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1. 发明申请

WO2004060317A3 COMBINATION OF GALLIUM COMPOUNDS WITH NONCHEMOTHERAPEUTIC ANTICANCER AGENTS IN THE TREATMENT OF NEOPLASIA 审中-公开
标题翻译：凝胶化合物与非化学治疗药物在治疗神经细胞中的组合
公开(公告)号：WO2004060317A3
公开(公告)日：2005-12-22
申请号：PCT/US0341746
申请日：2003-12-31
申请人： GENTA INC , WARRELL RAYMOND P JR , GRANT STEFAN C , BROWN BOB D
发明人： WARRELL RAYMOND P JR , GRANT STEFAN C , BROWN BOB D
IPC分类号： A61K20060101 , A61K33/24 , A61K39/395 , A61K45/06 , A61K51/02
CPC分类号： A61K51/02 , A61K33/24 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a combination of a pharmaceutical composition comprising a gallium compound, especially gallium nitrate, and one or more nonchemotherapeutic anticancer agents (NCAA) including antibodies, antisense molecules, anti-telomerase agents, aptamers, biologic response modifiers, bisphosphonates, cytotoxic fusion proteins, immunomodulatory agents, immunostimulatory agents, molecular decoys, molecular inhibitors, proteasome inhibitors, protein kinase inhibitors, retinoids, transcription factors and arsenic compounds, for the treatment of neoplasic disease in a mammal in need of treatment thereof.
摘要翻译：本发明涉及包含镓化合物，特别是硝酸镓的药物组合物和一种或多种非化学治疗性抗癌剂（NCAA）的组合，包括抗体，反义分子，抗端粒酶试剂，适体，生物反应调节剂，双膦酸盐，细胞毒性融合蛋白，免疫调节剂，免疫刺激剂，分子诱饵，分子抑制剂，蛋白酶体抑制剂，蛋白激酶抑制剂，类维生素A，转录因子和砷化合物，用于治疗需要治疗的哺乳动物中的新生儿疾病。

2. 发明申请

WO1992007864A1 IMPROVED PROCESS FOR THE SYNTHESIS OF OLIGOMERS 审中-公开
标题翻译：用于合成低聚物的改进方法
公开(公告)号：WO1992007864A1
公开(公告)日：1992-05-14
申请号：PCT/US1991007630
申请日：1991-10-21
申请人： GENTA, INC.
发明人： GENTA, INC. , KLEM, Robert, E. , MARVIN, William, B. , RILEY, Timothy, A.
IPC分类号： C07H15/12
CPC分类号： C07H21/00
摘要： Methods of synthesizing oligomers using low water oxidizer reagents which result in high coupling efficiencies are provided. These methods are suitable for larger scale preparations of methylphosphonate oligomers.
摘要翻译：提供了使用低水氧化剂试剂合成寡聚物的方法，其导致高耦合效率。这些方法适用于甲基膦酸酯低聚物的较大规模制备。

3. 发明申请

WO2007123779A3 IMPROVED DOSING AND SCHEDULING OF OLIGOMERS 审中-公开
标题翻译：改进剂量和排列低聚物
公开(公告)号：WO2007123779A3
公开(公告)日：2008-11-06
申请号：PCT/US2007008038
申请日：2007-03-31
申请人： GENTA INC , BROWN BOB D
发明人： BROWN BOB D
IPC分类号： A01N47/00
CPC分类号： A61K31/70
摘要： The present invention relates to a method for treating a human patient having a proliferative disorder by administering an effective amount of a pre-treatment to the patient prior to administering an effective amount of a nucleotide-based composition that inhibits the over-expression of a target gene that causes the proliferative disorder. The present invention includes pre-treatment with one or more radiotherapy such as an X ray, a proton beam, an electron beam; hyperthermic therapy, ultrasonic therapy, chemotherapy and a biologic therapy. The invention also relates to an improved dose and scheduling sequence for treating a human patient in need thereof with such a nucleotide-based inhibitor of gene expression.
摘要翻译：本发明涉及通过在施用有效量的抑制靶标过表达的基于核苷酸的组合物之前向患者施用有效量的预处理来治疗具有增殖性病症的人类患者的方法导致增殖性疾病的基因。本发明包括用X射线，质子束，电子束等一种或多种放射治疗进行预处理。超声治疗，超声治疗，化疗和生物治疗。本发明还涉及用这种基于核苷酸的基因表达抑制剂治疗有需要的人类患者的改进的剂量和调度序列。

