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1. 发明申请

WO2007079288A1 CARDIAC THERAPY SYSTEM INCLUDING A TRIBOELECTRIC SENSOR 审中-公开
标题翻译： CARDIAC治疗系统，包括三电位传感器
公开(公告)号：WO2007079288A1
公开(公告)日：2007-07-12
申请号：PCT/US2006/060959
申请日：2006-11-16
申请人： MEDTRONIC, INC. , FEREK-PETRIC, Bozidar
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61N1/365
CPC分类号： A61N1/36514
摘要： Mechanical activity of a heart is sensed by a cardiac lead that carries a triboelectric sensor. The triboelectric sensor produces a triboelectric signal in response to cardiac contractions. A lead fabricated according to the invention can be used for a variety of purposes, including without limitation, pacing capture verification, electromechanical conductivity status of the myocardium (including detecting relatively reduced myocardial activity indicative of ischemia, myocyte necrosis, arterial stenosis and the like). The sensor allows detection of mechanical activity without signal blanking traditionally utilized to stimulate and sense cardiac activity. Traditional circuitry can be employed to stimulate/sense while a triboelectric sensor unit(s) detect evoked and/or intrinsic mechanical cardiac activity. A reduction from a prior amplitude signal can be used to set patient (or clinician) alert signals, set a logical flag regarding possible lead dislodgement, compare prior and current signals, store same in memory, and/or provide via telemetry for display.
摘要翻译：通过携带摩擦电传感器的心脏引线感测心脏的机械活动。摩擦电传感器响应于心脏收缩产生摩擦电信号。根据本发明制造的引线可以用于各种目的，包括但不限于起搏捕捉验证，心肌的机电导电性状态（包括检测指示缺血，心肌细胞坏死，动脉狭窄等的相对降低的心肌活动）。传感器允许检测机械活动，而传统上不用信号消隐来刺激和感测心脏活动。当摩擦电传感器单元检测到诱发和/或内在的机械心脏活动时，可以采用传统的电路来刺激/感测。可以使用来自先前幅度信号的减少来设置患者（或临床医生）警报信号，设置关于可能的引线移动的逻辑标志，比较先前和当前信号，将其存储在存储器中和/或通过遥测提供显示。

2. 发明申请

WO2009058638A1 IMPLANTABLE SYSTEM FOR FLOW MEASUREMENT INCLUDING CHARGE AMPLIFIER 审中-公开
标题翻译：用于流量测量的可扩展系统，包括充电放大器
公开(公告)号：WO2009058638A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/080864
申请日：2008-10-23
申请人： MEDTRONIC, INC , CINBIS, Can , FEREK-PETRIC, Bozidar , BREYER, Branko
发明人： CINBIS, Can , FEREK-PETRIC, Bozidar , BREYER, Branko
IPC分类号： A61B5/027 , A61N1/37
CPC分类号： A61N1/056 , A61B5/027 , A61N1/08 , A61N1/36514 , A61N1/36571 , A61N1/375
摘要： An implantable medical device lead (70) having a flow measurement sensor (14', 16') mounted thereon is provided with a capsule (72) mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.
摘要翻译：具有安装在其上的流量测量传感器（14'，16'）的可植入医疗装置引线（70）设置有靠近传感器安装的胶囊（72）。胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线上的阻抗直接影响传感器和电路之间的信号传输。电路包括用于处理来自传感器的信号的电荷放大器。在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。

3. 发明申请

WO2004093987A2 METHODS AND APPARATUS FOR ATRIOVENTRICULAR SEARCH 审中-公开
标题翻译：方法和装置的ATRIOVENTRICULAR SEARCH
公开(公告)号：WO2004093987A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011496
申请日：2004-04-14
申请人： MEDTRONIC, INC. , FEREK-PETRIC, Bozidar
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： In general, the invention provides for commencing an atrioventricular (AV) search in response to an indicator of an autonomic nervous system (ANS) activity. An implantable medical device (IMD) may be configured to apply this technique, and also to apply rate adaptive ventricular pacing. In response to ANS activity such as an abrupt increase in cardiac sympathetic nervous activity, the IMD performs an AV search to find the intrinsic AV interval of the patient. The invention includes selection of a maximum AV delay so that the AV search will not adversely affect hemodynamic function.
摘要翻译：通常，本发明提供响应于自主神经系统（ANS）活动的指标开始房室（AV）搜索。可植入医疗装置（IMD）可以被配置为应用这种技术，并且还可以应用速率适应性心室起搏。响应ANS活动，例如心脏交感神经活动的突然增加，IMD进行AV搜索以找到患者的内在AV间隔。本发明包括选择最大AV延迟，使得AV搜索不会不利地影响血液动力学功能。

