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41. 发明申请

WO2019179494A1 取代的十五烷二酸化合物及药物组合物及其用途审中-公开
公开(公告)号：WO2019179494A1
公开(公告)日：2019-09-26
申请号：PCT/CN2019/079045
申请日：2019-03-21
申请人：深圳市塔吉瑞生物医药有限公司
发明人：王义汉 , 刘志强 , 赵九洋
IPC分类号： C07C59/245 , C07C59/29 , A61K31/194 , A61K31/20 , A61P3/06 , A61P9/10
摘要：提供一种取代的十五烷二酸化合物及包含该化合物的组合物及其用途，所述十五烷二酸化合物为如式（I）所示的化合物或其药学上可接受的盐、前药、水合物或溶剂合物、晶型、立体异构体或同位素变体，式（I）所述化合物至少含有一个氘原子。所述十五烷二酸化合物可用于治疗或预防心血管疾病或血脂异常，具有更优药代动力学性质。

42. 发明申请

WO2019035989A1 PREVENTION OF CALCIUM OXALATE KIDNEY STONES BY POTASSIUM HYDROXYCITRATE 审中-公开
公开(公告)号：WO2019035989A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000270
申请日：2018-08-17
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： PAK, Charles , MOE, Orson , HU, Ming-Chang , MAALOUF, Naim
IPC分类号： A61K31/194 , A61K45/06 , C07C59/245
摘要： Disclosed herein are methods for preventing or treating calcium oxalate kidney stones in a subject by administrating a composition comprising an effective amount of potassium hydroxycitrate (KOHCit). KOHCit increases urinary pH mildly to modestly but increases the inhibitor activity.

43. 发明申请

WO2009134856A3 PHARMACEUTICAL GALLIUM COMPOUNDS, COMPOSITION AND METHODS OF PREPARATION 审中-公开
标题翻译：制药玻璃化合物，组合物和制备方法
公开(公告)号：WO2009134856A3
公开(公告)日：2010-01-28
申请号：PCT/US2009042064
申请日：2009-04-29
申请人： GENTA INC , BROWN BOB D , WARRELL RAYMOND P JR
发明人： BROWN BOB D , WARRELL RAYMOND P JR
IPC分类号： C07C51/41 , A61K31/194 , A61K31/225 , A61P11/00 , A61P19/00 , A61P19/08 , A61P31/04 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/245 , C07C59/255 , C07C59/265 , C07C69/70 , C07C69/704
CPC分类号： C07C59/265 , C07C51/412 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/245 , C07C59/255 , C07C69/704
摘要： The present invention provides novel pharmaceutical gallium compositions, as well as methods for their preparation and methods for treating conditions and diseases such as cancer, hypercalcemia, osteoporosis, osteopenia, Paget's disease, and infections.
摘要翻译：本发明提供新颖的药物镓组合物及其制备方法以及治疗疾病如癌症，高钙血症，骨质疏松症，骨质减少症，佩吉特氏病和感染的方法。

44. 发明申请

WO2009014235A1 ヒドロキシ酸アミン塩およびその製造方法並びにそれを含むゴム組成物审中-公开
标题翻译：羟基胺盐，其制备方法和含有它们的橡胶组合物
公开(公告)号：WO2009014235A1
公开(公告)日：2009-01-29
申请号：PCT/JP2008/063471
申请日：2008-07-18
申请人：横浜ゴム株式会社 , 松田敬 , 崔源文
发明人：松田敬 , 崔源文
IPC分类号： C07C211/62 , C07C51/41 , C07C59/245 , C07C59/255 , C07C211/63 , C08K5/17 , C08L21/00
CPC分类号： C07C211/62 , C07C51/412 , C07C55/10 , C07C59/245 , C07C59/255 , C07C2601/14 , C08K3/28 , C08K5/17 , C08K5/19 , C08L21/00
摘要：下記一般式（Ｉ）：（式中、Ｒ 1 、Ｒ 2 、Ｒ 3 、Ｒ 4 、ｋ、ｌ、ｍおよびｎは明細書に定義したとおり）により表わされるヒドロキシ酸アミン塩及びその製造方法並びに当該ヒドロキシ酸アミン塩を含むゴム組成物を開示する。
摘要翻译：公开了由下述通式（I）表示的羟基酸胺盐。还公开了制备这种羟基酸胺盐的方法和含有这种羟基酸胺盐的橡胶组合物。（式中，R 1，R 2，R 3，R 4，k，l，m和n如说明书中所定义）

