允许液体从含液体室流入p 一个密封出口，适合于与减压室流体连通的密封出口，用于使液体从压力释放室流出液体容器，并基于液体的粘度和分配装置的几何形状来定尺寸，出口密封件适于在压力释放室中的液体施加流体压力时打开，用于从液体容器分配液体，并防止在输送之前液体溢出和飞溅，控制液体向接收器的传送速率，并提供触觉强制流量信息反馈给管理员。

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