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1. 发明申请

WO2012051084A4 THERMOPLASTIC MULTILAYER INTERLAYER POLYMER FILM AND RELATED GLASS LAMINATE COMPOSITE INCLUDING SAME 审中-公开
公开(公告)号：WO2012051084A4
公开(公告)日：2012-09-27
申请号：PCT/US2011055542
申请日：2011-10-10
申请人： LIVEGLASS INC , FRIEDMAN MICHAEL L , LANG BARBARA JOANNE , FRIEDMAN BORIS M , ANSARI AI
发明人： FRIEDMAN MICHAEL L , LANG BARBARA JOANNE , FRIEDMAN BORIS M , ANSARI AI
IPC分类号： B32B27/08 , B32B17/10 , B32B27/40
CPC分类号： B32B17/10036 , B32B17/10743 , B32B17/1077 , B32B17/10788 , B32B27/08 , B32B27/20 , B32B27/306 , B32B27/308 , B32B27/40 , B32B2250/05 , B32B2250/24 , B32B2250/40 , Y10T156/10 , Y10T428/2495 , Y10T428/269 , Y10T428/31551
摘要： A multilayer interlayer polymer film and a high clarity safety glass laminate made using the same include: (1) a core layer comprising one of an ionomer polymer material and a thermoplastic polyurethane polymer material; (2) at least one intermediate layer laminated to the core layer and comprising the other of the ionomer polymer material and the thermoplastic polyurethane polymer material; and (3) at least one skin layer laminated to the at least one intermediate layer and comprising a non-ionomer polyolefin polymer material. The multilayer interlayer polymer film provides the high clarity safety glass laminate with enhanced performance with respect to optical properties and manufacturability. In an alternative embodiment the at least one skin layer may be omitted when the intermediate layer comprises a thermoplastic polyurethane material with adequate adhesion to glass.

2. 发明申请

WO2009152133A1 NOVEL TRICYCLIC COMPOUNDS 审中-公开
标题翻译：新型三聚体化合物
公开(公告)号：WO2009152133A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/046714
申请日：2009-06-09
申请人： ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/42
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

3. 发明申请

WO2005074603A3 AMINOBENZOXAZOLES AS THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2005074603A3
公开(公告)日：2005-08-18
申请号：PCT/US2005/003196
申请日：2005-02-03
申请人： ABBOTT LABORATORIES , WISHART, Neil , FRIEDMAN, Michael , ARNOLD, Lee, D. , YANG, Bryant , FIX-STENZEL, Shannon, R. , ERICSSON, Anna , MICHAELIDES, Michael R., , QIAN, Xiao-dong , HOLMES, James, H. , STEINMAN, Douglas, H. , TIAN, Zhengping , WITTENBERGER, Steven, J.
发明人： WISHART, Neil , FRIEDMAN, Michael , ARNOLD, Lee, D. , YANG, Bryant , FIX-STENZEL, Shannon, R. , ERICSSON, Anna , MICHAELIDES, Michael R., , QIAN, Xiao-dong , HOLMES, James, H. , STEINMAN, Douglas, H. , TIAN, Zhengping , WITTENBERGER, Steven, J.
IPC分类号： C07D487/04 , C07D513/06 , C07D295/03 , C07D239/70 , C07D263/54 , A61K31/519 , A61K31/5377 , A61K31/381
摘要： A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

