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    • 79. 发明申请
    • SYSTEM AND METHOD FOR ANALYTE MEASUREMENT USING A NONLINEAR SAMPLE RESPONSE
    • 使用非线性样本响应进行分析测量的系统和方法
    • WO2008138553A1
    • 2008-11-20
    • PCT/EP2008/003732
    • 2008-05-09
    • ROCHE DIAGNOSTICS GmbHF. HOFFMANN-LA ROCHE AG
    • BUCK, Harvey B.
    • G01N33/487C12Q1/00G01N27/02G01N27/49
    • C12Q1/006G01N27/3273
    • The systems and methods of the present invention utilize a linear component of a non-linear, Faradaic current response generated by a biological fluid sample when an AC excitation potential sufficient to produce such a Faradaic current response is applied to the sample, in order to calculate the concentration of a medically significant component in the biological fluid sample. The current response is created by the excitation of electrochemical processes within the sample by the applied potential. Typically, the linear component of the current response to an applied AC potential contains phase angle and/or admittance information that may be correlated to the concentration of the medically significant component. Also typically, the fundamental linear component of the current response is utilized in the disclosed systems and methods. Harmonics of the fundamental linear component may also be used. Other methods and devices are disclosed.
    • 当将足以产生这样的法拉第电流响应的AC激励电势应用于样品时,本发明的系统和方法利用由生物流体样品产生的非线性法拉第电流响应的线性分量,以便计算 生物流体样品中医学上重要的组分的浓度。 当前的响应是通过施加电位的样品内电化学过程的激发产生的。 通常,对施加的AC电位的电流响应的线性分量包含可以与医学上重要的组分的浓度相关的相位角和/或导纳信息。 通常,在所公开的系统和方法中利用电流响应的基本线性分量。 也可以使用基本线性分量的谐波。 公开了其它方法和装置。