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51. 发明申请

WO2006115877A1 VAGAL NERVE STIMULATION USING VASCULAR IMPLANTED DEVICES FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译： VAGAL神经刺激使用血管植入装置治疗ATRIAL FIBRILLATION
公开(公告)号：WO2006115877A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/014387
申请日：2006-04-18
申请人： KENERGY, INC. , DENKER, Stephen , BULKES, Cherik , BEUTLER, Arthur, J.
发明人： DENKER, Stephen , BULKES, Cherik , BEUTLER, Arthur, J.
IPC分类号： A61N1/372 , A61N1/39 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/37205 , A61N1/37211 , A61N1/3787 , A61N1/395
摘要： An abnormally rapid ventricular cardiac rate that results from atrial fibrillation can be reduced by stimulating a vagal nerve of the heart. An apparatus for such stimulation includes a power transmitter that emits a radio frequency signal. A stimulator, implanted in a blood vessel adjacent the vagal nerve, has a pair of electrodes and an electrical circuit thereon. The electrical circuit receives the radio frequency signal and derives an electrical voltage from the energy of that signal. The electrical voltage is applied in the form of pulses to the pair of electrodes, thereby stimulating the vagal nerve. The pattern of that stimulating pulses can be varied in response to characteristics of the atrial fibrillation or the ventricular contractions.
摘要翻译：通过刺激心脏的迷走神经可以减少心房颤动引起的异常快速的心室心率。用于这种刺激的装置包括发射射频信号的功率发射器。植入在迷走神经附近的血管中的刺激器在其上具有一对电极和电路。电路接收射频信号，并根据该信号的能量导出电压。以脉冲的形式将电压施加到该对电极，从而刺激迷走神经。刺激脉冲的模式可以响应于心房颤动或心室收缩的特征而变化。

52. 发明申请

WO2004110550A2 VAGAL STIMULATION FOR ANTI-EMBOLIC THERAPY 审中-公开
标题翻译： VAGAL刺激抗肿瘤治疗
公开(公告)号：WO2004110550A2
公开(公告)日：2004-12-23
申请号：PCT/IL2004/000496
申请日：2004-06-10
申请人： BIOCONTROL MEDICAL LTD. , BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir
发明人： BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir
IPC分类号： A61N
CPC分类号： A61N1/0556 , A61B5/4035 , A61N1/36114 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： Apparatus (20) for treating a subject (30) suffering from spontaneous atrial fibrillation includes an electrode device (22), adapted to be coupled to a site of the subject (30) selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30), and a control unit (32), adapted to drive the electrode device (22) to apply an electrical current to the site, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.
摘要翻译：用于治疗患有自发性心房颤动的受试者（30）的装置（20）包括电极装置（22），其适于耦合到选自以下的列表中的受试者（30）的位置：迷走神经（24）受试者（30）的心外膜脂肪垫，受试者（30）的肺静脉，受试者（30）的颈动脉，受试者（30）的颈动脉窦，体外受试者（30）的静脉和静脉内部的颈内静脉和控制单元（32），其适于驱动电极装置（22）向该部位施加电流，并且配置目前为了维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

53. 发明申请

WO2004105870A1 心臓治療装置及び心臓治療方法审中-公开
标题翻译：心脏治疗装置和心脏治疗方法
公开(公告)号：WO2004105870A1
公开(公告)日：2004-12-09
申请号：PCT/JP2004/007568
申请日：2004-05-26
申请人：テルモ株式会社 , 福井美仁
发明人：福井美仁
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3956
摘要：致死的不整脈の予防と治療を行うため、抗頻脈治療後の予防治療の制御を行うことが可能な心臓治療装置であり、頻脈の発生を検出した結果をもって頻脈予防手段及び頻脈治療手段(頻脈停止手段)を制御することにより抗頻脈治療を行う。この抗頻脈治療においては、カルジオバージョンや除細動などの心臓への電気ショックの供給後に、迷走神経に対する賦活電流、あるいは交感神経に対する抑制電流を低減もしくは停止する機構を備えているので、血行動態の悪化や致死的不整脈の再発、心房細動などの上室性不整脈の惹起を防ぐことができる。
摘要翻译：可以控制抗心律失常治疗后的预防治疗从而预防和治疗致命性心律失常的心脏治疗仪。在该装置中，基于心动过速的检测结果来控制防止心动过速的手段和治疗心动过速的手段（停止心动过速的手段），从而进行抗心律失常治疗。在这种抗心律失常疗法中，对心脏给予心律转复或除颤等电击，然后降低或停止迷走神经的活化电流或交感神经的抑制电流。由于这种机制，可以防止血流动力学恶化，可以防止致命性心律失常复发或室性心律失常的诱导等室颤。

