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1. 发明申请

WO2007106987A1 CONTINUOUS DOSING REGIMENS FOR NEURAL STEM CELL PROLIFERATING AGENTS AND NEURAL STEM CELL DIFFERENTIATING AGENTS 审中-公开
标题翻译：用于神经干细胞增殖剂和神经干细胞分化试剂的连续剂量方案
公开(公告)号：WO2007106987A1
公开(公告)日：2007-09-27
申请号：PCT/CA2007/000427
申请日：2007-03-16
申请人： STEM CELL THERAPEUTICS CORP. , WEISS, Samuel , GREGG, Christopher , DAVIDOFF, Allen , TUCKER, Joseph
发明人： WEISS, Samuel , GREGG, Christopher , DAVIDOFF, Allen , TUCKER, Joseph
IPC分类号： A61K38/24 , A61K38/18 , A61K38/22 , A61P25/28
CPC分类号： A61K38/1816 , A61K38/24
摘要： The present invention provides effective dosing regimes for neural stem cell proliferating agents, kits containing effective dosing regimes for neural stem cell proliferating agents, and uses thereof. In particular, neural stem cell proliferating agents, such as hCG, prolactin and EPO are delivered to mammalian subjects at low doses in a continuous fashion over several days, as opposed to delivery of high doses in a short period of time.
摘要翻译：本发明提供神经干细胞增殖剂的有效给药方案，含有神经干细胞增殖剂的有效给药方案的试剂盒及其用途。特别地，神经干细胞增殖剂，例如hCG，催乳素和EPO在几天内以连续的方式以低剂量递送到哺乳动物受试者，而不是在短时间内递送高剂量。

2. 发明申请

WO2007093036A1 USE OF LOCAL IMMUNE SUPPRESSION TO ENHANCE ONCOLYTIC VIRAL THERAPY 审中-公开
标题翻译：使用本地免疫抑制来增强肿瘤病毒治疗
公开(公告)号：WO2007093036A1
公开(公告)日：2007-08-23
申请号：PCT/CA2007/000187
申请日：2007-02-09
申请人： ONCOLYTICS BIOTECH INC. , COFFEY, Matthew, C. , THOMPSON, Bradley, G.
发明人： COFFEY, Matthew, C. , THOMPSON, Bradley, G.
IPC分类号： A61K35/76 , A61N5/00 , A61P35/00
CPC分类号： A61N5/10 , A61K35/765 , A61N2005/1098
摘要： Provided herein are methods for treating or ameliorating a solid tumor in a subject comprising administering oncolytic viruses and immunosuppressive agents at or near the site of the tumor.
摘要翻译：本文提供了治疗或改善受试者中的实体瘤的方法，包括在肿瘤部位或其附近施用溶瘤病毒和免疫抑制剂。

3. 发明申请

WO2007085088A1 THREE DIMENSIONAL GEOMETRIC PUZZLE 审中-公开
标题翻译：三维几何拼图
公开(公告)号：WO2007085088A1
公开(公告)日：2007-08-02
申请号：PCT/CA2007/000115
申请日：2007-01-29
申请人： TBL SUBSTAINABILITY GROUP , COOK, Roger, C.
发明人： COOK, Roger, C.
IPC分类号： A63F9/12
CPC分类号： A63F9/1204 , A63F2009/1212 , A63F2009/124 , A63F2250/1063
摘要： Disclosed is a geometric puzzle comprising a plurality of three-dimensional components of at least one type, each component of the same type being derived by notionally dividing a fundamental shape into a plurality of equal parts, said fundamental shape being selected from the group consisting of a regular tetrahedron having edges of equal length and a regular pyramid with a square base and also having edges of equal length, said components being capable of assembly into multiple composite shapes. Each component may be equal and identical to one another or each pair of components may comprise mirror images of one another. Surfaces of said components may be provided attractive magnetic elements to hold said components in a composite shape.
摘要翻译：公开了一种几何拼图，其包括至少一种类型的多个三维分量，相同类型的每个分量通过将基本形状划分成多个相等的部分而导出，所述基本形状选自具有相等长度的边缘的正四面体和具有方形基底并且具有相等长度的边缘的规则金字塔，所述部件能够组装成多个复合形状。每个组件可以彼此相等和相同，或者每对组件可以包括彼此的镜像。所述部件的表面可以被提供有吸引力的磁性元件以将所述部件保持在复合形状。

