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    • 5. 发明申请
    • INSERTABLE NEURAL PROBE WITH FLEXIBLE STRUCTURE
    • 具有灵活结构的绝对神经探测器
    • WO2012170340A2
    • 2012-12-13
    • PCT/US2012040709
    • 2012-06-04
    • UNIV MICHIGANYOON EUISIKWU FAN
    • YOON EUISIKWU FAN
    • A61N1/05A61L27/54A61L27/58A61N1/36
    • A61B5/04001A61B5/0478A61B5/40A61L29/148A61N1/0529A61N1/0551A61N1/3605A61N5/0622
    • A neural probe (10) is provided for in vivo communication with biological tissue, including stimulating neurons and/or recording neural electrical activity. The probe (10) may be constructed so that the immune response by the biological tissue in which the device is implanted is reduced over known implantable probes. The probe (10) can be constructed with a tip (16) that has a branched configuration, with electrodes (24) located along each of the branches (20). A biodegradable coating (18) is disposed over at least the tip (16) of the probe (10) to provide the probe (10) with sufficient integrity for insertion into the biological tissue and to degrade after insertion. The biodegradable coating (18) can have an anti-inflammatory drug or other bioagent distributed therein for localized release of the bioagent to further reduce the immune response.
    • 提供神经探针(10)用于与生物组织的体内通信,包括刺激神经元和/或记录神经电活动。 可以构造探针(10),使得通过已知的可植入探针减少其中植入装置的生物组织的免疫应答。 探针(10)可以由具有分支构造的尖端(16)构成,电极(24)沿着每个分支(20)定位。 至少在探针(10)的尖端(16)上设置可生物降解的涂层(18),从而为探针(10)提供足够的完整性以插入生物组织中并在插入后降解。 可生物降解的涂层(18)可以具有分布在其中的抗炎药物或其它生物剂,用于生物制剂的局部释放以进一步降低免疫应答。