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71. 发明申请

WO2005112845A1 BALLOON CATHETER WITH BALLOON COMPRISING NANOTUBES 审中-公开
标题翻译：带有包含纳米管的气泡的气泡导管
公开(公告)号：WO2005112845A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017635
申请日：2005-05-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , HOKANSON, John, Michael , CHEN, John, Jianhua
发明人： WEBER, Jan , HOKANSON, John, Michael , CHEN, John, Jianhua
IPC分类号： A61F7/12
CPC分类号： A61M25/104 , A61F7/123 , A61L29/126 , A61M25/10 , B82Y5/00 , B82Y30/00
摘要： Medical devices including nanotubes, such as carbon nanotubes, are described. In some embodiments, a medical system includes an elongated shaft (22) carrying an expandable balloon (24). The balloon can include a polymer and nanotubes. The balloon may be used for cooling.
摘要翻译：描述了包括纳米管在内的医疗装置，例如碳纳米管。在一些实施例中，医疗系统包括承载可膨胀气囊（24）的细长轴（22）。气球可以包括聚合物和纳米管。气球可用于冷却。

72. 发明申请

WO2005072788A2 FUNCTIONAL COATINGS AND DESIGNS FOR MEDICAL IMPLANTS 审中-公开
标题翻译：医用植入物的功能涂层和设计
公开(公告)号：WO2005072788A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/001437
申请日：2005-01-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , HOLMAN, Tom , EIDENSCHINK, Tracee , CHEN, John, Jianhua
发明人： WEBER, Jan , HOLMAN, Tom , EIDENSCHINK, Tracee , CHEN, John, Jianhua
IPC分类号： A61L31/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0068 , A61L31/082 , A61L31/146 , A61L2300/606
摘要： The present invention regards an implant that may be uniquely shaped to enhance its functionality and that may also be coated with a coating system that affects its functionality. In one embodiment the implant may have a first surface that is covered with a filter material, the filter material being in contact with a catalyst that promotes the decomposition of Hydrogen Peroxide into Hydrogen and Oxygen. In this and other embodiments, this filter material may be made from ceramic materials and may be meso-porous. In another embodiment, the implant may or may not be coated with this system and may have at least one strut with a tapered cross-section, the cross-section becoming smaller in area when moving from a reference point on the inside of the implant to the outside of the implant.
摘要翻译：本发明涉及一种植入物，其可以被独特地成形以增强其功能并且还可以被涂覆有影响其功能的涂层系统。在一个实施方案中，植入物可以具有覆盖有过滤材料的第一表面，过滤材料与促进过氧化氢分解为氢和氧的催化剂接触。在这个和其它实施例中，这种过滤材料可以由陶瓷材料制成并且可以是中孔。在另一个实施例中，植入物可以或可以不用该系统涂覆并且可以具有至少一个具有锥形横截面的支柱，当从植入物内侧上的参考点移动到截面时，横截面的面积变小植入物的外部。

73. 发明申请

WO2005072786A1 SEQUENTIAL COATING OF A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的顺序涂层
公开(公告)号：WO2005072786A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/003017
申请日：2005-01-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SPENCER, Steven, M. , WEBER, Jan
发明人： SPENCER, Steven, M. , WEBER, Jan
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/61 , A61L2300/622
摘要： A multi-step method of manufacturing a medical device containing therapeutic agents that results in a lower maximum error in the amount of therapeutic agents actually disposed thereon and that allows for differential drug release kinetics along the length of the medical device.
摘要翻译：一种制造含有治疗剂的医疗装置的多步骤方法，其导致实际设置在其上的治疗剂量的最大误差较小，并且允许沿着医疗装置长度的差别药物释放动力学。

74. 发明申请

WO2012125676A1 IMPLANTABLE MEDICAL DEVICES INCORPORATING X-RAY MIRRORS 审中-公开
标题翻译：包含X射线镜的可植入医疗器械
公开(公告)号：WO2012125676A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028996
申请日：2012-03-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , FLANAGAN, Aiden
发明人： WEBER, Jan , FLANAGAN, Aiden
IPC分类号： A61L27/04 , A61L27/10 , A61L29/18 , A61L31/02 , A61L31/18
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61L27/04 , A61L27/10 , A61L29/18 , A61L31/022 , A61L31/026 , B82Y10/00 , G21K1/062
摘要： An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.
摘要翻译：可植入医疗装置包括设置有x射线反射镜的射线可透射部件，该X射线反射镜反射入射的X射线辐射以使装置可视化。 x射线镜包括具有通过具有第一折射率的原子层沉积沉积的第一金属或陶瓷层的交替层的多层纳米材料，以及通过原子层沉积沉积的具有不同于第二折射率的第二金属或陶瓷层从第一折射率。纳米层压材料总共包括至少四层。

75. 发明申请

WO2012078465A1 DRUG ELUTING BALLOONS WITH ABILITY FOR DOUBLE TREATMENT 审中-公开
标题翻译：具有双重治疗能力的药物气球
公开(公告)号：WO2012078465A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063068
申请日：2011-12-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , WETZELS, Jos
发明人： WEBER, Jan , WETZELS, Jos
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61L29/08 , A61L29/146 , A61L29/16 , A61L2300/61 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088
摘要： In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents.
摘要翻译：在实施例中，诸如气囊导管的医疗装置可将生物活性物质递送至患者的身体组织。医疗装置包括海绵输送层，其可以将多个剂量的一种或多种治疗剂递送至身体组织。医疗装置还可以包括药物储存器，其可以向输送层提供一种或多种治疗剂。

