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61. 发明申请

WO2018081017A1 IMPLANTABLE MEDICAL DEVICE WITH PRESSURE SENSOR 审中-公开
标题翻译：带压力传感器的植入式医疗设备
公开(公告)号：WO2018081017A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/057929
申请日：2017-10-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , HAASL, Benjamin J. , MAILE, Keith R.
IPC分类号： A61N1/375 , A61B5/0215 , A61N1/365
摘要： An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing, a pressure sensor and a fluid filled cavity. The housing has a diaphragm that is exposed to the environment outside of the housing. The pressure sensor has a pressure sensor diaphragm that is responsive to a pressure applied to the pressure sensor diaphragm and provides a pressure sensor output signal that is representative of the pressure applied to the pressure sensor diaphragm. The fluid filled cavity is in fluid communication with both the diaphragm of the housing and the pressure sensor diaphragm of the pressure sensor. The fluid filled cavity is configured to communicate a measure related to the pressure applied by the environment to the diaphragm of the housing to the pressure sensor diaphragm of the pressure sensor.
摘要翻译：可植入医疗设备（IMD）配置有压力传感器。 IMD包括一个外壳，一个压力传感器和一个充满流体的腔体。壳体具有暴露于壳体外部环境的隔膜。压力传感器具有压力传感器膜片，该膜片响应施加到压力传感器膜片的压力并提供代表施加到压力传感器膜片的压力的压力传感器输出信号。流体填充腔与壳体的隔膜和压力传感器的压力传感器隔膜流体连通。流体填充腔被配置为将与由环境施加的压力有关的措施传递到壳体的隔膜到压力传感器的压力传感器隔膜。

62. 发明申请

WO2018039652A1 SYSTEMS AND METHODS FOR DETERMINING AN ABNORMAL GLYCEMIC EVENT USING SURROGATES FOR GLUCOSE 审中-公开
标题翻译：用于使用葡萄糖的血浆测定异常血糖事件的系统和方法
公开(公告)号：WO2018039652A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048766
申请日：2017-08-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , MAILE, Keith R.
IPC分类号： A61B5/145 , A61B5/1459 , A61B5/0205 , A61B5/024 , A61B5/0472 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/0205 , A61B5/02405 , A61B5/04001 , A61B5/0468 , A61B5/0472 , A61B5/076 , A61B5/082 , A61B5/11 , A61B5/1451 , A61B5/14546 , A61B5/1459 , A61B5/16 , A61B5/40 , A61B5/4035 , A61B5/686
摘要： Systems and methods for determining an abnormal glycemic event using surrogates for glucose are disclosed herein. In an embodiment, a medical system includes a medical device associated with a subject and a processor communicatively coupled to the medical device. The medical device is configured to sense a signal corresponding to a presence of a compound in at least one of: an exhalation breath, interstitial fluid, blood and urine, wherein the compound is a surrogate for glucose. The processor is configured to receive the signal corresponding to the presence of the compound; determine the presence of the compound based on the received signal; and determine the subject is experiencing an abnormal glycemic event in response to the determined presence of the compound.
摘要翻译：本文公开了使用替代葡萄糖来确定异常血糖事件的系统和方法。在一个实施例中，医疗系统包括与对象相关联的医疗设备以及通信地耦合到医疗设备的处理器。医疗设备被配置为感测与呼气，间质液，血液和尿中的至少一个中的化合物的存在相对应的信号，其中所述化合物是葡萄糖的替代物。处理器被配置为接收对应于化合物存在的信号; 基于接收到的信号确定化合物的存在; 并且确定受试者响应于所确定的化合物的存在而正在经历异常血糖事件。