4. 发明申请

WO2007055885A3 PHARMACEUTICAL GALLIUM COMPOSITIONS AND METHODS 审中-公开
标题翻译：药物镓组合物和方法
公开(公告)号：WO2007055885A3
公开(公告)日：2007-07-12
申请号：PCT/US2006040986
申请日：2006-10-20
申请人： GENTA INC , JULIAN THOMAS N
发明人： JULIAN THOMAS N
IPC分类号： A61K31/28
CPC分类号： C07C229/76 , C07C235/60 , Y10S424/06 , Y10S514/97
摘要： Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailability relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormally increased calcium resorption is desired, including cancer, hypercalcemia, osteoporosis, osteopenia and Paget's disease. Methods for preparation and treatment are also provided.
摘要翻译：公开了新颖的药物镓组合物，包括相对于未配合的镓盐具有增加的口服生物利用度的镓配合物。这类组合物可用于治疗需要抑制异常增加的钙吸收的病症和疾病，包括癌症，高钙血症，骨质疏松症，骨质减少和佩吉特病。还提供了制备和治疗的方法。

5. 发明申请

WO2004056971A3 METHODS OF TREATMENT OF A BCL-2 DISORDER USING BCL-2 ANTISENSE OLIGOMERS 审中-公开
标题翻译：使用BCL-2抗体寡聚体治疗BCL-2型疾病的方法
公开(公告)号：WO2004056971A3
公开(公告)日：2005-03-10
申请号：PCT/US0341433
申请日：2003-12-19
申请人： GENTA INC , WARRELL RAYMOND P
发明人： WARRELL RAYMOND P
IPC分类号： A61K31/27 , A61K38/00 , A61K39/395 , A61K45/06 , C12N15/113 , C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04
CPC分类号： C12N15/1135 , A61K31/27 , A61K38/00 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
摘要翻译：本发明涉及bcl-2反义寡聚体用于治疗和预防bcl-2相关疾病的用途。这些疾病包括癌症，肿瘤，癌和细胞增殖相关疾病。在本发明的一个实施方案中，以高剂量施用bcl-2反义寡聚体。本发明还涉及预防或治疗bcl-2相关病症，特别是癌症的方法，包括短时间施用bcl-2反义寡聚体。本发明进一步涉及使用bcl-2反义寡聚体来增加受试者对癌症治疗剂的敏感性。本发明还涉及包含一种或多种bcl-2反义寡聚体的药物组合物，其可以包含一种或多种癌症治疗剂。

6. 发明申请

WO2004026267A3 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： TRI（烷基乙氧基）镓（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A3
公开(公告)日：2004-06-10
申请号：PCT/US0330792
申请日：2003-09-22
申请人： GENTA INC , JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
发明人： JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
IPC分类号： A61K31/28 , C07C51/41 , C07C53/126 , C07F5/00 , C30B7/10
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新的三（烷基羧基）镓（III）化合物，例如三棕榈酸镓（III），其制备方法，含有它们的药物组合物，以及使用该药物组合物的方法。

7. 发明申请

WO0217852A3 METHODS OF TREATMENT OF A BCL-2 DISORDER USING BCL-2 ANTISENSE OLIGOMERS 审中-公开
标题翻译：使用BCL-2抗体寡聚体治疗BCL-2病症的方法
公开(公告)号：WO0217852A3
公开(公告)日：2003-04-03
申请号：PCT/US0126414
申请日：2001-08-23
申请人： GENTA INC , WARREL RAYMOND P JR , KLEM ROBERT E , FINGERT HOWARD
发明人： WARREL RAYMOND P JR , KLEM ROBERT E , FINGERT HOWARD
IPC分类号： C12N15/09 , A61K31/337 , A61K31/4164 , A61K31/4745 , A61K31/513 , A61K31/664 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K31/7076 , A61K31/7088 , A61K31/711 , A61K33/24 , A61K38/00 , A61K48/00 , A61P35/00 , C12N15/113 , C12N15/12 , A61K51/04 , C07H21/04
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315
摘要： The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
摘要翻译：本发明涉及bcl-2反义寡聚体用于治疗和预防bcl-2相关疾病的用途。这些疾病包括癌症，肿瘤，癌和细胞增殖相关疾病。在本发明的一个实施方案中，以高剂量施用bcl-2反义寡聚体。本发明还涉及预防或治疗bcl-2相关病症，特别是癌症的方法，包括短时间施用bcl-2反义寡聚体。本发明进一步涉及使用bcl-2反义寡聚物来增加受试者对癌症治疗剂的敏感性。本发明还涉及包含一种或多种bcl-2反义寡聚体的药物组合物，其可以包含一种或多种癌症治疗剂。