4. 发明申请

WO2007059630A1 MULTIFUNCTIONAL NANOSTRUCTURE AND METHOD 审中-公开
标题翻译：多功能纳米结构与方法
公开(公告)号：WO2007059630A1
公开(公告)日：2007-05-31
申请号：PCT/CA2006/001935
申请日：2006-11-28
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , MA, Dongling , SIMARD, Benoit
发明人： MA, Dongling , SIMARD, Benoit
IPC分类号： B82B1/00 , B82B3/00 , H01F1/06 , H01F1/20 , H01L29/12
CPC分类号： B82Y25/00 , H01F1/0054 , Y10T428/2991
摘要： A functional nanoparticle for use in the ultrasensitive identification of bacteria and gene species has a magnetic core, an insulating first shell surrounding the magnetic core, and a luminescent second shell surrounding the first shell.
摘要翻译：用于细菌和基因物种的超敏感鉴定的功能性纳米颗粒具有磁芯，围绕磁芯的绝缘的第一壳和围绕第一壳的发光的第二壳。

5. 发明申请

WO2007051293A1 SWEPT SOURCE OCT APPARATUS 审中-公开
标题翻译： SWEPT来源OCT装置
公开(公告)号：WO2007051293A1
公开(公告)日：2007-05-10
申请号：PCT/CA2006/001782
申请日：2006-10-31
申请人： OTI OPHTHALMIC TECHNOLOGIES INC. , ROGERS, John, A. , HATHAWAY, Mark
发明人： ROGERS, John, A. , HATHAWAY, Mark
IPC分类号： A61B6/03 , A61B3/10 , G01N21/84
CPC分类号： A61B3/102 , G01N21/4795
摘要： A method of performing spectral OCT imaging on a target involves repeatedly scanning said target along a transverse scanning line with an object beam derived from an OCT interferometer having a narrowband source. The wavelength of the narrowband source is modulated over a range of wavelengths at a rate that is slow relative to the rate of scanning the target. The object beam returned from the target is detected to produce a set of data obtained from multiple scans along said scanning line over the entire range of wavelengths. The data is then processed to extract an OCT image (typically a B-scan) of the target containing depth information.
摘要翻译：在目标上进行光谱OCT成像的方法涉及用具有窄带源的OCT干涉仪衍生的物体光束沿着横向扫描线重复扫描所述目标。窄带源的波长以相对于扫描目标的速率较慢的速率在波长范围内进行调制。检测从目标物返回的目标光束，以产生在整个波长范围内沿着扫描线从多次扫描获得的一组数据。然后处理数据以提取包含深度信息的目标的OCT图像（通常为B扫描）。