63. 发明申请

WO2018038920A1 SYSTEMS AND METHODS FOR DETERMINING PRESENCE OF AN ANALYTE USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于确定使用可植入医疗装置的分析物的存在的系统和方法
公开(公告)号：WO2018038920A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/046116
申请日：2017-08-09
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , MAILE, Keith R. , STAHMANN, Jeffrey E.
IPC分类号： A61B5/1459 , A61B5/1455 , A61B5/145
摘要： Systems and methods to determine presence of an analyte using an implantable medical device are disclosed. In an embodiment, a medical system includes an implantable medical device, a light source, an optical sensor and a processor. The implantable medical device includes an indicator tag, which is responsive to an analyte. The light source is configured to emit light onto the indicator tag, where the emitted light comprises at least one wavelength of light, and where the indicator tag emanates light, in response to the emitted light, that corresponds to whether the indicator tag is exposed the analyte. The optical sensor is configured to receive at least a portion of the emanated light, which includes at least one wavelength of light. And, the processor is configured to determine whether the indicator tag is exposed to the analyte based on the received light.
摘要翻译：公开了使用可植入医疗装置来确定分析物的存在的系统和方法。在一个实施例中，医疗系统包括可植入医疗设备，光源，光学传感器和处理器。可植入医疗装置包括指示标签，其响应于分析物。光源被配置为将光发射到指示标签上，其中发射的光包括至少一个波长的光，并且其中响应于发射的光，指示标签发出光，其对应于指示标签是否暴露分析物。光学传感器被配置为接收发出的光的至少一部分，该发出的光包括至少一个波长的光。并且，处理器被配置为基于接收到的光确定指示标签是否暴露于分析物。

64. 发明申请

WO2018017361A1 METHOD AND SYSTEM FOR DETERMINING PACE TIMING IN A LEADLESS CARDIAC PACEMAKER SYSTEM 审中-公开
标题翻译：用于确定无绳心脏起搏器系统中的走时序的方法和系统
公开(公告)号：WO2018017361A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/041562
申请日：2017-07-11
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , STAHMANN, Jeffrey E. , THAKUR, Pramodsingh Hirasingh , KANE, Michael J. , YU, Yinghong , MAILE, Keith R.
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/056 , A61B7/00 , A61N1/36507 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36585 , A61N1/3706 , A61N1/37205 , A61N1/375 , A61N1/3756
摘要： A leadless cardiac pacemaker (LCP) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The LCP may include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart. A controller is disposed within the housing and is operably coupled to the first electrode and the second electrode such that the controller is capable of receiving, via the first electrode and the second electrode, electrical cardiac signals of the heart. The LCP may include a pressure sensor and/or an accelerometer. The controller may determine a pace time for a cardiac cycle based at least in part upon a signal from the pressure sensor.
摘要翻译：无引线心脏起搏器（LCP）被配置为感测心脏活动并且起搏患者的心脏并且可以放置在患者心脏的心室内。 LCP可以包括壳体，相对于壳体固定并且间隔开的第一电极和第二电极。控制器设置在壳体内并且可操作地耦合到第一电极和第二电极，使得控制器能够经由第一电极和第二电极接收心脏的心电信号。 LCP可以包括压力传感器和/或加速度计。控制器可以至少部分地基于来自压力传感器的信号来确定心动周期的起搏时间。

65. 发明申请

WO2017040153A1 SYSTEMS AND METHODS FOR BEHAVIORALLY RESPONSIVE SIGNAL DETECTION AND THERAPY DELIVERY 审中-公开
标题翻译：行为有效的信号检测和治疗方法的系统和方法
公开(公告)号：WO2017040153A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/048444
申请日：2016-08-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , LINDER, William J. , JUFFER, Lance Eric , HAASL, Benjamin J. , SCHMIDT, Brian L. , HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/378 , A61B5/11 , A61N1/365
CPC分类号： A61N1/36535 , A61B5/1116 , A61B5/1118 , A61B2560/0209 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/37247 , A61N1/3756 , A61N1/378
摘要： Systems, devices, and methods for adjusting functionality of an implantable medical device based on posture are disclosed. In some instances, a method for operating a leadless cardiac pacemaker implanted into a patient, where the patient has two or more predefined behavioral states, may include detecting a change in the behavioral state of the patient, and in response, changing a sampling rate of a sensor signal generated by a sensor of the leadless cardiac pacemaker. In some embodiments, the method may further include using the sampled sensor signal to determine an updated pacing rate of the leadless cardiac pacemaker and providing pacing to the patient at the updated pacing rate.
摘要翻译：公开了用于基于姿势来调整可植入医疗装置的功能的系统，装置和方法。在一些情况下，用于操作植入患者中的无引线心脏起搏器的方法，其中患者具有两个或更多个预定义的行为状态，可以包括检测患者的行为状态的变化，并且作为响应，改变患者的行为状态的变化由无引线心脏起搏器的传感器产生的传感器信号。在一些实施例中，该方法还可以包括使用采样的传感器信号来确定无引线心脏起搏器的更新的起搏速率并且以更新的起搏速率向患者提供起搏。

