专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1993014199A1 A PUMP-1 CATALYZED METHOD OF MAKING LOW MOLECULAR WEIGHT UROKINASE-TYPE PLASMINOGEN ACTIVATOR 审中-公开
标题翻译：制备低分子量尿激酶型PLASMINOGEN激活剂的PUMP-1催化方法
公开(公告)号：WO1993014199A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000146
申请日：1993-01-08
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MARCOTTE, Patrick, A.
IPC分类号： C12N09/48
CPC分类号： C12N9/6462 , A61K38/00 , C12Y304/21073
摘要： The present invention provides a method of making low molecular weight urokinase-type plasminogen activator comprising cleaving high molecular weight urokinase-type plasminogen activator with the metalloproteinase pump-1. Pharmaceutical compositions and methods of thrombolysis or preventing blood clot formation using that low molecular weight urokinase-type plasminogen activator are also provided.
摘要翻译：本发明提供一种制备低分子量尿激酶型纤溶酶原激活物的方法，其包括用金属蛋白酶泵-1切割高分子量尿激酶型纤溶酶原激活物。还提供了使用该低分子量尿激酶型纤溶酶原激活剂溶栓或预防血块形成的药物组合物和方法。

2. 发明申请

WO1989007641A1 ENHANCEMENT OF THE THERAPEUTIC PROPERTIES OF GLYCOPROTEIN 审中-公开
标题翻译：增加糖蛋白的治疗性质
公开(公告)号：WO1989007641A1
公开(公告)日：1989-08-24
申请号：PCT/US1989000458
申请日：1989-02-06
申请人： GENZYME CORPORATION
发明人： GENZYME CORPORATION , RASMUSSEN, James, R. , BERGH, Michel , HIRANI, Shirish
IPC分类号： C12N09/48
CPC分类号： C12N9/6462 , C12N9/48 , C12N9/82 , C12Y304/21073
摘要： A mammal in need of administration of a glycoprotein is treated by providing the glycoprotein, treating the glycoprotein with a peptide-N -(N-acetyl- beta -glucosaminyl) asparagine amidase to form a modified glycoprotein, admixing the modified glycoprotein with a pharmaceutically acceptable carrier substance to form a therapeutic composition, and administering a pharmaceutically effective amount of the therapeutic composition to the said mammal. Also, modified human tissue plasminogen activator is prepared by providing human tissue plasminogen activator and treating the human tissue plasminogen activator with a peptide-N -(N-acetyl- beta -glucosaminyl) asparagine amidase to convert the asparagine residue at positon 448 to an aspartate residue, without completely deglycosylating the asparagine residue at position 117. Also, modified prourokinase is prepared by the process of providing prourokinase and treating the prourokinase with a peptide-N -(N-acetyl- beta -glucosaminyl) asparagine amidase to convert the asparagine residue at position 302 to an aspartate residue.
摘要翻译：通过提供糖蛋白处理需要施用糖蛋白的哺乳动物，用肽-N 4 - （N-乙酰基-β-葡糖胺酰基）天冬酰胺酰胺酶处理糖蛋白以形成修饰的糖蛋白，将修饰的糖蛋白与用于形成治疗组合物的药学上可接受的载体物质，以及向所述哺乳动物施用药学上有效量的治疗组合物。此外，通过提供人组织纤溶酶原激活剂和用肽-N 4 - （N-乙酰基-β-葡糖胺酰基）天冬酰胺酰胺酶处理人组织纤溶酶原激活物以在位置448处转化天冬酰胺残基来制备修饰的人组织纤溶酶原激活物到天冬氨酸残基，而没有完全去糖基化117位的天冬酰胺残基。此外，通过提供尿激酶原的方法和用肽-N 4 - （N-乙酰基-β-葡糖胺酰基）天冬酰胺处理原尿激酶的方法制备修饰的尿激酶原将位置302处的天冬酰胺残基转化为天冬氨酸残基的酰胺酶。

3. 发明申请

WO1998008941A1 THIOMETHYLENE GROUP-CONTAINING ALDEHYDE CYSTEINE AND SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：含甲醛组合的二氢嘧菌胺和丝氨酸蛋白酶抑制剂
公开(公告)号：WO1998008941A1
公开(公告)日：1998-03-05
申请号：PCT/US1997015238
申请日：1997-08-28
申请人： CEPHALON INC.
发明人： CEPHALON INC. , CHATTERJEE, Sankar
IPC分类号： C12N09/48
CPC分类号： C07C323/60 , C07C317/44
摘要： The present invention is directed to novel thiomethylene group-containing aldehyde inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
摘要翻译：本发明涉及半胱氨酸或丝氨酸蛋白酶的新型含硫代亚甲基基团的醛抑制剂。还描述了使用蛋白酶抑制剂的方法。