4. 发明申请

WO2002098657A2 MULTILAYER POLYMERIC ARTICLE WITH INTERCROSSLINKED POLYMER LAYERS AND METHOD OF MAKING SAME 审中-公开
标题翻译：具有交错聚合物层的多层聚合物及其制备方法
公开(公告)号：WO2002098657A2
公开(公告)日：2002-12-12
申请号：PCT/US2002/017684
申请日：2002-06-04
申请人： SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATION , TUKACHINSKY, Alexander , FRIEDMAN, Michael, L. , ORTIZ, Paul, W.
发明人： TUKACHINSKY, Alexander , FRIEDMAN, Michael, L. , ORTIZ, Paul, W.
IPC分类号： B32B27/00
CPC分类号： B32B27/08 , B32B1/02 , B32B1/08 , B32B7/04 , B32B27/322 , B32B37/153 , B32B2038/0076 , B32B2250/242 , B32B2310/0831 , B32B2310/085 , B32B2310/0856 , B32B2310/0887 , B32B2323/16 , B32B2327/18 , H01B3/441 , H01B3/445 , Y10S428/906 , Y10T428/1393 , Y10T428/31536 , Y10T428/3154 , Y10T428/31544 , Y10T428/31931
摘要： Disclosed is an intercrosslinked multilayer polymeric article, comprising; (A) at least one thermoplastic polymer layer in contact with (B) at least one crosslinkable polymer layer, wherein (A) and (B) are incompatible with each other, and wherein (A) and (B) are secured together by intercrosslinking. Also disclosed is a method for preparing an intercrosslinked multilayer polymeric article.
摘要翻译：公开了一种交联的多层聚合物制品，其包含：（A）与（B）至少一种可交联聚合物层接触的至少一种热塑性聚合物层，其中（A）和（B）彼此不相容，并且其中（A）和（B）通过交联固定在一起。还公开了一种制备交联的多层聚合物制品的方法。

5. 发明申请

WO2002076986A1 PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗剂的吡唑并嘧啶
公开(公告)号：WO2002076986A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/008996
申请日：2002-03-22
申请人： ABBOTT GMBH & CO. KG , HIRST, Gavin C., , RAFFERTY, Paul , RITTER, Kurt , CALDERWOOD, David , WISHART, Neil , ARNOLD, Lee D., , FRIEDMAN, Michael M.,
发明人： HIRST, Gavin C., , RAFFERTY, Paul , RITTER, Kurt , CALDERWOOD, David , WISHART, Neil , ARNOLD, Lee D., , FRIEDMAN, Michael M.,
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein.
摘要翻译：本发明提供式I化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2和R 3如本文所述定义。

6. 发明申请

WO0119829A2 PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗剂的吡唑并嘧啶
公开(公告)号：WO0119829A2
公开(公告)日：2001-03-22
申请号：PCT/US0025468
申请日：2000-09-15
申请人： BASF AG , HIRST GAVIN C , CALDERWOOD DAVID , WISHART NEIL , RAFFERTY PAUL , RITTER KURT , ARNOLD LEE D , FRIEDMAN MICHAEL M
发明人： HIRST GAVIN C , CALDERWOOD DAVID , WISHART NEIL , RAFFERTY PAUL , RITTER KURT , ARNOLD LEE D , FRIEDMAN MICHAEL M
IPC分类号： A61K31/519 , A61K31/5377 , A61K38/22 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/16 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D487/04 , C07F9/6561
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, R3 are defined as described herein.
摘要翻译：本发明提供式（I）化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2，R 3如本文所述定义。

7. 发明申请

WO1998022091A1 PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED RELEASE OF 'beta'-LACTAM ANTIBIOTICS 审中-公开
标题翻译：用于控制释放β-LACTAM抗生素的药物制剂
公开(公告)号：WO1998022091A1
公开(公告)日：1998-05-28
申请号：PCT/IL1997000368
申请日：1997-11-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KATZHENDLER, Ifat , HOFFMAN, Amnon , FRIEDMAN, Michael
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K09/10
CPC分类号： A61K31/545 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K31/43 , A61K2300/00
摘要： The present invention relates to a pharmaceutical controlled-release oral drug delivery system comprising as active ingredient at least one beta -lactam antibiotic agent, having a specific absorption site in the small intestine in combination with a polymeric matrix, optionally further containing additional pharmaceutically acceptable constituents, wherein at least 50 % of the beta -lactam antibiotic agent are released from the matrix within from about 3 to about 4 hours from oral administration and the remainder of the pharmaceutical agent is released at a controlled rate. The drug delivery system according to the invention optionally further comprises a beta -lactamase inhibitor, preferably in combination with amoxicillin and/or amoxicillin trihydrate as the active ingredient. The polymeric matrix of the pharmaceutical controlled-release oral drug delivery system of the invention may be of hydrophilic and/or hydrophobic nature and the delivery system may further comprise pharmaceutically acceptable additive. The pharmaceutical controlled-release oral drug delivery system of the invention is preferably in dosage unit form.
摘要翻译：本发明涉及药物控释口服药物递送系统，其包含至少一种β-内酰胺抗生素作为活性成分，其在小肠中具有与聚合物基质组合的特异性吸收部位，任选地还含有另外的药学上可接受的成分，其中至少50％的β-内酰胺抗生素试剂在口服给药约3至约4小时内从基质释放，并且药物的其余部分以受控的速率释放。根据本发明的药物递送系统任选地还包含β-内酰胺酶抑制剂，优选与阿莫西林和/或阿莫西林三水合物作为活性成分组合。本发明的药物控释口服药物递送系统的聚合物基质可具有亲水性和/或疏水性质，并且递送系统还可包含药学上可接受的添加剂。本发明的药物控释口服药物递送系统优选为剂量单位形式。