66. 发明申请

WO2016148928A1 COMMUNICATIONS IN A MEDICAL DEVICE SYSTEM WITH TEMPORAL OPTIMIZATION 审中-公开
标题翻译：具有时间优化的医疗设备系统中的通信
公开(公告)号：WO2016148928A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/020648
申请日：2016-03-03
申请人： CARDIAC PACEMAKERS, INC.
发明人： LUDWIG, Jacob M. , KANE, Michael J. , KOOP, Brendan E. , LINDER, William J. , MAILE, Keith R. , STAHMANN, Jeffrey E.
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： H04B7/24 , A61B5/0028 , A61B2560/0209 , A61N1/362 , A61N1/37217 , A61N1/37252 , A61N1/37288 , H04B13/005 , H04L1/12
摘要： Systems and methods for managing communication strategies between implanted medical devices. Methods include temporal optimization relative to one or more identified conditions in the body. A selected characteristic, such as a signal representative or linked to a biological function, is assessed to determine its likely impact on communication capabilities, and one or more communication strategies may be developed to optimize intra-body communication.
摘要翻译：用于管理植入式医疗设备之间的通信策略的系统和方法。方法包括相对于身体中的一个或多个所识别的条件的时间优化。评估所选择的特征，例如代表或与生物功能相关联的信号，以确定其对通信能力的可能影响，并且可以开发一种或多种通信策略以优化体内通信。

67. 发明申请

WO2016126968A1 SYSTEMS AND METHODS FOR SAFE DELIVERY OF ELECTRICAL STIMULATION THERAPY 审中-公开
标题翻译：用于安全输送电刺激治疗的系统和方法
公开(公告)号：WO2016126968A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/016608
申请日：2016-02-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： HUELSKAMP, Paul , LUDWIG, Jacob M. , JUFFER, Lance E. , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/362 , A61N1/365
CPC分类号： A61N1/3622 , A61N1/365 , A61N1/36514 , A61N1/37217 , A61N1/3756
摘要： Systems and methods for treating arrhythmias are disclosed. In one embodiment an LCP comprises a housing, a plurality of electrodes for sensing electrical signals emanating from outside of the housing, an energy storage module disposed within the housing, and a control module disposed within the housing and operatively coupled to the plurality of electrodes. The control module may be configured to receive electrical signals via two or more of the plurality of electrodes and determine if the received electrical signals are indicative of a command for the LCP to deliver ATP therapy. If the received electrical signals are indicative of a command for the LCP to deliver ATP therapy, the control module may additionally determine whether a triggered ATP therapy mode of the LCP is enabled. If the triggered ATP therapy mode is enabled, the control module may cause the LCP to deliver ATP therapy via the plurality of electrodes.
摘要翻译：公开了用于治疗心律失常的系统和方法。在一个实施例中，LCP包括壳体，用于感测从壳体外部发出的电信号的多个电极，设置在壳体内的能量存储模块以及设置在壳体内并可操作地耦合到多个电极的控制模块。控制模块可以被配置为经由两个或多个多个电极接收电信号，并确定所接收的电信号是否指示LCP递送ATP治疗的命令。如果所接收的电信号指示LCP提供ATP治疗的命令，则控制模块可另外确定是否启用了LCP的触发ATP治疗模式。如果触发的ATP治疗模式被启用，则控制模块可以使LCP通过多个电极传递ATP治疗。

68. 发明申请

WO2016007657A1 POWER SAVING COMMUNICATION FOR MEDICAL DEVICES 审中-公开
标题翻译：省电通信医疗器械
公开(公告)号：WO2016007657A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039590
申请日：2015-07-08
申请人： CARDIAC PACEMAKERS, INC.
发明人： HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/372 , A61N1/368 , A61N1/39 , A61N1/362 , A61N1/37 , A61N1/375 , A61B5/046 , A61B5/0464 , A61B5/0472
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/11 , A61B5/14542 , A61B5/686 , A61B5/7275 , A61B5/7282 , A61B7/023 , A61B2560/0209 , A61B2560/0214 , A61N1/3622 , A61N1/3625 , A61N1/3684 , A61N1/3708 , A61N1/37205 , A61N1/37276 , A61N1/37288 , A61N1/3756 , A61N1/3956
摘要： Power saving communication techniques for communicating in a medical device system. One example medical device system may be for delivering electrical stimulation therapy to a heart of a patient, and may include a first implantable medical device implanted in a first chamber of the heart and configured to determine one or more parameters, a medical device physically spaced from and communicatively coupled to the first implantable medical device, the medical device configured to deliver electrical stimulation therapy to the heart of the patient, wherein the first implantable medical device is further configured to: compare a value of a first determined parameter to a first threshold; if the value of the first determined parameter passed the first threshold, communicate a first indication to the medical device; and if the value of the first determined parameter has not passed the first threshold, not communicating the first indication to the medical device.
摘要翻译：用于在医疗设备系统中进行通信的节电通信技术。一个示例性的医疗设备系统可以用于将电刺激治疗递送到患者的心脏，并且可以包括植入心脏的第一腔室中并被配置为确定一个或多个参数的第一可植入医疗设备，医疗设备物理上与并且通信地耦合到所述第一可植入医疗装置，所述医疗装置被配置为向患者的心脏递送电刺激治疗，其中所述第一可植入医疗装置还被配置为：将第一确定参数的值与第一阈值进行比较; 如果第一确定参数的值通过第一阈值，则将第一指示传达到医疗设备; 并且如果第一确定参数的值没有超过第一阈值，则不将第一指示传达到医疗设备。

