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81. 发明申请

WO2014116987A1 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有集成状态指示的药物输送泵的驱动机构
公开(公告)号：WO2014116987A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/013005
申请日：2014-01-24
申请人： UNITRACT SYRINGE PTY LTD , AGARD, Ryan M.
发明人： AGARD, Ryan M. , HANSON, Ian B. , CICCARELLI, Nicholas J. , O'CONNOR, Sean M. , BOKELMAN, Kevin , BENTE IV, Paul F.
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/14566 , A61M2205/58
摘要： A drive mechanism 2100 includes a housing 2130, a piston 2110 adapted to impart movement to a plunger seal 2060 within a drug container 2050, a plurality of biasing members 2106, 2122 disposed in parallel, and a retainer 2115. The biasing members 2106, 2122 are disposed to release energy to cause movement of the piston 2110 from a retracted first position to the extended second position, the piston 2110 bearing against the plunger seal 2060 to dispense medicine. The retainer 2115 is disposed to maintain the biasing members 2106, 2122 in the energized position and to release the biasing members 2106, 2122 to permit the piston 2110 to dispense the medicine. The drive mechanism 2100 may also include an end-of-dose indicator 2133 to identify at least one of when the sleeve assembly 2120 is disposed subjacent a window 2131 in the housing 2130, the relative motion of the sleeve assembly 2120 with reference to the window 2131 or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
摘要翻译：驱动机构2100包括壳体2130，活塞2110，其适于向药物容器2050内的柱塞密封件2060施加活动，多个平行设置的偏压构件2106,2212和保持器2115.偏置构件2106,2122 被设置为释放能量以使活塞2110从缩回的第一位置移动到延伸的第二位置，活塞2110抵靠柱塞密封件2060以分配药物。保持器2115设置成将偏置构件2106,22122保持在通电位置并且释放偏压构件2106,2122以允许活塞2110分配药物。驱动机构2100还可以包括剂量末端指示器2133，用于识别当套筒组件2120位于壳体2130内的窗口2131的下方时的至少一个，套筒组件2120参考窗口的相对运动 2131或其他参考组件，停止此类运动，以及运动速率的额定值或变化。

82. 发明申请

WO2014116274A1 INTEGRATED SLIDING SEAL FLUID PATHWAY CONNECTION AND DRUG CONTAINERS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：集成滑动密封流体路径连接和药物输送泵的药物容器
公开(公告)号：WO2014116274A1
公开(公告)日：2014-07-31
申请号：PCT/US2013/030478
申请日：2013-03-12
申请人： UNITRACT SYRINGE PTY LTD , CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE IV, Paul F. , AGARD, Ryan M. , CICCARELLI, Nicholas J.
发明人： CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE IV, Paul F. , AGARD, Ryan M. , CICCARELLI, Nicholas J.
IPC分类号： A61M5/158 , A61M39/18 , A61M5/142 , A61M5/315
CPC分类号： A61M39/04 , A61M5/14248 , A61M5/1452 , A61M5/158 , A61M5/3157 , A61M39/18
摘要： A fluid pathway connection (300) includes a piercing member (330), a connection hub (310), and a sliding pierceable seal (56), wherein the sliding pierceable seal (56) is configured to move from a first position, where the piercing member (330) is initially retained within a sterile cavity (311) between the connection hub (310) and the sliding pierceable seal (56), to a second position, where the pierceable seal (56) has been penetrated by the piercing member (330). A filter (309) may be utilized to enclose the sterile cavity (311) from the outside environment. The fluid pathway connection (300) may further be configured to move to a third position where one or more interconnects (61, 102) and/or one or more corresponding contacts (62, 104) are permitted to transmit a signal to the user. Such fluid pathway connections (300) may be integrated into a drug container (50) having a barrel (58) and a plunger seal (60). A drug delivery pump (10) includes such integrated fluid pathway connections (300) and drug containers (50).
摘要翻译：流体通道连接件（300）包括刺穿构件（330），连接毂（310）和可滑动的可刺穿密封件（56），其中，所述滑动可刺穿密封件（56）构造成从第一位置移动，穿刺构件（330）最初被保持在连接毂（310）和滑动可刺穿密封件（56）之间的无菌空腔（311）内的第二位置，其中可刺破密封件（56）已被刺穿构件（330）。可以使用过滤器（309）将无菌空腔（311）从外部环境封闭。流体路径连接（300）还可以被配置成移动到第三位置，其中允许一个或多个互连（61,102）和/或一个或多个对应的触点（62,104）向用户发送信号。这种流体通路连接（300）可以集成到具有桶（58）和柱塞密封件（60）的药物容器（50）中。药物输送泵（10）包括这样的集成流体通路连接（300）和药物容器（50）。

