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51. 发明申请

WO1994002204A1 MICROWAVE TREATMENT APPARATUS 审中-公开
标题翻译：微波处理设备
公开(公告)号：WO1994002204A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001439
申请日：1993-07-09
申请人： MICROWAVE ENGINEERING DESIGNS LIMITED , THOMPSON, Alan , GRIST, Arron
发明人： MICROWAVE ENGINEERING DESIGNS LIMITED
IPC分类号： A61N05/02
CPC分类号： A61B18/1815 , A61B18/18 , A61B2018/1861
摘要： Apparatus for microwave thermal treatment comprising a probe, a microwave antenna support structure for locating the antenna within the probe near a distal end thereof, the support structure comprising means engaging the probe at a proximal end thereof and adjustment means for effecting controlled relative movement between the engaging means and the support structure whereby to adjust the longitudinal position of the antenna relative to the probe. The support structure further comprises a duct which together with the interior of a disposable catheter forming the probe provides a means of circulating coolant through the catheter externally of the structure.
摘要翻译：用于微波热处理的装置，包括探针，微波天线支撑结构，用于将天线定位在靠近其远端的探针内，所述支撑结构包括在其近端处接合所述探针的装置和用于实现所述探针之间受控的相对运动的调节装置接合装置和支撑结构，从而调节天线相对于探头的纵向位置。支撑结构还包括管道，其与形成探针的一次性导管的内部一起提供使冷却剂循环通过结构外部的导管的装置。

52. 发明申请

WO1992022350A1 TUMOR TREATMENT 审中-公开
标题翻译：肿瘤治疗
公开(公告)号：WO1992022350A1
公开(公告)日：1992-12-23
申请号：PCT/US1992004141
申请日：1992-05-15
申请人： WILLIAMS, Jeffery, A.
IPC分类号： A61N05/02
CPC分类号： A61M25/1011 , A61B2017/00084 , A61M5/427 , A61M27/006 , A61M39/0208 , A61M39/0247 , A61M2025/1013 , A61M2039/0211 , A61M2205/32 , A61M2210/0687 , A61M2210/0693 , A61N1/40 , A61N1/403 , A61N5/1014 , A61N5/1015 , A61N7/02 , A61N2005/1021 , A61M2230/005
摘要： A completely implantable apparatus (26) is provided for treatment of tissue surrounding a cavity (24) left by surgical removal of a brain tumor (18). The apparatus (26) includes an inflatable balloon (28) constructed for placement in the cavity (24). A subcutaneously implantable treatment fluid receptacle (30) is provided for receiving a transdermal injection of a treatment fluid. A catheter (32) connects the receptacle (30) to the inflatable balloon (28). Various embodiments provide for simultaneous application of heat therapy and/or radiation therapy and/or chemotherapy to the remaining tissue surrounding the cavity (24) from which the tumor was removed.
摘要翻译：提供了一种完全可植入装置（26），用于治疗通过手术切除脑肿瘤（18）而留下的空腔（24）周围的组织。设备（26）包括构造用于放置在空腔（24）中的可膨胀气囊（28）。提供皮下植入式治疗液容器（30），用于接受治疗液的透皮注射。导管（32）将容器（30）连接到可充气球囊（28）。各种实施方案提供了将热疗和/或放射治疗和/或化学疗法同时应用于肿瘤被移除的空腔（24）周围的剩余组织。

53. 发明申请

WO1992018199A1 CATHETERS FOR TREATING PROSTATE DISEASE 审中-公开
标题翻译：治疗前列腺疾病的导管
公开(公告)号：WO1992018199A1
公开(公告)日：1992-10-29
申请号：PCT/US1991002509
申请日：1991-04-12
申请人： MMTC, INC.
发明人： MMTC, INC. , STERZER, Fred
IPC分类号： A61N05/02
CPC分类号： A61M25/10 , A61B18/18 , A61B18/1815 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61M25/1002 , A61M25/104
摘要： Applying squeezing pressure to a diseased prostate, by means of a urethral and/or rectal catheter (100) incorporating an inflatable prostate balloon (122); to compress the prostate while it is being irradiated from a microwave antenna (116), increases the therapeutic temperature to which the prostate tissue more distal to the microwave antenna (116) can be heated without heating any non-prostate tissue beyond a maximum safe temperature, and reduces the temperature differential between the heated more distal and more proximate prostate tissue from the microwave antenna (116).
摘要翻译：通过结合有可膨胀的前列腺气囊（122）的尿道和/或直肠导管（100）将压迫压力施加到患病前列腺; 在从微波天线（116）照射前压缩前列腺时，增加可以加热远离微波天线（116）的前列腺组织的治疗温度，而不加热超过最大安全温度的任何非前列腺组织并且降低来自微波天线（116）的被加热的更远端和更靠近的前列腺组织之间的温度差。

