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71. 发明申请

WO2005120636A9 High frequency atrial burst pacing for improved ventricular rate control during atrial arrhythima 审中-公开
标题翻译：高频心房爆发起搏，用于改善房性心律失常的心室率
公开(公告)号：WO2005120636A9
公开(公告)日：2006-05-11
申请号：PCT/US2005018904
申请日：2005-05-26
申请人： MEDTRONIC INC , EULER DAVID E
发明人： EULER DAVID E
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3622
摘要： A method and device for delivering cardiac stimulation that includes a first electrode, positioned within a first chamber of a heart, sensing cardiac signals associated with the first chamber and capable of delivering stimulation to the first chamber, and a second electrode, positioned within a second chamber of the heart, sensing cardiac signals associated with the second chamber and capable of delivering stimulation to the second chamber. A processing unit processes the sensed signals and controls the stimulation delivery via the first electrode and the second electrode, determining whether a predetermined rhythm is detected in the first chamber, and delivering high-frequency burst pacing to the first chamber in response to a predetermined rate being sensed in the second chamber during the predetermined rhythm.
摘要翻译：一种用于递送心脏刺激的方法和装置，其包括位于心脏的第一腔室内的第一电极，感测与第一腔室相关联并能够向第一腔室递送刺激的心脏信号，以及位于第二腔室内的第二电极心脏的腔室，感测与第二腔室相关联的心脏信号并且能够将刺激传递给第二腔室。处理单元处理感测到的信号并且控制经由第一电极和第二电极的刺激传递，确定在第一室中是否检测到预定的节律，以及响应于预定的速率将高频脉冲起搏递送到第一腔室在预定的节奏期间在第二室中被感测。

72. 发明申请

WO2005120636A2 HIGH FREQUENCY ATRIAL BURST PACING FOR IMPROVED VENTRICULAR RATE CONTROL DURING ATRIAL ARRHYTHMIA 审中-公开
标题翻译：高频ATRR治疗急性心律失常
公开(公告)号：WO2005120636A2
公开(公告)日：2005-12-22
申请号：PCT/US2005018904
申请日：2005-05-26
申请人： MEDTRONIC INC , EULER DAVID E
发明人： EULER DAVID E
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622
摘要： A method and device for delivering cardiac stimulation that includes a first electrode, positioned within a first chamber of a heart, sensing cardiac signals associated with the first chamber and capable of delivering stimulation to the first chamber, and a second electrode, positioned within a second chamber of the heart, sensing cardiac signals associated with the second chamber and capable of delivering stimulation to the second chamber. A processing unit processes the sensed signals and controls the stimulation delivery via the first electrode and the second electrode, determining whether a predetermined rhythm is detected in the first chamber, and delivering high-frequency burst pacing to the first chamber in response to a predetermined rate being sensed in the second chamber during the predetermined rhythm.
摘要翻译：一种用于递送心脏刺激的方法和装置，其包括位于心脏的第一腔室内的第一电极，感测与第一腔室相关联并能够向第一腔室递送刺激的心脏信号，以及位于第二腔室内的第二电极心脏的腔室，感测与第二腔室相关联的心脏信号并且能够将刺激传递给第二腔室。处理单元处理感测到的信号并且控制经由第一电极和第二电极的刺激传递，确定在第一室中是否检测到预定的节律，以及响应于预定的速率将高频脉冲起搏递送到第一腔室在预定的节奏期间在第二室中被感测。