83. 发明申请

WO2013138392A1 FILL-FINISH CARTRIDGES FOR STERILE FLUID PATHWAY ASSEMBLIES AND DRUG DELIVERY DEVICES INCORPORATING FILL-FINISH CARTRIDGES 审中-公开
标题翻译：用于完整的流体路径组装和药物递送装置的包装盒，包装完整的盒子
公开(公告)号：WO2013138392A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/030624
申请日：2013-03-12
申请人： UNITRACT SYRINGE PTY LTD , HANSON, Ian, B. , BENTE IV, Paul, F. , O'CONNOR, Sean, M. , CLEMENTE, Matthew, J. , AGARD, Ryan, M. , CICCARELLI, Nicholas, J.
发明人： HANSON, Ian, B. , BENTE IV, Paul, F. , O'CONNOR, Sean, M. , CLEMENTE, Matthew, J. , CICCARELLI, Nicholas, J.
IPC分类号： A61M5/162 , A61M5/145 , A61M5/158
CPC分类号： A61M5/162 , A61L2/00 , A61M5/1452 , A61M5/14566 , A61M5/158 , A61M5/1626 , A61M2005/1585 , A61M2205/12 , Y10T29/49826
摘要： A fluid pathway assembly 20, 120, 220, 320, 420, 520 includes a needle insertion mechanism 24, 124, 224, 324, 424, 524, a fluid conduit 26, 126, 226, 326, 426, 526, and a fluid pathway connection 22, 122, 222, 322, 422, 522. The fluid pathway assembly may further include a drug container 18, 118, 218, 318, 418, 518 to hold a drug fluid prior to initiation of the injection. The assembly may include a carrier 140, 141, 142, 240, 242, 280, 341a, 341b, 342 disposed along at least a portion of the fluid pathway assembly and/or a drug container. A fill-finish cartridge 16, 116, 216, 316, 416, 516 functions to retain the components of the fluid pathway assembly in a sterile condition, while allowing for easy integration of the fluid pathway assembly and the drug container into a standard fill-finish process. Methods of constructing a cartridge, filling a drug container included in a cartridge, and incorporating the same into a drug delivery device 10, 310 are disclosed.
摘要翻译：流体路径组件20,120,220,320,420,520包括针插入机构24,124,224,324,424,524，流体导管26,126,226,326,426,526和流体通路连接22,122,222,322,422,522。流体通路组件还可以包括药物容器18,118,218,318,418,518以在注射开始之前保持药物流体。组件可以包括沿着流体通路组件和/或药物容器的至少一部分设置的载体140,141,142,240,242,280,341a，341b，342。填充整理盒16,116,216,316,416和516用于将流体通道组件的部件保持在无菌状态，同时允许流体通道组件和药物容器容易地集成到标准的填充 - 完成过程。公开了构建药筒的方法，将包含在药筒中的药物容器填充并将其并入药物输送装置10,310中。