4. 发明申请

WO2006004699A1 ELECTRODE LOCATION MAPPING SYSTEM AND METHOD 审中-公开
标题翻译：电极位置映射系统和方法
公开(公告)号：WO2006004699A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/022831
申请日：2005-06-22
申请人： MEDTRONIC, INC. , FEREK-PETRIC, Bozidar
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B5/0422 , A61B5/062 , A61B5/743 , A61B8/0833 , A61B8/0883 , A61B8/4245 , A61B8/5238 , A61B2034/2053
摘要： A mapped location of one or more electrodes within an electrical mapping volume is superimposed onto an ultrasound image corresponding to the electrical mapping volume.
摘要翻译：电对映体积内的一个或多个电极的映射位置被叠加到对应于电映射体积的超声图像上。

5. 发明申请

WO2005013818A1 MONITORING P-WAVES TO DETECT DEGRADATION OF ATRIAL MYOCARDIUM 审中-公开
标题翻译：监测波形以检测ATRIAL MYOCARDIUM的降解
公开(公告)号：WO2005013818A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/020627
申请日：2004-06-28
申请人： MEDTRONIC, INC. , FEREK-PETRIC, Bozidar
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61N1/362
摘要： An implantable medical device (IMD) (10) monitors at least one characteristic of P-waves within an electrogram signal. By monitoring changes in the characteristic over time, the IMD detects degradation of the atrial myocardium. In some embodiments, the IMD detects ischemia, an increased probability of the occurrence of angina, or a risk of future atrial fibrillation based on changes in the characteristic over time. The IMD can include a memory to store information relating to the detection and other diagnostic information for retrieval and evaluation by a clinician, and/or an alarm to alert the patient of the detection. In some embodiments, the IMD switches out of an atrial-tracking ventricular pacing mode, decreases the maximum tracking rate for an atrial-tracking ventricular pacing mode, increases the aggressiveness of rate-responsive atrial pacing, and/or initiates or modifies delivery of a therapy, such as a drug or neurostimulation, in response to the identification.
摘要翻译：可植入医疗装置（IMD）（10）监测电描记图信号内的P波的至少一个特征。通过监测随时间变化的特征，IMD检测心房心肌的退化。在一些实施方案中，IMD基于特征随时间的变化来检测缺血，发生心绞痛的可能性增加或未来心房颤动的风险。 IMD可以包括用于存储与检测有关的信息的存储器和用于临床医生进行检索和评估的其它诊断信息，和/或用于警告患者检测的警报。在一些实施例中，IMD从心房跟踪心室起搏模式切换，降低心房跟踪心室起搏模式的最大跟踪率，增加速率响应心房起搏的积极性，和/或启动或修改治疗，例如药物或神经刺激，以响应鉴定。

6. 发明申请

WO2003090860A3 ULTRASOUND METHODS AND IMPLANTABLE MEDICAL DEVICES USING SAME 审中-公开
公开(公告)号：WO2003090860A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012595
申请日：2003-04-24
申请人： MEDTRONIC, INC.
发明人： BREYER, Branko , FEREK-PETRIC, Bozidar
IPC分类号： A61N1/365
摘要： An ultrasound method and medical devices using same provide for various techniques of sampling blood flow velocity, e.g., at several sampling rates. To minimize the energy required for ultrasound monitoring, pulsed Doppler signal packages provided by a pulsed ultrasound circuit are switched in such a way that the repetition rate is the lowest possible and yet sufficiently high to be able to record the blood flow velocity within the heart. For example, an ultrasound circuit may be activated only within a part of the cardiac cycle designated as the Doppler Measurement Interval (DMI); the ultrasound circuit may be switched between an on state and an off state during the DMI; and/or the ultrasound circuit may also be switched on and off in different sampling modes: detection mode and measurement mode (e.g., using different sampling rates).

7. 发明申请

WO2004069334A1 AUTOMATIC ADJUSTMENT OF CAPTURE TEST FREQUENCY 审中-公开
标题翻译：自动调整捕获频率
公开(公告)号：WO2004069334A1
公开(公告)日：2004-08-19
申请号：PCT/US2004/002173
申请日：2004-01-27
申请人： MEDTRONIC, INC.
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： In general, the invention is directed to techniques for capture testing of a capture threshold in cooperation with measurement of other cardiac parameters. Physiological or non-physiological parameters may indicate a possible change in the capture threshold, and a significant change in a cardiac parameter may trigger more frequent monitoring of the capture threshold. In addition, measurement of cardiac parameters in relation to measurement of the capture threshold may be useful in diagnosing problems and forecasting possible loss of capture.
摘要翻译：通常，本发明涉及与其他心脏参数的测量相结合捕获阈值的捕获测试技术。生理或非生理参数可能指示捕获阈值的可能变化，并且心脏参数的显着变化可触发对捕获阈值的更频繁监测。此外，与捕获阈值的测量相关的心脏参数的测量可能有助于诊断问题并预测可能的捕获损失。

