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1. 发明申请

WO2009117112A2 POWDER DISPERSION APPARATUS, METHOD OF MAKING AND USING THE APPARATUS, COMPONENTS THAT CAN BE USED ON THE APPARATUS AND OTHER DEVICES, AND VARIOUS ACTIVE AGENTS 审中-公开
标题翻译：粉末分散装置，制造和使用装置的方法，可用于装置和其他装置的组件以及各种活性剂
公开(公告)号：WO2009117112A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/001716
申请日：2009-03-18
申请人： NOVARTIS AG , GLUSKER, Mark , ALSTON, William, W. , AXFORD, George, S. , PALMER-FELGATE, John , WILKINS, Jonathan , FOSS, Willard, R. , RAO, Nagaraja , POSTICH, Mark , PAKALA, Neeraj R. , MALTZ, David S. , WEERS, Jeffry G. , COHEN, Gal , UNG, Keith Try
发明人： GLUSKER, Mark , ALSTON, William, W. , AXFORD, George, S. , PALMER-FELGATE, John , WILKINS, Jonathan , FOSS, Willard, R. , RAO, Nagaraja , POSTICH, Mark , PAKALA, Neeraj R. , MALTZ, David S. , WEERS, Jeffry G. , COHEN, Gal , UNG, Keith Try
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0035 , A61M15/0038 , A61M15/0041 , A61M2202/064
摘要： Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
摘要翻译：用于肺部输送组合物的方法和装置，例如用于分散用于吸入患者的干粉药物的方法和装置。装置的元件或方面，包括插座穿孔机构，去电装置，插座冲击装置以及插座锁定装置或系统。

2. 发明申请

WO2003000329A2 FLOW REGULATOR FOR AEROSOL DRUG DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：流量调节器用于气雾剂递送装置和方法
公开(公告)号：WO2003000329A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/019388
申请日：2002-06-18
申请人： INHALE THERAPEUTIC SYSTEMS, INC. , ALSTON, William , SMEULDERS, Stephen
发明人： ALSTON, William , SMEULDERS, Stephen
IPC分类号： A61M16/20
CPC分类号： G05D7/012 , A61M15/0015 , A61M15/002 , A61M15/0091 , A61M15/0093 , A61M16/208 , A61M39/228 , A61M2039/2413 , A61M2202/064 , A61M2202/30 , F16K15/147
摘要： An aerosolization device comprises a housing having a mouthpiece, and a flow path arrangement in fluid communication with the mouthpiece. The flow path arrangement has a flow regulating valve and a threshold valve, where the threshold valve is configured to open at a first vacuum level and to close at a second vacuum level that is less than the first vacuum level. The housing includes a region that is adapted to hold a powder in fluid communication with the flow path arrangement so that air drawn through the mouthpiece opens the threshold valve once the first vacuum level is exceeded and remains open until the vacuum falls below the second vacuum level. The flow rate of the air drawn through the mouthpiece is regulated by the flow regulating valve to remain within a certain range while the threshold valve remains open.
摘要翻译：雾化装置包括具有吸嘴的壳体以及与吸嘴流体连通的流路装置。流动路径装置具有流量调节阀和阈值阀，其中阈值阀配置成在第一真空度下打开并且在小于第一真空度的第二真空度下关闭。壳体包括适于保持与流动路径装置流体连通的粉末的区域，使得一旦超过第一真空水平，通过吸嘴吸入的空气打开阈值阀门并保持打开，直到真空降至第二真空水平以下。通过吸嘴吸入的空气的流速由流量调节阀调节，以保持阈值阀保持打开的一定范围内。

3. 发明申请

WO2009117112A3 POWDER DISPERSION APPARATU 审中-公开
标题翻译：粉末分散装置
公开(公告)号：WO2009117112A3
公开(公告)日：2010-04-22
申请号：PCT/US2009001716
申请日：2009-03-18
申请人： NOVARTIS AG , GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAJ R , MALTZ DAVID S , WEERS JEFFRY G , COHEN GAL , UNG KEITH TRY
发明人： GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAJ R , MALTZ DAVID S , WEERS JEFFRY G , COHEN GAL , UNG KEITH TRY
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0035 , A61M15/0038 , A61M15/0041 , A61M2202/064
摘要： Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms (H), deoccluding devices (G), receptacle impacting devices (N), and receptacle lock devices (M) or systems.
摘要翻译：用于肺部输送组合物的方法和装置，例如用于分散用于吸入患者的干粉药物的方法和装置。装置的元件或方面，包括插座穿孔机构（H），去电装置（G），插座冲击装置（N）和插座锁定装置（M）或系统。

