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1. 发明申请

WO0029434A2 IDENTIFICATION AND CHARACTERIZATION OF NOVEL PNEUMOCOCCAL CHOLINE BINDING PROTEINS, CbpG AND CbpD, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：新型肺炎胆汁结合蛋白，CbpG和CbpD的鉴定和表征及其诊断和治疗用途
公开(公告)号：WO0029434A2
公开(公告)日：2000-05-25
申请号：PCT/US9927526
申请日：1999-11-19
申请人： ST JUDE CHILDRENS RES HOSPITAL , TUOMANEN ELAINE I , GOSINK KHOOSHEH , MASURE ROBERT
发明人： TUOMANEN ELAINE I , GOSINK KHOOSHEH , MASURE ROBERT
IPC分类号： A61K38/00 , A61K39/00 , C07K14/315 , C07K16/12 , G01N33/569 , G01N33/68 , A61K39/09 , C12N15/00
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , G01N33/56944 , G01N33/68 , G01N2333/315
摘要： The present invention provides isolated polypeptides comprising an amino acid sequence of a choline binding protein CbpG ou CbpD. This invention provides an isolated polypeptide comprising an amino acid sequence of a choline binding polypeptide CbpG or CbpD or N-terminal CbpG or CbpD truncate, including analogs, variants, mutants, derivatives and fragments thereof. This invention further provides an isolated immunogenic polypeptide comprising an amino acid sequence of a choline binding protein CbpG or CbpD. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a choline binding protein CbpG or CbpD. This invention provides pharmaceutical compositions, vaccines, and disgnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids. Assays for compounds which alter or inactivate the polypeptides of the present invention for use in therapy are also provided.
摘要翻译：本发明提供了分离的多肽，其包含胆碱结合蛋白CbpG o CbpD的氨基酸序列。本发明提供了分离的多肽，其包含胆碱结合多肽CbpG或CbpD或N-末端CbpG或CbpD截短物的氨基酸序列，包括其类似物，变体，突变体，衍生物和片段。本发明还提供了分离的免疫原性多肽，其包含胆碱结合蛋白CbpG或CbpD的氨基酸序列。本发明提供编码包含胆碱结合蛋白CbpG或CbpD的氨基酸序列的多肽的分离的核酸。本发明提供药物组合物，疫苗以及使用分离的多肽和核酸的预后和治疗方法。还提供了用于改变或灭活本发明的多肽用于治疗的化合物的测定。

2. 发明申请

WO2008039838A3 SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE 审中-公开
标题翻译：合成链球菌肺炎疫苗
公开(公告)号：WO2008039838A3
公开(公告)日：2008-05-15
申请号：PCT/US2007079527
申请日：2007-09-26
申请人： ST JUDE CHILDRENS RES HOSPITAL , EL KASMI KARIM C , JORDAN BRAD , KRIWACKI RICHARD , MANN BETH , ORIHUELA CARLOS J , TUOMANEN ELAINE
发明人： EL KASMI KARIM C , JORDAN BRAD , KRIWACKI RICHARD , MANN BETH , ORIHUELA CARLOS J , TUOMANEN ELAINE
IPC分类号： C07K14/315
CPC分类号： C07K14/3156 , A61K39/00
摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.
摘要翻译：提供了预防和治疗肺炎球菌感染的组合物和方法。组合物包括新多肽，其包含对应于CbpA的R21或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段，其中所述多肽以期望的构象，特别是环构象稳定。可以将本发明的多肽工程化以包含第一和第二半胱氨酸残基，从而导致形成使多肽稳定在所需构象的二硫键。或者，可修饰本发明的多肽以在存在于多肽内的第一和第二氨基酸残基之间产生合成连接，其中合成连接使多肽稳定在所需构象中。本发明的多肽可以进一步包含T细胞表位的氨基酸序列。组合物还包括编码本发明多肽的分离的核酸分子，包含所公开多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

