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61. 发明申请

WO2008100695A2 SYSTEM AND METHOD FOR ADJUSTING THE SPHERICAL ABERRATION OF OBJECTIVE LENSES 审中-公开
标题翻译：用于调整目标镜片的球面抛光的系统和方法
公开(公告)号：WO2008100695A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/052158
申请日：2008-01-28
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , FOMITCHOV, Pavel A. , VERMA, Kaushal , MASINO, Joseph
发明人： FOMITCHOV, Pavel A. , VERMA, Kaushal , MASINO, Joseph
IPC分类号： G02B7/04
CPC分类号： G02B27/0068
摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.
摘要翻译：公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

62. 发明申请

WO2008039669A1 NUCLEIC ACID PURIFICATION METHOD 审中-公开
标题翻译：核酸纯化方法
公开(公告)号：WO2008039669A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/078898
申请日：2007-09-19
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , TAKKELLAPATI, Sudhakar Rao , AMBAT, Rajesh
发明人： TAKKELLAPATI, Sudhakar Rao , AMBAT, Rajesh
IPC分类号： C12N15/10
CPC分类号： C12N15/101
摘要： The invention provides an improved method for the purification of nucleic acid molecules, which method comprises generating a cellular lysate containing the nucleic acid; contacting the lysate with an anion exchanger bound to a solid support matrix under conditions such that the anion exchanger binds the nucleic acid; followed by eluting the nucleic acid from the anion exchanger with an aqueous mobile phase comprising an elution solution; and desalting the eluted nucleic acid such that it is suitable for downstream applications. The improvement of the method includes providing the anion exchanger in a packed column, wherein the column is packed using a salt solution containing an antimicrobial agent. In addition, the salt solution has a salt concentration similar to that of the lysate, such that the column does not need equilibration prior to sample loading.
摘要翻译：本发明提供了一种用于纯化核酸分子的改进方法，该方法包括产生含有核酸的细胞裂解物; 使所述裂解物与阴离子交换剂接触，所述阴离子交换剂在使所述阴离子交换剂结合所述核酸的条件下与固体支持基质结合; 随后用含有洗脱溶液的水性流动相从阴离子交换剂洗脱核酸; 并使洗脱的核酸脱盐，使其适合于下游应用。该方法的改进包括在填充柱中提供阴离子交换剂，其中使用含有抗微生物剂的盐溶液填充柱。此外，盐溶液的盐浓度与裂解物的盐浓度相似，使得柱在样品加载之前不需要平衡。

63. 发明申请

WO2019228857A1 BIOREACTOR SYSTEM AND METHOD OF BIOPROCESSING 审中-公开
公开(公告)号：WO2019228857A1
公开(公告)日：2019-12-05
申请号：PCT/EP2019/063072
申请日：2019-05-21
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： KILAR, Alexander, Mark
IPC分类号： C12M1/00 , C12M1/34
摘要： A bioreactor system includes a vessel having a bottom floor, a flexible bioprocessing bag disposed within the vessel, and a flexible bladder positioned intermediate the bottom floor of the vessel and the bioprocessing bag. The flexible bladder is selectively inflatable to vary at least one of a geometry or configuration of the bioprocessing bag to provide for improved drainability or an increased turndown ratio for the bioreactor system.

64. 发明申请

WO2019210067A1 INFLATABLE BIOREACTOR AND METHOD OF USE 审中-公开
公开(公告)号：WO2019210067A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/029143
申请日：2019-04-25
申请人： GE HEALTHCARE BIO-SCIENCES CORP.
发明人： SAUKKONEN, Hanna-Leena , STANKOWSKI, Ralph
IPC分类号： C12M1/00 , C12M3/06
摘要： An inflatable bioreactor (110, 210) may include one or more sheets joined to form a bag (111, 211) including a top sheet (118, 218) and a bottom sheet (119, 219) formed from the one or more sheets and being inflatable to provide an internal volume (117, 217) suitable for retaining a volume of culture liquid (10) during flow of the culture liquid resulting from a rocking motion (R) of the bag, and one or more perturbing protrusions (116, 116', 116'', 216) extending upwardly from the bottom sheet toward, but not as far as, the top sheet and extending transversely to, or obliquely to, a direction of wave motion (W) of the culture liquid. The resulting construction may provide improved flow for low initial volumes of the culture liquid in the bag.

65. 发明申请

WO2019129570A1 PROBE ASSEMBLY AND METHOD FOR SECURING AND INSERTING A PROBE 审中-公开
公开(公告)号：WO2019129570A1
公开(公告)日：2019-07-04
申请号：PCT/EP2018/085817
申请日：2018-12-19
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： OUELLETTE, Matthew
IPC分类号： B01L9/00 , C12M1/12 , C12M1/00
摘要： A probe assembly for inserting a probe into a vessel or tubing includes a probe sheath having a proximal end and a distal end and being configured for operative coupling to a vessel or tubing, the probe sheath being configured to receive a probe and to permit movement of the probe towards the distal end of the probe sheath, and a locking mechanism configured to restrain longitudinal movement of the probe with respect to the sheath in a locked state. The locking mechanism may be unlocked to allow for movement of the probe with respect to the sheath.