45. 发明申请

WO02038148A1 ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING omega -HYDROXYFATTY ACIDS 审中-公开
标题翻译：反应剂，含有ω-羟基酸的食物或食物和饮料
公开(公告)号：WO02038148A1
公开(公告)日：2002-05-16
申请号：PCT/JP2001/009661
申请日：2001-11-05
IPC分类号： A61K31/122 , A61K31/19 , A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/357 , A61K31/365 , A61P35/00 , A61P35/04 , C07C59/245 , A61K7/00
CPC分类号： A61K31/365 , A61K31/122 , A61K31/19 , A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/357
摘要： Drugs, in particular, anticancer agents. More particularly speaking, anticancer agents which contain as the active ingredient(s) one or more compounds selected from among omega -hydroxyfatty acids having a specific chemical structural formula and salts and esters thereof, hydroxyoxofatty acids and salts and esters thereof, lactone compounds, macrocyclic ketones and macrocyclic diesters. The above-described compounds have a carcinostatic effect, an extremely high effect of preventing cancer metastasis, an effect of preventing recurrence of cancer, an effect of preventing the occurrence of cancer and little cytotoxicity. Moreover, these compounds are efficacious only in a small dose. Owing to these characteristics, these compounds enable the provision of anticancer agents with little side effect. The effect of preventing cancer metastasis can be further enhanced by the combined use with known anti-malignant tumor agents. Among the anticancer agents as described above, omega -hydroxyfatty acids can be very conveniently obtained at a high purity by hydrolyzing lactone compounds which are also the anticancer agents as described herein.
摘要翻译：药物，特别是抗癌剂。更具体地说，含有作为活性成分的一种或多种选自具有特定化学结构式的ω-羟基脂肪酸及其盐和酯，羟基异烟酸及其盐和酯的化合物的抗癌剂，内酯化合物，大环酮和大环二酯。上述化合物具有防癌效果，预防癌症转移的极高效果，预防癌症复发的效果，防止癌症发生的效果和细胞毒性小的效果。而且，这些化合物只能以小剂量有效。由于这些特性，这些化合物能够提供几乎没有副作用的抗癌剂。通过与已知的抗恶性肿瘤剂的组合使用，可以进一步提高预防癌症转移的效果。在如上所述的抗癌剂中，通过水解也是如本文所述的抗癌剂的内酯化合物，可以非常方便地以高纯度获得ω-羟基脂肪酸。

46. 发明申请

WO01066508A2 PROCESS FOR THE RECOVERY OF ORGANIC ACIDS FROM AQUEOUS SOLUTIONS 审中-公开
标题翻译：有机酸从水溶液中回收的方法
公开(公告)号：WO01066508A2
公开(公告)日：2001-09-13
申请号：PCT/US2001/007140
申请日：2001-03-06
IPC分类号： B01D9/02 , C07C51/43 , C07C51/47 , C07C59/215 , C07C53/02 , C07C53/08 , C07C53/122 , C07C53/124 , C07C55/10 , C07C57/13 , C07C57/145 , C07C59/08 , C07C59/105 , C07C59/19 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/347 , C07D307/62
CPC分类号： C07C51/43 , Y02P20/582 , Y10S435/803 , Y10S435/876 , Y10S435/896 , C07C59/347
摘要： A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s). Specific examples of suitable organic acids include, but are not limited to, ascorbic, succinic, tartaric, glyconic, gulonic, citric, lactic, malic, maleic, acetic, formic, gluconic pyruvic, propionic, butyric, itaconic acids and mixtures thereof. One embodiment of the present invention relates to the recovery of 2-keto-L-gulonic acid (KLG) from aqueous solutions such as fermentation baths.
摘要翻译：从溶液中回收所需有机酸的方法包括以下步骤：提供包含至少一种所需有机酸或其酸阴离子的水溶液; 将所述水溶液中的质子浓度调节到所需的水平，其中所需质子浓度至少部分地被选择与需要回收的所需有机酸的酸性阴离子缔合所需的可用质子的量和/或弱于所需有机酸的酸性阴离子; 以及从所述水相中回收所述至少一种所需有机酸的至少一部分。期望的质子浓度可以基于可用质子的量大于，小于或基本上等于与所需有机酸的阴离子和酸阴离子相比所需的质子的量，其弱于所需的有机酸。合适的有机酸的具体实例包括但不限于抗坏血酸，琥珀酸，酒石酸，葡萄糖酸，古洛糖酸，柠檬酸，乳酸，苹果酸，马来酸，乙酸，甲酸，葡糖酸丙酮酸，丙酸，丁酸，衣康酸及其混合物。本发明的一个实施方案涉及从水溶液如发酵浴中回收2-酮-L-古洛糖酸（KLG）。

