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81. 发明申请

WO2017197286A1 DEPLOYABLE REFLECTOR ANTENNA 审中-公开
标题翻译：可展开的反射器天线
公开(公告)号：WO2017197286A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/032446
申请日：2017-05-12
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , SOUTHWEST RESEARCH INSTITUTE
发明人： WALKER, Christopher K. , SMITH, Ira Steve
IPC分类号： H01Q1/08 , H01Q15/20 , H01Q19/10
CPC分类号： H01Q1/082 , H01Q1/288 , H01Q15/161 , H01Q15/163
摘要： A balloon reflector antenna for a satellite, including a spherical balloon with a surface transparent to electromagnetic waves and a reflective surface opposite the transparent surface. The balloon reflector antenna may further include a feed system extending from the center of the balloon that receives electromagnetic waves reflected off the reflective surface and/or outputs electromagnetic waves that are reflected off the reflective surface.
摘要翻译：用于卫星的气球反射器天线，包括具有对电磁波透明的表面的球形气球和与透明表面相对的反射表面。气球反射器天线可以进一步包括从气囊的中心延伸的馈送系统，其接收从反射表面反射的电磁波和/或输出反射离开反射表面的电磁波。

82. 发明申请

WO2017192558A1 THERMOACOUSTIC IMAGE-GUIDED MICROWAVE THERAPY SYSTEM 审中-公开
标题翻译：热声图像引导微波治疗系统
公开(公告)号：WO2017192558A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030599
申请日：2017-05-02
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： WITTE, Russell , XIN, Hao , MARTIN, Diego
IPC分类号： A61N7/02
CPC分类号： A61B18/1815 , A61B2017/00053 , A61B2017/00106 , A61B2017/008 , A61B2018/00333 , A61B2018/00446 , A61B2018/00529 , A61B2018/00577 , A61B2018/00642 , A61B2018/00809 , A61B2018/1853 , A61B2018/1884 , A61B2090/378 , A61N1/403 , A61N5/025 , A61N2005/027
摘要： A method and system capable of applying microwave therapy guided by thermoacoustic imaging and/or thermoacoustic thermometry is disclosed. The system includes a thermoacoustic imaging system and/or a thermoacoustic thermometry system that generate(s) a map of a region of interest; and a microwave therapy system that targets the region of interest using the 5 map, and that applies the microwave therapy to the targeted region of interest. Treatment of the targeted region of interest may be employed by the microwave therapy system using real-time feedback from the thermoacoustic imaging system and/or the thermoacoustic thermometry system. Imaging and therapy may be automatically co-registered.
摘要翻译：公开了一种能够应用通过热声成像和/或热声测温引导的微波疗法的方法和系统。该系统包括产生感兴趣区域的图的热声成像系统和/或热声测温系统; 以及使用该地图针对感兴趣区域的微波疗法系统，并且将微波疗法应用于目标感兴趣区域。利用来自热声成像系统和/或热声测温系统的实时反馈，微波治疗系统可以使用目标感兴趣区域的治疗。成像和治疗可能会自动共同注册。

83. 发明申请

WO2017184845A1 METHODS AND SYSTEMS FOR RNA OR DNA DETECTION AND SEQUENCING 审中-公开
标题翻译：用于RNA或DNA检测和测序的方法和系统
公开(公告)号：WO2017184845A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028591
申请日：2017-04-20
申请人： THE ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA
发明人： WOROBEY, Michael , WATTS, Thomas
IPC分类号： C12Q1/68 , C12Q1/70 , C07H21/04
CPC分类号： C12Q1/6844 , C12Q1/70 , C12Q1/703 , C12Q2521/107 , C12Q2525/204 , C12Q2537/143
摘要： Disclosed are methods and systems for detecting RNA and sequencing RNA in a wide range of samples such as samples with low concentrations of nucleic acid, samples with degraded nucleic acid, samples that would not otherwise be amenable to conventional sequencing or RNA detection methods, poor quality samples, high quality samples in which rare mutations are sought, formalin-fixed paraffin-embedded samples, blood samples, etc. The methods of the present invention may use paired, large panels of primers to amplify many short fragments that overlap between but not within each panel. Each panel's amplicon set may fill the gaps between those of the opposing panel, thereby providing complete gene or genomic coverage. A preliminary, multiplex amplification step amplifies target nucleic acid for all downstream reactions such as Sanger sequencing, cloning, and Next Generation Sequencing (NGS).
摘要翻译：公开了用于在广泛范围的样品中检测RNA和测序RNA的方法和系统，例如具有低浓度核酸的样品，具有降解的核酸的样品，否则将不适合常规测序或RNA检测方法，质量差的样品，寻求罕见突变的高质量样品，福尔马林固定的石蜡包埋样品，血液样品等。本发明的方法可以使用成对的大型引物组来扩增许多在每个面板之间但不在每个面板之间重叠的短片段每个小组的扩增子组可填补相对小组之间的空白，从而提供完整的基因或基因组覆盖。初步的多重扩增步骤扩增所有下游反应的目标核酸，如Sanger测序，克隆和下一代测序（NGS）。