73. 发明申请

WO2004045385A8 A DEVICE AND METHOD TO DISCRIMINATE BETWEEN SUPRA VENTRICULAR TACHYCARDIAS AND VENTRICULAR ARRHYTHMIAS 审中-公开
标题翻译：一种辨别SUPRA静脉注射液和静脉注射甲状腺炎的装置和方法
公开(公告)号：WO2004045385A8
公开(公告)日：2005-12-08
申请号：PCT/US0337099
申请日：2003-11-20
申请人： UNIV PITTSBURGH , SABA FAWZI SAMIR
发明人： SABA FAWZI SAMIR
IPC分类号： A61B20060101 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962
摘要： This invention provides a method to discriminate between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following antitachycardia pacing. Also disclosed is an implantable cardiac defibrillator(13) that is capable of simultaneous atrioventricular anti-tachycardia pacing bursts produced from a signal generator (14)and detecting an earliest arriving electrical signal. This discrimination capability reduces the incidence of inappropriate shocks from dual-chamber implantable cardiac defibrillators to near zero and provides a method to differentially diagnose supraventricular tachycardia from ventricular tachycardia.
摘要翻译：本发明提供一种通过在抗心律失常起搏之后检测最早到达的电信号来区分室性心律失常和室上性心动过速的方法。还公开了一种可植入的心脏除颤器（13），其能够同时从信号发生器（14）产生的房室性心动过速起搏脉冲并检测最早到达的电信号。这种辨别能力降低了从双室可植入心脏除颤器到不到零的不适当冲击的发生率，并且提供了一种区分性诊断室性心动过速从室性心动过速的方法。

74. 发明申请

WO2005099815A1 DYNAMIC PACING INTERVAL EXTENSION FOR DETECTION OF INTRINSIC VENTRICULAR ACTIVITY 审中-公开
标题翻译：用于检测内部静脉活动的动态切片间隔延伸
公开(公告)号：WO2005099815A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/011854
申请日：2005-04-08
申请人： MEDTRONIC, INC. , OOSTENHOFF, Peter , DE BRUYN, Henricus, W. M.
发明人： OOSTENHOFF, Peter , DE BRUYN, Henricus, W. M.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/371 , A61N1/3712
摘要： In general, the invention is directed to identification of intrinsic ventricular activity occurring within a ventricular signal. In particular, the invention involves the analysis of ventricular signal morphology to determine if the signal contains intrinsic ventricular activity while delivering pacing pulses separated by nearly constant time intervals. Furthermore, the invention specifies an extension of a pacing interval based on whether or not the signal contains intrinsic ventricular activity. In this manner, the pacing interval is only extended when it is likely for intrinsic ventricular activity to occur.
摘要翻译：通常，本发明涉及确定在心室信号内发生的内在心室活动。特别地，本发明涉及心室信号形态的分析，以确定信号是否包含固有心室活动，同时输送以几乎恒定的时间间隔分开的起搏脉冲。此外，本发明基于信号是否包含固有心室活动来指定起搏间隔的延伸。以这种方式，起搏间隔仅在可能发生内在心室活动时才延长。

75. 发明申请

WO2005056108A3 METHOD AND APPARATUS FOR DETERMINING AN EFFICACIOUS ATRIOVENTRICULAR DELAY INTERVAL 审中-公开
标题翻译：用于确定有效的心律失常延迟间隔的方法和装置
公开(公告)号：WO2005056108A3
公开(公告)日：2005-09-09
申请号：PCT/US2004040521
申请日：2004-12-03
申请人： MEDTRONIC INC , CHINCHOY EDWARD , SHETH NIRAV VIJAY , HILPISCH KATHRYN E , MULLEN THOMAS J , BURNES JOHN E
发明人： CHINCHOY EDWARD , SHETH NIRAV VIJAY , HILPISCH KATHRYN E , MULLEN THOMAS J , BURNES JOHN E
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Determining an optimal atrioventricular interval is of interest for proper delivery of cardiac resynchronization therapy. Although device optimization is gradually and more frequently being performed through a referral process with which the patient undergoes an echocardiographic optimization, the decision of whether to optimize or not is still generally reserved for the implanting physician. Recent abstracts have suggested a formulaic approach for setting A-V interval based on intrinsic electrical sensing, that may possess considerable appeal to clinicians versus a patient average nominal A-V setting of 100 ms. The present invention presents a methods of setting nominal device settings based on entering patient cardiac demographics to determine what A-V setting may be appropriate. The data is based on retrospective analysis of the MIRACLE trial to determine what major factors determined baseline A-V settings.
摘要翻译：确定最佳房室间隔对于正确递送心脏再同步治疗是有意义的。尽管通过与患者经历超声心动图优化的转诊过程逐渐且更频繁地进行装置优化，但仍然通常为植入医生保留是否优化的决定。最近的摘要提出了一种基于固有电学感测设置A-V间隔的公式化方法，这可能对临床医生具有相当大的吸引力，而患者平均标称A-V设置为100 ms。本发明提供了一种基于输入患者心脏人口统计学来设定标称装置设置以确定什么A-V设置可能适合的方法。数据基于MIRACLE试验的回顾性分析，以确定确定基线A-V设置的主要因素。

