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1. 发明申请

WO2018060523A3 COMPUTER DEVICE FOR DETECTING AN OPTIMAL CANDIDATE COMPOUND AND METHODS THEREOF 审中-公开
公开(公告)号：WO2018060523A3
公开(公告)日：2018-04-05
申请号：PCT/EP2017/075003
申请日：2017-10-02
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： FUENTES, Emmanuel, Israel , AVINASH, Gopal, Biligeri , GRAVES, Robert, John , THATTE, Abhijit, Vijay , KODESH, Afek , JEFFEREY, Caron , DAS, Sharmistha
IPC分类号： G06F19/00 , G06F19/18
摘要： The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-labeland a class for each cell of the samples based on the image data,detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore,the invention also relates to corresponding computer device, a computer program, and a computer program product.

2. 发明申请

WO2018060523A2 COMPUTER DEVICE FOR DETECTING AN OPTIMAL CANDIDATE COMPOUND AND METHODS THEREOF 审中-公开
标题翻译：用于检测最佳候选化合物的计算机装置及其方法
公开(公告)号：WO2018060523A2
公开(公告)日：2018-04-05
申请号：PCT/EP2017/075003
申请日：2017-10-02
申请人： GE HEALTHCARE BIO-SCIENCES CORP , GE HEALTHCARE UK LIMITED
发明人： FUENTES, Emmanuel, Israel , AVINASH, Gopal, Biligeri , GRAVES, Robert, John , THATTE, Abhijit, Vijay , KODESH, Afek , JEFFEREY, Caron , DAS, Sharmistha
IPC分类号： G06F19/00
摘要： The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-labeland a class for each cell of the samples based on the image data,detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles. Furthermore,the invention also relates to corresponding computer device, a computer program, and a computer program product.
摘要翻译：本发明涉及用于计算机装置的方法，用于基于包含细胞系和一种或多种生物标志物的多个样品和板图构造来检测最佳候选化合物，其中所述板图谱配置是提供包含暴露于一种或多种生物标志物和不同浓度的形成至少一种浓度梯度的候选化合物的细胞系的样品位置，所述候选化合物包含在多种候选化合物中，所述方法包括产生（310）表型其中产生表型谱包括获得（312）图像数据的步骤，所述图像数据描绘包含在浓度梯度中的每个样品基于图像数据为样本的每个单元生成（314）班级和班级，通过评估关于多个化合物概况的比较标准来检测（320）最佳候选化合物。此外，本发明还涉及相应的计算机设备，计算机程序和计算机程序产品。

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