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1. 发明申请

WO1981002105A1 THERAPEUTIC COMPOSITIONS & METHODS FOR MANUFACTURE AND USE 审中-公开
标题翻译：用于制造和使用的治疗组合物和方法
公开(公告)号：WO1981002105A1
公开(公告)日：1981-08-06
申请号：PCT/US1981000003
申请日：1981-01-02
申请人： BAXTER TRAVENOL LAB INC
发明人： BAXTER TRAVENOL LAB INC , ANDARY T , BERKEBILE L , TSE D , THOMAS W
IPC分类号： A61K35/14
CPC分类号： C12N9/647 , A61K38/00 , C12N9/6429 , C12Y304/21005
摘要： An improved method for producing activated prothrombin complex concentrate which comprises controlling the degree of activation by determining the activation state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation or the starting material to arrive at a predetermined activation level. Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.
摘要翻译：一种用于生产活化的凝血酶原复合物浓缩物的改进方法，其包括通过确定原料的活化状态来控制活化程度，然后根据活化进程或起始物质的分析来改变至少一种活化条件在预定的激活水平。组合物，以单位/ ml，因子VIII修复活性，约2-35; 凝血酶原，约1-10; 凝血酶，小于约0.003; 因子VII，约为37-190; 因子VIIa，约8-80; 总因子IX，约15-112; 因子IX前体，0至约30; 因子X，约1-30; 并且约1-10个因子Xa以治疗有效量用于治疗凝血因子抑制剂。

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