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1. 发明申请

WO1982003871A1 PROCESS FOR MAKING NOVEL BLOOD CLOTTING ENZYME COMPOSITIONS 审中-公开
标题翻译：制备新型血液衣物组合物的方法
公开(公告)号：WO1982003871A1
公开(公告)日：1982-11-11
申请号：PCT/US1982000366
申请日：1982-03-25
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , THOMAS WILLIAM R
IPC分类号： C12N09/48
CPC分类号： C12N7/00 , A61K31/14 , A61K35/14 , A61K38/00 , A61K38/48 , A61K39/12 , A61K39/29 , A61L2/0023 , A61L2/04 , C12N9/00 , C12N9/50 , C12N9/6429 , C12N9/647 , C12N2770/32461 , C12Q1/56 , C12Y304/21005 , G01N2333/974 , Y02A50/464
摘要： Viruses, particularly hepatitis viruses, in blood clotting enzyme compositions are inactivated with little enzyme activity loss by heating the compositions in the dry state. The novel products which result are therapeutically and diagnostically useful.
摘要翻译：通过在干燥状态下加热组合物，血液凝固酶组合物中的病毒，特别是肝炎病毒被灭活，几乎没有酶活性损失。结果的新产品在治疗和诊断上有用。

2. 发明申请

WO1982003298A1 VOLTAGE REGULATOR IN MOTOR CONTROL 审中-公开
标题翻译：电机控制中的电压调节器
公开(公告)号：WO1982003298A1
公开(公告)日：1982-09-30
申请号：PCT/US1982000193
申请日：1982-02-16
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , FELDMAN GARY
IPC分类号： H02J07/00
CPC分类号： H02P7/288 , Y10S388/91
摘要： Battery-operated motor control circuit. An adjustable voltage reference (18, 26, 28) is coupled to the battery (10), with the output of the adjustable voltage reference being coupled to the positive input of an operational amplifier (34). The negative input of the operational amplifier (34) is coupled to ratio control means (60) for setting the gain of the operational amplifier (34) and thus setting the motor (54) to a selected speed. A transistor-pair amplifier (38, 40) is coupled to the output of the operational amplifier (34), with a negative feedback line (50) being coupled from the output of the transistor amplifier to the negative input of the operational amplifier. The motor is also coupled to the output of the transistor amplifier.
摘要翻译：电池驱动电机控制电路。可调参考电压（18,26,28）耦合到电池（10），可调电压基准的输出端耦合到运算放大器（34）的正输入端。运算放大器（34）的负输入耦合到比率控制装置（60），用于设置运算放大器（34）的增益，从而将电动机（54）设置为选定的速度。晶体管对放大器（38,40）耦合到运算放大器（34）的输出，负反馈线（50）从晶体管放大器的输出端耦合到运算放大器的负输入端。电机也耦合到晶体管放大器的输出端。

3. 发明申请

WO1982001480A1 METHOD AND CHAMBER FOR SEPARATING GRANULOCYTES FROM WHOLE BLOOD 审中-公开
标题翻译：用于从全血中分离颗粒细胞的方法和室
公开(公告)号：WO1982001480A1
公开(公告)日：1982-05-13
申请号：PCT/US1981001334
申请日：1981-10-02
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , CULLIS HERBERT M , GUTIERREZ LUIS F
IPC分类号： B04B09/12
CPC分类号： B04B5/0428
摘要： Procede de separation du sang en ses composants mis en oeuvre a l'interieur d'une chambre de separation montee dans une centrifugeuse pendant la centrifugation de la chambre, la chambre possedant des surfaces de paroi interieure (130) et exterieure (160) ainsi qu'un premier (131, 132; 181, 182, 183) et un deuxieme (133, 134; 185, 186) bord lateral. Le procede consiste a: disposer et amenager la chambre de maniere qu'elle possede (a) un orifice d'entree (142) sur le premier cote (131, 132; 181, 182, 183) au travers duquel le sang penetre dans la chambre, (b) un premier orifice de sortie superieur (122) sur le sommet de la chambre d'ou l'on peut extraire le plasma avec les particules qu'il contient, (c) un deuxieme orifice de sortie inferieur (190) sur la paroi exterieure de la chambre dans un coin inferieur de celle-ci d'ou l'on peut extraire les globules rouges, et (d) la surface de la paroi interieure (130) positionnee dans un plan comprenant une tangente a un cercle autour de l'axe de rotation, le plan etant positionne a peu pres perpendiculairement (dans une direction verticale) par rapport a un rayon s'etendant de l'axe de rotation de la centrifugeuse. Le procede et la chambre dirigent le sang a l'interieur de la chambre depuis le premier cote (131, 132; 181, 182, 183) vers un point entre le fond et le sommet de la chambre. Des particules plus lourdes telles que les globules rouges sont dirigees vers le bas et vers l'exterieur le long de la surface de paroi exterieure (160) vers le coin inferieur de la chambre (190) a proximite du fond. Simultanement, le plasma est achemine vers le haut le long de la surface de paroi interieure de la chambre de maniere a obtenir une separation des leucocytes, notamment des granulocytes, du sang, ces particules etant acheminees avec le plasma, vers le premier orifice de sortie (122) de la chambre.