4. 发明申请

WO1996028542A1 AN ENZYME WITH AMINOPEPTIDASE ACTIVITY 审中-公开
标题翻译：具有氨基酸酶活性的酶
公开(公告)号：WO1996028542A1
公开(公告)日：1996-09-19
申请号：PCT/DK1996000104
申请日：1996-03-15
申请人： NOVO NORDISK A/S , KAUPPINEN, Sakari , SI, Joan, Qi , SPENDLER, Tina , DAMBMANN, Claus , HALKIER, Torben , OSTERGAARD, Peter, Rahbek
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/48
CPC分类号： C12N9/48 , A21D8/042
摘要： The invention relates to a 35 kDa enzyme exhibiting aminopeptidase activity which is derived from a fungal microorganism, a DNA construct comprising a DNA sequence encoding said enzyme, a recombinant expression vector comprising said DNA construct, and a cell comprising said DNA sequence. It is also an object of the invention to provide a method for producing said enzyme exhibiting aminopeptidase activity, and an enzyme preparation comprising said enzyme, a bread-improving or dough-improving composition comprising the aminopeptidase of the invention. Finally the invention relates to the use of said enzyme exhibiting aminopeptidase activity or enzyme preparations or compositions thereof.
摘要翻译：本发明涉及一种表现出来自真菌微生物的氨基肽酶活性的35kDa酶，包含编码所述酶的DNA序列的DNA构建体，包含所述DNA构建体的重组表达载体和包含所述DNA序列的细胞。本发明的另一个目的是提供一种生产表现出氨基肽酶活性的酶的方法，以及包含所述酶的酶制剂，包含本发明氨基肽酶的面包改良组合物或面团改良组合物。最后，本发明涉及所述显示氨基肽酶活性的酶或酶制剂或其组合物的用途。

5. 发明申请

WO1995001427A1 PRO-UROKINASE MUTANTS 审中-公开
公开(公告)号：WO1995001427A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007278
申请日：1994-06-28
申请人： NEW ENGLAND DEACONESS HOSPITAL CORPORATION
发明人： NEW ENGLAND DEACONESS HOSPITAL CORPORATION , LIU, Jian-Ning , GUREWICH, Victor
IPC分类号： C12N09/48
CPC分类号： C12Y304/21073 , A61K38/00 , C12N9/6459 , C12N9/6462 , C12Y304/21069
摘要： The invention relates to thrombolytically active pro-urokinase (pro-UK) mutants comprising the amino acid sequence of native pro-UK, but including a mutation which causes the pro-UK mutants to induce less fibrinogenolysis and non-specific plasminogen activation than native pro-UK, to have at least a 10-fold lower intrinsic activity than native pro-UK, and to have substantially the same fibrin promotion and thrombolytic activity after plasmin activation compared to native pro-UK when administered to a patient. The figure depicts the flexible loop (amino acids 297-313), in which a substitution occurs.
摘要翻译：本发明涉及包含天然亲UK的氨基酸序列的溶栓活性的原尿激酶（pro-UK）突变体，但是包括引起前UK突变体诱导的纤维蛋白原分解和非特异性纤溶酶原激活的突变比天然pro -UK与天然亲UK相比具有至少10倍的内在活性，并且当给予患者时，与原始亲UK相比，在纤溶酶活化后具有基本上相同的纤维蛋白促进和血栓溶解活性。该图描绘了发生替换的柔性环（氨基酸297-313）。

6. 发明申请

WO1993012225A1 NOVEL TISSUE PLASMINOGEN ACTIVATOR VARIANTS 审中-公开
标题翻译：新组织PLASMINOGEN ACTIVATOR VARIANTS
公开(公告)号：WO1993012225A1
公开(公告)日：1993-06-24
申请号：PCT/US1992010677
申请日：1992-12-14
申请人： GENENTECH, INC. , HEYNEKER, Herbert, L. , VEHAR, Gordon, A. , PAONI, Nicholas, F. , BENNETT, William, F.
发明人： GENENTECH, INC.
IPC分类号： C12N09/48
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： Biologically active variant tissue plasminogen activators are disclosed. The disclosure focuses on position 276 variants that exhibit enhanced fibrin specificity.
摘要翻译：公开了生物活性变体组织纤溶酶原激活剂。本公开集中于显示增强的纤维蛋白特异性的位置276变体。

7. 发明申请

WO1998013482A1 DETERGENT-FREE HEPATITIS C PROTEASE 审中-公开
标题翻译：无免疫抗体C蛋白
公开(公告)号：WO1998013482A1
公开(公告)日：1998-04-02
申请号：PCT/US1997017029
申请日：1997-09-23
申请人： MERCK & CO., INC. , SARDANA, Vinod, V. , BLUE, Jeffrey, T.
发明人： MERCK & CO., INC.
IPC分类号： C12N09/48
CPC分类号： C12N9/503
摘要： The protease of Hepatitis C virus (HCV) is purified without detergent, and is useful as a screening tool for HCV antivirals as well as a diagnostic tool for diseases resulting from HCV infection.
摘要翻译：丙型肝炎病毒（HCV）的蛋白酶纯化无洗涤剂，可用作HCV抗病毒药物的筛选工具以及HCV感染引起的疾病的诊断工具。