76. 发明申请

WO2011022623A2 MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：包含治疗剂的医疗设备
公开(公告)号：WO2011022623A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/046125
申请日：2010-08-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HINGSTON, John , ROBICHAUD, Michael , WEBER, Jan , MCNAMARA, Adrian , FLANAGAN, Aiden , HORGAN, Fergal
发明人： HINGSTON, John , ROBICHAUD, Michael , WEBER, Jan , MCNAMARA, Adrian , FLANAGAN, Aiden , HORGAN, Fergal
IPC分类号： A61L31/08
CPC分类号： A61L31/088 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2400/12
摘要： According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after implantation in a subject. In various embodiments, a therapeutic agent delivery profile of this type is provided by employing a temporary barrier layer which initially permits little to no release of the therapeutic agent, but which layer permits much greater release levels after a predetermined period of time. Other aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其可以在植入受试者后将一种或多种治疗剂的释放延迟预定时间。在各种实施方案中，通过使用临时阻挡层来提供这种类型的治疗剂递送特征，所述临时阻挡层最初几乎不允许释放治疗剂，但是该层在预定的时间段之后允许更大的释放水平。本发明的其它方面涉及形成这种装置的方法和使用这种装置的方法。

77. 发明申请

WO2010096516A3 BIOERODIBLE ENDOPROSTHESIS 审中-公开
公开(公告)号：WO2010096516A3
公开(公告)日：2010-08-26
申请号：PCT/US2010/024520
申请日：2010-02-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
发明人： SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
IPC分类号： A61L29/02 , A61L29/14 , A61L31/02 , A61L31/14 , C22C38/04 , C22C38/02
摘要： A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics.

78. 发明申请

WO2010014510A1 COILS FOR VASCULAR IMPLANTS OR OTHER USES 审中-公开
标题翻译：用于血管植入物或其他用途的线圈
公开(公告)号：WO2010014510A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/051690
申请日：2009-07-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan
发明人： WEBER, Jan
IPC分类号： A61F2/00
CPC分类号： A61F2/88 , A61F2/0077 , A61F2220/0016 , A61F2250/0067
摘要： Medical devices comprising implants for use in blood vessels or other body lumens. The implant comprises an elongate member that, in its native configuration, follows a generally helical path. The elongate member is formed of one or more strands that are wound into a coil of minor windings, wherein the coil of minor windings is itself wound into the generally helical path. The one or more strands are formed of materials that provide the elongate member with the desired flexibility. In some cases, the elongate member may be capable of delivering a therapeutic agent. This can be accomplished by, for example, using capsules, swellable materials, corrodable elements, magnetically-sensitive particles, coatings, and/or core wires. Also provided are a method of treating a superficial femoral artery and a method of making an implant.
摘要翻译：包括用于血管或其他体腔的植入物的医疗装置。植入物包括细长构件，其在其天然构造中遵循大致螺旋形路径。细长构件由一个或多个缠绕在小绕组线圈中的线构成，其中小绕组的线圈本身缠绕在大致螺旋状的路径中。一根或多根股线由提供细长部件所需的柔性的材料形成。在一些情况下，细长构件可以能够递送治疗剂。这可以通过例如使用胶囊，可膨胀材料，可腐蚀元件，磁敏颗粒，涂层和/或芯线来实现。还提供了治疗浅表股动脉的方法和制造植入物的方法。

79. 发明申请

WO2009148821A2 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：WO2009148821A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/044597
申请日：2009-05-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEWE, Scott, R. , WEBER, Jan , ZOROMSKI, Michele , WARNER, Robert, W.
发明人： SCHEWE, Scott, R. , WEBER, Jan , ZOROMSKI, Michele , WARNER, Robert, W.
IPC分类号： A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/082 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/608 , A61L2300/62 , A61L2420/08
摘要： An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), includes a surface, a first layer having a polyelectrolyte deposited on the surface, a plurality of polymeric particles deposited on the first layer, and a coating of a porous material deposited on the plurality of polymeric particles. At least one particle of the plurality of polymeric particles includes a polymer matrix and a drug distributed in the polymer matrix. A method of making the endoprosthesis is also disclosed.
摘要翻译：内置假体，例如支架（例如，药物洗脱支架）包括表面，沉积在表面上的聚电解质的第一层，沉积在第一层上的多个聚合物颗粒和沉积在多孔材料上的涂层在多个聚合物颗粒上。多个聚合物颗粒中的至少一个颗粒包括分散在聚合物基质中的聚合物基质和药物。还公开了制造内用假体的方法。

80. 发明申请

WO2009140257A2 COATING FOR MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒涂层
公开(公告)号：WO2009140257A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043591
申请日：2009-05-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan
发明人： WEBER, Jan
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14
CPC分类号： A61L31/16 , A61L27/04 , A61L27/28 , A61L27/58 , A61L31/022 , A61L31/08 , A61L31/148 , A61L2300/102 , A61L2300/22 , A61L2300/624 , A61L2400/12 , A61L2420/04
摘要： A medical implant can include a body including a bioerodible metal and a coating overlying a surface of the bioerodible metal. The coating can include a matrix that includes a fatty acid salt and nano-particles within the matrix.
摘要翻译：医疗植入物可以包括包括生物腐蚀性金属的物体和覆盖在生物腐蚀性金属的表面上的涂层。涂层可以包括在基质内包含脂肪酸盐和纳米颗粒的基质。

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