4. 发明申请

WO1982000205A1 NON-A,NON-B HEPATITIS ASSAY AND VACCINE 审中-公开
标题翻译：非A，非乙型肝炎测定和疫苗
公开(公告)号：WO1982000205A1
公开(公告)日：1982-01-21
申请号：PCT/US1981000869
申请日：1981-06-24
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , COURSAGET P , MAUPAS PHILLIPPE C
IPC分类号： G01N33/54
CPC分类号： G01N33/5767 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , C12N2770/24234 , Y10S436/804 , Y10S436/82
摘要： Une particule nouvelle decouverte dans l'urine et le serum de patients atteints d'hepatite non A, non B a ete associee a l'hepatite non A, non B. La particule ressemble a un togavirus et a un diametre de 50-60nm avec un noyau separe d'environ 40nm de diametre. Le virus perd son caractere infectieux sur une culture de tissus en chauffant a 25 C en suspension aqueuse ou par exposition a l'ether. La particule peut etre cultivee in vitro ou recuperee a partir des fluides ou tissus du corps pour effectuer des immunoessais et des vaccins. Les immuno essais peuvent etre utilises pour detecter les antigenes des particules ou anticorps dans des echantillons d'essais.

5. 发明申请

WO1981003283A1 DISPOSABLE SWAB 审中-公开
标题翻译：不可思议的SWAB
公开(公告)号：WO1981003283A1
公开(公告)日：1981-11-26
申请号：PCT/US1981000500
申请日：1981-04-15
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , HITCHCOCK J , NEVENS C
IPC分类号： A61M35/00
CPC分类号： A61B17/205 , A61F2013/00302 , A61M35/006
摘要： A disposable swab for application of medicament and the like to the skin, which comprises a flat, sheet-like strip (12) and a pad member (14) centrally attached at least one side of the strip. The first inner pair of fold lines (18) is transversely positioned in the strip, with each fold line of the first pair being positioned on opposite sides of, and adjacent opposite ends of, the pad member (14) by generally equal distances, to permit opposed terminal portions of the strip (12) to be folded rearwardly relative to the pad. A second, outer pair of fold lines (22) may be transversely positioned in the strip (12), each fold line of the second pair being positioned adjacent opposite ends of the strip (12) by generally equal distances to permit end portions of the rearwardly folded terminal portions to be pinched by the fingers together into flat, abutting relation. Accordingly the strip (12) can form a structure which is generally triangular in cross section, with the base (26) of the triangular cross section carrying the pad member (14).

6. 发明申请

WO1981002980A1 CONTROL SYSTEM FOR FLUID FLOW APPARATUS 审中-公开
标题翻译：流体流量控制系统
公开(公告)号：WO1981002980A1
公开(公告)日：1981-10-29
申请号：PCT/US1981000335
申请日：1981-03-16
申请人： BAXTER TRAVENOL LAB
发明人： BAXTER TRAVENOL LAB , BILSTAD A , BROWN R
IPC分类号： A61M01/03
CPC分类号： A61M39/285 , A61M1/3496
摘要： A flow control system, for example for blood plasma or other medical fluids, comprises a plurality of flexible, collapsible flow conduits (16, 18, 20, 22) for the selective and aseptic transfer of fluids between various locations through said conduits. Switching means are provided for selectively collapsing a plurality of separate sections of the conduit to block fluid flow therethrough, to selectively define specific and variable fluid flow paths in the flow conduit. In accordance with this invention, the switching means defines a cam plate (32), which in turn defines a generally flat face (35) positioned adjacent portions of the flow conduit. Pivot means (42) are provided causing the cam plate (32) to be rotatable about an axis normal to the flat face (35). Also, a cam connecting system (44, 46) is disclosed, to adapt it to pass through an openable door.
摘要翻译：流量控制系统，例如用于血浆或其它医疗流体，包括多个柔性的，可折叠的流动管道（16,18,20,22），用于通过所述导管在不同位置之间的流体的选择性和无菌传递。提供开关装置用于选择性地塌陷导管的多个分离部分以阻止流过其中的流体流动，以选择性地限定流动导管中的特定且可变的流体流动路径。根据本发明，切换装置限定凸轮板（32），凸轮板又限定了邻近流动管道的部分定位的大致平坦的面（35）。设置枢转装置（42），使得凸轮板（32）能够绕垂直于平面（35）的轴线旋转。此外，公开了凸轮连接系统（44,46），以使其适于通过可打开的门。

