专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO00027782A1 NEW METHOD FOR MAKING PHOTOCURABLE HALOFLUORINATED ACRYLATES 审中-公开
标题翻译：制备可光化卤化丙烯酸酯的新方法
公开(公告)号：WO00027782A1
公开(公告)日：2000-05-18
申请号：PCT/US1999/026583
申请日：1999-11-09
IPC分类号： G02B6/12 , C07C29/147 , C07C29/149 , C07C31/42 , C07C51/093 , C07C51/285 , C07C55/32 , C07C67/08 , C07C67/14 , C07C69/63 , C07C69/653 , C08F8/00 , C08F8/04 , C08F8/06 , C08F8/26 , C08F14/18 , C08G63/682 , C08G64/10 , C08G69/42 , C07C67/39 , C08F120/24 , G02B1/04
CPC分类号： C07C51/285 , C07C29/149 , C07C31/42 , C07C67/08 , C07C69/653 , C08F8/00 , C08F8/04 , C08F8/06 , C08F8/10 , C08F8/14 , C08F2800/10 , C08F2810/30 , Y10S526/914 , C07C55/32 , C07C69/63 , C08F20/00 , C08F214/24
摘要： Halofluorinated alkylene monomers are made by a method comprising the steps of: (a) subjecting a first polymer which is the reaction product of a fluorinated vinyl monomer and a vinyl comonomer to dehydrohalogenation to form a second polymer; (b) treating the second polymer with an oxidizing agent to form an oxidation product consisting of a alpha , omega -dicarboxylic acid or an ester derivative thereof; and (c) treating said oxidation product with a reducing agent to form a reduction product consisting of a alpha , omega -diol. Preferably, the first polymer has a structure of -[CH2CYZ(CF2CFX)n]m- wherein X and Y = F, C1 or Br; X and Y may be the same or different; Z = H, F, C1, Br, alkyl or perfluoroalkyl containing from about 1 to about 10 carbon atoms; n = an integer larger than about 1; and m is an integer between about 2 and about 10 . The alpha , omega -dicarboxylic acids and alpha , omega -diols produced herein can be directly used as polycondensation monomers. Alternatively, the alpha , omega -dicarboxylic acids and alpha , omega -diols can be further derivitized to tri-, tetra- or other multifunctional alcohols which may be directly used as condensation monomers or they may be converted to acrylates which may be photocured in the presence of a radical photoinitiator into transparent polymers which are useful as optical waveguiding materials.
摘要翻译：通过包括以下步骤的方法制备卤代亚烷基单体：（a）使作为氟化乙烯基单体和乙烯基共聚单体的反应产物的第一聚合物进行脱卤化氢以形成第二聚合物; （b）用氧化剂处理第二聚合物以形成由α，ω-二羧酸或其酯衍生物组成的氧化产物; 和（c）用还原剂处理所述氧化产物以形成由α，ω-二醇组成的还原产物。优选地，第一聚合物具有 - [CH 2 CYZ（CF 2 CFX）n] m - 其中X和Y = F，Cl或Br的结构; X和Y可以相同或不同; Z = H，F，C1，Br，含有约1至约10个碳原子的烷基或全氟烷基; n =大于1的整数; m为约2至约10 5之间的整数。本文生产的α，ω-二羧酸和α，ω-二醇可以直接用作缩聚单体。或者，可以将α，ω-二羧酸和α，ω-二醇进一步衍生为可以直接用作缩合单体的三元，四元或其它多官能醇，或者它们可以转化成丙烯酸酯，其可以在将自由基光引发剂存在于用作光波导材料的透明聚合物中。