54. 发明申请

WO2004093975A2 METHODS AND APPARATUS FOE DECREASING INCIDENCES OF EARLY RECURRENCE OF ATRIAL FIBRILLATION 审中-公开
标题翻译：方法和装置减少早期复发的复发
公开(公告)号：WO2004093975A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011237
申请日：2004-04-09
申请人： MEDTRONIC, INC. , MUSLEY, Shaelesh Kuma V. , EULER, David, E. , WARMAN, Eduardo, N.
发明人： MUSLEY, Shaelesh Kuma V. , EULER, David, E. , WARMAN, Eduardo, N.
IPC分类号： A61N1/00
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： Implantable cardioverter/defibrillators (ICDs) providing atrial cardioversion/defibrillation (C/D) shock therapies in response to detected atrial tachyarrhythmias, particularly atrial fibrillation (AF) or in response to a patient command generated by a patient experiencing AF symptoms are disclosed. The early recurrence of atrial fibrillation (ERAF) following delivery of an atrial C/D shock is detected and delivery of any subsequent atrial C/D shock therapies is delayed for an ERAF sustained duration.
摘要翻译：公开了用于响应于检测到的心房快速性心律失常，特别是心房颤动（AF）或响应于患有AF症状的患者产生的患者指令的心房复律/除颤（C / D）休克疗法的植入式心律转复器/除颤器（ICD）。检测到心房C / D休克后出现心房颤动（ERAF）的早期复发，并且随后的心房C / D休克疗法的递送延迟了ERAF持续时间。

55. 发明申请

WO02087684A3 CARDIAC STIMULATION APPARATUS AND METHOD FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译：心脏刺激装置及其治疗方法
公开(公告)号：WO02087684A3
公开(公告)日：2003-05-22
申请号：PCT/US0213237
申请日：2002-04-26
申请人： QUETZAL BIOMEDICAL INC
发明人： FUKA MARY Z , MATHIS SCOTT C , PRENTICE JOHN K , SCHMIDT JOHN A , ROTTENBERG WILLIAM E
IPC分类号： A61N1/05 , A61N1/368 , A61N1/39 , A61N1/18
CPC分类号： A61N1/3956 , A61N1/056 , A61N1/3684 , A61N1/395
摘要： A cardiac stimulation apparatus (100) and multi-electrode pacing lead (14) for prevention or treatment of atrial fibrillation. The multi-electrode lead will distribute electrodes (16) throughout the right atrium to provide a choice of pacing sites at locations best suited to multi-focal control of the rapid atrial heartbeats that may precede atrial fibrillation. Cardiac electrical activity is sensed in four dimensions (three spatial dimensions, X, Y, and Z, and in time). The system triangulates the location of a given event in three spatial dimensions, and then paces the heart in areas that will disrupt the propagation of the arrhythmia. Termination involves delivering low voltage pulses to large areas of the heart, either simultaneously or in rapid sequence.
摘要翻译：心脏刺激装置（100）和用于预防或治疗心房颤动的多电极起搏引线（14）。多电极引线将电极（16）分布在整个右心房中，以便在最适合多焦点控制心房颤动之前的快速心房心跳的位置提供起搏位置的选择。心脏电活动在四个维度（三个空间维度，X，Y和Z，及时）中被感测。该系统在三个空间维度上对给定事件的位置进行三角测量，然后在将破坏心律失常传播的区域中心脏起搏。终止包括同时或以快速顺序将低电压脉冲输送到心脏的大部分区域。

