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81. 发明申请

WO2010096781A1 DIRECT MODULATED MODIFIED VERTICAL CAVITY SURFACE EMITTING LASERS 审中-公开
标题翻译：直接调制的垂直孔表面发射激光
公开(公告)号：WO2010096781A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/024951
申请日：2010-02-22
申请人： BRENNER, Mary, K. , JOHNSON, Klein, L. , CHOQUETTE, Kent, D. , CHEN, Chen
发明人： BRENNER, Mary, K. , JOHNSON, Klein, L. , CHOQUETTE, Kent, D. , CHEN, Chen
IPC分类号： H01S3/082
CPC分类号： H01S5/18302 , H01S5/06226 , H01S5/1021 , H01S5/18313 , H01S5/1833
摘要： A laser system having separately electrically operable cavities for emitting modulated narrow linewidth light with first, second and third mirror structures separated by a first active region between the first and the second and by a second active region between the second and the third. The second mirror structure has twenty or more periods of mirror pairs.
摘要翻译：一种激光系统，其具有单独的电动可操作的空腔，用于发射经第一和第二反射镜结构与第二和第三之间的第二有源区分隔开的第一，第二和第三镜像结构的调制窄线宽光。第二镜结构具有二十个以上的镜对。

82. 发明申请

WO2006110461A3 DRILLING WITH CASING 审中-公开
标题翻译：钻孔与钻孔
公开(公告)号：WO2006110461A3
公开(公告)日：2009-03-19
申请号：PCT/US2006012853
申请日：2006-04-07
申请人： HALLIBURTON ENERGY SERV INC , CHEN CHEN-KANG D , RAO M VIKRAM
发明人： CHEN CHEN-KANG D , RAO M VIKRAM
IPC分类号： E21B7/20 , E21B7/00 , E21B7/06 , E21B10/26 , E21B17/08 , E21B17/10
CPC分类号： E21B7/067 , E21B7/20 , E21B10/26 , E21B17/08 , E21B17/1092
摘要： A borehole may be drilled utilizing the bottom hole assembly! 0, 50 with a downhole motor 14, 110, which may offset at a selected bend angle. A bend for directional drilling may be provided by a PDM1 or by a RSD. A gauge section 36 secured to the pilot bit 18 has a uniform diameter bearing surface along an axial length of at least 60% of the pilot bit diameter. The bit or reamer 16 has a bit face defining the cutting diameter of the drilled hole. The axial spacing between the bend and the bit face is controlled to less than fifteen times the bit diameter. The downhole motor, pilot bit and bit may be retrieved from the well while leaving the casing string in the well.
摘要翻译：钻孔可以利用底孔组件钻孔！ 0,50具有井下电动机14,110，其可以以选定的弯曲角度偏移。用于定向钻孔的弯曲可由PDM1或RSD提供。固定到导向钻头18的标尺部分36沿着导向钻头直径的至少60％的轴向长度具有均匀的直径支承表面。钻头或铰刀16具有限定钻孔的切割直径的钻头面。弯头与钻头面之间的轴向间距被控制在钻头直径的十五倍以下。井下电机，导向钻头和钻头可以从井中取出，同时将套管柱留在井中。

83. 发明申请

WO2008044582A1 METHOD AND APPARATUS FOR LOCATING SPEECH KEYWORD AND SPEECH RECOGNITION SYSTEM 审中-公开
标题翻译：用于定位语音关键词和语音识别系统的方法和装置
公开(公告)号：WO2008044582A1
公开(公告)日：2008-04-17
申请号：PCT/JP2007/069409
申请日：2007-09-27
申请人： SHARP KABUSHIKI KAISHA , LI, Fengqin , WU, Yadong , YANG, Qinqtao , CHEN, Chen
发明人： LI, Fengqin , WU, Yadong , YANG, Qinqtao , CHEN, Chen
IPC分类号： G10L15/02 , G10L15/06
CPC分类号： G10L15/02 , G10L15/10 , G10L15/142 , G10L2015/025 , G10L2015/088
摘要： It is an object of the present invention to provide a method and apparatus for locating a keyword of a speech and a speech recognition system. The method includes the steps of: by extracting feature parameters from frames constituting the recognition target speech, forming a feature parameter vector sequence that represents the recognition target speech; by normalizing of the feature parameter vector sequence with use of a codebook containing a plurality of codebook vectors, obtaining a feature trace of the recognition target speech in a vector space; and specifying the position of a keyword by matching prestored keyword template traces with the feature trace. According to the present invention, a keyword template trace and a feature space trace of a recognition target speech are drawn in accordance with an identical codebook. This causes resampling to be unnecessary in performing linear movement matching of speech wave frames having similar phonological feature structures. This makes it possible to improve the speed of location and recognition while ensuring the precision of recognition.
摘要翻译：本发明的目的是提供一种用于定位语音和语音识别系统的关键词的方法和装置。该方法包括以下步骤：通过从构成识别目标语音的帧中提取特征参数，形成表示识别目标语音的特征参数向量序列; 通过使用包含多个码本向量的码本来归一化特征参数矢量序列，获得矢量空间中的识别目标语音的特征轨迹; 并通过将预先存储的关键字模板跟踪与特征跟踪相匹配来指定关键字的位置。根据本发明，根据相同的码本绘制关键字模板跟踪和识别对象语音的特征空间轨迹。这导致在执行具有相似的语音特征结构的语音波帧的线性移动匹配中，重新采样是不必要的。这样可以提高位置和识别的速度，同时确保识别精度。

