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51. 发明申请

WO1994015641A1 METHOD FOR MODULATING TRANSENDOTHELIAL MIGRATION OF CELLS PROMOTING INFLAMMATION, AND RELATED METHODS OF MEASUREMENT THEREOF 审中-公开
标题翻译：用于调节促进炎症的细胞的交联移植的方法及其相关的测量方法
公开(公告)号：WO1994015641A1
公开(公告)日：1994-07-21
申请号：PCT/US1994000416
申请日：1994-01-12
申请人： THE ROCKEFELLER UNIVERSITY , MULLER, William, A.
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K31/43 , A61K38/1774 , A61K39/395 , A61K45/06 , G01N33/5047 , G01N2800/52 , A61K31/70 , A61K31/545 , A61K2300/00
摘要： The transendothelial migration of leukocytes and other cells during acute and/or chronic inflammation can be inhibited by the administration of anti-PECAM-1 reagents. In particular, transendothelial migration appears to be mediated by the activity of platelet endothelial cell adhesion molecule (PECAM); as inhibition of neutrophil and monocyte TEM occurs in the presence of recombinant soluble PECAM or a monoclonal anti-PECAM antibody. Methods for controlling transendothelial migration and corresponding agents are disclosed, as are related diagnostic methods and drug discovery assays. Inhibition of such transendothelial migration will play a role in the prevention and/or diminishment of organ damage in inflammation, and the present method may be especially useful in the treatment of chronic inflammation, as well as in treating acute inflammation.
摘要翻译：在急性和/或慢性炎症期间白细胞和其它细胞的跨内皮迁移可通过施用抗PECAM-1试剂来抑制。特别是，跨内皮迁移似乎是由血小板内皮细胞粘附分子（PECAM）的活性介导的; 因为在重组可溶性PECAM或单克隆抗PECAM抗体存在下，嗜中性粒细胞和单核细胞TEM的抑制发生。公开了用于控制跨内皮迁移的方法和相应的试剂，以及相关的诊断方法和药物发现测定法。这种跨内皮迁移的抑制将在预防和/或减少炎症中的器官损伤中起作用，并且本方法可以特别用于治疗慢性炎症以及治疗急性炎症。

52. 发明申请

WO1994006813A1 MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES AND MODIFICATIONS THEREOF 审中-公开
标题翻译：主要组氨酸复合分子及其修饰
公开(公告)号：WO1994006813A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008715
申请日：1993-09-15
申请人： THE ROCKEFELLER UNIVERSITY , GELIEBTER, Jan , KESARI, Krishna, V.
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： C07H21/00
CPC分类号： C07K14/70539 , A61K38/00 , A61K48/00
摘要： Modified MHC molecules are disclosed which facilitate the recognition of antigens by antibodies and cellular immune system components. This is particularly useful for increasing tumor recognition by the immune system. The modified MHC can be considered a universal allogen, since it may render any cell containing it antigenic. Genes which code on expression for the modified MHC, cells containing modified MHC, antibodies and cellular components which recognize the transformed species are included.
摘要翻译：公开了通过抗体和细胞免疫系统组分促进抗原识别的修饰的MHC分子。这对于增加免疫系统的肿瘤识别特别有用。修饰的MHC可以被认为是普遍的同种异体，因为它可以使任何含有抗原的细胞。编码修饰的MHC的表达的基因，包含修饰的MHC的细胞，识别转化物种的抗体和细胞成分。

53. 发明申请

WO1993024834A1 METHOD AND PRODUCT FOR THE SEQUENCE DETERMINATION OF PEPTIDES USING A MASS SPECTROMETER 审中-公开
标题翻译：使用质谱仪序列测定肽的方法和产品
公开(公告)号：WO1993024834A1
公开(公告)日：1993-12-09
申请号：PCT/US1993005070
申请日：1993-05-27
申请人： THE ROCKEFELLER UNIVERSITY , CHAIT, Brian, T. , BEAVIS, Ronald , WANG, Rong , KENT, Stephen, B., H.
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： G01N33/44
CPC分类号： G01N33/6842 , C07K1/107 , C07K1/128 , G01N33/6824 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
摘要翻译：描述了通过形成包含一系列多肽的肽梯级来测序多肽的方法，其中该序列的相邻成员变化一个氨基酸残基，并通过质谱确定多肽中每个氨基酸的同一性和位置。