76. 发明申请

WO2005042083A3 INTRAVENOUS CARDIAC PACING SYSTEM WITH WIRELESS POWER SUPPLY 审中-公开
标题翻译：无线电源静脉心脏起搏系统
公开(公告)号：WO2005042083A3
公开(公告)日：2005-06-16
申请号：PCT/US2004036059
申请日：2004-10-28
申请人： KENERGY INC , DENKER STEPHEN , BEUTLER ARTHUR J
发明人： DENKER STEPHEN , BEUTLER ARTHUR J
IPC分类号： A61N1/05 , A61N1/362 , A61N1/372 , A61N1/375 , A61N1/378 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/24 , A61N1/30 , A61N1/36 , A61N1/365 , A61N1/368
CPC分类号： A61N1/05 , A61N1/362 , A61N1/372 , A61N1/37205 , A61N1/37258 , A61N1/375 , A61N1/3787
摘要： A cardiac pacemaker includes a power transmitter which periodically transmits a pulse of a radio frequency signal to a vascular electrode-stent that is implanted in a vein or artery of an animal. The vascular electrode-stent employs energy from the radio frequency signal to charge a storage device which serves as an electrical power supply. The vascular electrode-stent also detects a cardiac signal emitted from the sinus node of the heart and responds thereto by applying a pulse of voltage from the storage device to a pair of electrodes implanted in the vascular system of the animal. Application of the voltage pulse to the electrodes stimulates contraction of the heart.
摘要翻译：心脏起搏器包括功率发射器，其周期性地将射频信号的脉冲发送到植入动物的静脉或动脉中的血管电极支架。血管电极支架采用来自射频信号的能量对充当电源的存储装置充电。血管电极支架还检测从心脏窦房结发射的心脏信号，并通过将来自存储装置的电压脉冲施加到植入在动物血管系统中的一对电极来响应心脏信号。电压脉冲施加到电极刺激心脏收缩。

77. 发明申请

WO2005011809A3 MULTIPLE ELECTRODE VECTORS FOR IMPLANTABLE CARDIAC TREATMENT DEVICES 审中-公开
标题翻译：用于植入式心脏治疗设备的多电极向量
公开(公告)号：WO2005011809A3
公开(公告)日：2005-05-06
申请号：PCT/US2004024426
申请日：2004-07-28
申请人： CAMERON HEALTH INC , WARREN JAY A , BARDY GUST H
发明人： WARREN JAY A , BARDY GUST H
IPC分类号： A61B5/024 , A61B5/0402 , A61B5/042 , A61B5/0424 , A61B5/0428 , A61B5/07 , A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61B5/0424 , A61B5/0402 , A61B5/042 , A61B5/04288 , A61B5/076 , A61B5/7207 , A61N1/3622 , A61N1/3925
摘要： The implantable cardiac treatment system of the present invention is capable of choosing the most appropriate electrode vector to sense within a particular patient. In certain embodiments, the implantable cardiac treatment system determines the most appropriate electrode vector for continuous sensing based on which electrode vector results in the greatest signal amplitude, or some other useful metric such as signal-to-noise ratio (SNR). The electrode vector possessing the highest quality as measured using the metric is then set as the default electrode vector for sensing. Additionally, in certain embodiments of the present invention, a next alternative electrode vector is selected based on being generally orthogonal to the default electrode vector. In yet other embodiments of the present invention, the next alternative electrode vector is selected based on possessing the next highest quality metric after the default electrode vector. In some embodiments, if analysis of the default vector is ambiguous, the next alternative electrode vector is analyzed to reduce ambiguity.
摘要翻译：本发明的可植入心脏处置系统能够选择最合适的电极矢量以在特定患者内感测。在某些实施例中，植入式心脏处理系统基于哪个电极矢量导致最大的信号幅度或某个其他有用的度量（例如信噪比（SNR））来确定用于连续感测的最合适的电极矢量。然后将使用度量测量的具有最高质量的电极矢量设置为用于感测的默认电极矢量。另外，在本发明的某些实施例中，基于通常与默认电极矢量正交来选择下一替代电极矢量。在本发明的其他实施例中，基于拥有在默认电极矢量之后的下一个最高质量度量来选择下一个替代电极矢量。在一些实施例中，如果默认向量的分析不明确，则分析下一替代电极向量以减少模糊性。