3. 发明申请

WO1995006732A2 BACTERIAL EXPORTED PROTEINS AND ACELLULAR VACCINES BASED THEREON 审中-公开
标题翻译：细菌出口蛋白质和基于其的细菌疫苗
公开(公告)号：WO1995006732A2
公开(公告)日：1995-03-09
申请号：PCT/US1994009942
申请日：1994-09-01
申请人： THE ROCKEFELLER UNIVERSITY , MASURE, H., Robert , PEARCE, Barbara, J , TUOMANEN, Elaine
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： C12N15/52
CPC分类号： C12N9/0008 , A61K39/00 , C07K14/3156 , C07K2319/02 , C12N9/00 , C12N9/14 , C12N15/52 , C12Y102/03003
摘要： The present invention relates to the identification of Gram positive bacterial exported proteins, and the genes encoding such proteins. In particular, the invention relates to adhesion associated exported proteins, and to antigens common to many or all strains of a species of Gram positive bacterium. The invention also relates to acellular vaccines to provide protection from Gram positive bacterial infection using such genes or such proteins, and to antibodies against such proteins for use in diagnosis and passive immune therapy. In specific embodiments, fragments of ten genes encoding exported proteins of S. pneumoniae are disclosed, and the functional activity of some of these proteins in adherence is demonstrated.
摘要翻译：本发明涉及革兰氏阳性菌导出蛋白质的鉴定，以及编码这种蛋白质的基因。特别地，本发明涉及粘附相关的输出蛋白质，以及许多或所有革兰氏阳性细菌菌株共有的抗原。本发明还涉及使用这样的基因或这种蛋白质提供保护免受革兰氏阳性细菌感染的抗细胞疫苗以及用于诊断和被动免疫治疗的这种蛋白质的抗体。在具体实施方案中，公开了编码肺炎链球菌的出口蛋白质的十个基因的片段，并且证明了其中一些蛋白质在粘附中的功能活性。

4. 发明申请

WO2012134975A1 METHODS AND COMPOSITIONS EMPLOYING IMMUNOGENIC FUSION PROTEINS 审中-公开
标题翻译：使用免疫原性融合蛋白的方法和组合物
公开(公告)号：WO2012134975A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030241
申请日：2012-03-23
申请人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL , TUOMANEN, Elaine , MANN, Elizabeth, R.
发明人： TUOMANEN, Elaine , MANN, Elizabeth, R.
IPC分类号： C07K14/315 , C12N15/62 , A61K39/02 , C12N5/10
CPC分类号： A61K39/092 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/55583 , A61K2039/575 , A61K2039/6068 , A61K2039/645 , C07K14/3156 , C07K14/47 , C07K2319/00 , C07K2319/40
摘要： Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof.
摘要翻译：提供组合物和方法用于预防和治疗细菌感染，包括肺炎球菌感染。本文提供的组合物包含多种免疫原性融合蛋白，其中给定融合蛋白的至少一种多肽组分包含CbpA多肽和/或细胞溶质多肽，或其活性变体或片段。提供了通过使用具有至少一种包含CbpA多肽和/或细胞溶质多肽的多肽组分的各种免疫原性融合蛋白或其活性变体或片段来预防和治疗细菌感染（包括肺炎球菌感染）的方法。