8. 发明申请

WO2013119482A1 APPARATUS AND METHODS FOR CONTROLLED DELIVERY OF HEATED FLUIDS TO A SUBJECT 审中-公开
标题翻译：用于控制将加热流体输送到主体的装置和方法
公开(公告)号：WO2013119482A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/024562
申请日：2013-02-04
申请人： FRIEDMAN, Michael
发明人： FRIEDMAN, Michael
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F2007/0059
摘要： Apparatus and methods are disclosed for controlled irrigation of a subject during surgical procedures, where a pump is used to provide controlled delivery of heated fluids to irrigate the patient undergoing surgery and where the tubing system includes tubing for insertion in an infusion pump without the need of opening the tubing system.
摘要翻译：公开了用于受试者在外科手术期间的受控灌洗的装置和方法，其中使用泵来提供受控流体的受控输送以灌溉经历手术的患者，并且其中管道系统包括用于插入输液泵的管道，而不需要打开管道系统。

9. 发明申请

WO2011068881A1 NOVEL TRICYCLIC COMPOUNDS 审中-公开
标题翻译：新型三聚体化合物
公开(公告)号：WO2011068881A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058572
申请日：2010-12-01
申请人： ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/58
CPC分类号： C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要： The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

10. 发明申请

WO2011027346A1 A GASTRORETENTIVE DOSAGE FORM FOR ORAL TREATMENT OF DOMESTIC ANIMALS 审中-公开
标题翻译：用于口腔治疗国内动物的气味剂型
公开(公告)号：WO2011027346A1
公开(公告)日：2011-03-10
申请号：PCT/IL2010/000724
申请日：2010-09-02
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , FRIEDMAN, Michael , HOFFMAN, Amnon , LAVY, Eran
发明人： FRIEDMAN, Michael , HOFFMAN, Amnon , LAVY, Eran
IPC分类号： A61K9/20 , A61K9/00
CPC分类号： A61K9/0065 , A61K9/2027 , A61K9/2054 , A61K9/2072
摘要： Gastroretentive oral dosage forms for an animal are described herein, as well as formulations and processes useful for preparation of same. The oral dosage form comprises a therapeutically active agent and a pharmaceutically acceptable solid carrier, and swells when in a stomach of the animal from a first size and shape to a second size and shape, wherein a short axis of the second size and shape is at least 50 % longer than a short axis of the first size and shape. The first size and shape of the dosage form are selected suitable for being swallowed as a whole by the animal, and the second size and shape are selected so as to prevent passage of the dosage form while in a stomach of the animal through the pylorus of the animal. The dosage form is capable of continuously releasing a therapeutically effective amount of the therapeutically active agent over a period of at least 2 days.
摘要翻译：本文描述了动物的胃肠道口服剂型，以及可用于制备动物的制剂和方法。口服剂型包含治疗活性剂和药学上可接受的固体载体，并且在动物的胃中从第一尺寸和形状膨胀到第二尺寸和形状，其中第二尺寸和形状的短轴在比第一尺寸和形状的短轴长50％。剂型的第一尺寸和形状被选择为适于被动物整体吞咽，并且选择第二尺寸和形状以便防止剂型在动物的胃中通过幽门这个动物。该剂型能够在至少2天的时间内连续释放治疗有效量的治疗活性剂。

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