66. 发明申请

WO2018220086A1 A HOLLOW FIBER FILTER ARRANGEMENT 审中-公开
公开(公告)号：WO2018220086A1
公开(公告)日：2018-12-06
申请号：PCT/EP2018/064304
申请日：2018-05-30
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE LIMITED
发明人： ALI, Yasser, S.
IPC分类号： B01D63/02 , B01D65/00 , C12M1/00
CPC分类号： C12M25/02 , B01D29/117 , B01D35/30 , B01D63/02 , B01D65/00 , B01D2313/20 , B01D2313/23 , B01D2313/58 , C12M23/14 , C12M23/26 , C12M29/16
摘要： Disclosed is a hollow fiber filter arrangement (1; 101; 201) and a bioreactor system comprising such a hollow fiber filter arrangement. The hollow fiber filter arrangement comprising: an inlet (3; 103; 203) for receiving a sample to be filtered in the hollow fiber filter arrangement; an outlet (5; 105; 205) for delivering of the filtered sample out from the hollow fiber filter arrangement; a bundle of elongate hollow fibers (7; 107; 207) connected at a first end (9a; 109a; 209a) to the inlet (3; 103; 203) and connected at an opposite second end (9b; 109b; 209b) to the outlet (5; 105; 205); and an outer housing (13; 113; 213) enclosing the bundle (7; 107; 207), wherein a filtrate/waste collection space (15; 115; 215) is provided between the outer housing and the at least one elongated hollow fiber, and wherein the outer housing (13; 113; 213) is made from a flexible material.

67. 发明申请

WO2018060523A3 COMPUTER DEVICE FOR DETECTING AN OPTIMAL CANDIDATE COMPOUND AND METHODS THEREOF 审中-公开
公开(公告)号：WO2018060523A3
公开(公告)日：2018-04-05
申请号：PCT/EP2017/075003
申请日：2017-10-02
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： FUENTES, Emmanuel, Israel , AVINASH, Gopal, Biligeri , GRAVES, Robert, John , THATTE, Abhijit, Vijay , KODESH, Afek , JEFFEREY, Caron , DAS, Sharmistha
IPC分类号： G06F19/00 , G06F19/18
摘要： The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-labeland a class for each cell of the samples based on the image data,detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore,the invention also relates to corresponding computer device, a computer program, and a computer program product.

68. 发明申请

WO2016116507A1 PROCESS SIMULATION IN CELL A PROCESSING FACILITY 审中-公开
标题翻译：细胞处理设备中的过程模拟
公开(公告)号：WO2016116507A1
公开(公告)日：2016-07-28
申请号：PCT/EP2016/051142
申请日：2016-01-20
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： BAKSH, Dolores , KUNTER, Akbay, Seref , WOOD, Nichole, Lea , SMITH, Reginald, Donovan
IPC分类号： G06F19/00
CPC分类号： G06Q10/06313 , G06F19/00 , G06Q10/063118 , G06Q10/0633 , G16H10/40
摘要： The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. Process simulation may be used to determine the optimal arrangement and/or quantity of cell processing equipment needed. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.
摘要翻译：本发明提供了以有效和可扩展的方式并行处理生物细胞样品的改进方法，设备和系统。本发明能够以空间和时间有效的方式平行处理生物细胞样品，例如患者样品。可以使用过程模拟来确定所需的细胞处理设备的最佳排列和/或数量。本发明的方法，设备和系统在处理用于细胞治疗的患者样品中特别有用。

69. 发明申请

WO2016012459A3 PARALLEL CELL PROCESSING METHOD AND FACILITY 审中-公开
公开(公告)号：WO2016012459A3
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066666
申请日：2015-07-21
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： GHOUZE, Firman , VANEK, Philip
IPC分类号： G01N35/00
摘要： The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.

70. 发明申请

WO2016012220A1 CELL PROCESSING METHOD 审中-公开
标题翻译：细胞处理方法
公开(公告)号：WO2016012220A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/065300
申请日：2015-07-06
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , GE HEALTHCARE BIO-SCIENCES AB
发明人： AMARATUNGA, Mohan, Mark , THOMAS, Nicholas , VANEK, Philip
IPC分类号： G06F19/00 , B01L3/00 , G06Q50/24
CPC分类号： G16H10/40 , B01L3/5453 , G01N1/40 , G01N35/00732 , G01N2001/007 , G01N2035/00831 , G01N2035/00851 , G06F19/00 , G06F19/366 , G06K7/10009
摘要： The present invention provides improved methods for maintaining the physical separation and identity integrity of a biological cellular sample from a patient during processing. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods of the invention find particular utility in processing patient samples for use in cell therapy.
摘要翻译：本发明提供了用于在处理期间保持生物细胞样品与患者的物理分离和身份完整性的改进方法。本发明能够以空间和时间有效的方式平行处理生物细胞样品，例如患者样品。本发明的方法在处理用于细胞治疗的患者样品中特别有用。

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