47. 发明申请

WO01058850A1 A PROCESS FOR THE PREPARATION OF SALTS OF L-CARNITINE AND ALKANOYL L-CARNITINE WITH MUCIC ACID 审中-公开
标题翻译：一种制备L-卡尼丁和碱性L-卡尼汀与肌酸的盐的方法
公开(公告)号：WO01058850A1
公开(公告)日：2001-08-16
申请号：PCT/IT2001/000056
申请日：2001-02-09
IPC分类号： C07C227/18 , C07C51/41 , C07C59/245 , C07C59/285 , C07C229/22
CPC分类号： C07C59/285 , C07C229/22
摘要： An improved process is described for the industrial preparation of L-carnitine or alkanoyl L-carnitine mucate, which allows operations in a homogeneous phase in conditions of greater dilution, in a normal chemical reactor with stirring, in a batch process.
摘要翻译：描述了用于工业制备L-肉毒碱或烷酰基L-肉毒碱粘液的改进方法，其允许在分批方法中在正常化学反应器中在搅拌下在较大稀释条件下在均相中进行操作。

48. 发明申请

WO1996036585A1 A NEW PROCESS FOR THE PRODUCTION OF POTASSIUM HYDROXY CITRIC ACID, AND COMPOSITIONS CONTAINING THE POTASSIUM HYDROXY CITRIC ACID 审中-公开
标题翻译：用于生产羟基磷酸钾的新方法，以及含有羟基羟基酸的组合物
公开(公告)号：WO1996036585A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006554
申请日：1996-05-15
申请人： SABINSA CORPORATION , MAJEED, Muhammed , BADMAEV, Vladimir , RAJENDRAN, R.
发明人： SABINSA CORPORATION
IPC分类号： C07C59/245
CPC分类号： C07C59/245 , Y10S514/909
摘要： The present invention provides new processes for the synthesis or isolation of hydroxy citric acid in the form of a potassium salt from Garcinia fruit. The present invention also provides compositions containing the potassium hydroxy citrate for use as appetite suppressants.
摘要翻译：本发明提供了合成或分离藤黄果实钾盐形式的羟基柠檬酸的新方法。本发明还提供了含有用作食欲抑制剂的羟基柠檬酸钾的组合物。

49. 发明申请

WO9119692A3 CALCIUM CITRATE MALATE COMPOSITION 审中-公开
标题翻译：钙柠檬酸钙组合物
公开(公告)号：WO9119692A3
公开(公告)日：1992-03-19
申请号：PCT/US9103779
申请日：1991-05-30
申请人： PROCTER & GAMBLE
发明人： FOX MARY MORA , HECKERT DAVID CLINTON , LUHRSEN KENNETH RAY
IPC分类号： A61K31/19 , A61P1/02 , A61P3/00 , A61P3/14 , A61P43/00 , C07C51/41 , C07C59/245 , C07C59/265
CPC分类号： C07C51/412 , C07C59/265 , C07C59/245
摘要： A metastable complex of calcium, citrate and malate is disclosed. This material is highly bioavailable, and is soluble in both neutral and acid solutions. The salt is prepared by the reaction of calcium carbonate, calcium hydroxide or calcium oxide with citric and malic acids in aqueous solution. The reaction mixture is dried at a temperature of less than 100 °C, and the resultant solid is a metastable solid. The solid can be ground to reduce the particle size for easier tabletting or adding to foods and beverages. Preferred salts are neutral and acidic salts which can be expressed by molar ratios.

50. 发明申请

WO1990004581A1 METHOD FOR PREPARING (+)-ISOCITRIC ACID AND ITS DERIVATIVES 审中-公开
标题翻译：制备（+） - 异柠檬酸及其衍生物的方法
公开(公告)号：WO1990004581A1
公开(公告)日：1990-05-03
申请号：PCT/DE1989000678
申请日：1989-10-23
申请人： SCHMIDT, Günter
IPC分类号： C07C59/245
CPC分类号： C07C51/363 , C07C51/367 , C07C55/32 , C07C59/245
摘要： To prepare (+)-isocitric acid and its derivatives, maleic acid and/or fumaric acid and/or their derivatives are added to haloacetic acid and its derivatives at high temperature under the action of photomechanical energy and the halogen group is then replaced by a hydroxyl group. The photomechanical energy is UV light with a wavelength of approximately 200 to 300 nm.

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