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81. 发明申请

WO99034758A1 TECHNIQUE FOR USING BRAIN HEAT FLOW MANAGEMENT TO TREAT BRAIN DISORDERS 审中-公开
标题翻译：使用脑热管理来治疗脑疾病的技术
公开(公告)号：WO99034758A1
公开(公告)日：1999-07-15
申请号：PCT/US1999/000374
申请日：1999-01-12
IPC分类号： A61B17/00 , A61B17/22 , A61F7/00 , A61F7/02 , A61F7/12 , A61N1/36
CPC分类号： A61F7/00 , A61B2017/00084 , A61B2017/22082 , A61F7/12 , A61F2007/0008 , A61F2007/0075 , A61F2007/0078 , A61F2007/0095 , A61F2007/0295 , A61F2007/126 , A61N1/36025 , A61N1/36064 , A61N1/36075 , A61N1/36082 , A61N1/36135
摘要： A method of treating a brain disorder by heat transfer from brain tissue comprising the steps of surgically cutting a heat transfer aperture into a patient's skull, thereby exposing a predetermined portion of patient's brain; surgically implanting into said heat transfer aperture a heat pump (1) having one or more electrical sensor elements (3, 4, 18), and one or more temperature sensor elements; surgically implanting a heat transfer management unit (8) in a body cavity of said patient such that a micro-controller of the heat transfer management unit is connected to one or more activity sensor elements one or more temperature sensor elements contacting brain tissue and connecting the heat transfer management unit to said heat pump via a lead bundle (2). Optionally, the heat transfer unit may be located external to the patient's body. Responsive to signals from one or more activity or temperature sensor elements, mathematical algorithms of the heat transfer management unit determine abnormal brain activity, causing the heat pump to remove heat from the brain tissue into a heat sink, thereby cooling the predetermined portion of the patient's brain.
摘要翻译：一种通过从脑组织传热来治疗脑疾病的方法，包括以下步骤：将热传递孔手术切割到患者的颅骨中，从而暴露患者脑部的预定部分; 将具有一个或多个电传感器元件（3,4,18）和一个或多个温度传感器元件的热泵（1）手术植入所述传热孔中; 将热传递管理单元（8）手术植入所述患者的体腔中，使得传热管理单元的微控制器连接到一个或多个活动传感器元件，一个或多个温度传感器元件接触脑组织并将热传递管理单元经由引线束（2）传送到所述热泵。可选地，传热单元可以位于患者身体的外部。响应于来自一个或多个活动或温度传感器元件的信号，传热管理单元的数学算法确定异常大脑活动，导致热泵将热量从脑组织移走到散热器中，从而冷却患者的预定部分脑。

82. 发明申请

WO1993017628A1 A BRAIN AND NERVE HEALING POWER APPARATUS AND METHOD 审中-公开
标题翻译：脑和神经治疗电力设备和方法
公开(公告)号：WO1993017628A1
公开(公告)日：1993-09-16
申请号：PCT/US1992001810
申请日：1992-03-03
申请人： SCHURIG, Alma, K. , SCHURIG, Janet, S.
IPC分类号： A61B17/52
CPC分类号： A61N1/36025 , A61M21/00 , A61M2205/054 , A61M2205/057 , A61N2/002 , A61N2/006
摘要： An apparatus and method is provided for supplying healing power to the brain and nervous system which includes applying a constant magnetic field in a cap (2) worn on the head of a subject (1) and stimulating the nerves with electric signals applied by electrodes (21) to neural pathways in the hands while the subject listens to and watches an auditory/visual stimulation means (22). By means of control lines (25) to the audio/video source (23), electric signal source (20), it is possible to synchronize by controls (24) auditory and/or visual stimulation with magnetic and electrical stimulation.
摘要翻译：提供了一种用于向大脑和神经系统提供愈合力的装置和方法，其包括在佩戴在对象（1）的头部上的帽（2）中施加恒定的磁场，并用电极施加的电信号刺激神经 21）到手中的神经通路，而受试者听和观察听觉/视觉刺激手段（22）。借助于音频/视频源（23）的控制线（25），电信号源（20），可以通过磁刺激和电刺激的控制（24）听觉和/或视觉刺激来同步。

83. 发明申请

WO2019121910A1 APPARATUS AND METHOD FOR CREATING RESONANT STANDING WAVES IN BIOLOGICAL TISSUE 审中-公开
公开(公告)号：WO2019121910A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085838
申请日：2018-12-19
申请人： INNOVARIUS LTD.
发明人： NUNEZ, Albert , MILLER, Eric , MINKER, Gary , NUNEZ, Alex
IPC分类号： A61N1/40 , A61N5/02 , A61N1/06 , A61N1/36 , A61N1/04
CPC分类号： A61N1/403 , A61N1/0464 , A61N1/0468 , A61N1/06 , A61N1/36002 , A61N1/36021 , A61N1/36025 , A61N1/36034 , A61N5/025
摘要： An apparatus for or method of creating resonant standing waves in biological tissue of a subject in treating oncological disorders, in particular tumors, comprising applying AM modulated and FM modulated carrier signals simultaneously to a subject in order to create resonant standing waves in the tissue.