4. 发明申请

WO2008051621A2 POWDER DISPERSION APPARATUS, METHOD OF MAKING AND USING THE APPARATUS, AND COMPONENTS THAT CAN BE USED ON THE APPARATUS AND OTHER DEVICES 审中-公开
标题翻译：粉末扩散装置，制造和使用该装置的方法以及可用于该装置和其他装置的部件
公开(公告)号：WO2008051621A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022830
申请日：2007-10-25
申请人： NEKTAR THERAPEUTICS , GLUSKER, Mark , ALSTON, William, W. , AXFORD, George, S. , PALMER-FELGATE, John , WILKINS, Jonathan , FOSS, Willard, R. , RAO, Nagaraja , POSTICH, Mark , PAKALA, Neeraf, R. , MALTZ, David, S. , UNG, Keith
发明人： GLUSKER, Mark , ALSTON, William, W. , AXFORD, George, S. , PALMER-FELGATE, John , WILKINS, Jonathan , FOSS, Willard, R. , RAO, Nagaraja , POSTICH, Mark , PAKALA, Neeraf, R. , MALTZ, David, S. , UNG, Keith
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0036 , A61M15/0041 , A61M15/0048 , A61M15/0051 , A61M15/0081 , A61M15/0093 , A61M15/0096 , A61M2016/0015 , A61M2202/064 , A61M2205/43 , A61M2205/581 , A61M2205/582
摘要： Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
摘要翻译：用于肺部递送组合物的方法和设备，例如用于分散干粉药物以供患者吸入的方法和设备。装置的元件或方面，包括插座穿刺机构，去阻挡装置，插座撞击装置和插座锁装置或系统。

5. 发明申请

WO2005048982A3 EFFICIENT INTRODUCTION OF AN AEROSOL INTO A VENTILATOR CIRCUIT 审中-公开
标题翻译：空气动力学导入电磁阀电路的有效介绍
公开(公告)号：WO2005048982A3
公开(公告)日：2005-07-28
申请号：PCT/US2004038503
申请日：2004-11-17
申请人： NEKTAR THERAPEUTICS , ALSTON WILLIAM W , DWIVEDI SARAVAJNA K , TUCKER GUY V
发明人： ALSTON WILLIAM W , DWIVEDI SARAVAJNA K , TUCKER GUY V
IPC分类号： A61K9/12 , A61K31/7036 , A61K38/14 , A61M11/00 , A61M15/00 , A61M16/00 , A61M16/08 , A61M16/14 , A61M16/20 , A62B9/02 , B05B12/02
CPC分类号： A61M11/00 , A61K31/7036 , A61M11/005 , A61M15/00 , A61M16/0009 , A61M16/08 , A61M16/0816 , A61M16/0825 , A61M16/0833 , A61M16/14 , A61M16/147 , A61M16/20 , A61M16/204 , A61M16/208 , A61M2016/0036
摘要： An aerosol introducer is provided for introducing an aerosolized pharmaceutical formulation into a ventilator circuit. The ventilator circuit comprises an endotracheal tube, an inhalation line extending from a ventilator, and an exhalation line extending from the ventilator. The aerosol introducer comprises a first end connectable to the inhalation line and the exhalation line; a second end connectable to the endotracheal tube; a first channel extending from the first end to the second end; a second channel extending from the first end to the second end; an inlet in the first channel, the inlet being adapted to receive an aerosolized pharmaceutical formulation; and a valving mechanism comprising one or more valves that reduce the loss of aerosolized pharmaceutical formulation to the exhalation line.
摘要翻译：提供了一种气溶胶导引器，用于将雾化的药物制剂引入呼吸机回路中。呼吸机回路包括气管插管，从呼吸机延伸的吸入管和从呼吸机延伸的呼气管。气溶胶导引器包括可连接到吸入管线和呼气管线的第一端口; 可连接到气管内管的第二端; 从第一端延伸到第二端的第一通道; 从所述第一端延伸到所述第二端的第二通道; 第一通道中的入口，入口适于接收雾化的药物制剂; 以及阀机构，其包括一个或多个阀，其减少雾化药物制剂对呼气管线的损失。