8. 发明申请

WO1996023064A1 PRODUCTION OF ENZYMATICALLY ACTIVE RECOMBINANT CARBOXYPEPTIDASE B 审中-公开
标题翻译：生物活性重组羧化酶B
公开(公告)号：WO1996023064A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000995
申请日：1996-01-25
申请人： BIO-TECHNOLOGY GENERAL CORP. , HARTMAN, Jacob , FULGA, Netta , MENDELOVITCH, Simona , GORECKI, Marian
发明人： BIO-TECHNOLOGY GENERAL CORP.
IPC分类号： C12N09/48
CPC分类号： C12N9/48 , C07K14/62
摘要： The subject invention provides a method of producing enzymatically active CPB which comprises treating a recombinant cell containing DNA encoding ProCPB, so that the DNA directs expression of the ProCPB, recovering from the cell the ProCPB so expressed, treating the recovered ProCPB under conditions permitting folding of the ProCPB, subjecting the folded ProCPB to enzymatic cleavage to produce enzymatically active CPB and purifying the enzymatically active CPB.
摘要翻译：本发明提供了一种生产酶活性CPB的方法，其包括处理含有编码ProCPB的DNA的重组细胞，使得DNA指导ProCPB的表达，从细胞中回收如此表达的ProCPB，在允许折叠的条件下处理回收的ProCPB ProCPB，对经折叠的ProCPB进行酶切以产生酶活性CPB并纯化酶活性CPB。

9. 发明申请

WO1996014404A1 TRIPEPTIDYL AMINOPEPTIDASE 审中-公开
标题翻译： TRIPEPTIYY AMINOPEPTIDASE
公开(公告)号：WO1996014404A1
公开(公告)日：1996-05-17
申请号：PCT/DK1995000446
申请日：1995-11-08
申请人： NOVO NORDISK A/S , HOLM, Kaj, André , RASMUSSEN, Grethe , HALKIER, Torben , LEHMBECK, Jan
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/48
CPC分类号： C12N9/48
摘要： A tripeptidyl aminopeptidase (TPAP) which is encoded by a DNA construct comprising: i) the DNA sequence shown in SEQ ID No. 1, 2 or 3, or ii) the partial TPAP encoding DNA sequence of DSM 9570, or iii) a nucleotide sequence which hybridizes to an oligonucleotide probe prepared on the basis of the DNA sequences shown in SEQ ID No. 1, 2 or 3 or on the basis of any of the amino acid sequences shown in SEQ ID Nos. 4-14, and which encodes a TPAP. The TPAP may be obtained by recombinant DNA technology. TPAP-deficient production strains may be produced by inactivating or modifying a TPAP-encoding DNA sequence.
摘要翻译：由DNA构建体编码的三肽基氨基肽酶（TPAP），其包含：i）SEQ ID No.2或3所示的DNA序列，或ii）DSM 9570的部分TPAP编码DNA序列，或iii）核苷酸其与基于SEQ ID No.1,2或3所示的DNA序列或基于SEQ ID No.4-14所示的任何氨基酸序列制备的寡核苷酸探针杂交，并且其编码 TPAP。 TPAP可以通过重组DNA技术获得。可以通过灭活或修饰编码TPAP的DNA序列来产生TPAP缺陷型生产菌株。

10. 发明申请

WO1990013661A1 AUTOANTIBODIES WHICH ENHANCE THE RATE OF A CHEMICAL REACTION 审中-公开
标题翻译：提高化学反应速率的自动化
公开(公告)号：WO1990013661A1
公开(公告)日：1990-11-15
申请号：PCT/US1990002274
申请日：1990-04-25
申请人： IGEN, INC. , SUDHIR, Paul
发明人： IGEN, INC.
IPC分类号： C12N09/48
CPC分类号： C07K14/57563 , C07K16/06 , C07K16/26 , C07K2317/34 , C12N9/0002 , C12N9/48
摘要： Autoantibodies which enhance the rate of a chemical reaction of a substrate, processes for their preparation, their use and compositions thereof are disclosed. In particular, an autoantibody capable of catalyzing the hydrolysis of the peptide bond between amino acid residues Thr?7-Asp8, Arg14-Lys15, Gln16-Met17, Met17-Ala18, Ala18-Val19¿, Lys¿20?-Lys?21, Lys21-Tyr22¿ in the neurotransmitter vasoactive intestinal peptide (VIP) is disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式