84. 发明申请

WO2019012556A1 A DEVICE FOR NON-INVASIVE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
公开(公告)号：WO2019012556A1
公开(公告)日：2019-01-17
申请号：PCT/IN2018/050452
申请日：2018-07-10
申请人： INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI
发明人： RAMAKRISHNAN, Vibin , PANDEY, Gaurav , NEMADE, Harshal , SAIKIA, Jahnu , SASIDHARAN, Sajitha , CHAUDHARY, Nitin
IPC分类号： A61N5/02 , G01N33/68
CPC分类号： A61N1/36025 , A61N1/0536
摘要： The present invention provides a device for treating neurodegenerative diseases including but not limiting to Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis using electric field. More specifically, the invention provides a device which generates focused AC/DC electric field specifically targeting dense insoluble deposits of amyloid-beta (A) peptide outside and around neurons in the brain of a patient. This mode of action serves as a non-invasive therapeutic tool for disruption of the inherent -sheet conformation known to be the reason for fibril formation.

85. 发明申请

WO2017141257A1 NONINVASIVE ELECTRIC BRAIN STIMULATION SYSTEM 审中-公开
标题翻译：无创电脑刺激系统
公开(公告)号：WO2017141257A1
公开(公告)日：2017-08-24
申请号：PCT/IL2017/050218
申请日：2017-02-21
申请人： TECH INNOSPHERE ENGINEERING LTD.
发明人： SHAKOUR, Ehab , BADRAN, Yousef , SHAKOUR, Gabriel , SHACOUR, Rami
IPC分类号： A61N1/18 , A61N1/08 , A61N1/04 , A61N1/36
CPC分类号： A61N1/3603 , A61N1/0456 , A61N1/0476 , A61N1/0526 , A61N1/36025
摘要： Systems, devices and methods for electric stimulation are provided. The system comprises an electrodes' arrangement configured to be placed in the vicinity of a body region to be stimulated; a signal generator configured to supply electric stimulation signals to the electrodes' arrangement; and a control circuitry connected to the signal generator and to the electrodes' arrangement; the electrodes' arrangement comprises a plurality of electrode elements arranged in a spaced-apart relationship and being connected to the signal generator, so as to define spatial resolution of stimulation; the control circuitry determines data indicative of a profile of a stimulating electric field to be produced by the electrodes' arrangement to stimulate at least one desired target in said body region, and selectively assign, for stimulating each target, at least one pair of first and second effective electrodes, each being formed by one or more of said electrode elements, and enable operation of each of said assigned effective electrodes by the signal generator to produce the stimulating electric field.
摘要翻译：提供了用于电刺激的系统，装置和方法。该系统包括被配置为放置在待刺激的身体区域附近的电极装置; 信号发生器，其被配置为将电刺激信号供应给电极装置; 以及连接到信号发生器和电极装置的控制电路; 电极装置包括以间隔开的关系布置并连接到信号发生器的多个电极元件，以限定刺激的空间分辨率; 控制电路确定指示将由电极布置产生的刺激电场的分布的数据，以刺激所述身体区域中的至少一个期望的目标，并且为了刺激每个目标而选择性地分配至少一对第一和第二目标第二有效电极，每个电极由一个或多个所述电极元件形成，并且能够由信号发生器操作每个所述分配的有效电极，以产生激励电场。