6. 发明申请

WO2004041340A3 INCREASED DOSAGE METERED DOSE INHALER 审中-公开
标题翻译：增加剂量计量剂吸入剂
公开(公告)号：WO2004041340A3
公开(公告)日：2005-02-24
申请号：PCT/US0334473
申请日：2003-10-30
申请人： NEKTAR THERAPEUTICS , SCHULER CARLOS , CLARK ANDREW R , WALSH KEVIN R , ALSTON WILLIAM
发明人： SCHULER CARLOS , CLARK ANDREW R , WALSH KEVIN R , ALSTON WILLIAM
IPC分类号： A61M15/00 , B65D83/14 , B65D83/52
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus (100) comprises a container (105) containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus (100) further comprises a metering chamber (130) in communication with the container (105), the metering chambe (130) adapted to hold a metered amount of the pharmaceutical formulation, a valve (140) to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber (130) when the valve (140) is actuated, and a pressurizer (165) that applies pressure to the pharmaceutical formulation in the metering chamber (130) while the pharmaceutical formulation is being released from the metering chamber (130). In one version, the metering chamber (130) is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译：雾化装置（100）包括容纳药物制剂的容器（105），所述药物制剂包含活性剂和推进剂。雾化装置（100）还包括与容器（105）连通的计量腔室（130），计量腔体（130）适于容纳计量的药物制剂，阀（140）允许计量量所述药物制剂在所述阀（140）被致动时从所述计量室（130）释放;以及加压器（165），其在所述药物制剂被释放时向所述计量室（130）中的药物制剂施加压力从计量室（130）。在一个版本中，计量室（130）的尺寸使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

7. 发明申请

WO1996002924A1 SINGLE AND MULTI-LAYER VARIABLE VOLTAGE PROTECTION DEVICES AND METHODS OF MAKING SAME 审中-公开
标题翻译：单层和多层可变电压保护装置及其制造方法
公开(公告)号：WO1996002924A1
公开(公告)日：1996-02-01
申请号：PCT/US1995008808
申请日：1995-07-14
申请人： ORYX TECHNOLOGY CORPORATION , SHRIER, Karen, P. , BEHLING, Gerald, R. , INTRATER, James, B. , JOSHI, Kailash, C. , ALSTON, William, W., Jr.
发明人： ORYX TECHNOLOGY CORPORATION
IPC分类号： H01C07/10
CPC分类号： H01C7/10 , H01C7/105 , H01C7/12
摘要： Disclosed is a variable voltage protection device for electronic devices which in one aspect comprises a thin layer of neat dielectric polymer, glass or ceramic (12) positioned between a ground plane (14) and an electrical conductor (10) for overvoltage protection, wherein the neat polymer, glass or ceramic layer does not include the presence of conductive or semiconductive particles. Also disclosed is the combination of the neat dielectric polymer, glass or ceramic thin layer (12) positioned on a conventional variable voltage protection material (13) comprising a binder containing conductive, semiconductive or insulative particles. A multi-layer variable voltage protection component is disclosed comprising three layers of overvoltage protection material (15, 16, 17) wherein the outer two layers contain a lower percentage of conductive, semiconductive and/or insulative particles and wherein the inner layer contains a higher percentage of conductive, semiconductive and/or insulative particles. The multi-layer component can optionally be used in combination with the neat dielectric polymer, glass or ceramic layer (12, 12') and can optionally have interposed metal layers (18, 18'). A method is disclosed for dispersing colloidal insulative particles and conductive, semiconductive and/or insulative particles using a volatile solvent for dispersement of the colloidal insulative particles and the conductive, semiconductive or insulative particles before mixing the resultant particles with the binder.
摘要翻译：公开了一种用于电子设备的可变电压保护装置，其一方面包括位于接地平面（14）和电导体（10）之间的纯电介质聚合物薄层，玻璃或陶瓷（12），用于过电压保护，其中纯聚合物，玻璃或陶瓷层不包括导电或半导体颗粒的存在。还公开了位于常规可变电压保护材料（13）上的纯介电聚合物，玻璃或陶瓷薄层（12）的组合，其包含含有导电，半导电或绝缘颗粒的粘合剂。公开了一种多层可变电压保护组件，其包括三层过电压保护材料（15,16,17），其中外两层含有较低百分比的导电，半导电和/或绝缘颗粒，并且其中内层含有较高的导电，半导体和/或绝缘颗粒的百分比。多层组分可以任选地与纯介电聚合物，玻璃或陶瓷层（12,12'）组合使用，并且可以任选地具有插入的金属层（18,18'）。公开了一种用于在将所得颗粒与粘合剂混合之前使用挥发性溶剂分散胶体绝缘颗粒和导电，半导体和/或绝缘颗粒以分散胶体绝缘颗粒和导电半导体或绝缘颗粒的方法。