84. 发明申请

WO2004058735A3 LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
标题翻译： MELANOCORTIN受体的配体及其组合物及其相关方法
公开(公告)号：WO2004058735A3
公开(公告)日：2007-12-27
申请号：PCT/US0340931
申请日：2003-12-19
申请人： NEUROCRINE BIOSCIENCES INC , CHEN CHEN , TUCCI FABIO C , TRAN JOE ANH , CHEN WEI-CHUAN , WHITE NICOLE
发明人： CHEN CHEN , TUCCI FABIO C , TRAN JOE ANH , CHEN WEI-CHUAN , WHITE NICOLE
IPC分类号： C07D295/185 , A61K31/495 , A61K31/496 , C07D205/04 , C07D207/26 , C07D207/267 , C07D207/27 , C07D207/273 , C07D209/18 , C07D213/56 , C07D213/81 , C07D233/20 , C07D233/32 , C07D233/38 , C07D233/54 , C07D241/08 , C07D241/18 , C07D263/32 , C07D277/28 , C07D277/30 , C07D307/16 , C07D307/52 , C07D307/79 , C07D307/81 , C07D333/20 , C07D333/24
CPC分类号： C07D207/267 , C07D205/04 , C07D207/27 , C07D207/273 , C07D213/81 , C07D233/20 , C07D233/32 , C07D233/38 , C07D241/08 , C07D241/18 , C07D277/28 , C07D295/185 , C07D307/52 , C07D307/79 , C07D307/81 , C07D333/20
摘要： Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I) including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, B, m, n, p, q,
摘要翻译：作为黑皮质素受体配体起作用并可用于治疗基于黑皮质素受体的疾病的化合物。所述化合物具有以下结构（I），其包括立体异构体，前药和药学上可接受的盐，其中A，B，m，n，p，q，

85. 发明申请

WO2007098356A1 CONGENERS OF MILNACIPRAN AS MONOAMINE RE-UPTAKE 审中-公开
标题翻译： MILNACIPRAN作为单体反应的浓缩剂
公开(公告)号：WO2007098356A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/062187
申请日：2007-02-15
申请人： NEUROCRINE BIOSCIENCES, INC. , CHEN, Chen , DYCK, Brian , GREY, Jonathan , JOVIC, Florence , TAMIYA, Junko , VICKERS, Troy D. , ZHANG, Mingzhu
发明人： CHEN, Chen , DYCK, Brian , GREY, Jonathan , JOVIC, Florence , TAMIYA, Junko , VICKERS, Troy D. , ZHANG, Mingzhu
IPC分类号： C07D209/18 , C07D209/26 , C07D213/56 , C07D277/64 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07D405/06 , C07D409/06 , C07D413/06 , C07D495/04 , C07D401/06 , A61K31/335
CPC分类号： C07D409/06 , C07D209/18 , C07D209/26 , C07D213/56 , C07D277/64 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07D401/06 , C07D405/06 , C07D413/06 , C07D495/04
摘要： Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The compounds of this invention have the structure: wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 6 , R 7 , and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts, esters and solvates thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting monoamine re-uptake in a subject in need thereof.
摘要翻译：公开了单胺再摄取抑制剂，更具体地说可用于治疗男性和女性中枢或周围神经系统疾病的5-羟色胺和去甲肾上腺素再摄取抑制剂。本发明的化合物具有以下结构：其中R 1，R 2，R 3，R 4， R 5a，R 5b，R 6，R 7和n如本文所定义，包括立体异构体，前药和药学上可接受的盐，酯和溶剂合物。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中抑制单胺再摄取的方法。