54. 发明申请

WO1992007622A1 URETHRAL INSERTED APPLICATOR FOR PROSTATE HYPERTHERMIA 审中-公开
标题翻译： URETHRAL插入式应用程序用于前瞻性高血压
公开(公告)号：WO1992007622A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008183
申请日：1991-11-04
申请人： BSD MEDICAL CORPORATION
发明人： BSD MEDICAL CORPORATION , TURNER, Paul, F. , SCHAEFERMEYER, Theron, Neal , TUMEH, Amer, Mohammad , TERRY, Philip, A.
IPC分类号： A61N05/02
CPC分类号： A61N5/0601 , A61B5/01 , A61B17/2202 , A61B18/18 , A61B18/1815 , A61B2017/00057 , A61B2017/00084 , A61B2017/00132 , A61B2017/00274 , A61B2017/22021 , A61B2018/00035 , A61B2018/00166 , A61B2018/00547 , A61F7/12 , A61M2025/0177 , A61N7/022 , A61N2005/007 , A61N2005/061
摘要： A urethral insertable applicator for prostate hyperthermia includes an energy applicator (14) in association with a multi-tube, balloon-type catheter (18). The energy applicator (14) may be a microwave applicator or an ultrasound applicator, either of which, when inserted in the prostate, will cause heating of the prostate tissue surrounding the applicator. The applicator (14), with a radiometer (11), may serve as a means to measure temperature by measuring the thermal energy radiated from the prostate tissue. Provision may be made for circulating a cooling fluid through a cooling chamber (73) between the applicator (14) and the tissue to be heated. The difference in temperature of the inlet and outlet cooling fluid may also be used to indicate prostate tissue temperature. A measure of the temperature of the prostate tissue being heated is used to control application of energy to the applicator.
摘要翻译：用于前列腺热疗的尿道可插入施加器包括与多管气囊型导管（18）相关联的能量施加器（14）。能量施加器（14）可以是微波施加器或超声波施加器，其中当插入到前列腺中时，其将引起围绕施用器的前列腺组织的加热。具有辐射计（11）的施加器（14）可以用作通过测量从前列腺组织辐射的热能来测量温度的手段。可以设置使冷却流体循环通过施加器（14）和待加热组织之间的冷却室（73）。入口和出口冷却流体的温度差异也可用于指示前列腺组织温度。使用被加热的前列腺组织的温度的量度来控制对施用器的能量的施加。

55. 发明申请

WO1992003186A1 LASER FOCUS ADJUSTMENT SYSTEM 审中-公开
标题翻译：激光聚焦调整系统
公开(公告)号：WO1992003186A1
公开(公告)日：1992-03-05
申请号：PCT/US1991005647
申请日：1991-08-08
申请人： PHOENIX LASER SYSTEMS, INC.
发明人： PHOENIX LASER SYSTEMS, INC. , FOUNTAIN, William, D.
IPC分类号： A61N05/02
CPC分类号： B23K26/02 , A61B2090/0804 , A61F9/008 , A61F2009/00844
摘要： A laser beam delivery system has an improved focus adjustment for controlling the depth at which the beam focusses in the target. An objective lens (24) remains stationary with respect to the target (26), and focus depth is controlled by adjusting the separation between a pair of positive and negative lenses (46, 48) which are positioned a distance behind the objective lens at least one additional optical path (34) is folded onto the laser beam path upstream of the objective lens. Thus, the surgical laser axis and at least one further axis on which analysis, target imaging and other functions are performed are joined together upstream of the objective lens. In this way, the laser beam may be focussed to given depth in the target, without interrupting optics along the partially colinear axis. Also, the objective lens assembly, which may be quite massive, is not relied upon for quick-response focussing during a surgical procedure.
摘要翻译：激光束传送系统具有改进的聚焦调节，用于控制光束聚焦在目标物中的深度。物镜（24）相对于目标（26）保持静止，并且通过调整一对正和负透镜（46,48）之间的距离来控制聚焦深度，所述正和负透镜至少位于物镜后面一定距离一个附加光路（34）折叠到物镜上游的激光束路径上。因此，手术激光轴和进行分析，目标成像和其它功能的至少一个另外的轴在物镜的上游连接在一起。以这种方式，激光束可以被聚焦到目标中给定的深度，而不会沿着部分共线轴线中断光学器件。此外，可能相当巨大的物镜组件在外科手术过程中不依赖于快速响应聚焦。

56. 发明申请

WO1990007322A1 DIAGNOSIS AND TREATMENT OF VIRAL EFFECTS 审中-公开
标题翻译：诊断和治疗病毒效应
公开(公告)号：WO1990007322A1
公开(公告)日：1990-07-12
申请号：PCT/US1989005650
申请日：1989-12-18
申请人： GORDON, David
IPC分类号： A61N05/02
CPC分类号： A61K49/1863 , A61K9/5094 , A61K31/295 , A61K33/00 , A61K33/24 , A61K33/26 , A61K41/0052 , G01N33/56988 , A61K31/40 , A61K2300/00
摘要： This invention provides methods of treatment and/or diagnosis and/or siting of viruses including the AIDS virus and others as well as the cells which they infect. The method comprises introducing near, into or onto the virus or the cell which the virus infects, or both, minute particles. These particles possess ferromagnetic, paramagnetic or diamagnetic properties. After being localized near, in or on the virus or the viral-infected cell, the particles are inductively heated by application of an alternating electromagnetic field. The inductive heating is continued for a period of time sufficient to bring about a temperature rise to a minimum necessary to kill the virus or cell or to desirably alter the behavior of the virus or infected cell. Prior to, during or after treatment, these particles can be used diagnostically to locate and/or map the virus in the living tissue.
摘要翻译：本发明提供了治疗和/或诊断和/或选择病毒的方法，所述病毒包括AIDS病毒和其他病毒以及它们感染的细胞。该方法包括在病毒或病毒感染的细胞附近或之上或之外引入微量颗粒。这些颗粒具有铁磁性，顺磁性或抗磁性。在被定位在病毒或病毒感染细胞附近或之上时，通过施加交变电磁场感应加热颗粒。感应加热持续一段时间，足以使温度上升到杀死病毒或细胞所需的最低限度，或者期望地改变病毒或感染细胞的行为。在治疗之前，期间或之后，这些颗粒可以在诊断上用于将病毒定位和/或映射在活组织中。

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