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1. 发明申请

WO2015033237A1 NUCLEOTIDE SEQUENCES, NUCLEIC ACID SENSORS AND METHODS THEREOF 审中-公开
标题翻译：核苷酸序列，核酸传感器及其方法
公开(公告)号：WO2015033237A1
公开(公告)日：2015-03-12
申请号：PCT/IB2014/060734
申请日：2014-04-15
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES (NCBS-TIFR)
发明人： KRISHNAN, Yamuna , SHARMA, Suruchi
IPC分类号： C07H21/04 , C07H21/00
CPC分类号： G01N33/5308 , C07H21/00 , C07H21/04 , G01N33/5695
摘要： The present disclosure relates to particular nucleotide sequences comprising of at least one stem and/or loop structure and which optionally bind fluorescent labels, for example DFHBI and a process for obtaining said sequences. The present disclosure also provides nucleic acid sensor for cAMP comprising reporter domain, communication module and target recognition domain. Further, the present disclosure provides for ratiometric sensors 10 for quantifying cAMP using the nucleic sensors of the instant invention. The instant disclosure further provides method for obtaining the sensors, method for detecting and measuring small molecules, such as cAMP using the sensors of the instant disclosure and kits thereof.
摘要翻译：本公开涉及包含至少一个茎和/或环结构并且任选地结合荧光标记的特定核苷酸序列，例如DFHBI和获得所述序列的方法。本公开还提供了用于cAMP的核酸传感器，其包含报告域，通信模块和靶标识别结构域。此外，本公开提供了用于使用本发明的核酸传感器量化cAMP的比例传感器10。本公开还提供了用于获得传感器的方法，用于检测和测量小分子的方法，例如使用本发明的传感器及其试剂盒的cAMP。

2. 发明申请

WO2015159122A1 NUCLEIC ACID BASED SENSOR AND METHODS THEREOF 审中-公开
标题翻译：基于核酸的传感器及其方法
公开(公告)号：WO2015159122A1
公开(公告)日：2015-10-22
申请号：PCT/IB2014/060736
申请日：2014-04-15
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
发明人： KRISHNAN, Yamuna , SAHA, Sonali , PRAKASH, Ved
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6825 , C12Q2525/107 , C12Q2545/101 , C12Q2565/101 , C12Q2565/519 , C12Q2565/607
摘要： The present disclosure relates to a nucleic acid based sensor, comprising a sensing 5 module, a normalizing module and a targeting module. It also relates to a method of obtaining and targeting the sensor and its use to identify and optionally quantify a target in a specific cellular microenvironment.
摘要翻译：本公开涉及基于核酸的传感器，其包括感测5模块，归一化模块和目标模块。它还涉及获得和靶向传感器的方法及其用于鉴定和任选地定量特定细胞微环境中的靶标的方法。

3. 发明申请

WO2014132191A2 METHODS OF MULTIPLEXING DNA SENSORS AND LOCALIZING DNA SENSOR 审中-公开
标题翻译：多重DNA传感器和定位DNA传感器的方法
公开(公告)号：WO2014132191A2
公开(公告)日：2014-09-04
申请号：PCT/IB2014/059236
申请日：2014-02-25
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES (NCBS-TIFR)
发明人： KRISHNAN, Yamuna , MODI, Souvik , SURANA, Sunaina
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/6841 , C12Q2527/119 , C12Q2543/10 , C12Q2565/101
摘要： The present disclosure relates to a method of multiplexing DNA sensors and optionally measuring pH in cell, a method of localizing DNA sensor in Golgi Network of scFv-Furin expressing cell and a method of identifying optimal location of fluorophore pair on the DNA sensor for multiplexing DNA sensors. The DNA sensors of the present disclosure follow independent cellular pathways and do not interact with or compromise functionality of another DNA sensor.
摘要翻译：本发明涉及一种复用DNA传感器并任选地测量细胞中的pH的方法，一种在表达scFv-Furin的细胞的高尔基网络中定位DNA传感器的方法以及鉴定DNA传感器上的多核苷酸DNA上的荧光团对的最佳位置的方法传感器。本公开的DNA传感器遵循独立的细胞途径，并且不与另一DNA传感器的功能相互作用或损害其功能。