56. 发明申请

WO0121255A9 DEFIBRILLATION OR CARDIOVERSION WITH A WAVEFORM OPTIMIZED IN FREQUENCY DOMAIN 审中-公开
标题翻译：频域优化中的波形变换或缩放
公开(公告)号：WO0121255A9
公开(公告)日：2002-11-07
申请号：PCT/US0026238
申请日：2000-09-25
申请人： UNIV MISSOURI
发明人： MCDANIEL WAYNE C
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/36017 , A61N1/3906 , A61N1/395
摘要： An apparatus having a discharging energy source, two electrodes adapted to make electrical contact with a patient, a connecting mechanism forming an electrical circuit between the energy source and the electrodes and a controller operating the connecting mechanism. The apparatus delivers electrical energy from the energy source to the electrodes having a waveform optimized in the frequency domain to have a dominant frequency in a preset range.
摘要翻译：具有放电能源的装置，适于与患者电接触的两个电极，在能量源和电极之间形成电路的连接机构以及操作连接机构的控制器。该装置将电能从能量源传递到具有在频域中优化的波形的电极，以使主频在预设范围内。

57. 发明申请

WO02002007A1 A CARDIAC ARRHYTHMIA DETECTOR USING ECG WAVEFORM-FACTOR AND ITS IRREGULARITY 审中-公开
标题翻译：使用ECG波形因子的CARDIAC ARRHYTHMIA检测器及其不正常
公开(公告)号：WO02002007A1
公开(公告)日：2002-01-10
申请号：PCT/US2001/004006
申请日：2001-02-08
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39 , A61B5/04
CPC分类号： A61N1/39 , A61B5/046 , A61B5/0464 , A61N1/36514 , A61N1/3925 , A61N1/395 , A61N1/3956
摘要： A cardiac monitor is provided that monitors the condition of the heart of a cardiac patient and generates signals indicating one of several conditions, such as supraventricular tachycardia, ventricular tachycardia (116) and ventricular fibrillation (118). In order to generate these signals, the ECG from the patient is analyzed to determine a certain interval and heart rate, as well as a waveform factor and a waveform factor irregularity. The waveform factor is derived from the average of the ECG amplitudes during a cardiac interval and the peak value of the ECG during the same interval. Preferably, a running average is calculated over several intervals. This waveform factor is then used to detect shockable ventricular arrhythmia. The waveform factor irregularity is indicative of the variability of the waveform factor and is used to differentiate between ventricular tachycardia and ventricular fibrillation.
摘要翻译：提供了一种监测心脏病患者心脏状况的心脏监测器，并产生指示若干病情之一的信号，例如室上性心动过速，室性心动过速（116）和心室颤动（118）。为了产生这些信号，分析来自患者的ECG以确定一定的间隔和心率，以及波形因子和波形因子不规则性。波形因子来自心脏间隔期间的ECG幅度的平均值，以及在相同间隔期间的ECG的峰值。优选地，在几个间隔上计算运行平均值。然后将该波形因子用于检测可震荡的室性心律失常。波形因子不规则表示波形因子的变异性，用于区分室性心动过速和心室颤动。

