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61. 发明申请

WO03023829A2 SEALING SYSTEM AND PRESSURE CHAMBER ASSEMBLY INCLUDING THE SAME 审中-公开
标题翻译：包括相同的密封系统和压力室组件
公开(公告)号：WO03023829A2
公开(公告)日：2003-03-20
申请号：PCT/US0224026
申请日：2002-07-30
申请人： MICELL TECHNOLOGIES INC , WORM STEVE L , MCCLAIN JAMES P
发明人： WORM STEVE L , MCCLAIN JAMES P
IPC分类号： H01L21/00
CPC分类号： H01L21/67126
摘要： A pressure chamber assembly for retaining a fluid includes first and second relatively separable casings defining an enclosed chamber and a fluid leak path extending from the chamber to an exterior region. An inner seal member is disposed along the leak path to restrict flow of fluid from the chamber to the exterior region. An outer seal member is disposed along the leak path between the inner seal member and the exterior region to restrict flow of fluid from the chamber to the exterior region. The inner seal member is a cup seal.
摘要翻译：用于保持流体的压力室组件包括限定封闭室的第一和第二相对可分离壳体以及从室延伸到外部区域的流体泄漏路径。内部密封构件沿着泄漏路径设置以限制流体从腔室到外部区域的流动。外部密封构件沿内部密封构件与外部区域之间的泄漏路径设置，以限制流体从腔室流向外部区域。内密封件是杯形密封件。

62. 发明申请

WO2003023827A1 PRESSURE CHAMBER ASSEMBLY INCLUDING DRIVE MEANS 审中-公开
标题翻译：压力室组件包括驱动装置
公开(公告)号：WO2003023827A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/024004
申请日：2002-07-30
申请人： MICELL TECHNOLOGIES, INC. , WORM, Steve, L.
发明人： WORM, Steve, L.
IPC分类号： H01L21/00
CPC分类号： H01L21/68785 , B08B7/0021 , H01L21/67126 , H01L21/68792
摘要： A pressure chamber assembly (400) for processing a substrate (5) includes a pressure vessel defining an enclosed pressure chamber (410). A substrate holder (552) is disposed in the pressure chamber (410) and is adapted to hold the substrate (5). A drive assembly (580) is operable to move the substrate holder (552). The drive assembly (580) includes a first drive member (560, 590) connected to the substrate holder (552) for movement therewith relative to the pressure vessel and a second drive member (592, 594) fluidly isolated from the first drive member and the pressure chamber. A drive unit (582) is operable to move the second drive member (592, 594). The drive unit (582) is fluidly isolated from the first drive member (560, 590) and the pressure chamber (410). The second drive member (592, 594) is non-mechanically coupled to the first drive member (560, 590) such that the drive unit (582) can move the substrate holder (552) via the first and second drive members.
摘要翻译：用于处理衬底（5）的压力室组件（400）包括限定封闭压力室（410）的压力容器。衬底保持器（552）设置在压力室（410）中并且适于保持衬底（5）。驱动组件（580）可操作以移动衬底保持器（552）。驱动组件（580）包括连接到衬底保持器（552）上以便相对于压力容器移动的第一驱动构件（560,590）和与第一驱动构件流体隔离的第二驱动构件（592,594）和压力室。驱动单元（582）可操作以移动第二驱动构件（592,594）。驱动单元（582）与第一驱动构件（560,590）和压力室（410）流体隔离。第二驱动构件（592,594）非机械地联接到第一驱动构件（560,590），使得驱动单元（582）可以经由第一和第二驱动构件移动衬底保持器（552）。

63. 发明申请

WO2003023826A2 METHODS AND APPARATUS FOR HOLDING A SUBSTRATE IN A PRESSURE CHAMBER 审中-公开
标题翻译：用于在压力室中保持基底的方法和装置
公开(公告)号：WO2003023826A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/024003
申请日：2002-07-30
申请人： MICELL TECHNOLOGIES, INC. , WORM, Steve, L.
发明人： WORM, Steve, L.
IPC分类号： H01L21/00
CPC分类号： H01L21/67051 , H01L21/6838 , Y10S134/902
摘要： A process chamber assembly for use with a substrate includes a vessel and a substrate holder. The vessel defines a chamber. The substrate holder has a rotational axis and includes front and rear opposed surfaces. The front surface is adapted to support the substrate. At least one impeller vane extends rearwardly from the rear surface and radially with respect to the rotational axis. The impeller vane is operative to generate a pressure differential tending to hold the substrate to the substrate holder when the substrate holder is rotated about the rotational axis. Preferably, the process chamber assembly includes a plurality of the impeller vanes extending rearwardly from the rear surface and radially with respect to the rotational axis.
摘要翻译：用于衬底的处理室组件包括容器和衬底保持器。容器限定一个室。衬底保持器具有旋转轴线并且包括前和后相对表面。前表面适于支撑基底。至少一个叶轮叶片从后表面向后延伸并且相对于旋转轴线径向延伸。当衬底保持器围绕旋转轴线旋转时，叶轮叶片可操作以产生趋向于将衬底保持到衬底保持器的压差。优选地，处理室组件包括从后表面向后延伸并且相对于旋转轴线径向延伸的多个叶轮叶片。