2. 发明申请

WO9109025A3 PARTIALLY FLUORINATED COMPOUNDS AND POLYMERS 审中-公开
标题翻译：部分氟化合物和聚合物
公开(公告)号：WO9109025A3
公开(公告)日：1991-07-25
申请号：PCT/US9007052
申请日：1990-12-07
申请人： DU PONT
发明人： ANTON DOUGLAS ROBERT , FARNHAM WILLIAM BROWN , HUNG MING-HONG , MCKINNEY RONALD JAMES , RESNICK PAUL RAPHAEL
IPC分类号： C07C43/313 , C07C55/32 , C07C69/63 , C07C211/15 , C07C235/10 , C07C255/04 , C07C255/07 , C07C255/10 , C07D305/10 , C07D317/16 , C07D317/20 , C07D317/22 , C07D317/28 , C07D317/30 , C07D317/42 , C08F14/18 , C08G63/682 , C08G69/26 , C08G73/10 , C08G63/68 , C08G69/42
CPC分类号： C07D317/42 , C07C43/313 , C07C55/32 , C07C69/63 , C07C211/15 , C07C255/10 , C07D305/10 , C07D317/16 , C07D317/28 , C07D317/30
摘要： Partially fluorinated compounds of specified formulas that are useful as chemical intermediates and monomers are disclosed. Partially fluorinated polymers prepared from one of these compounds are also disclosed. Fluoro-2,2-dimethyldioxolanes and copolymers thereof are further disclosed.

3. 发明申请

WO2012175534A1 (PER)FLUOROPOLYETHER BLOCK COPOLYMERS 审中-公开
标题翻译：（PER）氟聚醚嵌段共聚物
公开(公告)号：WO2012175534A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061782
申请日：2012-06-20
申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A. , TONELLI, Claudio Adolfo Pietro , FONTANA, Simonetta, Antonella , GALIMBERTI, Marco , GAVEZOTTI, Piero
发明人： TONELLI, Claudio Adolfo Pietro , FONTANA, Simonetta, Antonella , GALIMBERTI, Marco , GAVEZOTTI, Piero
IPC分类号： C08G65/08 , C08G65/18
CPC分类号： C07C271/24 , C07C41/22 , C07C43/126 , C07C55/32 , C07C67/00 , C07C69/708 , C07C269/02 , C08G65/007
摘要： The invention relates to (per)fluoropolyether block copolymers comprising: A) a fluoropolyoxyalkylene segment (chain R a ) comprising one or more units of formula (CHXCF 2 CF 2 O)- in which X is hydrogen or fluorine; B) a (per)fluoropolyoxyalkylene segment (chain Rf), that is to say a segment comprising recurring units having at least one catenary ether bond and at least one fluorocarbon moiety, said (per)fluoropolyoxyalkylene segment being different from chain R a and having a molecular weight higher than 400 g/mol. These copolymers are endowed with improves lubricant properties or with improved water and oil-repellence properties.
摘要翻译：本发明涉及（全）含氟聚醚嵌段共聚物，其包含：A）包含一种或多种式（CHXCF 2 CF 2 O）单元的氟聚氧亚烷基链（链Ra），其中X是氢或氟; B）（全）氟聚氧亚烷基链段（链Rf），也就是说包含具有至少一个链状醚键的重复单元和至少一个碳氟化合物部分的链段，所述（全）氟聚氧亚烷基链段不同于链Ra，并具有分子量高于400g / mol。这些共聚物具有改善的润滑剂性能或具有改善的防水和防油性能。

4. 发明申请

WO1990004581A1 METHOD FOR PREPARING (+)-ISOCITRIC ACID AND ITS DERIVATIVES 审中-公开
标题翻译：制备（+） - 异柠檬酸及其衍生物的方法
公开(公告)号：WO1990004581A1
公开(公告)日：1990-05-03
申请号：PCT/DE1989000678
申请日：1989-10-23
申请人： SCHMIDT, Günter
IPC分类号： C07C59/245
CPC分类号： C07C51/363 , C07C51/367 , C07C55/32 , C07C59/245
摘要： To prepare (+)-isocitric acid and its derivatives, maleic acid and/or fumaric acid and/or their derivatives are added to haloacetic acid and its derivatives at high temperature under the action of photomechanical energy and the halogen group is then replaced by a hydroxyl group. The photomechanical energy is UV light with a wavelength of approximately 200 to 300 nm.