84. 发明申请

WO2017180911A1 METHODS AND SYSTEMS FOR DETECTING OR MONITORING AGGREGATION RELATED TO AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：用于检测或监测与肌萎缩侧索硬化相关的聚集的方法和系统
公开(公告)号：WO2017180911A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027485
申请日：2017-04-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： SCHWARTZ, Jacob , MOINPOUR, Mahta
IPC分类号： G01N33/53 , G01N33/52 , G01N33/68
CPC分类号： G01N33/533 , C07K1/1136 , C07K1/13 , G01N33/52 , G01N33/57484 , G01N33/582 , G01N33/60 , G01N33/68 , G01N33/6803 , G01N33/6896
摘要： Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as amyotrophic lateral sclerosis (ALS).
摘要翻译：用于检测分子聚集，折叠或相互作用的方法，系统和组合物，其特征在于将测试样品中感兴趣的分子如蛋白质的标记量与对照，例如其中感兴趣的分子变性的样品。如果与对照样品相比，测试样品中存在较少的标记，则测试样品可以包含聚集形式，折叠形式或交互形式的感兴趣分子，例如与另一种分子如蛋白质分子，DNA分子相互作用或RNA分子。本发明可以用于检测或监测诸如肌萎缩侧索硬化症（ALS）的疾病或病症。

85. 发明申请

WO2017180889A1 METHODS AND SYSTEMS FOR DETERMINING STATES OF MOLECULE FOLDING, CONFORMATION, OR INTERACTION 审中-公开
标题翻译：用于确定分子折叠，构象或相互作用状态的方法和系统
公开(公告)号：WO2017180889A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027444
申请日：2017-04-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： SCHWARTZ, Jacob , JEWETT, John, C. , MOINPOUR, Mahta , SHADMEHR, Mehrdad
IPC分类号： C12P13/22 , G01N33/68 , G01N33/533
CPC分类号： G01N33/533 , C07K1/1136 , C07K1/13 , G01N33/52 , G01N33/57484 , G01N33/582 , G01N33/60 , G01N33/68 , G01N33/6803 , G01N33/6896
摘要： Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule.
摘要翻译：用于检测分子聚集，折叠或相互作用的方法，系统和组合物，其特征在于将测试样品中感兴趣的分子如蛋白质的标记量与对照，例如其中感兴趣的分子变性的样品。如果与对照样品相比，测试样品中存在较少的标记，则测试样品可以包含聚集形式，折叠形式或交互形式的感兴趣分子，例如与另一种分子如蛋白质分子，DNA分子相互作用或RNA分子。

86. 发明申请

WO2017176901A1 DIFFRACTION-BASED LIGHT BEAM SCANNER 审中-公开
标题翻译：基于衍射的光束扫描仪
公开(公告)号：WO2017176901A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026174
申请日：2017-04-05
申请人： ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA
发明人： BLANCHE, Pierre, Alexandre , LYNN, Brittany
IPC分类号： H02S40/22 , H01L31/052 , H01L31/054 , F24J2/06 , G02B19/00 , G02B27/10 , A01H3/02
CPC分类号： G02B26/0808 , F24S23/00 , G02B26/0833 , G02B26/101 , G02B26/106 , Y02E10/52
摘要： System and method utilizing a reconfigurable in real-time phase-modulating diffractive device (in a specific case - a 2D array of micro-mirror elements) in conjunction with another diffractive element (active or passive) to spatially steer a beam of polychromatic light such that light reaches the identified target without being substantially angularly dispersed.
摘要翻译：利用可重构的实时相位调制衍射装置（在特定情况下 - 微镜元件的二维阵列）与另一衍射元件（有源或无源）结合的系统和方法以空间地转向一束多色光，使得光到达所识别的目标而基本上没有角度分散。

