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41. 发明申请

WO2013089868A2 NEURONAL BIOSENSOR FOR DETECTION OF TOXINS 审中-公开
标题翻译：神经生物传感器检测毒素
公开(公告)号：WO2013089868A2
公开(公告)日：2013-06-20
申请号：PCT/US2012056579
申请日：2012-09-21
申请人： UNIV SAINT LOUIS
发明人： KUTOSKY HANNAH , KUNTZ WILLITS REBECCA , HARKINS AMY B , MINTEER SHELLEY
IPC分类号： C12Q1/00
CPC分类号： G01N33/5014 , G01N33/5026 , G01N33/5058 , G01N33/52 , G01N33/582 , G01N33/587 , G01N2458/00
摘要： A biosensor combines a neuron with an optical sensor to detect toxins in fluids. The present disclosure provides an embodiment for an instrument that can utilize neurons as a biosensor that can provide optical methods to detect and measure low amounts of toxin exposure in humans.
摘要翻译：生物传感器将神经元与光学传感器结合起来检测流体中的毒素。本公开提供了可以利用神经元作为生物传感器的仪器的实施方式，其可以提供光学方法来检测和测量人体中低量的毒素暴露量。

42. 发明申请

WO2013037836A1 METHOD FOR PREPARING TOPOGRAPHICALLY STRUCTURED MICROARRAYS 审中-公开
标题翻译：制备地层结构微量元素的方法
公开(公告)号：WO2013037836A1
公开(公告)日：2013-03-21
申请号：PCT/EP2012/067856
申请日：2012-09-12
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , GOBAA, Samy , LUTOLF, Matthias
发明人： GOBAA, Samy , LUTOLF, Matthias
IPC分类号： C12Q1/02 , B41J2/15 , C12N5/00
CPC分类号： G01N33/5041 , B01J19/0046 , B01J2219/00385 , B01J2219/00509 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C12N5/0068 , C12N2535/10 , C12Q1/02 , G01N33/5026 , G01N33/5032 , G03F7/20 , G03F7/32 , G03F7/36
摘要： A method for preparing a topographically structured hydrogel microarray is described comprising the steps of a) providing one or more types of biomolecule(s) on top of micropillars of an array of micropillars, preferably by means of robotical spotting, b) providing a partially crosslinked hydrogel on a substrate, preferably attached to a substantially rigid and/or planar sub- strate, c) simultaneously soft-embossing a hydrogel microwell array and transferring the biomolecule(s) from the micropillars to the microwells by pressing the micropillars of the array of step a) onto the partially crosslinked layer of hydrogel of step b) until substantial completion of crosslinking and d) demolding the array of micropillars of step a) from the hydrogel microwell array of step c). The method according to the invention has the advantages of resulting in higher biochemical patterning precision, allowing for modulation of biochemical parameters by interfacing microarray manufacture with robotic technology and rendering the microarrays obtained compatible with existing read-out systems such as microscopes. Further, the elasticity of the hydrogel can be varied by tuning its shear modulus.
摘要翻译：描述了一种用于制备地形结构的水凝胶微阵列的方法，其包括以下步骤：a）优选通过机器人点样，在微柱阵列的微柱体的顶部提供一种或多种类型的生物分子，b）提供部分交联的基底上的水凝胶，优选地连接到基本上刚性和/或平面的基底上，c）同时软化压花水凝胶微孔阵列，并将生物分子从微透镜转移到微孔中，方法是通过将微阵列的微阵列步骤a）到步骤b）的部分交联的水凝胶层上，直到基本完成交联，和d）将步骤a）的微柱阵列从步骤c）的水凝胶微孔阵列脱模。根据本发明的方法具有产生更高的生物化学图案化精度的优点，允许通过将微阵列制造与机器人技术相连接并使获得的微阵列与现有的读出系统如显微镜相兼容来调制生物化学参数。此外，水凝胶的弹性可以通过调节其剪切模量来改变。

43. 发明申请

WO2012129360A2 ISOLATION AND CHARACTERIZATION OF TUMOR CELLS USING SHEAR STRESS MEASUREMENTS 审中-公开
标题翻译：使用剪切应力测量法分离和表征肿瘤细胞
公开(公告)号：WO2012129360A2
公开(公告)日：2012-09-27
申请号：PCT/US2012030034
申请日：2012-03-22
申请人： UNIV IOWA RES FOUND , HENRY MICHAEL D , BARNES J MATTHEW
发明人： HENRY MICHAEL D , BARNES J MATTHEW
IPC分类号： C12Q1/24 , C12N5/09 , C12N13/00
CPC分类号： G01N1/40 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2400/0475 , C12N5/0693 , C12N2521/00 , G01N33/487 , G01N33/5026 , G01N33/5044 , G01N33/5091 , G01N33/574
摘要： Methods for isolating viable cancer cells from a sample that comprises a mixture of cancerous cells and normal (non-cancerous) cells are provided. In the methods, a fluid preparation comprising a mixture of cancerous and normal cells is repeatedly exposed to fluid shear stresses, whereby the repeated exposure to the fluid shear stresses preferentially imparts fluid shear stress-resistance to the cancerous cells.
摘要翻译：提供了从包含癌细胞和正常（非癌性）细胞的混合物的样品中分离活细胞癌细胞的方法。在这些方法中，包含癌细胞和正常细胞的混合物的流体制剂被重复地暴露于流体剪切应力，由此反复暴露于流体剪切应力优先地赋予对癌细胞的流体剪切应力抗性。