8. 发明申请

WO2002068047A2 SYSTEM AND METHOD FOR REMOTE PROGRAMMING OF AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于远程编程的可植入医疗器械的系统和方法
公开(公告)号：WO2002068047A2
公开(公告)日：2002-09-06
申请号：PCT/US2002/001583
申请日：2002-01-17
申请人： MEDTRONIC, INC.
发明人： HALLER, Markus , FEREK-PETRIC, Bozidar , DONDERS, Adrianus, P.
IPC分类号： A61N1/372
CPC分类号： A61N1/37264 , A61B5/0031 , A61N1/08 , A61N1/37211 , A61N1/37282 , G06F8/65 , G06F19/00 , G06F19/3418 , G16H40/40
摘要： A method and corresponding system for updating or installing new software loaded into the memory of an implantable medical device (IMD) implanted within a body of a patient is described. The updated or new software may be installed in the memory of the IMD without the patient having to travel to a clinic or hospital, and may be effected by employing modern telecommunication and Internet techniques in conjunction with a remote computer system.
摘要翻译：描述了一种用于更新或安装加载到植入在患者身体内的可植入医疗装置（IMD）的存储器中的新软件的方法和对应系统。更新的或新的软件可以安装在IMD的存储器中，而不需要病人去诊所或医院，并且可以通过结合远程计算机系统采用现代电信和因特网技术来实现。

9. 发明申请

WO2001052934A1 SYSTEM AND METHOD OF COMMUNICATING BETWEEN AN IMPLANTABLE MEDICAL DEVICE AND A REMOTE COMPUTER SYSTEM OR HEALTH CARE PROVIDER 审中-公开
标题翻译：可移植医疗设备与远程计算机系统或健康护理提供者之间的通信系统和方法
公开(公告)号：WO2001052934A1
公开(公告)日：2001-07-26
申请号：PCT/US2001/001639
申请日：2001-01-18
申请人： MEDTRONIC, INC.
发明人： HALLER, Markus , DONDERS, Andrianus, P. , FEREK-PETRIC, Bozidar
IPC分类号： A61N1/36
CPC分类号： A61N1/37264 , A61B5/0031 , A61N1/37211 , A61N1/37282 , G06F19/00 , G06F19/3418
摘要： A medical information communication system and corresponding methods are described. The system permits monitoring the performance of an implantable medical device (IMD) (14) implanted within a body of a patient, monitoring the health of the patient, or remotely delivering a therapy to the patient through the IMD. The IMD is capable of bi-directional communication with a communication module (100/110), a mobile telephone and/or personal data assistant (PDA) located outside the patient's body. The system may comprise the IMD, the communication module and/or mobile telephone and/or a PDA, a remote computer system (131), and a communication system (120) capable of bi-directional communication, where the communication module, the mobile telephone and/or the PDA are capable of receiving information from the IMD or relaying information thereto.
摘要翻译：描述医疗信息通信系统及相应的方法。该系统允许监测植入在患者身体内的可植入医疗装置（IMD）（14）的性能，监测患者的健康状况，或通过IMD远程传递给患者的治疗。 IMD能够与位于患者体外的通信模块（100/110），移动电话和/或个人数据助理（PDA）进行双向通信。该系统可以包括IMD，通信模块和/或移动电话和/或PDA，远程计算机系统（131）和能够进行双向通信的通信系统（120），其中通信模块，移动电话和/或PDA能够从IMD接收信息或向其传送信息。

10. 发明申请

WO2003090861A1 CAPTURE MANAGEMENT IN MULTI-SITE PACING 审中-公开
标题翻译：多地面捕捞管理
公开(公告)号：WO2003090861A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012744
申请日：2003-04-24
申请人： MEDTRONIC, INC.
发明人： FEREK-PETRIC, Bozidar
IPC分类号： A61N1/37
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/3627 , A61N1/371 , A61N1/3714 , A61N1/3716
摘要： Methods and apparatus for capture management in multi-chamber pacing are disclosed. In one embodiment, the invention includes determining a combination of electrodes from a plurality of electrodes that yields the lowest polarization potential immediately following delivery of an electrical stimulus to a heart; and performing capture detection using that combination of electrodes. In order to distinguish loss of capture in one ventricle in bi-ventricular pacing, certain embodiments may also include measuring a width of a QRS complex and determining when the width is greater than a predetermined value. A method for detecting single ventricular loss of capture in bi-ventricular pacing is also described utilizing comparison of evoked QRS complex morphology to a predefined waveform.
摘要翻译：披露了多室起搏采集管理方法和装置。在一个实施例中，本发明包括从多个电极确定电极的组合，所述多个电极在将电刺激递送到心脏之后立即产生最低极化电位; 并使用该组合的电极执行捕获检测。为了区分双心室起搏中的一个心室的捕获损失，某些实施例还可以包括测量QRS复合体的宽度并确定该宽度何时大于预定值。还通过将诱发QRS复合物形态与预定波形的比较来描述用于检测双心室起搏中单次心室收缩损失的方法。

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