7. 发明申请

WO1981002239A1 RED CELL STORAGE SOLUTION 审中-公开
标题翻译：红细胞储存解决方案
公开(公告)号：WO1981002239A1
公开(公告)日：1981-08-20
申请号：PCT/US1980001749
申请日：1980-12-29
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , GRODE G , MIRIPOL J
IPC分类号： A01N01/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： An aqueous red cell storage solution for packed cells which permits removal of essentially all plasma from a unit of blood, followed by reconstitution of the packed cells of the unit in preferably about 80 to 150 ml. of solution for improved cell viability on long term storage. The red cell storage solution contains adenine, glucose or fructose, sodium chloride, and mannitol.

8. 发明申请

WO1981002105A1 THERAPEUTIC COMPOSITIONS & METHODS FOR MANUFACTURE AND USE 审中-公开
标题翻译：用于制造和使用的治疗组合物和方法
公开(公告)号：WO1981002105A1
公开(公告)日：1981-08-06
申请号：PCT/US1981000003
申请日：1981-01-02
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , ANDARY T , BERKEBILE L , TSE D , THOMAS W
IPC分类号： A61K35/14
CPC分类号： C12N9/647 , A61K38/00 , C12N9/6429 , C12Y304/21005
摘要： An improved method for producing activated prothrombin complex concentrate which comprises controlling the degree of activation by determining the activation state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation or the starting material to arrive at a predetermined activation level. Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.
摘要翻译：一种用于生产活化的凝血酶原复合物浓缩物的改进方法，其包括通过确定原料的活化状态来控制活化程度，然后根据活化进程或起始物质的分析来改变至少一种活化条件在预定的激活水平。组合物，以单位/ ml，因子VIII修复活性，约2-35; 凝血酶原，约1-10; 凝血酶，小于约0.003; 因子VII，约为37-190; 因子VIIa，约8-80; 总因子IX，约15-112; 因子IX前体，0至约30; 因子X，约1-30; 并且约1-10个因子Xa以治疗有效量用于治疗凝血因子抑制剂。

9. 发明申请

WO1981001728A1 MINIATURE INFUSION PUMP 审中-公开
标题翻译：微型输液泵
公开(公告)号：WO1981001728A1
公开(公告)日：1981-06-25
申请号：PCT/US1980001560
申请日：1980-11-20
申请人： BAXTER TRAVENOL LAB INC , OLSON R
发明人： BAXTER TRAVENOL LAB INC
IPC分类号： F04B43/12
CPC分类号： F04B43/1253 , A61M5/142
摘要： A pressure pump apparatus (10) for fluids in flexible tubing (12), which comprises a pressure member (30) of generally circular periphery adapted for orbital motion about an axis of rotation (32). A sleeve member (34) is positioned about the pressure member (30) and defines channel means (36, 38) for receiving and retaining the flexible tubing (12) in a predetermined position between the pressure member (30) and sleeve member (34), and surrounding the pressure member (30). The sleeve member (34) may be divided into a pair of substantially semi-circular jaws (34a, 34b) attached together at one end in hinged relation, to permit opening and closing of the jaws about the pressure member (30) to facilitate installation of the tubing (12).

10. 发明申请

WO1981001654A1 LUER LOCK CONNECTION DEVICE 审中-公开
标题翻译： LUER LOCK连接装置
公开(公告)号：WO1981001654A1
公开(公告)日：1981-06-25
申请号：PCT/US1980000985
申请日：1980-07-29
申请人： BAXTER TRAVENOL LAB INC , DENNEHEY T
发明人： BAXTER TRAVENOL LAB INC
IPC分类号： A61M03/00
CPC分类号： A61M39/10 , A61M2039/1033 , Y10S604/905
摘要： A luer lock connection device for medical use, for example, in continuous ambulatory peritoneal dialysis in which a solution container (20) is coupled via flexible tubing (22) to a patient's tube (36) that communicates with the patient's peritoneal cavity. The luer lock connection device includes a cooperating male luer lock connector (34) and a female luer lock connector (30), with visual indicating means (60) provided to indicate that the male and female connectors (34, 30) are assembled properly for use when they are in a predetermined relationship. The male and female luer lock connectors (34, 30) are structured to provide a double sealing arrangement for aiding in maintaining an uncontaminated connection.

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