84. 发明申请

WO2013119591A1 PLUNGER SUB-ASSEMBLIES AND AUTO-INJECTORS HAVING LOW RETRACTION ACTIVATION FORCE 审中-公开
标题翻译：具有低回复激活力的串联组件和自动注射器
公开(公告)号：WO2013119591A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/024819
申请日：2013-02-06
申请人： UNITRACT SYRINGE PTY LTD , ADLON, Katlin M. , WEAVER, Philip A.
发明人： ADLON, Katlin M. , WEAVER, Philip A.
IPC分类号： A61M5/20 , A61M5/315 , A61M5/32
CPC分类号： A61M5/2033 , A61M5/31511 , A61M5/322 , A61M5/46 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2207/00 , Y10T29/49826
摘要： A low retraction activation force plunger sub-assembly (200) for an automatic injector (100) includes: a plunger outer (220) having one or more engagement prongs (220A), a plunger inner (210) having a shoulder (210A), and a plunger biasing member (270) retained in a first energized state between said plunger outer (220) and plunger inner (210) when the engagement prongs (220A) of the plunger outer (220) are releasably engaged with the shoulder (210A) of the plunger inner (210). An automatic injector (100) includes a housing (14, 16), an activation mechanism (12), an actuation mechanism (10), and a syringe cartridge (20) having the plunger sub-assembly (200) and a needle assembly (40), wherein the actuation mechanism (10) comprises an actuation biasing member (102) residing in an initial energized state substantially within an upper portion of an actuation pill (104). A method of assembling the automatic injector (100) includes the steps of: assembling the plunger sub-assembly (200) and inserting the plunger sub-assembly (200) into the housing (14,16) such that a proximal end of the plunger sub-assembly (200) contacts the actuation pill (104).
摘要翻译：用于自动喷射器（100）的低回缩启动力柱塞子组件（200）包括：具有一个或多个接合插脚（220A）的柱塞外部（220），具有肩部（210A）的柱塞内部（210）以及当所述柱塞外部（220）的接合叉（220A）可释放地与所述肩部（210A）接合时，柱塞偏置构件（270）在所述柱塞外部（220）和柱塞内部（210）之间保持第一通电状态，的柱塞内部（210）。自动注射器（100）包括壳体（14,16），启动机构（12），致动机构（10）和具有柱塞子组件（200）和针组件（200）的注射器药筒（20）其中所述致动机构（10）包括基本上位于致动丸（104）的上部内的初始激励状态的致动偏压构件（102）。组装自动注射器（100）的方法包括以下步骤：组装柱塞子组件（200）并将柱塞子组件（200）插入壳体（14,16）中，使得柱塞的近端子组件（200）接触致动丸（104）。

85. 发明申请

WO2013033467A3 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有集成状态指示的药物输送泵的驱动机构
公开(公告)号：WO2013033467A3
公开(公告)日：2013-04-25
申请号：PCT/US2012053241
申请日：2012-08-30
申请人： UNITRACT SYRINGE PTY LTD , O'CONNOR SEAN M , BOKELMAN KEVIN , HANSON IAN B , BENTE IV PAUL F
发明人： O'CONNOR SEAN M , BOKELMAN KEVIN , HANSON IAN B , BENTE IV PAUL F
IPC分类号： A61M5/145
CPC分类号： A61M5/172 , A61M5/1452 , A61M5/14566 , A61M2005/14506 , A61M2205/58
摘要： A drive mechanism (100) having integrated status indication includes a drive housing (130), a status switch interconnect (132), a drive biasing member (122), a piston (110), and a drug container (50) having a cap (52), a pierceable seal (56), a barrel (58), and a plunger seal (60), wherein the drive biasing member (122) is configured to bear upon an interface surface (110C) of the piston (110). Drive mechanism (100) may include an incremental status stem (650) having a stem interconnect (652), wherein the stem (650) resides within the drive housing (630) and the piston (610), and wherein the stem (650) has an interconnect which engages one or more contacts on the piston (610) to provide incremental feedback. A drug delivery pump (10) with integrated status indication includes a housing (12) and an assembly platform (20), upon which an activation mechanism (14), an insertion mechanism (200), a fluid pathway connection (300), a power and control system (400), and the drive mechanism (100) having a drug container (50) may be mounted.
摘要翻译：具有集成状态指示的驱动机构（100）包括驱动壳体（130），状态开关互连（132），驱动偏压构件（122），活塞（110）和具有盖（52），可刺破密封件（56），筒体（58）和柱塞密封件（60），其中驱动偏置构件（122）构造成承载在活塞（110）的界面（110C）上，。驱动机构（100）可以包括具有杆互连（652）的增量状态杆（650），其中杆（650）位于驱动器壳体（630）和活塞（610）内，并且其中杆（650）具有与活塞（610）上的一个或多个触点接合以提供增量反馈的互连。具有集成状态指示的药物输送泵（10）包括壳体（12）和组装平台（20），激活机构（14），插入机构（200），流体通路连接（300），电力和控制系统（400）和具有药物容器（50）的驱动机构（100）。