4. 发明申请

WO2005085276A1 A NOVEL POTASSIUM CHANNEL MODULATOR PEPTIDE 审中-公开
标题翻译：新型钾通道调节剂肽
公开(公告)号：WO2005085276A1
公开(公告)日：2005-09-15
申请号：PCT/IB2004/003278
申请日：2004-10-08
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES , KRISHNAN, Kozhalmannom, Subramaniasastry , BALARAM, Padmanabhan
发明人： KRISHNAN, Kozhalmannom, Subramaniasastry , BALARAM, Padmanabhan
IPC分类号： C07K7/02
CPC分类号： C07K14/43504 , A61K38/00 , C07K14/705
摘要： A novel 13-residue peptide Mo1659 has been isolated from the venom of a vermivorous cone snail, Conus monile. HPLC fractions of the venom extract yielded an intense UV absorbing fraction with a mass of 1659 Da. De novo sequencing using both matrix assisted laser desorption and ionization and electrospray MS/MS methods together with analysis of proteolytic fragments successfully yielded the amino acid sequence, FHGGSWYRFPWGY-NH 2 . This was further confirmed by comparison with the chemically synthesized peptide and by conventional Edman sequencing. Mo1659 has an unusual sequence with a preponderance of aromatic residues and the absence of apolar, aliphatic residues like Ala, Val, Leu, Ile. Mo1659 has no disulfide bridges distinguishing it from the conotoxins and bears no sequence similarity with any of the acyclic peptides isolated thus far from the venom of cone snails. Electrophysiological studies on the effect of Mo 1659 on measured currents in dorsal root ganglion neurons suggest that the peptide targets non-inactivating voltage dependent potassium channels.
摘要翻译：已经从蜗牛蜗牛Conus monile的毒液中分离出一种新的13残基肽Mo1659。毒液提取物的HPLC级分产生强烈的UV吸收级分，质量为1659Da。使用基质辅助激光解吸和电离和电喷雾MS / MS方法的重新测序与蛋白水解片段的分析成功产生了氨基酸序列FHGGSWYRFPWGY-NH2。通过与化学合成的肽和常规的Edman测序比较进一步证实了这一点。 Mo1659具有不寻常的序列，具有优势的芳香族残基和无极性的脂族残基如Ala，Val，Leu，Ile。 Mo1659没有将二硫键与芋螺毒素区分开，并且与锥形蜗牛毒液分离的任何非循环肽都没有序列相似性。对Mo 1659对背根神经节神经元测量电流的影响的电生理研究表明，该肽靶向非灭活电压依赖性钾通道。

5. 发明申请

WO2005030801A1 A NOVEL CONOTOXIN MODULATING SODIUM CHANNELS 审中-公开
标题翻译：新的内毒素调节钠通道
公开(公告)号：WO2005030801A1
公开(公告)日：2005-04-07
申请号：PCT/IB2004/003092
申请日：2004-09-23
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES , KRISHNAN, Kozhalmannom, Subramaniasastry , BALARAM, Padmanabhan
发明人： KRISHNAN, Kozhalmannom, Subramaniasastry , BALARAM, Padmanabhan
IPC分类号： C07K14/435
CPC分类号： C07K14/435 , A61K38/00
摘要： A 26 residue peptide (Am2766) with the sequence CKQAGESCDIFSQNCCVGTCAFICIE-NH 2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected of the southeastern coast of India. Chemical modification and mass spectrometric studies establish that Am2766 has three disulfide bridges. Cterminal amidation has been demonstrated by mass measurements on the C-terminal fragments obtained by proteolysis. Sequence alignments establish that Am2766 belongs to the δ-conotoxin family. Am2766 inhibits the decay of the sodium current in brain rNavl .2a voltage-gated Na + channel, stably expressed in Chinese hamster ovary (CHO) cells. Unlike δ-conotoxins have previously been isolated from molluscivorous snails, Am 2766 inhibits inactivation of mammalian sodium channel.
摘要翻译：已经从印度东南海岸的软体动物蜗牛（Conus amadis）的毒液中分离和纯化了具有序列CKQAGESCDIFSQNCCVGTCAFICIE-NH2的26个残基肽（Am2766）。化学修饰和质谱研究表明Am2766具有三个二硫键。通过对通过蛋白水解获得的C末端片段的质量测量证明了C末端酰胺化。序列比对确定Am2766属于δ-芋螺毒素家族。 Am2766在中国仓鼠卵巢（CHO）细胞中稳定表达，抑制大脑rNav2.2电压门控Na +通道中钠电流的衰减。与以前从软体动物蜗牛分离的δ-芋螺毒素不同，Am 2766抑制哺乳动物钠通道的失活。

6. 发明申请

WO2020035880A1 INHIBITORS TO TARGET HIV-1 NEF-CD80/CD86 INTERACTIONS FOR THERAPEUTIC INTERVENTION 审中-公开
公开(公告)号：WO2020035880A1
公开(公告)日：2020-02-20
申请号：PCT/IN2019/050594
申请日：2019-08-13
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES-TIFR , CENTRE FOR CELLULAR AND MOLECULAR PLATFORMS NCBS-TIFR , INDIAN INSTITUTE OF INTEGRATIVE MEDICINE , INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
发明人： MAYOR, Satyajit , MUNJAL, Akankshi , SAIYED, Taslimarif , KARUMBATI, Anandi , VISHWAKARMA, Ram Aysre , SINGH, Parvinder Pal , SHARMA, Shweta , MUNAGALA, Gurunadham , YEMPALLA, Kushalava Reddy , AMBALA, Srinivas , JAMEEL, Shahid , RATH, Satyajit
IPC分类号： A61K31/519
摘要： The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.

