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1. 发明申请

WO2010061297A1 METHODS OF DIAGNOSIS AND TREATING WOUNDS AND SCREENING FOR ELECTRICAL MARKERS FOR WOUNDS PROGNOSIS 审中-公开
标题翻译：诊断和治疗伤口的方法和电子标记的筛查方法
公开(公告)号：WO2010061297A1
公开(公告)日：2010-06-03
申请号：PCT/IB2009/054708
申请日：2009-10-25
申请人： LIFEWAVE LTD. , AFARGAN, Michel , RICCI, Elia Bernardino
发明人： AFARGAN, Michel , RICCI, Elia Bernardino
IPC分类号： A61B5/00
CPC分类号： A61B5/04 , A61B5/7257 , A61N1/326 , A61N1/36014
摘要： Described herein are electrical markers, specifically alternate current (AC) signals whose appearance in patients with wounds, specifically chronic wounds, correlates to the prognosis of the wounds. Related methods that can be used for diagnosis and treatment of wounds are disclosed. Also described herein are methods that can be used to identify electrical signals of wounds.
摘要翻译：这里描述的是电子标记，特别是交替电流（AC）信号，其在伤口患者中的出现，特别是慢性伤口与伤口的预后相关。公开了可用于伤口诊断和治疗的相关方法。本文还描述了可用于识别伤口的电信号的方法。

2. 发明申请

WO2006072948A3 GASTRO-RETENTIVE DIAGNOSTIC ASSEMBLIES 审中-公开
标题翻译：胃气道诊断装置
公开(公告)号：WO2006072948A3
公开(公告)日：2006-11-02
申请号：PCT/IL2006000017
申请日：2006-01-05
申请人： INTEC PHARMA LTD , YISSUM RES DEV CO , AFARGAN MICHEL , KIRMAYER DAVID , LAPIDOT NOA , FRIEDMAN MICHAEL , HOFFMAN AMNON
发明人： AFARGAN MICHEL , KIRMAYER DAVID , LAPIDOT NOA , FRIEDMAN MICHAEL , HOFFMAN AMNON
IPC分类号： A61K9/48 , A61K49/18 , A61K51/12
CPC分类号： A61K49/1818 , A61K9/0065 , A61K49/0002 , A61K51/1251
摘要： The present invention provides a gastro-retentive diagnostic assembly (GRDA) for use in determining a condition of a subject's gastrointestinal tract (GI tract), comprising a folded single or multi-layered device comprising a diagnostic utility, such as a contrasting agent, the device prior to folding being essentially planar, and included in a delivery system for oral intake, the delivery system being adapted to release the device once in the stomach, whereupon release said device unfolds into an unfolded shape that results in the retention of the device in the stomach. Further provided are methods of determining a condition of a subject's GI tract by the use of the GRDA of the invention, as well as uses of a single or multi-layered device comprising a diagnostic utility when in a folded or unfolded shape, and method of preparing the GRDA of the invention.
摘要翻译：本发明提供了一种用于确定受试者的胃肠道（GI道）的状况的胃滞留诊断组件（GRDA），其包括折叠的单层或多层设备，其包括诊断实用程序，例如造影剂，折叠前的装置基本上是平面的，并且包括在用于口服进入的输送系统中，所述输送系统适于在胃中释放装置一次，于是释放所述装置展开成展开形状，导致装置保持在肚子还提供了通过使用本发明的GRDA来确定受试者的胃肠道状况的方法，以及当处于折叠或展开形状时包括诊断用途的单层或多层设备的使用，以及方法准备本发明的GRDA。

3. 发明申请

WO2011015998A1 METHODS OF DIAGNOSIS AND OF SCREENING FOR ELECTRICAL MARKERS FOR HIDDEN MALADIES 审中-公开
标题翻译：用于隐藏马达的电子标记的诊断和筛选方法
公开(公告)号：WO2011015998A1
公开(公告)日：2011-02-10
申请号：PCT/IB2010/053531
申请日：2010-08-04
申请人： LIFEWAVE LTD. , AFARGAN, Michel , RICCI, Elia Bernardino
发明人： AFARGAN, Michel , RICCI, Elia Bernardino
IPC分类号： A61B5/00
CPC分类号： A61B5/0488 , A61B5/04012 , A61B5/4076 , A61B5/7257
摘要： A method for diagnosing non- visible (occult) maladies in a human patient, the method comprising: (a) deploying at least two electrodes spaced apart on the skin of the patient; (b) detecting and recording a bioelectrical signal in and around said electrodes, the bioelectrical signal being a stochastic signal; (c) transforming the stochastic signal into a voltage versus frequency spectra using a Fast Fourier Transform (FFT) algorithm; (d) comparing a graph of a resultant FFT level of the patient to at least one graph of a baseline FFT level; and (e) determining a presents of a non- visible (occult) malady based on said comparison. Methods for monitoring a treatment regimen for non-visible (occult) maladies and for modulating the amplitude of endogenous bioelectrical stochastic signals in a human patient are also disclosed.
摘要翻译：一种用于诊断人类患者中的不可见（隐匿）疾病的方法，所述方法包括：（a）在所述患者的皮肤上展开间隔开的至少两个电极; （b）在所述电极内和周围检测和记录生物电信号，所述生物电信号是随机信号; （c）使用快速傅立叶变换（FFT）算法将随机信号转换成电压对频谱; （d）将患者的合成FFT电平的图与基线FFT电平的至少一个图比较; 和（e）基于所述比较确定不可见（隐匿）疾病的呈现。还公开了用于监测非可见（隐匿）疾病的治疗方案和用于调节人类患者内源性生物电随机信号的幅度的方法。