86. 发明申请

WO2013022772A1 CANNULA WITH CONTROLLED DEPTH OF INSERTION 审中-公开
标题翻译：具有受控深入深度的肛门
公开(公告)号：WO2013022772A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049575
申请日：2012-08-03
申请人： UNITRACT SYRINGE PTY LTD , DECKER, Robert , SHETTY, Gautam N. , SELL, Devin
发明人： DECKER, Robert , SHETTY, Gautam N. , SELL, Devin
IPC分类号： A61M5/32 , A61M5/46
CPC分类号： A61M5/158 , A61F11/00 , A61M5/16813 , A61M5/329 , A61M5/46 , A61M2005/1585 , A61M2005/1587 , A61M2210/0668 , Y10T29/49826
摘要： A cannula (24) for administration of a medicine to a target location (26) includes a tube 40 ()with at least one nodule (50) disposed along the circumferential surface (46) and spaced at a defined distance (54) from the distal end (42) of the tube (40). An arrangement (20) for delivery of a medicine to a target location (26) includes the cannula (24) and a pump (22) fluidly coupled to the cannula (24). The distal end (42) of the cannula (24) may be inserted into a target location (26) until the nodule (50) reaches a surface (46) that limits a depth of penetration before delivery of the medication.
摘要翻译：用于向目标位置（26）施用药物的套管（24）包括管40（），其具有沿着周向表面（46）设置并且与所述至少一个结节（50）限定距离（54）的至少一个结节管（40）的远端（42）。用于将药物输送到目标位置（26）的装置（20）包括套管（24）和与套管（24）流体连接的泵（22）。套管（24）的远端（42）可以插入到目标位置（26）中，直到结节（50）到达在输送药物之前限制穿透深度的表面（46）。

87. 发明申请

WO2011137488A1 SYRINGE BARREL ADAPTER AND NEEDLE ASSEMBLY 审中-公开
标题翻译：注射棒适配器和针组件
公开(公告)号：WO2011137488A1
公开(公告)日：2011-11-10
申请号：PCT/AU2011/000515
申请日：2011-05-04
申请人： UNITRACT SYRINGE PTY LTD , THORLEY, Craig Stephen , KAAL, Joseph Hermes , RAFFERTY, Christopher Charles
发明人： THORLEY, Craig Stephen , KAAL, Joseph Hermes , RAFFERTY, Christopher Charles
IPC分类号： A61M5/32 , A61M5/50
CPC分类号： A61M5/34 , A61M5/344 , A61M5/345 , A61M5/346 , A61M5/50 , A61M2039/1077
摘要： An adapter mountable to a retractable syringe barrel comprises a body that includes a needle portion and a barrel-engaging portion and a needle aperture. The adapter facilitates mounting a needle assembly to the barrel. The needle assembly comprises a needle body and cannula and an immobile, compressible needle seal, wherein the needle body and the needle seal are releasably engaged. The needle seal is engageable with a needle portion of the adapter. The needle body comprises one or more fluid reclaim channels that facilitate efficient delivery of the fluid contents of the retractable syringe. The retractable syringe also comprises dual locking systems to impede or prevent re-use.
摘要翻译：可安装到可缩回的注射器筒的适配器包括一个主体，其包括针部分和针筒部分以及针孔。适配器有助于将针组件安装到筒体上。针组件包括针体和插管以及不可移动的可压缩针密封件，其中针体和针密封件可释放地接合。针密封件可与适配器的针部分接合。针体包括一个或多个流体回收通道，其有助于可伸缩注射器的流体内容物的有效输送。可伸缩注射器还包括用于阻止或阻止再使用的双重锁定系统。