87. 发明申请

WO2017172839A1 USE OF BIOMARKERS ASSOCIATED WITH LINE-1 审中-公开
标题翻译：使用与LINE-1相关的生物标记
公开(公告)号：WO2017172839A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024633
申请日：2017-03-28
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： RAMOS, Kenneth , REYES-REYES, Elsa, M. , BOJANG, Pasano
IPC分类号： C07K16/18 , C12N9/00 , G01N33/574
CPC分类号： C07K16/18 , C07K2317/34 , C12N9/00 , C12N15/1136 , C12N2310/14 , G01N33/66 , G01N2333/9128 , G01N2800/122 , G01N2800/52
摘要： The present invention provides a method for treating a subject having a clinical condition associated with increased level of L1 expression. The method generally includes determining the expression level of L1 in a subject and administering a TGF-β1 inhibitor to a subject having an increased level of L1 expression. The clinical conditions that can be treated using the method of the invention include, but are not limited to, cancer, chronic obstructive pulmonary disease (COPD), atherosclerosis and pulmonary vascular disease as well as other fibrotic and inflammatory diseases.
摘要翻译：本发明提供了治疗患有与L1表达水平升高相关的临床病症的受试者的方法。该方法一般包括测定受试者中L1的表达水平，并将TGF-β1抑制剂给予L1表达水平升高的受试者。可以使用本发明的方法治疗的临床病症包括但不限于癌症，慢性阻塞性肺病（COPD），动脉粥样硬化和肺血管疾病以及其他纤维化和炎性疾病。

88. 发明申请

WO2017120494A1 METHODS AND SYSTEMS FOR DETECTING PSYCHOTIC DISORDERS ASSOCIATED WITH SEROTONIN 2A RECEPTOR DEFICIENCIES 审中-公开
标题翻译：用于检测与血清素2A受体缺陷相关的精神病的方法和系统
公开(公告)号：WO2017120494A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012571
申请日：2017-01-06
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： GALLITANO-MENDEL, Amelia, L.
IPC分类号： A61K31/403 , A61K31/4045 , A61K38/00 , C12Q1/00 , C12Q3/00
CPC分类号： A61K31/403 , A61K31/4045 , A61K38/00 , A61K49/00 , C12Q3/00 , G01N33/54366
摘要： Methods for detecting resistance to sedation caused by antipsychotic drugs including methods for detecting psychotic disorders such as but not limited to schizophrenia or bipolar I disorder featuring administering to a patient a dose of an antipsychotic medication; and subjecting the patient to an evaluation at a time point following administration of the dose of the antipsychotic medication. The evaluation is adapted to determine a level of sedation resulting from the dose of the antipsychotic medication. A resulting level of sedation may be one of the following: completely sedated, significantly sedated, moderately sedated, not significantly sedated and completely alert. If the individual is not completely sedated or significantly sedated, or is completely alert, then the patient may have a likelihood of having a psychotic disorder such as schizophrenia.
摘要翻译：检测抗精神病药物引起的镇静抗性的方法，包括检测精神障碍例如但不限于精神分裂症或双相I病症的方法，其特征在于给予患者一定剂量的抗精神病药物; 并且在施用剂量的抗精神病药物之后的时间点对患者进行评估。该评估适合于确定由抗精神病药物剂量引起的镇静水平。由此产生的镇静水平可能是以下情况之一：完全镇静，显着镇静，中度镇静，不显着镇静和完全警觉。如果个体没有完全镇静或显着镇静或完全警觉，则患者可能有精神障碍如精神分裂症的可能性。

89. 发明申请

WO2017112921A1 SYSTEMS AND METHODS FOR CHARACTERIZING SEPSIS 审中-公开
标题翻译：用于表征脓毒症的系统和方法
公开(公告)号：WO2017112921A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/068487
申请日：2016-12-23
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： HECKER, Louise , SLEPIAN, Marvin J. , BIME, Christian , ZHOU, Tong , WANG, Ting
IPC分类号： G01N33/53 , G01N33/68 , G01N33/66 , G01N33/574
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2800/26 , G01N2800/52
摘要： The present disclosure relates to methods of characterizing disease. In particular, this invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects suffering from sepsis, based on the characterization of genes associated with a reactive oxygen species (ROS) molecular signature.
摘要翻译：本公开涉及表征疾病的方法。具体而言，本发明涉及基于与活性氧（ROS）分子标记相关的基因的表征，选择治疗，治疗和预测罹患败血症的受试者的存活时间的方法。

90. 发明申请

WO2017112693A1 COMPOSITIONS AND METHODS FOR TREATMENT, AMELIORATION, AND PREVENTION OF ANESTHESIA-INDUCED HYPOTHERMIA 审中-公开
标题翻译：用于治疗，改善和预防麻醉诱导的低温的组合物和方法
公开(公告)号：WO2017112693A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067825
申请日：2016-12-20
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , DIGNITY HEALTH
发明人： PATWARDHAN, Amol , PORRECA, Frank , ROMANOVSKY, Andrej
IPC分类号： A61K31/165 , A61K31/198 , A61K31/44 , A61K45/06 , A61M16/01
CPC分类号： A61K31/165 , A61K31/357 , A61K31/416 , A61K31/506 , A61K31/55 , A61M16/01
摘要： Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
摘要翻译：提供了组合物和方法用于治疗，改善和预防哺乳动物受试者中的麻醉诱导的低体温和/或术后相关的痛觉过敏，所述方法包括给所述受试者施用有效量的离子通道TRPV1抑制剂。 / p>

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