5. 发明申请

WO2015123091A1 FACTOR XIA INHIBITORS 审中-公开
标题翻译：因子XIA抑制剂
公开(公告)号：WO2015123091A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/014708
申请日：2015-02-06
申请人： MERCK SHARP & DOHME CORP. , NEELAMKAVIL, Santhosh, F. , EDMONDSON, Scott, D. , GUO, Zhuyan , HRUZA, Alan, W. , HUSSAIN, Zahid , MONINGKA, Remond , KEVIN, Nancy Jo
发明人： NEELAMKAVIL, Santhosh, F. , EDMONDSON, Scott, D. , GUO, Zhuyan , HRUZA, Alan, W. , HUSSAIN, Zahid , MONINGKA, Remond , KEVIN, Nancy Jo
IPC分类号： A01N37/12
CPC分类号： C07D217/24 , C07C55/32 , C07D209/46 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译：本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

6. 发明申请

WO1983001951A1 NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：新的前体化合物及其制备方法
公开(公告)号：WO1983001951A1
公开(公告)日：1983-06-09
申请号：PCT/DE1982000222
申请日：1982-11-25
申请人： SCHERING AKTIENGESELLSCHAFT , NICKOLSON, Robert , VORBRÜGGEN, Helmut , CASALS-STENZEL, Jorge , HABEREY, Martin
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D307/935
CPC分类号： C07D307/935 , C07C51/09 , C07C51/38 , C07C55/32 , C07C57/52 , C07C405/00 , C07C405/0033 , C07D307/937 , C07D407/12 , C07F7/1804 , C07F9/4015
摘要： Prostacyclin derivatives having the general formula I wherein R1 is either the OR3 rest, wherein R3 may be hydrogen or an alkyl group with 1 to 10 atoms of carbon and optionally substituted by halogen, aryl, C1-C4-alkoxy or C1-C4-dialkyl-amino, a cyclo-alkyl group, an aryl group or an heterocyclic group, or the rest NHR4, wherein R4 may be hydrogen, an alkanoyl or alkane-sulfonyl group with 1 to 10 atoms of carbon, A represents either -CH2-CH2- , or -CH=CH- (trans), W represents either wherein the group OH is either esterified with a benzoyl rest or an alkanoyl rest having 1 to 4 atoms of carbon, or is etherified with a tetra-hydro-pyranyl, tetra-hydro-furanyl, alkoxy-alkyl (1 to 4 atoms of carbon) or tri-(C1 to C4-alkyl)-silyl rest, the free or esterified OH group being in the position alpha or beta ; the symbols D and E representing in common a direct bond or the symbol D representing itself an alkyl group in a straight or branched chain with 1 to 5 atoms of carbon and the symbol E representing an oxygen atom or a direct bond, the symbol R2 represents an alkyl group with a straight or branched chain having 1 to 6 atoms of carbon, an alkenyl group with a straight or branched chain having 2 to 6 atoms of carbon, group which may be substituted by phenyl, halogen or alkyl with 1 to 4 atoms of carbon or then, when the symbols D and E designate a direct bond, an alkinyl group with 2 to 6 atoms of carbon, optionally substituted in position 1 by halogen or alkyl with 1 to 4 atoms of carbon, the symbol R5 represents a hydroxy group which may be either esterified by an alkanoyl rest having 1 to 4 atoms of carbon, or etherified by a tetra-hydro-pyranyl, tetra-hydro-furanyl, alkoxy-alkyl or tri-alkyl-silyl rest and, providing that R3 is hydrogen, the salts of such derivatives with physiologically acceptable bases. Said compounds are characterized by a hypotensive activity and an inhibiting activity of thrombocyte aggregation. The invention also relates to preparation processes of such compounds.
摘要翻译：具有通式I的前列环素衍生物，其中R 1为OR 3残基，其中R 3可为氢或具有1至10个碳原子并且任选被卤素，芳基，C 1 -C 4烷氧基或C 1 -C 4烷氧基取代的烷基， C4-二烷基 - 氨基，环烷基，芳基或杂环基，或其余NHR4，其中R4可以是氢，具有1-10个碳原子的烷酰基或烷 - 磺酰基，A代表 - CH 2 -CH 2 - 或-CH = CH-（反式），W表示其中基团OH用苯甲酰基取代基或具有1-4个碳原子的烷酰基取代基进行酯化，或者与四 - 氢 - 吡喃基，四氢呋喃基，烷氧基 - 烷基（1至4个碳原子）或三 - （C1至C4烷基） - 甲硅烷基，游离或酯化的OH基位于α或β位置; 符号D和E表示直接键合的符号D或符号D表示其具有1至5个碳原子的直链或支链中的烷基，符号E表示氧原子或直接键，符号R2表示具有1至6个碳原子的直链或支链的烷基，具有2至6个碳原子的直链或支链的烯基，可被苯基取代的基团，卤素或具有1至4个原子的烷基的碳，或者当符号D和E表示直接键时，具有2至6个碳原子的炔基，任选在1位被卤素取代或具有1至4个碳原子的烷基，符号R5表示羟基基团可以被具有1-4个碳原子的烷酰基基团酯化，或者被四氢吡喃基，四氢呋喃基，烷氧基 - 烷基或三烷基 - 甲硅烷基取代的醚化，并且R 3是氢，这些衍生物的盐与生理学可接受的基础。所述化合物的特征在于血小板聚集的低血压活性和抑制活性。本发明还涉及这些化合物的制备方法。