88. 发明申请

WO2011057335A1 VACCINATION SYRINGE 审中-公开
标题翻译：疫苗注射
公开(公告)号：WO2011057335A1
公开(公告)日：2011-05-19
申请号：PCT/AU2010/001505
申请日：2010-11-11
申请人： UNITRACT SYRINGE PTY LTD , THORLEY, Craig Stephen , KAAL, Joseph Hermes , RAFFERTY, Christopher Charles , JOHNSON, Ian , SIU, Eric , READE, Andrew
发明人： THORLEY, Craig Stephen , KAAL, Joseph Hermes , RAFFERTY, Christopher Charles , JOHNSON, Ian , SIU, Eric , READE, Andrew
IPC分类号： A61M5/32
CPC分类号： A61M5/3234 , A61M5/502 , A61M2005/3231 , A61M2005/3241 , A61M2005/5033 , A61M2202/30 , Y10T29/49826
摘要： A replaceable needle assembly is provided for a retractable, prefilled syringe comprising a barrel having a mounting member and a plunger, whereby the retractable needle can be replaced by a user without affecting the retraction mechanism. The replaceable needle assembly comprises a needle fitted to a retractable needle mount and a needle retainer. The needle mount is removably, screw-threadedly mountable to the mounting member of the barrel. The needle retainer comprises a plurality of fingers that releasably engage the retractable needle to thereby prevent inadvertent retraction of the retractable needle before engagement by the plunger. The plunger comprises a plunger seal comprising an outer member and an inner member that engages the needle for spring-driven retraction. At the end of retraction, a lock is formed between the plunger and barrel to prevent re-use of the syringe.
摘要翻译：提供了一种用于可缩回的预充式注射器的可更换的针组件，其包括具有安装构件和柱塞的筒体，由此可伸缩的针可以由使用者代替而不影响回缩机构。可更换的针组件包括装配到可缩回针座和针保持器上的针。针座是可拆卸的，螺纹螺纹安装到枪管的安装构件上。针保持器包括可释放地接合可缩回针的多个指状物，从而防止可伸缩针在被柱塞接合之前的意外收回。柱塞包括柱塞密封件，其包括外部构件和内部构件，所述内部构件与针头接合以用于弹簧驱动的缩回。在收缩结束时，在柱塞和筒之间形成锁以防止注射器的再次使用。

89. 发明申请

WO2006108243A2 CONTROLLED RETRACTION SYRINGE AND PLUNGER THEREFOR 审中-公开
标题翻译：控制回收注射器和排气管
公开(公告)号：WO2006108243A2
公开(公告)日：2006-10-19
申请号：PCT/AU2006/000516
申请日：2006-04-18
申请人： UNITRACT SYRINGE PTY LTD , JUDD, Damien , KAAL, Joseph Hermes , THORLEY, Craig Stephen
发明人： JUDD, Damien , KAAL, Joseph Hermes , THORLEY, Craig Stephen
IPC分类号： A61M5/32 , A61M5/50
CPC分类号： A61M5/3234 , A61M5/502 , A61M5/508 , A61M2005/3231 , A61M2005/3235 , A61M2005/3236 , A61M2005/3241
摘要： A retractable syringe (11) and plunger (20) therefore are provided, whereby the plunger comprises a controlling means (62) which facilitates control of the rate of retraction of the retractable needle. By controlling the rate of needle retraction, the likelihood of blood spattering is reduced, thereby improving the user-friendliness and appeal of the retractable syringe. Typically, the syringe is a prefilled syringe. Following plunger depression, a symmetrical ejector member (92) releases the retractable needle (40) from a retaining member (30) to thereby allow retraction of the retractable needle. Needle retraction is facilitated by a biasing means (70), such as a spring or other compressible and/or de-compressible device. The plunger comprises a plunger housing (21), in which is located the controlling means. The controlling means may be a pneumatic air space (324) inside the plunger housing which automatically acts against the retracting needle to thereby control or regulate the rate of retraction.
摘要翻译：因此，提供可伸缩注射器（11）和柱塞（20），由此柱塞包括控制装置（62），其有助于控制可缩回针的缩回速率。通过控制针回缩的速度，血液溅射的可能性降低，从而提高可伸缩注射器的用户友好性和吸引力。通常，注射器是预充式注射器。在柱塞下压之后，对称的顶出件（92）将可伸缩针（40）从保持件（30）释放，从而允许可缩回的针头缩回。通过诸如弹簧或其它可压缩和/或不可压缩装置的偏置装置（70）来促进针回缩。柱塞包括柱塞壳体（21），其中位于控制装置中。控制装置可以是柱塞壳体内部的气动空气空间（324），其自动地作用在回缩针上，从而控制或调节回缩速率。