58. 发明申请

WO9952593A8 ATRIAL DEFIBRILLATION SYSTEM HAVING PATIENT SELECTABLE ATRIAL FIBRILLATION DETECTION 审中-公开
标题翻译：具有患者选择性ATRIAL FIBRILLATION检测的ATRIAL DEFIBRILLATION系统
公开(公告)号：WO9952593A8
公开(公告)日：2001-02-08
申请号：PCT/US9903168
申请日：1999-02-12
申请人： CARDIAC PACEMAKERS INC
发明人： WHITE HARLEY G
IPC分类号： A61N1/372 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/395
摘要： An atrial defibrillation system includes an implanted atrial defibrillator (30) having an atrial defibrillation detector (70) for detecting atrial fibrillation, and a cardioverter (76) for cardioverting the atria of a heart (16). The implanted atrial defibrillator (30) further includes a receiver (105) for receiving commands from an external non-implanted transmitter (100). A non-implanted communication device (110) includes a transmitter (116) for transmitting a command to the receiver (105). The command causes only the atrial fibrillation detector (70) to be activated resulting only in the detection for atrial fibrillation without committing to atrial fibrillation cardio-version should atrial fibrillation be detected.
摘要翻译：心房除颤系统包括具有用于检测心房纤维性颤动的心房除颤检测器（70）的植入式心房除颤器（30）和用于心脏转移心脏心房（16）的心律转复器（76）。植入的心房除颤器（30）还包括用于从外部非植入式发射器（100）接收命令的接收器（105）。非植入通信设备（110）包括用于向接收机（105）发送命令的发射机（116）。该命令仅使心房纤维性颤动检测器（70）被激活，从而仅在心房颤动的检测中，而不致心房纤维颤动，心房颤动被检测。

59. 发明申请

WO99052593A1 ATRIAL DEFIBRILLATION SYSTEM HAVING PATIENT SELECTABLE ATRIAL FIBRILLATION DETECTION 审中-公开
标题翻译：具有患者选择性ATRIAL FIBRILLATION检测的ATRIAL DEFIBRILLATION系统
公开(公告)号：WO99052593A1
公开(公告)日：1999-10-21
申请号：PCT/US1999/003168
申请日：1999-02-12
IPC分类号： A61N1/372 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/395
摘要： An atrial defibrillation system includes an implanted atrial defibrillator (30) having an atrial defibrillation detector (70) for detecting atrial fibrillation, and a cardioverter (76) for cardioverting the atria of a heart (16). The implanted atrial defibrillator (30) further includes a receiver (105) for receiving commands from an external non-implanted transmitter (100). A non-implanted communication device (110) includes a transmitter (116) for transmitting a command to the receiver (105). The command causes only the atrial fibrillation detector (70) to be activated resulting only in the detection for atrial fibrillation without committing to atrial fibrillation cardio-version should atrial fibrillation be detected.
摘要翻译：心房除颤系统包括具有用于检测心房纤维性颤动的心房除颤检测器（70）的植入式心房除颤器（30）和用于心脏转移心脏心房（16）的心律转复器（76）。植入的心房除颤器（30）还包括用于从外部非植入式发射器（100）接收命令的接收器（105）。非植入通信设备（110）包括用于向接收机（105）发送命令的发射机（116）。该命令仅使心房纤维性颤动检测器（70）被激活，从而仅在心房颤动的检测中，而不致心房纤维颤动，心房颤动被检测。

60. 发明申请

WO99047206A1 SYSTEM FOR TREATING SUPRAVENTRICULAR TACHYARRHYTHMIAS 审中-公开
标题翻译：用于治疗子宫内膜异位症的系统
公开(公告)号：WO99047206A1
公开(公告)日：1999-09-23
申请号：PCT/US1999/006083
申请日：1999-03-19
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A system and method for treating atrial fibrillation using atrial pacing pulses to convert an atrial fibrillation to non-fibrillation atrial arrhythmia prior to delivering a low energy cardioversion/defibrillation shock. The system and method treats atrial fibrillations by first applying a plurality of pacing pulses to the atria which converts the atrial fibrillation to non-fibrillation atrial arrhythmia. Ventricular intervals are concurrently sensed and analyzed while the plurality of electrical pacing pulses are being applied. Upon detecting a period of stable ventricular intervals, the system then proceeds to deliver a low-energy cardioverting/defibrillating pulse of electrical energy across the atria of the heart.
摘要翻译：一种用于在递送低能量心律转复/除颤休克之前使用心房起搏脉冲来治疗心房颤动以将心房颤动转换为非纤维性心房心律失常的系统和方法。该系统和方法通过首先将多次起搏脉冲施加到将心房颤动转变为非纤维性心房心律不齐的心房来治疗房颤。在施加多个起搏脉冲的同时，同时感测和分析心室间隔。在检测到稳定的心室间隔的时间段时，系统然后继续在心脏的心房上提供电能的低能量心律转复/除颤脉冲。

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