6. 发明申请

WO2007051292A1 EN-FACE OCT WITH PARALLEL DETECTOR ARRAY 审中-公开
标题翻译：具有平行检测器阵列的EN-FACE OCT
公开(公告)号：WO2007051292A1
公开(公告)日：2007-05-10
申请号：PCT/CA2006/001781
申请日：2006-10-31
申请人： OTI OPHTHALMIC TECHNOLOGIES INC. , ROGERS, John, A. , HATHAWAY, Mark
发明人： ROGERS, John, A. , HATHAWAY, Mark
IPC分类号： A61B6/03 , A61B3/10 , G01N21/84 , G02B27/22 , G03H1/00
CPC分类号： G01N21/4795 , A61B3/102
摘要： In an OCT apparatus, an object light beam is returned from a target and interferes with a reference light beam. Image information is obtained from a depth Z in the target that depends on the optical path difference between the object and reference beams with a resolution that depends on the coherence length of the light. A scanner transversely scans the target with the object beam over a plurality of image points defined by the resolution of the apparatus. Interface optics directs the reference and object beams onto an array of detector elements such that the optical path difference between the reference beam and the object beam varies across the array. The reference beam and the object beam interfere with each other over the array of detector elements for individual image points on the target during each transverse scan. A memory stores a subset of data points corresponding to each individual image point obtained from each detector elements of the array. A processor processes one or more of the subsets of data points to derive image information extending over a range of depths in the target for each individual image point. The obtained image information is displayed on a displace device.
摘要翻译：在OCT设备中，物体光束从目标返回并干扰参考光束。图像信息从目标中的深度Z获得，其取决于取决于光的相干长度的分辨率的对象和参考光束之间的光程差。扫描仪在由装置的分辨率限定的多个图像点上用对象光束横向扫描目标。接口光学器件将参考光束和物体光束引导到检测器元件的阵列上，使得参考光束和物体光束之间的光程差在阵列上变化。参考光束和物体光束在每个横向扫描期间在目标上的各个图像点的检测器元件阵列上彼此干涉。存储器存储对应于从阵列的每个检测器元件获得的每个单独图像点的数据点的子集。处理器处理数据点的一个或多个子集以导出在每个单独图像点的目标中的深度范围上延伸的图像信息。获得的图像信息显示在位移装置上。

7. 发明申请

WO2007036033A1 OLIGODENDROCYTE PRECURSOR CELL PROLIFERATION REGULATED BY PROLACTIN 审中-公开
标题翻译：前列腺细胞增殖调节前列腺素
公开(公告)号：WO2007036033A1
公开(公告)日：2007-04-05
申请号：PCT/CA2006/001589
申请日：2006-09-27
申请人： STEM CELL THERAPEUTICS CORP. , GREGG, Christopher , WEISS, Samuel
发明人： GREGG, Christopher , WEISS, Samuel
IPC分类号： A61K38/22 , A61K35/30 , A61K38/18 , A61P25/00 , A61P25/28 , C12N5/06 , C12N5/08
CPC分类号： A61K35/30 , A61K31/197 , A61K38/2257 , A61K2300/00
摘要： A method for treating a disease associated with demyelmation by increasing oligodendrocytes and oligodendrocyte precursor cells in a mammal through administration of prolactin. Prolactin can be used alone, or in conjunction with administration of neural stem cells or oligodendrocyte precursor cells. Optionally, additional compounds that improve oligodendrocyte proliferation, differentiation or survival are administered concurrently with prolactin.
摘要翻译：一种用于通过施用催乳素来增加哺乳动物中的少突胶质细胞和少突胶质细胞前体细胞来治疗与脱髓鞘相关的疾病的方法。催乳素可以单独使用，或与神经干细胞或少突胶质细胞前体细胞的给药联合使用。任选地，与催乳素同时施用改善少突胶质细胞增殖，分化或存活的其它化合物。

8. 发明申请

WO2007025365A1 TREATMENT WITH AN ONCOLYTIC VIRUS AND AN IMMUNOSTIMULANT FOR IN VIVO ENHANCEMENT OF IMMUNE SYSTEM RECOGNITION OF NEOPLASMS 审中-公开
标题翻译：用免疫系统感染神经病毒和免疫球蛋白治疗免疫系统识别神经细胞
公开(公告)号：WO2007025365A1
公开(公告)日：2007-03-08
申请号：PCT/CA2006/001377
申请日：2006-08-22
申请人： ONCOLYTICS BIOTECH INC. , COFFEY, Matthew C. , THOMPSON, Bradley G.
发明人： COFFEY, Matthew C. , THOMPSON, Bradley G.
IPC分类号： A61K39/39 , A61K31/00 , A61K31/7084 , A61K35/76 , A61P35/00 , A61P37/04 , C07H21/04 , C12N7/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/7084 , A61K35/765 , A61K2039/55561 , C12N2720/12032 , A61K2300/00
摘要： This invention provides novel methods of treating or alleviating neoplasms in a mammal and enhancing the efficacy of oncolytic viruses by using a combination of an oncolytic virus and an immunostimulant, comprising administering a reovirus to a host and enhancing an immune response by the addition of an immunostimulant such as a CpG oligodeoxynucleotide or at least one antigen of said virus that is delivered to a host by dendritic cells.
摘要翻译：本发明提供了治疗或减轻哺乳动物肿瘤的新方法，并通过使用溶瘤病毒和免疫刺激剂的组合来提高溶瘤病毒的功效，包括向宿主施用呼肠孤病毒，并通过加入免疫刺激剂增强免疫应答例如CpG寡脱氧核苷酸或通过树突状细胞递送至宿主的所述病毒的至少一种抗原。

