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1. 发明申请

WO2004062708A2 INFLATABLE BALLOON CATHETER STRUCTURAL DESIGNS AND METHODS FOR TREATING DISEASED TISSUE OF A PATIENT 审中-公开
标题翻译：可充气气球导管结构设计及治疗患者疾病组织的方法
公开(公告)号：WO2004062708A2
公开(公告)日：2004-07-29
申请号：PCT/US2003/040495
申请日：2003-12-19
申请人： MMTC, INC.
发明人： STERZER, Fred , MAWHINNEY, Daniel
IPC分类号： A61M
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/00232 , A61B2018/00642 , A61B2018/1846 , A61B2018/1861
摘要： Each of various modifications of an integrated-structure inflatable balloon catheter design includes a longitudinal structure having a sharply-pointed insertion needle at a distal end of the longitudinal structure and an inflatable balloon situated intermediate a proximate end and the distal end of the longitudinal structure which is attached to said longitudinal structure. With the inflatable balloon in a deflated state, the insertion needle may be used to puncture the patient's skin and underlying sub-cutaneous tissue and place the deflated balloon in proximity to the diseased sub-cutaneous tissue, The balloon is then inflated to press against and thereby spatially deform the diseased sub-cutaneous tissue, after which the deformed diseased sub-cutaneous tissue may be therapeutically heated. This heating may be sufficient to cause the creation of a permanent cavity in the deformed diseased sub-cutaneous tissue which persists after the catheter is withdrawn. This permits any selected one of various therapeutic substances to be introduced into this a permanent cavity. One modification employs a balloon having a selected non-uniform, odd pattern shape which, when inflated, cooperates with the shape of the diseased sub-cutaneous tissue. This one modification also may be beneficially used in prostate-treating balloon catheters, which do not have a sharply-pointed insertion needle at the distal end thereof.
摘要翻译：集成结构可充气球囊导管设计的各种修改包括纵向结构，其在纵向结构的远端具有尖锐的插入针，以及位于纵向结构的近端和远端之间的可充气气囊，附接到所述纵向结构。在充气气囊处于放气状态时，插入针可以用于刺穿患者的皮肤和下面的皮下组织，并将放气的球囊放置在患病的皮下组织附近。然后使气囊膨胀以压住和从而在空间上变形患病的皮下组织，之后变形的患病皮下组织可被治疗加热。这种加热可能足以导致在导管被拔出之后持续的变形的患病的皮下组织中产生永久性空腔。这允许将各种治疗物质中的任何选定的一种引入到该永久腔中。一种修改使用具有选定的不均匀的奇数图案形状的气球，当膨胀时，该气球与患病的皮下组织的形状配合。这种修改也可以有益地用于前列腺治疗气囊导管，其在其末端没有尖锐的插入针。

2. 发明申请

WO2019089275A1 PULSED ELECTROMAGNETIC THERAPY FOR DIRECTING AGENTS TO CANCER CELLS 审中-公开
公开(公告)号：WO2019089275A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/057041
申请日：2018-10-23
申请人： MMTC, INC.
发明人： STERZER, Fred
IPC分类号： A61N1/40 , A61N5/02 , A61N1/36 , A61N2/02 , A61N7/00
CPC分类号： A61K41/0028 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B8/5261 , A61K31/721 , A61K41/0047 , A61M37/0092 , A61M2037/0007 , A61N1/327 , A61N1/40 , A61N5/022 , A61P31/12 , A61P33/00 , A61P35/00
摘要： Provided among other things is a method of treating a diseased tissue that is a cancer tissue, virally infected tissue, or a tissue infected with an obligate intracellular parasite, in a large animal comprising: (a) administering a therapeutic agent effective for treating the disease to the animal; and (2) using over a period of time one or more phased arrays of antennas to direct pulses of radio frequency or microwave radiation in permeability-enhancing amount to the affected tissue, wherein the pulsed radiation is effective to promote the activity of the therapeutic agent against cells of the cancerous tissue or against the activity of the pathogen.

3. 发明申请

WO2016178802A1 WEARABLE MICROWAVE RADIOMETER 审中-公开
标题翻译：耐磨的微波辐射仪
公开(公告)号：WO2016178802A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/027053
申请日：2016-04-12
申请人： MMTC, INC.
发明人： STERZER, Fred , MAWHINNEY, Daniel, D.
IPC分类号： G01J5/60 , H01Q7/02 , G01J3/50
CPC分类号： H01Q21/08 , H01Q1/273
摘要： Provided among other things is a wearable microwave radiometer. For example, a wearable microwave radiometer apparatus for measuring relative temperature differences comprising: (a) a circumambient garment configured to fit snugly; (b) control flat, flexible radiometer antenna(s) fitted to, or configured to fit to, the garment; (c) active flat, flexible radiometer antenna(s) fitted to, or configured to fit to, the garment, which active antenna(s) are configured in the apparatus to be positioned in a spaced-apart manner relative to the control antenna(s); and (d) a radiometer configured to monitor microwave signal from the control and active antennas and fitted to, or configured to fit to, the garment, wherein the antennas are operatively connected to, or configured to connect to, the radiometer.
摘要翻译：其中提供的是可穿戴式微波辐射计。例如，一种用于测量相对温度差的可穿戴式微波辐射计装置，包括：（a）被配置成紧密配合的外衣; （b）控制装配或配置成适合于衣服的平坦，柔性的辐射计天线; （c）安装在或配置成适合于衣服的有源平面柔性辐射计天线，该有源天线被配置在设备中以相对于控制天线以间隔的方式定位（或多个）; 以及（d）辐射计，被配置为监测来自所述控制和有源天线的微波信号，并且被配置到或配置成适合于所述衣服，其中所述天线可操作地连接到或者被配置为连接到所述辐射计。

4. 发明申请

WO1992018199A1 CATHETERS FOR TREATING PROSTATE DISEASE 审中-公开
标题翻译：治疗前列腺疾病的导管
公开(公告)号：WO1992018199A1
公开(公告)日：1992-10-29
申请号：PCT/US1991002509
申请日：1991-04-12
申请人： MMTC, INC.
发明人： MMTC, INC. , STERZER, Fred
IPC分类号： A61N05/02
CPC分类号： A61M25/10 , A61B18/18 , A61B18/1815 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61M25/1002 , A61M25/104
摘要： Applying squeezing pressure to a diseased prostate, by means of a urethral and/or rectal catheter (100) incorporating an inflatable prostate balloon (122); to compress the prostate while it is being irradiated from a microwave antenna (116), increases the therapeutic temperature to which the prostate tissue more distal to the microwave antenna (116) can be heated without heating any non-prostate tissue beyond a maximum safe temperature, and reduces the temperature differential between the heated more distal and more proximate prostate tissue from the microwave antenna (116).
摘要翻译：通过结合有可膨胀的前列腺气囊（122）的尿道和/或直肠导管（100）将压迫压力施加到患病前列腺; 在从微波天线（116）照射前压缩前列腺时，增加可以加热远离微波天线（116）的前列腺组织的治疗温度，而不加热超过最大安全温度的任何非前列腺组织并且降低来自微波天线（116）的被加热的更远端和更靠近的前列腺组织之间的温度差。

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