90. 发明申请

WO2005072801A1 RETRACTABLE SYRINGE WITH PLUNGER DISABLING SYSTEM 审中-公开
标题翻译：可重复使用灭菌系统的注射器
公开(公告)号：WO2005072801A1
公开(公告)日：2005-08-11
申请号：PCT/AU2005/000107
申请日：2005-01-28
申请人： UNITRACT SYRINGE PTY LTD , KAAL, Joseph, Hermes , THORLEY, Craig, Stephen , JUDD, Damien
发明人： KAAL, Joseph, Hermes , THORLEY, Craig, Stephen , JUDD, Damien
IPC分类号： A61M5/50
CPC分类号： A61M5/3234 , A61M5/5066 , A61M5/508 , A61M2005/31518
摘要： A retractable, single use syringe (10) comprises a barrel (20), a collar (60) mounted to the barrel, a retraction spring (70), a needle mount (40) located at a needle end (23) of the barrel and a plunger (30). The plunger comprises a first plunger member (31) and a second plunger member (33) that are releasably coupled to co-operatively maintain the retraction spring in an initial compressed state. The second plunger member (33) further comprises a seal (34) to prevent fluid leakage between plunger (30) and barrel (20). After depression of the plunger to deliver the fluid contents of the syringe, the first plunger member (31) engages the needle mount (40) with needle (12) attached thereto and is rotatably uncoupled from the second plunger member (33) to allow decompression of the retraction spring (70), which forces retraction of the first plunger member (31), needle mount (40) and needle (12) engaged therewith. The first plunger member (31) and the collar (60) comprise elements that co-operatively form a disabling means that prevents or at least minimizes the likelihood of subsequent depression or withdrawal of the plunger (30). Also following retraction of the first plunger member (31), the second plunger member (33) and seal (34) remains at the needle end (23) of the barrel (20) thereby preventing refilling and re-use of the syringe.
摘要翻译：一种可收回的一次性注射器（10）包括筒体（20），安装在筒体上的套环（60），缩回弹簧（70），位于筒体针端（23）处的针座（40）和柱塞（30）。柱塞包括第一柱塞构件（31）和第二柱塞构件（33），第一柱塞构件（31）和第二柱塞构件（33）可释放地联接以将缩回弹簧共同维持在初始压缩状态。第二柱塞构件（33）还包括密封件（34），以防止柱塞（30）和筒体（20）之间的流体泄漏。在按压柱塞以输送注射器的流体内容物之后，第一柱塞构件（31）与针安装件（40）接合，针头（12）附接到其上并且可转动地与第二柱塞构件（33）脱开以允许减压的缩回弹簧（70），其迫使第一柱塞构件（31），针座（40）和与其接合的针（12）的缩回。第一柱塞构件（31）和套环（60）包括可同时形成禁用装置的元件，其阻止或至少最小化后续的压下或抽出柱塞（30）的可能性。此外，在第一柱塞构件（31）的缩回之后，第二柱塞构件（33）和密封件（34）保留在筒体（20）的针端（23）处，由此防止注射器的再填充和再次使用。

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