发明申请
WO02038148A1 ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING omega -HYDROXYFATTY ACIDS
审中-公开
基本信息:
- 专利标题: ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING omega -HYDROXYFATTY ACIDS
- 专利标题(英):ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING φ-HYDROXYFATTY ACIDS
- 专利标题(中):反应剂,含有ω-羟基酸的食物或食物和饮料
- 申请号:PCT/JP2001/009661 申请日:2001-11-05
- 公开(公告)号:WO02038148A1 公开(公告)日:2002-05-16
- 主分类号: A61K31/122
- IPC分类号: A61K31/122 ; A61K31/19 ; A61K31/20 ; A61K31/201 ; A61K31/23 ; A61K31/231 ; A61K31/357 ; A61K31/365 ; A61P35/00 ; A61P35/04 ; C07C59/245 ; A61K7/00
摘要:
Drugs, in particular, anticancer agents. More particularly speaking, anticancer agents which contain as the active ingredient(s) one or more compounds selected from among omega -hydroxyfatty acids having a specific chemical structural formula and salts and esters thereof, hydroxyoxofatty acids and salts and esters thereof, lactone compounds, macrocyclic ketones and macrocyclic diesters. The above-described compounds have a carcinostatic effect, an extremely high effect of preventing cancer metastasis, an effect of preventing recurrence of cancer, an effect of preventing the occurrence of cancer and little cytotoxicity. Moreover, these compounds are efficacious only in a small dose. Owing to these characteristics, these compounds enable the provision of anticancer agents with little side effect. The effect of preventing cancer metastasis can be further enhanced by the combined use with known anti-malignant tumor agents. Among the anticancer agents as described above, omega -hydroxyfatty acids can be very conveniently obtained at a high purity by hydrolyzing lactone compounds which are also the anticancer agents as described herein.
摘要(中):
药物,特别是抗癌剂。 更具体地说,含有作为活性成分的一种或多种选自具有特定化学结构式的ω-羟基脂肪酸及其盐和酯,羟基异烟酸及其盐和酯的化合物的抗癌剂,内酯化合物,大环 酮和大环二酯。 上述化合物具有防癌效果,预防癌症转移的极高效果,预防癌症复发的效果,防止癌症发生的效果和细胞毒性小的效果。 而且,这些化合物只能以小剂量有效。 由于这些特性,这些化合物能够提供几乎没有副作用的抗癌剂。 通过与已知的抗恶性肿瘤剂的组合使用,可以进一步提高预防癌症转移的效果。 在如上所述的抗癌剂中,通过水解也是如本文所述的抗癌剂的内酯化合物,可以非常方便地以高纯度获得ω-羟基脂肪酸。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/045 | .羟基化合物,例如醇类;其盐类,例如醇化物 |
----------A61K31/122 | ..含直接与环相连的氧原子的,例如醌类、维生素K1、地蒽酚 |