54. 发明申请

WO1993014750A2 AMINO ACIDS USEFUL AS INHIBITORS OF THE ADVANCED GLYCOSYLATION OF PROTEINS 审中-公开
标题翻译：氨基酸作为蛋白质高级蛋白酶抑制剂有用
公开(公告)号：WO1993014750A2
公开(公告)日：1993-08-05
申请号：PCT/US1993000709
申请日：1993-01-27
申请人： THE ROCKEFELLER UNIVERSITY , ALTEON INC.
发明人： THE ROCKEFELLER UNIVERSITY , ALTEON INC. , ULRICH, Peter, C. , CERAMI, Anthony
IPC分类号： A61K31/195
CPC分类号： G01N33/6842 , A61K8/43 , A61K31/155 , A61K31/195 , A61K31/415 , A61K31/4178 , A61K38/191 , A61K38/2006 , A61K38/217 , A61K38/38 , A61K39/0005 , A61K2039/6081 , A61Q19/08 , C07D405/14 , C07K16/28 , G01N33/533 , G01N33/573 , G01N33/582 , G01N33/68 , G01N33/6893 , G01N2333/922 , Y10S514/824 , Y10S514/825 , Y10S514/866 , A61K2300/00
摘要： The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents are amino acids and their derivatives which contain an active nitrogen-containing group. Particular agents comprise lysine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
摘要翻译：本发明涉及抑制蛋白质老化的组合物和方法。因此，公开了一种组合物，其包含能够通过与通过其初始糖基化形成的这些靶蛋白的早期糖基化产物的羰基部分反应来抑制靶蛋白的高级糖基化终产物形成的试剂或化合物。合适的试剂是含有活性含氮基团的氨基酸及其衍生物。特定的试剂包括赖氨酸及其混合物。该方法包括使靶蛋白与组合物接触。预想到本发明的工业和治疗应用，因为可以处理食物腐败和动物蛋白质老化。

55. 发明申请

WO1992019646A1 ANALOG OF ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE (ELAM) 审中-公开
标题翻译：内分泌杆菌粘附分子模拟（ELAM）
公开(公告)号：WO1992019646A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003701
申请日：1992-05-04
申请人： THE ROCKEFELLER UNIVERSITY , TUOMANEN, Elaine , MASURE, H., Robert
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： C07K07/08
CPC分类号： C07K14/235 , A61K38/00 , A61K39/00 , A61K47/6829 , A61K47/6849 , C07K14/70564 , C07K16/1225 , C07K16/2854 , Y10S514/885
摘要： Proteins, peptides, analogs thereof and antibodies thereto which will inhibit the adhesion of circulating molecules such as leukocytes to endothelia and epithelia.
摘要翻译：蛋白质，肽，其类似物和其抗体将抑制循环分子如白细胞对内皮和上皮的粘附。

56. 发明申请

WO1992013865A1 PMN-DERIVED CR3 MODULATOR AND USES THEREOF 审中-公开
标题翻译： PMN衍生的CR3调制器及其用途
公开(公告)号：WO1992013865A1
公开(公告)日：1992-08-20
申请号：PCT/US1992000960
申请日：1992-02-03
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , WRIGHT, Samuel, D. , HERMANOWSKI-VOSATKA, Anne
IPC分类号： C07G17/00
CPC分类号： C07K14/705 , A61K35/15
摘要： The invention is concerned with the discovery, isolation and purification of an agent or factor named herein the CR3 modulator or CMF-1 that is synthesized by polymorphonuclear leukocytes (PMN) in response to agonists which enhance CD18 activity. The CR3 modulator binds to CD18 and activates its adhesion-promoting ability. The CR3 modulator appears to be transiently produced by PMN as an acidic amphiphilic lipid. The CR3 modulator can be assayed by adding dilutions of a CR3 modulator-containing solution to resting PMN and observing the ability of CR3 to mediate binding of erythrocytes coated with C3bi (EC3bi). The isolation of the CR3 modulator, its biological and physical properties and diagnostic and therapeutic uses are described.
摘要翻译：本发明涉及针对增强CD18活性的激动剂响应由多形核白细胞（PMN）合成的CR3调节剂或CMF-1的药剂或因子的发现，分离和纯化。 CR3调节剂结合CD18并激活其粘附促进能力。 CR3调节剂似乎由PMN瞬时产生，作为酸性两亲性脂质。可以通过向含有CR3调节剂的溶液中稀释稀释的静息PMN并观察CR3介导用C3bi（EC3bi）涂覆的红细胞结合的能力来测定CR3调节剂。描述了CR3调节剂的分离，其生物和物理性质以及诊断和治疗用途。