86. 发明申请

WO2017075223A1 TRANSCRANIAL CONTROL OF PROCEDURAL MEMORY RECONSOLIDATION FOR SKILL ACQUISITION 审中-公开
标题翻译：程序记忆重组技术在技能获取中的经常性控制
公开(公告)号：WO2017075223A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059129
申请日：2016-10-27
申请人： HRL LABORATORIES, LLC
发明人： PILLY, Praveen, K. , HOWARD, Michael, D. , BHATTACHARYYA, Rajan
IPC分类号： A61B5/0482 , A61B5/0478 , A61B5/048 , A61B5/00
CPC分类号： A61N1/36025 , A61B5/0476 , A61B5/0482 , A61B5/4836 , A61N1/0456 , G09B19/003
摘要： Described is a system for the therapeutic modification of human behavior and, more specifically, a system: for the transcranial control of procedural memory reconsolidation for the purposes of enhanced skill acquisition. During operation the system records a practice pattern. The practice pattern is a recording of a sensed brain activity from a sensor array when a subject is performing a skill. The practice pattern is converted to brain activity voxels and stored as both an uncompressed practice pattern and a compressed practice pattern.
摘要翻译：描述了一种用于对人类行为进行治疗性修饰的系统，并且更具体地描述了一种系统：用于经颅增强技能获取目的的经颅磁控制程序记忆再巩固。在操作期间，系统记录练习模式。练习模式是当受试者正在执行技能时从传感器阵列记录感测到的大脑活动。练习模式转换为大脑活动体素并作为未压缩练习模式和压缩练习模式存储。

87. 发明申请

WO2017006327A1 ELECTRICAL TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默病的电疗法
公开(公告)号：WO2017006327A1
公开(公告)日：2017-01-12
申请号：PCT/IL2016/050728
申请日：2016-07-07
申请人： RAINBOW MEDICAL LTD.
发明人： GROSS, Yossi
IPC分类号： A61N1/32 , A61N1/30
CPC分类号： A61N1/0529 , A61N1/20 , A61N1/30 , A61N1/325 , A61N1/36025
摘要： An electrical amyloid beta-clearance system (20) for treating a subject identified as at risk of or suffering from Alzheimer's disease is provided. The system (20) includes (a) midplane treatment electrodes (30), adapted to be disposed over a superior sagittal sinus (40), outside and in electrical contact with a skull (42) of a head (44) of the subject; and (b) lateral treatment electrodes (32), adapted to be disposed between 1 and 12 cm of a sagittal midplane (46) of the skull (42). The system (20) further includes control circuitry (34), configured to clear amyloid beta from a subarachnoid space (50) to the superior sagittal sinus (40), by applying one or more treatment currents between (a) one or more of the midplane treatment electrodes (30) and (b) one or more of the lateral treatment electrodes (32). Other embodiments are also described.
摘要翻译：提供了用于治疗被认定为患有或患有阿尔茨海默病的受试者的电淀粉样蛋白β-清除系统（20）。所述系统（20）包括（a）中平面处理电极（30），其适于设置在上矢状窦（40）上方，与所述受试者的头部（44）的头骨（42）外部并与之电接触; 和（b）横向治疗电极（32），适于设置在颅骨（42）的矢状中平面（46）的1至12cm之间。所述系统（20）还包括控制电路（34），其配置成通过在（a）一个或多个所述至少一个或多个所述治疗电流之间施加一个或多个治疗电流，将淀粉样蛋白β从蛛网膜下腔（50）清除到所述上矢状窦（40）中间面处理电极（30）和（b）一个或多个侧面处理电极（32）。还描述了其它实施例。

88. 发明申请

WO2016182947A1 MONTAGE DESIGN FOR CLOSED LOOP SENSING AND NEUROSTIMULATION OF THE DORSAL LATERAL PREFRONTAL CORTEX AND/OR MOTOR CORTEX 审中-公开
标题翻译：闭合环路感测和背景侧视角和/或电机角膜神经元的蒙特利尔设计
公开(公告)号：WO2016182947A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/031321
申请日：2016-05-06
申请人： HRL LABORATORIES, LLC
发明人： ZIEGLER, Matthias , CHOE, Jaehoon , PHILLIPS, Matthew, E.
IPC分类号： A61N1/36 , A61N1/08
CPC分类号： A61N1/08 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/165 , A61B5/4836 , A61N1/36 , A61N1/36025
摘要： Described is a system for automatic adjustment of neurostimulation. The system controls stimulation of specific neural regions through a neural device positioned on a human subject, while simultaneously performing recordings from the neural device using a targeted arrangement of stimulating electrodes and distinct types of recording electrodes of the neural device. Stimulation of the specific neural regions is adjusted in real-time based on the recordings from the neural device.
摘要翻译：描述了一种自动调节神经刺激的系统。该系统通过定位在人类对象上的神经装置来控制对特定神经区域的刺激，同时使用神经装置的刺激电极和不同类型的记录电极的目标排列同时执行来自神经装置的记录。基于神经元的记录，实时调整特定神经区域的刺激。