9. 发明申请

WO2006133567A1 HELIX 12 DIRECTED NON-STEROIDAL ANTIANDROGENS 审中-公开
标题翻译： HELIX 12指定的非甾体抗体
公开(公告)号：WO2006133567A1
公开(公告)日：2006-12-21
申请号：PCT/CA2006/000992
申请日：2006-06-16
申请人： ENDORECHERCHE, INC. , LABRIE, Fernand , BRETON, Rock , SINGH, Shankar, Mohan , MALTAIS, Rene
发明人： LABRIE, Fernand , BRETON, Rock , SINGH, Shankar, Mohan , MALTAIS, Rene
IPC分类号： C07D233/42 , A61K31/4178 , A61K31/4166 , A61K31/5377 , C07D403/12 , C07D413/12
CPC分类号： C07D417/12 , C07D207/40 , C07D211/48 , C07D233/74 , C07D233/86
摘要： Compounds having the structure or their salts are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
摘要翻译：具有结构或其盐的化合物用于治疗或降低获得雄激素依赖性疾病如前列腺癌，良性前列腺增生症，多囊卵巢综合征，痤疮，多毛症，皮脂溢，雄激素性脱发和男性秃发的可能性。化合物可与药学上可接受的稀释剂或载体一起配制或以其它方式制成任何药物剂型。还公开了与其它活性药剂的组合。

10. 发明申请

WO2006133555A1 PSYCHOTROPIC DRUG SCREENING DEVICE BASED ON LONG-TERM PHOTOCONDUCTIVE STIMULATION OF NEURONS 审中-公开
标题翻译：基于长期光电刺激神经元的心肌药物筛选装置
公开(公告)号：WO2006133555A1
公开(公告)日：2006-12-21
申请号：PCT/CA2006/000973
申请日：2006-06-15
申请人： NEUROSILICON (1145990 Alberta Ltd.) , COLICOS, Michael, A.
发明人： COLICOS, Michael, A.
IPC分类号： C12Q1/02 , C40B30/00 , C40B40/00 , G01N1/44 , G01N27/00 , G01N33/15
CPC分类号： G01N33/5058
摘要： The invention pertains generally to the field of psychotropic drug discovery and neuroscience. More specifically, the invention refers to a device that allows the long-term stimulation of cultured neurons grown on a silicon die, thereby replacing the use of intact animal models. The device consists of a controlled sterile environment in which the neuronal cultures can grow, and into which specific candidate compounds (e.g., psychotropic drugs) are added. During the period of growth, which can be extended for months, specifically tailored patterned activity can be applied to the neuronal network, simulating the activity normally found in a brain. The neuronal networks are grown on a silicon surface which is targeted by a light source, which functions to alter the connectivity of the surface below a specific group of cells. Cells on this targeted region are caused to fire on a brief electrical pulse. Upon completion of the growth period the silicon die can be removed and subject to electrophysiological and biochemical analysis.
摘要翻译：本发明一般涉及精神药物发现和神经科学领域。更具体地，本发明涉及允许长期刺激在硅片上生长的培养神经元的装置，从而替代完整动物模型的使用。该装置由受控的无菌环境组成，其中神经元培养物可以生长，并且加入特定候选化合物（例如，精神药物）。在可以延长数月的生长期间，可以将具体定制的图案化活动应用于神经元网络，模拟大脑中通常发现的活动。神经元网络在由光源靶向的硅表面上生长，其功能是改变表面在特定组的细胞下的连通性。使该目标区域上的细胞以短暂的电脉冲发射。在生长周期完成后，可以去除硅晶片，进行电生理和生物化学分析。

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