64. 发明申请

WO2013177211A1 SAFE DRUG ELUTING STENT WITH ABSORBABLE COATING 审中-公开
标题翻译：具有可吸收涂层的安全药物涂抹手套
公开(公告)号：WO2013177211A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/042093
申请日：2013-05-21
申请人： MICELL TECHNOLOGIES, INC.
发明人： MCCLAIN, James, B. , TAYLOR, Charles, Douglas
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2300/63 , C08L67/04
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供的装置包括：a。支架; 湾在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

65. 发明申请

WO2012034079A3 MACROLIDE DOSAGE FORMS 审中-公开
标题翻译： MACROLIDE剂型
公开(公告)号：WO2012034079A3
公开(公告)日：2012-05-18
申请号：PCT/US2011051092
申请日：2011-09-09
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , CARLYLE WENDA C , TAYLOR CHARLES DOUGLAS
发明人： MCCLAIN JAMES B , CARLYLE WENDA C , TAYLOR CHARLES DOUGLAS
IPC分类号： A61K9/00
CPC分类号： A61K9/7007 , A61K9/0019 , A61K9/0021 , A61K31/436 , A61K47/34
摘要： Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.
摘要翻译：提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上，并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。

66. 发明申请

WO2012009684A2 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物交付医疗设备
公开(公告)号：WO2012009684A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/044263
申请日：2011-07-15
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Douglas , ZANI, Brett, G. , NEET, John , KIORPES, Timothy, Charles
发明人： MCCLAIN, James, B. , TAYLOR, Douglas , ZANI, Brett, G. , NEET, John , KIORPES, Timothy, Charles
IPC分类号： A61K9/70
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/1011
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，其包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种处于治疗上所需形态的药剂和/或至少一种活性生物药剂和任选的一种或多种药用载剂; 其中基本上所有药剂和/或活性生物药剂保留在所述涂层内并且在所述基底上，直到所述可植入装置被部署在受试者身体内的介入部位处，并且其中当所述医疗装置在所述受试者的身体内展开时一部分药剂和/或活性生物药剂与至少一部分聚合物和/或至少一部分药物携带剂一起在介入部位递送。

67. 发明申请

WO2010111196A3 PERIPHERAL STENTS HAVING LAYERS 审中-公开
标题翻译：具有层的外围手套
公开(公告)号：WO2010111196A3
公开(公告)日：2011-03-31
申请号：PCT/US2010028195
申请日：2010-03-22
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , TAYLOR DOUGLAS
发明人： MCCLAIN JAMES B , TAYLOR DOUGLAS
IPC分类号： A61F2/82 , A61L27/04 , A61L27/34 , A61L27/54 , A61L27/58
CPC分类号： A61L31/10 , A61F2/86 , A61F2240/001 , A61F2250/001 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：a。支架; 湾沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

68. 发明申请

WO2010111196A2 PERIPHERAL STENTS HAVING LAYERS 审中-公开
标题翻译：具有层的外围手套
公开(公告)号：WO2010111196A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028195
申请日：2010-03-22
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Douglas
发明人： MCCLAIN, James, B. , TAYLOR, Douglas
IPC分类号： A61F2/82 , A61L27/34 , A61L27/54 , A61L27/58 , A61L27/04
CPC分类号： A61L31/10 , A61F2/86 , A61F2240/001 , A61F2250/001 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供的是涂覆的冠状动脉支架，包括：a。支架; 湾沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

69. 发明申请

WO2008131131A1 STENTS HAVING BIODEGRADABLE LAYERS 审中-公开
标题翻译：具有生物可降解层的手套
公开(公告)号：WO2008131131A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060671
申请日：2008-04-17
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Douglas
发明人： MCCLAIN, James, B. , TAYLOR, Douglas
IPC分类号： A61L33/00 , A61F2/00
CPC分类号： A61L31/10 , A61F2/82 , A61F2230/0069 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising:. a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：一个。支架框架; 湾沉积在所述支架框架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

70. 发明申请

WO2007127363A3 COATINGS CONTAINING MULTIPLE DRUGS 审中-公开
标题翻译：包含多种药物的涂料
公开(公告)号：WO2007127363A3
公开(公告)日：2008-10-16
申请号：PCT/US2007010227
申请日：2007-04-26
申请人： MICELL TECHNOLOGIES INC , DEYOUNG JAMES , TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE
发明人： DEYOUNG JAMES , TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61F2/90 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/20 , A61L2300/216 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/61 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
摘要翻译：一种用于在基底上沉积包含聚合物和至少两种药剂的涂层的方法，包括以下步骤：提供支架框架; 在所述支架框架上沉积包含第一药剂的第一层; 沉积包含第二药剂的第二层; 其中所述第一和第二药剂选自两种不同类型的药剂。

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