4. 发明申请

WO2007093999A1 A GASTRO-RETENTIVE SYSTEM FOR THE DELIVERY OF MACROMOLECULES 审中-公开
标题翻译：用于输送大分子的气体保持系统
公开(公告)号：WO2007093999A1
公开(公告)日：2007-08-23
申请号：PCT/IL2007/000212
申请日：2007-02-15
申请人： INTEC PHARMA LTD. , LAPIDOT, Noa , AFARGAN, Michel , KIRMAYER, David , KLUEV, Lena , COHEN, Marina , MOOR, Eytan , NAVON, Nadav
发明人： LAPIDOT, Noa , AFARGAN, Michel , KIRMAYER, David , KLUEV, Lena , COHEN, Marina , MOOR, Eytan , NAVON, Nadav
IPC分类号： A61K9/70 , A61K9/48 , A61K38/00
CPC分类号： A61K9/7007 , A61K9/4808 , A61K38/29 , A61K38/34 , Y02A50/411
摘要： The present invention provides a gastro-retentive delivery assembly (GRDA) comprising a folded multi-layered device comprising a macromolecule-containing compartment bordered by enveloping layers and one or more enforcing strips, the device being adapted to unfold when in a subject's stomach, whereupon unfolding, the macromolecule is released from said device via at least one aperture in an enveloping layer. The invention also provides a method for gastroretentive delivery of macromolecules via the GRDA of the invention; a method of preparing the GRDA of the invention as well as the use of GRDA for the manufacture of a medicament for treating a subject for a pathological condition.
摘要翻译：本发明提供了一种包含折叠多层装置的折叠多层装置的胃滞留递送组件，所述多层装置包括由包层和一个或多个强化条带相邻的含大分子的隔间，该装置适于在受试者的胃中展开，展开时，大分子通过包络层中的至少一个孔从所述装置释放。本发明还提供了通过本发明的GRDA胃分泌递送大分子的方法; 制备本发明的GRDA的方法以及使用GRDA来制备用于治疗受试者病理状况的药物。

5. 发明申请

WO2006072948A2 GASTRO-RETENTIVE DIAGNOSTIC ASSEMBLIES 审中-公开
标题翻译：胃恢复诊断组件
公开(公告)号：WO2006072948A2
公开(公告)日：2006-07-13
申请号：PCT/IL2006/000017
申请日：2006-01-05
申请人： INTEC PHARMA LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY , AFARGAN, Michel , KIRMAYER, David , LAPIDOT, Noa , FRIEDMAN, Michael , HOFFMAN, Amnon
发明人： AFARGAN, Michel , KIRMAYER, David , LAPIDOT, Noa , FRIEDMAN, Michael , HOFFMAN, Amnon
IPC分类号： A61K9/48 , A61K51/12 , A61K49/18
CPC分类号： A61K49/1818 , A61K9/0065 , A61K49/0002 , A61K51/1251
摘要： The present invention provides a gastro-retentive diagnostic assembly (GRDA) for use in determining a condition of a subject's gastrointestinal tract (GI tract), comprising a folded single or multi-layered device comprising a diagnostic utility, such as a contrasting agent, the device prior to folding being essentially planar, and included in a delivery system for oral intake, the delivery system being adapted to release the device once in the stomach, whereupon release said device unfolds into an unfolded shape that results in the retention of the device in the stomach. Further provided are methods of determining a condition of a subject's GI tract by the use of the GRDA of the invention, as well as uses of a single or multi-layered device comprising a diagnostic utility when in a folded or unfolded shape, and method of preparing the GRDA of the invention.
摘要翻译：本发明提供用于确定受试者的胃肠道（胃肠道）状况的胃肠滞留性诊断组装体（GRDA），其包括折叠的单层或多层装置，所述装置包括诊断实用性，例如造影剂，折叠之前的装置基本上是平面的，并且包括在用于口服摄入的递送系统中，递送系统适于一旦在胃中释放装置，随后释放所述装置展开成展开形状，导致装置在胃中的滞留。进一步提供了通过使用本发明的GRDA确定受试者胃肠道状况的方法，以及当处于折叠或展开形状时包括诊断实用性的单层或多层装置的使用，以及准备发明的GRDA。

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