69. 发明申请

WO2015191893A2 SYSTEMS AND METHODS FOR RATE RESPONSIVEPACING WITH A LEADLESS CARDIAC PACEMAKER 审中-公开
标题翻译：用无铅CARDIAC PACEMAKER进行速率响应的系统和方法
公开(公告)号：WO2015191893A2
公开(公告)日：2015-12-17
申请号：PCT/US2015/035389
申请日：2015-06-11
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , STAHMANN, Jeffrey E. , MAILE, Keith R.
CPC分类号： A61N1/36585 , A61N1/0563 , A61N1/36521 , A61N1/36542 , A61N1/3684 , A61N1/37288 , A61N1/3756
摘要： Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (LCP) that is implanted within or proximate the heart. From this location, the LCP may provide pacing therapy to the heart based at least in part on the sensed cardiac electrical data. An implantable medical device located remotely from the heart may sense patient activity, and may wirelessly communicate patient activity data from the implantable medical device to the LCP, sometimes using conducted communication. The LCP may be then determine an adjustment to the provided pacing therapy (e.g. adjust the pacing rate) based at least in part on the received patient activity data signal.
摘要翻译：用于向患者的心脏提供速率响应起搏治疗的系统和方法。用于提供速率响应起搏治疗的一个示例性方法包括用植入心脏内或心脏附近的无引线心脏起搏器（LCP）来感测心脏电数据。从该位置，LCP可以至少部分地基于所感测的心脏电数据来向心脏提供起搏治疗。位于远离心脏的可植入医疗装置可以感测患者活动，并且可以有时使用进行的通信将患者活动数据从可植入医疗装置无线地传送到LCP。然后，LCP可以至少部分地基于所接收的患者活动数据信号来确定对所提供的起搏治疗的调整（例如调整起搏速率）。

70. 发明申请

WO2014014733A1 ELECTROSTATIC DISCHARGE PROTECTION CIRCUIT FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的静电放电保护电路
公开(公告)号：WO2014014733A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050032
申请日：2013-07-11
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith R. , JUFFER, Lance E. , LINDER, William J. , BALCZEWSKI, Ron A. , STESSMAN, Nicholas J. , JANSEN, Mark Duane
IPC分类号： A61N1/37 , H01L27/02 , H02H9/04
CPC分类号： H02H3/20 , A61N1/3718 , H01L27/0285 , H02H9/046
摘要： An implantable medical device can include an integrated circuit comprising an electrostatic discharge (ESD) protection circuit. The ESD protection circuit can include an active circuit, a first passive circuit, and a second passive circuit. For example, at least one of the first or second passive circuits can include an array of capacitors in a series configuration, a parallel configuration, or a combination of series and parallel configurations. The first and second passive circuits can be configured to establish a specified time constant, and, in response to an applied ESD, the first and second passive circuits can provide a control signal to active circuit to switch the active circuit from a substantially non-conductive mode to a substantially conductive mode.
摘要翻译：可植入医疗装置可以包括包括静电放电（ESD）保护电路的集成电路。 ESD保护电路可以包括有源电路，第一无源电路和第二无源电路。例如，第一或第二无源电路中的至少一个可以包括串联配置的电容器阵列，并联配置或串联和并联配置的组合。第一和第二无源电路可以被配置成建立指定的时间常数，并且响应于施加的ESD，第一和第二无源电路可以向有源电路提供控制信号，以将有源电路从基本上不导电模式到基本上导电的模式。

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