89. 发明申请

WO2016145232A3 SYSTEM AND METHOD FOR TRAINING AND ASSESSMENT 审中-公开
标题翻译：用于培训和评估的系统和方法
公开(公告)号：WO2016145232A3
公开(公告)日：2016-11-17
申请号：PCT/US2016021841
申请日：2016-03-10
申请人： HRL LAB LLC , PHILLIPS MATTHEW E , ZIEGLER MATTHIAS , CHOE JAEHOON
发明人： PHILLIPS MATTHEW E , ZIEGLER MATTHIAS , CHOE JAEHOON
IPC分类号： G09B9/08
CPC分类号： A61N1/36025 , A61B5/0075 , A61B5/0476 , A61B5/6803 , A61N1/0408 , A61N1/0456 , A61N1/0484 , A61N1/36014 , G09B5/00 , G09B7/00 , G09B9/08 , G09B9/24 , G09B19/165
摘要： Described is a system for training and assessment. In operation, the system classifies a subject's baseline brain state and, behavioral performance. Training goals are assessed to specify tasks the subject is to perform and a desired level of performance. The subject is subjected to neurological stimulation while the subject performs specified tasks. Behavioral data is assessed to determine if the subject has achieved the training goals. If the subject has achieved the training goals, the system stops. Alternatively, if the individual has not achieved the training goals, then neurological data is reviewed to identify activation states and values of the neurological stimulation that resulted in increased performance values from the baseline behavioral performance. The activation states and values of the neurological stimulation are adjusted to match those that resulted in increased performance values. The process is repeated until the subject has achieved the training goals.
摘要翻译：描述的是一个培训和评估系统。在操作中，系统将受试者的基线大脑状态和行为表现分类。评估培训目标以指定主题要执行的任务和期望的性能水平。受试者在受试者执行指定任务时受到神经刺激。评估行为数据以确定主体是否达到了培训目标。如果主题已达到培训目标，系统将停止。或者，如果个体尚未达到训练目标，则审查神经学数据以鉴定导致基线行为表现的性能值增加的神经刺激的激活状态和值。神经刺激的激活状态和值被调整以匹配导致性能值增加的那些。重复这个过程直到主题达到培训目标。

90. 发明申请

WO2016155773A1 DEVICE FOR THE TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE TRIGEMINAL NERVE 审中-公开
标题翻译： TRIGANNUSUS电刺激的TRIGEMINAL神经的装置
公开(公告)号：WO2016155773A1
公开(公告)日：2016-10-06
申请号：PCT/EP2015/056889
申请日：2015-03-30
申请人： CEFALY TECHNOLOGY SPRL
发明人： MULLER, Pierre-Yves , RIGAUX, Pierre
IPC分类号： A61N1/36 , A61N1/04 , A61N1/08
CPC分类号： A61N1/36021 , A61N1/0456 , A61N1/0492 , A61N1/08 , A61N1/36025 , A61N1/36034
摘要： The present invention provides a device for the transcutaneous electrical stimulation of the trigeminal nerve. The device comprises an elongated symmetrical support comprising at least one electrode pair, said support being suitable to be applied on the forehead of a person's face in the supraorbital region thereby covering the afferent paths of the supratrochlear and supraorbital nerves of the ophthalmic branch of the trigeminal nerve; each electrode pair being in contact with a self-adhesive conductive gel, said conductive gel covering at least partially one surface of the support for attaching said support to the forehead and being applied to two lateral zones with the exception of an insulating central zone, whereby each lateral zone comprises one electrode of the electrode pair; at least one electric circuit for supplying to the electrode pair electric pulses having a predefined intensity, and at least one measurement means for measuring the intensity of the supplied pulses, said measurement means being connected to the electric circuit.
摘要翻译：本发明提供了一种用于经皮电刺激三叉神经的装置。所述装置包括细长的对称支撑件，其包括至少一个电极对，所述支撑件适于施加在眶上区域的人脸的前额上，从而覆盖三叉神经眼科分支的上棘动脉和眶上神经的传入路径神经; 每个电极对与自粘性导电凝胶接触，所述导电凝胶至少部分地覆盖支撑件的一个表面，用于将所述支撑件附接到前额，并且被施加到除了绝缘中心区域之外的两个侧向区域，由此每个横向区域包括电极对的一个电极; 至少一个用于向电极对提供具有预定强度的电脉冲的电路，以及用于测量所提供的脉冲强度的至少一个测量装置，所述测量装置连接到电路。

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