8. 发明申请

WO2008051621A3 POWDER DISPERSION APPARATUS, METHOD OF MAKING AND USING THE APPARATUS, AND COMPONENTS THAT CAN BE USED ON THE APPARATUS AND OTHER DEVICES 审中-公开
标题翻译：粉末分散装置，制造和使用装置的方法以及可用于装置和其他装置的组件
公开(公告)号：WO2008051621A3
公开(公告)日：2008-11-13
申请号：PCT/US2007022830
申请日：2007-10-25
申请人： NEKTAR THERAPEUTICS , GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAF R , MALTZ DAVID S , UNG KEITH
发明人： GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAF R , MALTZ DAVID S , UNG KEITH
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0036 , A61M15/0041 , A61M15/0048 , A61M15/0051 , A61M15/0081 , A61M15/0093 , A61M15/0096 , A61M2016/0015 , A61M2202/064 , A61M2205/43 , A61M2205/581 , A61M2205/582
摘要： Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
摘要翻译：用于肺部递送组合物的方法和装置，例如用于分散用于吸入患者的干粉药物的方法和装置。装置的元件或方面，包括插座穿孔机构，去电装置，插座冲击装置以及插座锁定装置或系统。

9. 发明申请

WO2008051621A9 POWDER DISPERSION APPARATUS, METHOD OF MAKING AND USING THE APPARATUS, AND COMPONENTS THAT CAN BE USED ON THE APPARATUS AND OTHER DEVICES 审中-公开
标题翻译：粉末扩散装置，制造和使用该装置的方法以及可用于该装置和其他装置的部件
公开(公告)号：WO2008051621A9
公开(公告)日：2008-06-26
申请号：PCT/US2007022830
申请日：2007-10-25
申请人： NEKTAR THERAPEUTICS , GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAF R , MALTZ DAVID S , UNG KEITH
发明人： GLUSKER MARK , ALSTON WILLIAM W , AXFORD GEORGE S , PALMER-FELGATE JOHN , WILKINS JONATHAN , FOSS WILLARD R , RAO NAGARAJA , POSTICH MARK , PAKALA NEERAF R , MALTZ DAVID S , UNG KEITH
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0005 , A61M15/0016 , A61M15/0036 , A61M15/0041 , A61M15/0048 , A61M15/0051 , A61M15/0081 , A61M15/0093 , A61M15/0096 , A61M2016/0015 , A61M2202/064 , A61M2205/43 , A61M2205/581 , A61M2205/582
摘要： Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.
摘要翻译：用于肺部递送组合物的方法和设备，例如用于分散供患者吸入的干粉药物的方法和设备。装置的元件或方面，包括插座穿刺机构，去阻挡装置，插座撞击装置和插座锁定装置或系统。

10. 发明申请

WO2003057564A1 APPARATUS AND METHOD FOR SEALING CAVITIES 审中-公开
标题翻译：装置和方法密封CAVITIES
公开(公告)号：WO2003057564A1
公开(公告)日：2003-07-17
申请号：PCT/US2002/038922
申请日：2002-11-20
申请人： NEKTAR THERAPEUTICS , RASMUSSEN, Dennis, R. , SCHULER, Carlos, E. , ALSTON, William, W.
发明人： SCHULER, Carlos, E. , ALSTON, William, W.
IPC分类号： B65B7/16
CPC分类号： B65B7/2878 , B65B7/164 , B65B51/16
摘要： An apparatus is provided for sealing a first layer (150) to a second layer (130), the second layer comprising one or more cavities (135) adapted to contain a pharmaceutical formulation. The apparatus comprises a roller (110) comprising a heating element (125), and a surface (1159) adapted to support the first and second layers, the surface being translatable relative to the roller. The first layer is heat sealed to the second layer when contacted by the roller to contain the pharmaceutical formulation within the one or more cavities.
摘要翻译：提供了用于将第一层（150）密封到第二层（130）的装置，所述第二层包括适于容纳药物制剂的一个或多个空腔（135）。该装置包括一个包括加热元件（125）的辊子（110）和适于支撑第一和第二层的表面（1159），该表面可相对于辊子平移。当与辊接触时，第一层被热密封到第二层，以在一个或多个空腔内容纳药物制剂。

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