7. 发明申请

WO00069808A1 PROCESS FOR PREPARING R-(-)-CARNITINE FROM S-(-)-CHLOROSUCCINIC ACID OR FROM A DERIVATIVE THEREOF 审中-公开
标题翻译：从 - （ - ） - 氯化胆酸或其衍生物制备R - （ - ） - 卡尼汀的方法
公开(公告)号：WO00069808A1
公开(公告)日：2000-11-23
申请号：PCT/IT2000/000187
申请日：2000-05-12
IPC分类号： C07D307/60 , C07B53/00 , C07C51/363 , C07C51/377 , C07C51/48 , C07C51/56 , C07C55/32 , C07C55/40 , C07C69/63 , C07C227/08 , C07C227/30 , C07C227/32 , C07C229/22 , C07C309/66
CPC分类号： C07C309/66 , C07B2200/07 , C07C51/377 , C07C51/48 , C07C51/56 , C07C69/63 , C07C227/08 , C07C227/32 , C07C55/32 , C07C229/22
摘要： A process for the preparation of L-carnitine inner salt comprising the reduction, with a suitable reducing agent, of a compound of formula (I): where X1 and X2, which may be the same or different, are hydroxy, C1-C4 alkoxy, phenoxy, halogen, or X1 and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, the mesyloxy or the tosyloxy group: and subsequent treatment with water, then with a base and then with trimethylamine.
摘要翻译：一种制备左旋肉碱内盐的方法，包括用合适的还原剂还原式（I）化合物：其中X1和X2可以相同或不同，为羟基，C1-C4烷氧基，苯氧基，卤素或X 1和X 2，当一起为氧原子时，所得化合物为琥珀酸酐的衍生物; Y是卤素，甲磺酰氧基或甲苯磺酰氧基：然后用水处理，然后用碱，然后用三甲胺处理。