86. 发明申请

WO2005097818A2 AN ASSAY SYSTEM FOR SCREENING PROTEASE INHIBITORS 审中-公开
标题翻译：用于筛选蛋白酶抑制剂的测定系统
公开(公告)号：WO2005097818A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/008750
申请日：2005-03-15
申请人： KECK GRADUATE INSTITUTE , CHENG, Ting-Jen , KAN, Chen-Chen
发明人： CHENG, Ting-Jen , KAN, Chen-Chen
IPC分类号： C07H21/00
CPC分类号： C07K14/005 , C07K2319/50 , C07K2319/61 , C12N9/2471 , C12N9/503 , C12N9/506 , C12N2740/16222 , C12Q1/37 , C12Y302/01023 , G01N33/56988 , G01N2500/10
摘要： Compositions and methods for identifying agents that inhibit protease activity are provided. In particular, polynucleotides, recombinant expression vectors, and host cells are provided that may be used in a bacterial cell-based assay for identifying agents that are inhibitors of protease activity, such as inhibitors of HIV protease activity. The bacterial cells express a precursor of a protease and encode a reporter polypeptide that contains a protease recognition sequence, which can be cleaved by the mature, catalytically active protease such that the reporter activity of the reporter polypeptide is decreased or eliminated.
摘要翻译：提供了用于鉴定抑制蛋白酶活性的试剂的组合物和方法。特别地，提供了多核苷酸，重组表达载体和宿主细胞，其可用于基于细菌细胞的测定，用于鉴定作为蛋白酶活性抑制剂的试剂，例如HIV蛋白酶活性的抑制剂。细菌细胞表达蛋白酶的前体，并编码含有蛋白酶识别序列的报道多肽，其可被成熟的催化活性蛋白酶切割，使得报道多肽的报道活性降低或消除。

87. 发明申请

WO2005057672A2 SURFACE MOUNT LIGHT EMITTING CHIP PACKAGE 审中-公开
标题翻译：表面安装发光芯片包装
公开(公告)号：WO2005057672A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/041392
申请日：2004-12-09
申请人： GELCORE, LLC , WEAVER, Stanton, Earl, Jr. , CHEN, Chen-Lun Hsing , KOLODIN, Boris , STECHER, Thomas, Elliot , REGINELLI, James , HAITKO, Deborah, Ann , GAO, Xiang , ELIASHEVICH, Ivan
发明人： WEAVER, Stanton, Earl, Jr. , CHEN, Chen-Lun Hsing , KOLODIN, Boris , STECHER, Thomas, Elliot , REGINELLI, James , HAITKO, Deborah, Ann , GAO, Xiang , ELIASHEVICH, Ivan
IPC分类号： H01L33/00
CPC分类号： H01L33/64 , H01L25/0753 , H01L33/62 , H01L2224/48091 , H01L2924/10253 , H01L2924/12041 , H01L2924/00014 , H01L2924/00
摘要： A surface mount light emitting package includes a chip carrier having top and bottom principal surfaces. At least one light emitting chip is attached to the top principal surface of the chip carrier. A lead frame attached to the top principal surface of the chip carrier. When surface mounted to an associated support, the bottom principal surface of the chip carrier is in thermal contact with the associated support without the lead frame intervening therebetween.
摘要翻译：表面安装发光封装包括具有顶部和底部主表面的芯片载体。至少一个发光芯片附着到芯片载体的顶部主表面。连接到芯片载体的顶部主表面的引线框架。当表面安装到相关联的支撑件时，芯片载体的底部主表面与相关联的支撑件热接触，而没有引导框架介于其间。

88. 发明申请

WO2003011839A1 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 1,3,5-三嗪-2,4,6-TRIONES，制备和用作GONADOTROPIN-RELEASING HORMONE受体拮抗剂
公开(公告)号：WO2003011839A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/024451
申请日：2002-08-01
申请人： NEUROCRINE BIOSCIENCES, INC. , GUO, Zhiqiang , WU, Dongpei , CHEN, Chen , TUCCI, Fabio, C. , REGAN, Collin
发明人： GUO, Zhiqiang , WU, Dongpei , CHEN, Chen , TUCCI, Fabio, C. , REGAN, Collin
IPC分类号： C07D251/30
CPC分类号： C07D401/12 , C07D251/34 , C07D403/06 , C07D403/12 , C07D409/06 , C07D417/04 , C07D417/10 , C07D417/14
摘要： GnRH receptor antagonists of formula I are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了具有用于治疗男性和女性中各种性激素相关病症的功能的式I的GnRH受体拮抗剂。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