5. 发明申请

WO9957281A3 PEPTIDE ANTIBIOTICS WHICH INHIBIT THE GROWTH OF PNEUMOCOCCI, ABC TRANSPORTER AND TWO-COMPONENT SIGNAL TRANSDUCTION SYSTEM PROTEINS FROM STREPTOCOCCUS PNEUMONIAE, AND METHODS USING THE SAME 审中-公开
标题翻译：阻止PNEUMOCOCCI，ABC运输机和两组分信号转导系统蛋白质生长的肽抗生素，以及使用该方法的方法
公开(公告)号：WO9957281A3
公开(公告)日：2000-03-30
申请号：PCT/US9909792
申请日：1999-05-06
申请人： ST JUDE CHILDRENS RES HOSPITAL , NOVAK RODGER , TUOMANEN ELAINE I
发明人： NOVAK RODGER , TUOMANEN ELAINE I
IPC分类号： A61K38/00 , C07K7/08 , C07K14/315 , C12N9/12 , C12N9/14 , C12N15/31 , A61K39/09 , C07K16/12 , C12N15/54 , C12N15/55 , C12Q1/68
CPC分类号： C07K7/08 , A61K38/00 , C07K14/3156 , C12N9/1223 , C12N9/14
摘要： The present invention discloses antibiotic peptides, including naturally occurring peptides. The present invention also includes the nucleic acid sequences encoding such peptides and the corresponding amino acid sequences. Methods of identifying, making, and using the antibiotic peptides are also disclosed. The present invention further provides proteins involved in the regulation of bacterial autolysis.
摘要翻译：本发明公开了抗生素肽，包括天然存在的肽。本发明还包括编码这些肽的核酸序列和相应的氨基酸序列。还公开了鉴定，制备和使用抗生素肽的方法。本发明还提供参与细菌自溶调节的蛋白质。

6. 发明申请

WO9506732A3 BACTERIAL EXPORTED PROTEINS AND ACELLULAR VACCINES BASED THEREON 审中-公开
标题翻译：基于细菌输出的蛋白质和细胞疫苗
公开(公告)号：WO9506732A3
公开(公告)日：1995-06-01
申请号：PCT/US9409942
申请日：1994-09-01
申请人： UNIV ROCKEFELLER , MASURE H ROBERT , PEARCE BARBARA J , TUOMANEN ELAINE
发明人： MASURE H ROBERT , PEARCE BARBARA J , TUOMANEN ELAINE
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/00 , C12N9/02 , C12N9/14 , C12N15/31 , C12N15/52 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/46 , A61K31/72 , A61K38/43 , A61K39/09 , C12N15/53 , C12N15/55 , C12Q1/14
CPC分类号： C12N9/0008 , A61K39/00 , C07K14/3156 , C07K2319/02 , C12N9/00 , C12N9/14 , C12N15/52 , C12Y102/03003
摘要： The present invention relates to the identification of Gram positive bacterial exported proteins, and the genes encoding such proteins. In particular, the invention relates to adhesion associated exported proteins, and to antigens common to many or all strains of a species of Gram positive bacterium. The invention also relates to acellular vaccines to provide protection from Gram positive bacterial infection using such genes or such proteins, and to antibodies against such proteins for use in diagnosis and passive immune therapy. In specific embodiments, fragments of ten genes encoding exported proteins of S. pneumoniae are disclosed, and the functional activity of some of these proteins in adherence is demonstrated.
摘要翻译：本发明涉及鉴定革兰氏阳性细菌输出蛋白质和编码这些蛋白质的基因。具体而言，本发明涉及粘附相关的输出蛋白质，并涉及革兰氏阳性细菌物种的许多或全部菌株共有的抗原。本发明还涉及使用此类基因或此类蛋白质提供对革兰氏阳性细菌感染的保护的无细胞疫苗，以及针对用于诊断和被动免疫疗法的此类蛋白质的抗体。在具体的实施方案中，公开了编码肺炎链球菌输出蛋白的10个基因的片段，并证明了这些蛋白中一些在粘附中的功能活性。

7. 发明申请

WO1992019269A1 ANTIBODY RECOGNIZING ENDOTHELIAL CELL LIGAND FOR LEUKOCYTE CR3 审中-公开
标题翻译：抗体识别用于LEUKOCYTE CR3的内皮细胞配体
公开(公告)号：WO1992019269A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003725
申请日：1992-05-04
申请人： THE ROCKEFELLER UNIVERSITY , TUOMANEN, Elaine , Masure, H., Robert
发明人： THE ROCKEFELLER UNIVERSITY
IPC分类号： A61K39/40
CPC分类号： C07K16/1225 , A61K38/00 , A61K39/395 , A61K51/1009 , A61K2039/505 , A61K2123/00 , C07K14/235 , A61K2300/00
摘要： Antibodies, recognizing the RGD tripeptide of FHA, which will mimic the binding of the leukocyte integrin CR3 to the X-molecule of endothelial cells and their utility as therapeutic agents are described.
摘要翻译：描述了识别FHA的RGD三肽的抗体，其将模拟白细胞整联蛋白CR3与内皮细胞的X分子的结合及其作为治疗剂的效用。