7. 发明申请

WO2015186356A1 SYSTEM AND METHOD FOR OBTAINING FORCE BASED ON PHOTOELASTICITY 审中-公开
标题翻译：基于光敏性获得力的系统和方法
公开(公告)号：WO2015186356A1
公开(公告)日：2015-12-10
申请号：PCT/JP2015/002802
申请日：2015-06-02
申请人： OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION , NATIONAL CENTRE FOR BIOLOGICAL SCIENCES , BROWN UNIVERSITY
发明人： BANDI, Mahesh Maruthi , VENKADESAN, Madhusudhan , MANDRE, Shreyas Dilip
IPC分类号： G01L1/24 , G01L1/00
CPC分类号： G01L1/241 , B25J13/081
摘要： A method and system for obtaining force are provided, wherein the system includes a block made of a photoelastic material having multiple surfaces including a first surface on which an object is exerting the force to the block, and one or more polariscopes configured around the block, and wherein the method includes measuring photoelastic intensities by using three polariscopes simultaneously and obtaining each set of the photoelastic intensities sequentially in time to obtain a sequence of measured photoelastic intensities, and obtaining the force by using an optimization method based on the quantity associated with the difference between the measured and predicted photoelastic intensities.
摘要翻译：提供一种用于获得力的方法和系统，其中所述系统包括由具有多个表面的光弹性材料制成的块，所述多个表面包括物体施加到所述块的第一表面，以及围绕所述块配置的一个或多个偏振镜，并且其中所述方法包括通过同时使用三个偏振镜同时测量光弹性强度并及时获得每组光弹性强度以获得测量的光弹性强度序列，并且通过使用基于与差异相关联的量的优化方法来获得力在测量和预测的光弹性强度之间。

8. 发明申请

WO2014083546A2 METHOD OF DETERMINING EFFECT OF ANTI-OBESITY MOLECULE 审中-公开
标题翻译：确定抗肥胖分子效应的方法
公开(公告)号：WO2014083546A2
公开(公告)日：2014-06-05
申请号：PCT/IB2013/060517
申请日：2013-11-29
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
发明人： HASAN, Gaiti , SUBRAMANIAN, Manivannan
IPC分类号： A61K49/00
CPC分类号： A61K49/0008
摘要： The present disclosure relates to a method of determining the anti-obesity effect of a molecule, using mutant Drosophila strains. Specifically, the instant disclosure is useful for testing drugs developed to reduce appetite, reduce fatty acid uptake from the intestine and reduce excess fat deposits.
摘要翻译：本公开涉及使用突变果蝇属菌株测定分子的抗肥胖作用的方法。具体而言，本公开对于测试开发用于降低食欲，减少来自肠的脂肪酸摄取并减少过量脂肪沉积的药物是有用的。

9. 发明申请

WO2014072960A2 A METHOD TO IDENTIFY AND ISOLATE PLURIPOTENT STEM CELLS USING ENDOGENOUS BLUE FLUORESCENCE 审中-公开
标题翻译：使用内源性蓝色荧光鉴定和分离全脑干细胞的方法
公开(公告)号：WO2014072960A2
公开(公告)日：2014-05-15
申请号：PCT/IB2013/060076
申请日：2013-11-12
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
发明人： PANICKER, Mitradas M. , MENON, Radhika , THANGASELVAM, Muthusamy , MUKHERJEE, Odity
IPC分类号： C12Q1/00
CPC分类号： G01N21/6486 , C12N5/0606 , C12N5/0696 , C12N2501/115 , C12N2501/16 , C12N2501/2306 , C12N2501/727 , C12Q1/04
摘要： The instant disclosure provides for a method of identifying and isolating pluripotent stem cells and distinguishing pluripotent stem cells from differentiating/ differentiated cells, using the property of endogenous blue fluorescence emitted from intracellular lipid bodies which serves as an endogenous marker for the pluripotent state.
摘要翻译：本公开提供了使用从作为多能状态的内源性标记物的细胞内脂质体发射的内源性蓝色荧光的性质来鉴定和分离多能干细胞并区分分化/分化细胞的多能干细胞的方法。

10. 发明申请

WO2013054286A1 A NUCLEIC ACID ASSEMBLY, VECTOR, CELL, METHODS AND KIT THEREOF 审中-公开
标题翻译：核酸组件，载体，细胞，方法和工具包
公开(公告)号：WO2013054286A1
公开(公告)日：2013-04-18
申请号：PCT/IB2012/055515
申请日：2012-10-11
申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
发明人： KRISHNAN, Yamuna , MODI, Souvik
IPC分类号： C12N15/62 , C12Q1/68
CPC分类号： C12N15/85 , C07K16/44 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/82 , C07K2317/92 , C07K2319/00 , C12N15/113 , C12N2810/85 , C12N2810/859
摘要： The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM- NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting motif sequence and a cell comprising the vector. Further, the instant disclosure also provides a method to obtain the nucleic acid assembly, method of intracellular targeting and kit thereof.
摘要翻译：本公开涉及包含传感器结构域和手柄结构域的核酸组装体（NAA）; 任选地与细胞内靶向基序（ITM）序列的组装接口基序（AIM）序列; 和AIM-NAA复合物。它还涉及包含任选地与细胞内靶向基序序列的组装可接合基序序列的载体和包含载体的细胞。此外，本公开还提供了获得核酸组装，细胞内靶向方法及其试剂盒的方法。

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