78. 发明申请

WO2004093987A2 METHODS AND APPARATUS FOR ATRIOVENTRICULAR SEARCH 审中-公开
标题翻译：方法和装置的ATRIOVENTRICULAR SEARCH
公开(公告)号：WO2004093987A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011496
申请日：2004-04-14
申请人： MEDTRONIC, INC. , FEREK-PETRIC, Bozidar
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： In general, the invention provides for commencing an atrioventricular (AV) search in response to an indicator of an autonomic nervous system (ANS) activity. An implantable medical device (IMD) may be configured to apply this technique, and also to apply rate adaptive ventricular pacing. In response to ANS activity such as an abrupt increase in cardiac sympathetic nervous activity, the IMD performs an AV search to find the intrinsic AV interval of the patient. The invention includes selection of a maximum AV delay so that the AV search will not adversely affect hemodynamic function.
摘要翻译：通常，本发明提供响应于自主神经系统（ANS）活动的指标开始房室（AV）搜索。可植入医疗装置（IMD）可以被配置为应用这种技术，并且还可以应用速率适应性心室起搏。响应ANS活动，例如心脏交感神经活动的突然增加，IMD进行AV搜索以找到患者的内在AV间隔。本发明包括选择最大AV延迟，使得AV搜索不会不利地影响血液动力学功能。

79. 发明申请

WO2004091720A2 SUBCUTANEOUS CARDIAC DEVICE 审中-公开
标题翻译：婴幼儿心脏器官
公开(公告)号：WO2004091720A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010908
申请日：2004-04-09
申请人： CARDIAC PACEMAKERS, INC.
发明人： LOVETT, Eric, G. , FAVET, Mike , CATES, Adam, W. , LARSEN-KELLY, Kristine, M. , HAEFNER, Paul , SANDERS, Richard, S. , GILLIAM, F., Roosevelt, III
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/37 , A61N1/3752
摘要： A cardiac device includes a housing, and detection circuitry and energy delivery circuitry provided in the housing. One or more subcutaneous, non-intrathoracic electrodes may be coupled to the energy delivery and detection circuitry. A lead interface is provided on the housing and coupled to the energy delivery and detection circuitry. The lead interface is configured to receive at least one lead that includes one or more intrathoracic lead electrodes. A controller is provided in the housing and coupled to the lead interface and the energy delivery and detection circuitry. The system is operable in a multiplicity of configurations, such as a first configuration using the subcutaneous electrodes in the absence of the lead and a second configuration using at least one or more of the lead electrodes. Such configurations include cardiac activity monitoring/recording configurations and cardiac stimulation therapy configurations.
摘要翻译：心脏装置包括壳体，以及设置在壳体中的检测电路和能量输送电路。一个或多个皮下的非胸内电极可以耦合到能量输送和检测电路。引线接口设置在外壳上并耦合到能量输送和检测电路。引线接口被配置为接收包括一个或多个胸内引线电极的至少一个引线。控制器设置在壳体中并耦合到引线接口和能量输送和检测电路。该系统可以多种配置操作，例如在不存在引线的情况下使用皮下电极的第一配置以及使用至少一个或多个引线电极的第二配置。这样的配置包括心脏活动监测/记录配置和心脏刺激治疗配置。

80. 发明申请

WO2004069333A2 METHOD AND APPARATUS FOR SETTING PACING PARAMETERS 审中-公开
标题翻译：方法和设备的设置参数
公开(公告)号：WO2004069333A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002332
申请日：2004-01-28
申请人： CARDIAC PACEMAKERS INC. , DING, Jiang , YU, Yinghong , KRAMER, Andrew, P. , BAUMANN, Lawrence
发明人： DING, Jiang , YU, Yinghong , KRAMER, Andrew, P. , BAUMANN, Lawrence
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

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