8. 发明申请

WO2008039838A2 SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE 审中-公开
标题翻译：合成环孢菌素疫苗
公开(公告)号：WO2008039838A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/079527
申请日：2007-09-26
申请人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL , EL KASMI, Karim, C. , JORDAN, Brad , KRIWACKI, Richard , MANN, Beth , ORIHUELA, Carlos, J. , TUOMANEN, Elaine
发明人： EL KASMI, Karim, C. , JORDAN, Brad , KRIWACKI, Richard , MANN, Beth , ORIHUELA, Carlos, J. , TUOMANEN, Elaine
IPC分类号： C07K14/315
CPC分类号： C07K14/3156 , A61K39/00
摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.
摘要翻译：提供了预防和治疗肺炎球菌感染的组合物和方法。组合物包括包含对应于CbpA的R2i或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段的新型多肽，其中所述多肽被稳定为期望的构象，特别是环构象。本发明的多肽可被工程化以包含第一和第二半胱氨酸残基，从而导致二硫键的形成，从而将多肽稳定在所需构象。或者，可以修饰本发明的多肽以在多肽内存在的第一和第二氨基酸残基之间产生合成连接，其中所述合成连接使所述多肽以所需构象稳定。本发明的多肽还可以包含T细胞表位的氨基酸序列。组合物还包括编码本发明多肽的分离的核酸分子，包含所公开的多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

9. 发明申请

WO2003042655A3 DIAGNOSTIC ASSAY FOR ANTIBIOTIC TOLERANCE 审中-公开
公开(公告)号：WO2003042655A3
公开(公告)日：2003-05-22
申请号：PCT/US2002/031285
申请日：2002-10-01
申请人： ST JUDE CHILDREN'S RESEARCH HOSPITAL , ATKINSON, Robyn , TUOMANEN, Elaine
发明人： ATKINSON, Robyn , TUOMANEN, Elaine
IPC分类号： G01N33/569
摘要： Allelic variation in the vex2, pep27 and vncS genes of bacteria responsible for tolerance to antibiotics such as penicillin and vancomycin, is taught. Methods for identifying antibiotic tolerant bacteria and subjects infected with such bacteria, particularly antibiotic tolerant Streptococcus pneumoniae , are provided. Test kits and components useful for performing such methods, particularly including oligonucleotide primers, are also provided.

10. 发明申请

WO2003042655A2 DIAGNOSTIC ASSAY FOR ANTIBIOTIC TOLERANCE 审中-公开
标题翻译：用于抗生素耐药性的诊断测定
公开(公告)号：WO2003042655A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/031285
申请日：2002-10-01
申请人： ST JUDE CHILDREN'S RESEARCH HOSPITAL , ATKINSON, Robyn , TUOMANEN, Elaine
发明人： ATKINSON, Robyn , TUOMANEN, Elaine
IPC分类号： G01N
CPC分类号： C12Q1/689 , C07K14/3156 , C12Q1/18 , C12Q2600/156
摘要： Allelic variation in the vex2, pep27 and vncS genes of bacteria responsible for tolerance to antibiotics such as penicillin and vancomycin, is taught. Methods for identifying antibiotic tolerant bacteria and subjects infected with such bacteria, particularly antibiotic tolerant Streptococcus pneumoniae , are provided. Test kits and components useful for performing such methods, particularly including oligonucleotide primers, are also provided.
摘要翻译：教导了负责抗生素如青霉素和万古霉素的细菌的vex2，pep27和vncS基因中的等位基因变异。提供用于鉴定抗生素耐受细菌和感染这种细菌，特别是抗生素耐受性肺炎链球菌的受试者的方法。还提供了用于进行这些方法的测试试剂盒和组分，特别是包括寡核苷酸引物。

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