57. 发明申请

WO1992013553A2 METHOD AND AGENTS FOR PROMOTING WOUND HEALING 审中-公开
标题翻译：促进创伤治疗的方法和药剂
公开(公告)号：WO1992013553A2
公开(公告)日：1992-08-20
申请号：PCT/US1992001026
申请日：1992-02-07
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , FAHEY, Thomas, J., III , SHERRY, Barbara, A. , CERAMI, Anthony
IPC分类号： A61K37/02
CPC分类号： C07K14/4702 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/523 , C07K14/525 , C07K16/18 , C07K16/24 , C07K16/241 , C07K16/38 , C12N5/0647 , C12N2501/21 , C12N2501/22 , C12P1/00 , C12Q1/02 , C12R1/91 , G01N33/5091 , G01N33/53 , G01N33/6863 , G01N2333/52 , G01N2400/40
摘要： The present invention relates to the treatment of wound healing dysfunction by the administration of one or more wound healing modulators. The wound healing modulator may be selected from appropriate wound healing agents and binding partners, and particularly agents that enhance wound healing. The agent may comprise a cytokine, or mixture of cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1, MIP-1 alpha , MIP-1 beta and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.
摘要翻译：本发明涉及通过施用一种或多种伤口愈合调节剂来治疗伤口愈合功能障碍。伤口愈合调节剂可以选自合适的伤口愈合剂和结合配偶体，特别是增强伤口愈合的药剂。该试剂可以包含细胞因子，或者也能够结合肝素的细胞因子混合物，以及当皮下投与时以多形核细胞浸润为特征的诱导局部炎症。特定药剂包括炎性细胞因子MIP-1，MIP-1α，MIP-1β和MIP-2。提出了诊断和治疗用途，同样阐述了药物组合物。

58. 发明申请

WO1992002237A1 ANALOGS OF ENDOTHELIN 审中-公开
标题翻译：内皮素类似物
公开(公告)号：WO1992002237A1
公开(公告)日：1992-02-20
申请号：PCT/US1991005056
申请日：1991-07-16
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , TAM, James, P.
IPC分类号： A61K37/02
CPC分类号： C07K14/57536 , A61K38/00
摘要： Endothelin analogs useful for modulation of blood pressure, compositions containing such analogs and methods for their use.
摘要翻译：可用于调节血压的内皮素类似物，含有此类类似物的组合物及其使用方法。

59. 发明申请

WO1992002216A2 ADVANCED GLYCATION INHIBITORS CONTAINING AMINO-BENZOIC ACIDS AND DERIVATIVES, AND METHODS OF USE 审中-公开
标题翻译：含有氨基苯甲酸和衍生物的先进的糖化抑制剂及其使用方法
公开(公告)号：WO1992002216A2
公开(公告)日：1992-02-20
申请号：PCT/US1991005457
申请日：1991-08-01
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , ULRICH, Peter, C. , CERAMI, Anthony
IPC分类号： A61K31/245
摘要： The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

60. 发明申请

WO1991015204A2 METHOD AND AGENTS FOR THE SELECTIVE REDUCTION OF Lp(a) 审中-公开
标题翻译：选择性还原Lp（a）的方法和试剂
公开(公告)号：WO1991015204A2
公开(公告)日：1991-10-17
申请号：PCT/US1991002427
申请日：1991-04-09
申请人： THE ROCKEFELLER UNIVERSITY
发明人： THE ROCKEFELLER UNIVERSITY , BRESLOW, Jan, L. , GAVISH, Dov
IPC分类号： A61K31/195
CPC分类号： A61K38/063 , A61K31/095 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/415 , A61K2300/00
摘要： The present invention relates to methods and corresponding agents for lowering plasma Lp(a) levels by the administration of agents that reduce Lp(a) and selectively separate therefrom the apo(a) component and/or prevent Lp(a) formation. Suitable agents include sulfhydryl reducers, such as N-acetylcysteine. The present method and agents may be administered alone or in conjunction with other therapy for the lowering of LDL cholesterol.
摘要翻译：本发明涉及通过给予减少Lp（a）并选择性地从其中分离载脂蛋白（a）成分和/或防止Lp（a）形成的药剂来降低血浆Lp（a）水平的方法和相应的药剂。合适的试剂包括巯基还原剂，例如N-乙酰半胱氨酸。本发明的方法和试剂可以单独施用或与降低LDL胆固醇的其它疗法联合施用。

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