8. 发明申请

WO98043946A1 PROCESS FOR THE PREPARATION OF N-(3-HYDROXY-SUCCINYL)-AMINO ACID DERIVATIVES 审中-公开
标题翻译：制备N-（3-羟基 - 磺酰基） - 氨基酸衍生物的方法
公开(公告)号：WO98043946A1
公开(公告)日：1998-10-08
申请号：PCT/GB1998/000913
申请日：1998-03-25
IPC分类号： C07C55/32 , C07C69/63 , C07C231/02 , C07C231/14 , C07C235/12 , C07C235/22 , C07C237/22 , C07C259/06 , C07C309/63 , C07D305/12
CPC分类号： C07C69/63 , C07B2200/07 , C07C55/32 , C07C231/14 , C07C259/06 , C07D305/12 , Y02P20/55 , C07C235/12 , C07C235/22
摘要： Processes for preparing compounds of the formula (I) are described: P OOC-CH(OH)-CHR -CONH-Z wherein P is hydrogen or a protecting group, Z is a group -CHR COOP or -CHR CONR R wherein P is hydrogen or a protecting group and R -R are values known in the TNF-inhibitor art. The compounds of the formula (I) are useful in inhibiting TNF and one or more matrix metalloproteinase enzymes. One intermediate in a process of the invention is formula (II).
摘要翻译：描述了制备式（I）化合物的方法：P 1 OOC-CH（OH）-CHR 1 -CONH-Z其中P 1是氢或保护基，Z是-CHR COOP 2或-CHR 2 CONR 3 R 4其中P 2是氢或保护基，R 1 -R 4是TNF-抑制剂中已知的值艺术。式（I）的化合物可用于抑制TNF和一种或多种基质金属蛋白酶。本发明方法中的一种中间体是式（II）。

9. 发明申请

WO1991009025A2 PARTIALLY FLUORINATED COMPOUNDS AND POLYMERS 审中-公开
标题翻译：部分氟化合物和聚合物
公开(公告)号：WO1991009025A2
公开(公告)日：1991-06-27
申请号：PCT/US1990007052
申请日：1990-12-07
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： E.I. DU PONT DE NEMOURS AND COMPANY , ANTON, Douglas, Robert , FARNHAM, William, Brown , HUNG, Ming-Hong , MCKINNEY, Ronald, James , RESNICK, Paul, Raphael
IPC分类号： C07D317/42
CPC分类号： C07D317/42 , C07C43/313 , C07C55/32 , C07C69/63 , C07C211/15 , C07C255/10 , C07D305/10 , C07D317/16 , C07D317/28 , C07D317/30
摘要： Partially fluorinated compounds of specified formulas that are useful as chemical intermediates and monomers are disclosed. Partially fluorinated polymers prepared from one of these compounds are also disclosed. Fluoro-2,2-dimethyldioxolanes and copolymers thereof are further disclosed.
摘要翻译：公开了可用作化学中间体和单体的具体化学式的部分氟化化合物。还公开了由这些化合物之一制备的部分氟化聚合物。进一步公开了氟-2,2-二甲基二氧戊环及其共聚物。

10. 发明申请

WO2019123342A1 METHODS OF MAKING POLYFUNCTIONAL POLYFLUORINATED COMPOUNDS 审中-公开
公开(公告)号：WO2019123342A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060386
申请日：2018-12-19
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HIRSCHBERG, Markus E. , HINTZER, Klaus , LAMANNA, William M. , SMITH, Sean M. , RÖSCHENTHALER, Gerd-Volker , PAJKERT, Romana , TVERDOMED, Sergey N.
IPC分类号： C07C51/31
CPC分类号： C07C51/31 , C07C55/32
摘要： A method of making a polyfunctional polyfluorinated compound includes combining first components that include a polyfluorinated cyclic compound having 4 to 7 ring carbon atoms and at least one of osmium tetroxide, ruthenium tetroxide or a precursor thereof and forming a polyfluorinated dicarboxylic acid. Two of the ring carbon atoms of the polyfluorinated cyclic compound form a double bond or an epoxide. The precursor reacts with an oxidant to form ruthenium tetroxide. Methods also include converting the polyfluorinated dicarboxylic acid to a polyfluorinated dicarboxylic acid halide and converting the polyfluorinated dicarboxylic acid halide to other polyfunctional polyfluorinated compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式