8. 发明申请

WO2009134856A3 PHARMACEUTICAL GALLIUM COMPOUNDS, COMPOSITION AND METHODS OF PREPARATION 审中-公开
标题翻译：制药玻璃化合物，组合物和制备方法
公开(公告)号：WO2009134856A3
公开(公告)日：2010-01-28
申请号：PCT/US2009042064
申请日：2009-04-29
申请人： GENTA INC , BROWN BOB D , WARRELL RAYMOND P JR
发明人： BROWN BOB D , WARRELL RAYMOND P JR
IPC分类号： C07C51/41 , A61K31/194 , A61K31/225 , A61P11/00 , A61P19/00 , A61P19/08 , A61P31/04 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/245 , C07C59/255 , C07C59/265 , C07C69/70 , C07C69/704
CPC分类号： C07C59/265 , C07C51/412 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/245 , C07C59/255 , C07C69/704
摘要： The present invention provides novel pharmaceutical gallium compositions, as well as methods for their preparation and methods for treating conditions and diseases such as cancer, hypercalcemia, osteoporosis, osteopenia, Paget's disease, and infections.
摘要翻译：本发明提供新颖的药物镓组合物及其制备方法以及治疗疾病如癌症，高钙血症，骨质疏松症，骨质减少症，佩吉特氏病和感染的方法。

9. 发明申请

WO2008058225A2 METHODS AND COMPOSITIONS FOR TREATING CANCER USING BCL-2 ANTISENSE OLIGOMERS, TYROSINE KINASE INHIBITORS, AND CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：使用BCL-2抗体寡聚体，酪氨酸激酶抑制剂和化学治疗剂治疗癌症的方法和组合物
公开(公告)号：WO2008058225A2
公开(公告)日：2008-05-15
申请号：PCT/US2007084014
申请日：2007-11-08
申请人： GENTA INC , BROWN BOB D
发明人： BROWN BOB D
IPC分类号： A61K31/337 , A61K31/282 , A61K31/404 , A61K31/435 , A61K31/4745 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/675 , A61K31/704 , A61K31/7076 , A61K48/00 , A61P35/00
CPC分类号： A61K31/404 , A61K31/282 , A61K31/337 , A61K31/435 , A61K31/4745 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/675 , A61K31/704 , A61K31/7076 , A61K48/00 , A61K2300/00
摘要： Methods and compositions are provided for treating cell-proliferative related disorders such as cancer. Methods of inhibiting the growth of cancer cells comprise contacting the cancer cells with a Bcl-2 antisense oligomer; contacting the cancer cells with a tyrosine kinase inhibitor; and contacting the cancer cells with a cytotoxic chemotherapeutic agent. Methods of treating cancer in a human comprise administering to the human a Bcl-2 antisense oligomer, a tyrosine kinase inhibitor, and a cytotoxic chemotherapeutic agent. Kits containing compositions in amounts sufficient for at least one cycle of treatment comprise a triplet combination therapy of a Bcl-2 antisense oligomer, a tyrosine kinase inhibitor, and a cytotoxic chemotherapeutic agent. In selected embodiments, the tyrosine kinase inhibitor is one that targets cell surface kinase receptors, such as VEGFR (e.g., VEGFR1, VEGFR2, VEGFR3), PDGFR, KIT, and FLT-3.
摘要翻译：提供了用于治疗细胞增殖性相关疾病如癌症的方法和组合物。抑制癌细胞生长的方法包括使癌细胞与Bcl-2反义寡聚体接触; 使癌细胞与酪氨酸激酶抑制剂接触; 并使癌细胞与细胞毒性化学治疗剂接触。治疗人类癌症的方法包括向人体施用Bcl-2反义寡聚体，酪氨酸激酶抑制剂和细胞毒性化学治疗剂。含有足以进行至少一个治疗周期的量的组合物的试剂盒包括Bcl-2反义寡聚体，酪氨酸激酶抑制剂和细胞毒性化学治疗剂的三联体组合疗法。在选择的实施方案中，酪氨酸激酶抑制剂是靶向细胞表面激酶受体的受体，如VEGFR（例如VEGFR1，VEGFR2，VEGFR3），PDGFR，KIT和FLT-3。

10. 发明申请

WO2004026267A2 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：三唑（ALKYLCARBOXYLATO）GALLIUM（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/030792
申请日：2003-09-22
申请人： GENTA INC. , JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
发明人： JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
IPC分类号： A61K
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新颖的三（烷基羧基）镓（III）化合物，其例子是三异氰酸镓（III），其制备方法，含有它们的药物组合物和使用该药物组合物的方法。

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