89. 发明申请

WO0155119A3 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 审中-公开
标题翻译：促性腺激素释放激素受体拮抗剂及其相关方法
公开(公告)号：WO0155119A3
公开(公告)日：2002-02-14
申请号：PCT/US0102740
申请日：2001-01-25
申请人： NEUROCRINE BIOSCIENCES INC , ZHU YUN FEI , CHEN CHEN , TUCCI FABIO C , GUO ZHIQIANG , GROSS TIMOTHY D , ROWBOTTOM MARTIN , STRUTHERS R SCOTT
发明人： ZHU YUN-FEI , CHEN CHEN , TUCCI FABIO C , GUO ZHIQIANG , GROSS TIMOTHY D , ROWBOTTOM MARTIN , STRUTHERS R SCOTT
IPC分类号： C07D239/52 , A61K31/513 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61P1/04 , A61P5/24 , A61P13/08 , A61P15/00 , A61P15/18 , A61P25/20 , A61P35/00 , A61P37/06 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/08 , C07D498/18 , C07D513/04 , A61K31/505 , A61P5/04 , C07D239/60 , C07D413/12
CPC分类号： C07D239/54 , A61K31/513 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/08 , C07D498/08 , C07D513/04
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure of formula (I) wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。本发明的化合物具有式（I）的结构，其中A，Q，R 1，R 2，R 3a，R 3b，R 4，R 5，R 6和n如本文所定义，包括立体异构体，前药和其药学上可接受的盐。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

90. 发明申请

WO1997029110A1 THIOPHENOPYRIMIDINES 审中-公开
公开(公告)号：WO1997029110A1
公开(公告)日：1997-08-14
申请号：PCT/EP1997000457
申请日：1997-01-30
申请人： JANSSEN PHARMACEUTICA N.V. , NEUROCRINE BIOSCIENCES INC. , CHEN, Chen , WEBB, Thomas, R. , McCARTHY, James, R. , MORAN, Terence, J.
发明人： JANSSEN PHARMACEUTICA N.V. , NEUROCRINE BIOSCIENCES INC.
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： This invention concerns compounds of formula (I) including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein X is S, SO or SO2; R is NR R or OR ; R is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R is hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxyC1-6alkyl; R is C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar CH2, C1-6alkyloxy-C1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6 alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl; or a radical of the formula: -Alk-O-CO-Ar ; or R and R taken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group; Ar is a phenyl, substituted phenyl, pyridinyl or substituted pyridinyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).
摘要翻译：本发明涉及包括立体异构体及其药学上可接受的酸加成盐形式的式（I）化合物，其中X是S，SO或SO 2; R 1是NR 4 R 5或OR 5; R 2是C 1-6烷基，C 1-6烷氧基或C 1-6烷硫基; R 3是氢，C 1-6烷基，C 1-6烷基磺酰基，C 1-6烷基磺酰基或C 1-6烷硫基; R 4是氢，C 1-6烷基，一或二（C 3-6环烷基）甲基，C 3-6环烷基，C 3-6烯基，羟基C 1-6烷基，C 1-6烷基羰基氧基C 1-6烷基或C 1-6烷氧基C 1-6烷基; R 5是C 1-8烷基，单或二（C 3-6环烷基）甲基，Ar 1 CH 2，C 1-6烷氧基-C 1-6烷基，羟基C 1-6烷基，C 3-6烯基，噻吩基甲基，呋喃基甲基，C 1-6烷硫基C 1 -C 6烷基，（C 1-6烷基）氨基C 1-6烷基，二（C 1-6烷基）氨基，C 1-6烷基羰基C 1-6烷基，被咪唑基取代的C 1-6烷基; 或下式的基团：-Alk-O-CO-Ar 1; 或R 4和R 5与它们所连接的氮原子一起可以形成任选取代的吡咯烷基，哌啶基，高哌啶基或吗啉基; Ar是苯基，取代的苯基，吡啶基或取代的吡啶基; 具有CRF受体拮抗特性; 含有这些化合物作为活性成分的药物组合物; 通过施用有效量的式（I）化合物来治疗与CRF过度分泌有关的疾病的方法，例如抑郁症，焦虑症，药物滥用。

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