44. 发明申请

WO2012098203A1 USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES 审中-公开
标题翻译：作为药物生物标志物的葡萄球菌使用呋喃巴比妥钠
公开(公告)号：WO2012098203A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050814
申请日：2012-01-19
申请人： BASILEA PHARMACEUTICA AG , LANE, Heidi Alexandra , BACHMANN, Felix
发明人： LANE, Heidi Alexandra , BACHMANN, Felix
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00
CPC分类号： G01N33/6872 , A61K31/4245 , G01N33/5011 , G01N33/5026 , G01N2800/44 , G01N2800/52
摘要： Use of glu-tubulin as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject to said compound, wherein the compound is a furazanobenzimidazole compound of general formula (I).
摘要翻译：使用葡萄 - 微管蛋白作为生物标志物来预测对化合物的反应，优选对所述化合物的受试者中的疾病如癌症的抗性，其中所述化合物是通式（I）的呋咱苯并咪唑化合物。

45. 发明申请

WO2010082009A1 SCREENING ASSAY 审中-公开
标题翻译：筛选测试
公开(公告)号：WO2010082009A1
公开(公告)日：2010-07-22
申请号：PCT/GB2009/002036
申请日：2009-08-20
申请人： EISAI R & D MANAGEMENT CO., LTD. , ELRAYESS, Mohamed , NISHIZAWA, Yukio , TERAMOTO, Tetsuyuki , NEAME, Stephen
发明人： ELRAYESS, Mohamed , NISHIZAWA, Yukio , TERAMOTO, Tetsuyuki , NEAME, Stephen
IPC分类号： G01N33/50
CPC分类号： G01N33/5026 , G01N33/5058
摘要： The present invention relates to a method of screening a candidate agent for the ability to stimulate differentiation of oligodendrocyte progenitor cells (OPCs) comprising i) contacting a cell with a candidate agent in the presence of a non-toxic amount of a cell division inhibitor and ii) determining if the candidate agent induces differentiation of the cell, wherein the OPC is a cell characterised as being capable of proliferating indefinitely. The invention further relates to candidate agents identified by the screening methods of the invention. Also included are methods of treating patients who suffer from or who are predisposed to suffer from Multiple Sclerosis (MS) or other demyelinating disorders.
摘要翻译：本发明涉及筛选候选药剂刺激少突胶质祖细胞（OPCs）分化能力的方法，其包括：i）在无毒量的细胞分裂抑制剂存在下使细胞与候选药剂接触;以及 ii）确定候选试剂是否诱导细胞的分化，其中OPC是被表征为能够无限增殖的细胞。本发明还涉及通过本发明的筛选方法鉴定的候选药剂。还包括治疗患有或易患多发性硬化症（MS）或其他脱髓鞘疾病的患者的方法。

46. 发明申请

WO2010055284A1 ASSAY 审中-公开
公开(公告)号：WO2010055284A1
公开(公告)日：2010-05-20
申请号：PCT/GB2009/002638
申请日：2009-11-09
申请人： ISIS INNOVATION LIMITED , PLATT, Frances , LLOYD-EVANS, Emyr
发明人： PLATT, Frances , LLOYD-EVANS, Emyr
IPC分类号： G01N33/50
CPC分类号： G01N33/5026 , G01N33/5091 , G01N33/84
摘要： The invention relates to a method of detecting an increased or decreased volume and/or pH of the late endosomal/lysosomal (Le/Lys) system in cell sample(s). The invention also concerns methods for diagnosing, treating and monitoring Le/Lys disorders, as well as methods of screening for compounds capable of increasing or decreasing the volume and/or pH of the Le/Lys system. Such compounds can be used to treat Le/Lys disorders.
摘要翻译：本发明涉及一种检测细胞样品中晚期内体/溶酶体（Le / Lys）系统的体积和/或pH的增加或减少的方法。本发明还涉及用于诊断，治疗和监测Le / Lys病症的方法，以及筛选能够增加或降低Le / Lys系统的体积和/或pH的化合物的方法。这些化合物可用于治疗Le / Lys病症。

47. 发明申请

WO2009126725A1 METHOD OF MODULATING NEOVASCULARIZATION 审中-公开
标题翻译：调节新生血管的方法
公开(公告)号：WO2009126725A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/039932
申请日：2009-04-08
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WEISS, Stephen , ROWE, Robert, G.
发明人： WEISS, Stephen , ROWE, Robert, G.
IPC分类号： C07K16/18 , C07K14/315 , C07K14/78 , A61K39/395 , A61K38/39 , A61P43/00 , A61P9/00
CPC分类号： C07K16/22 , A61K38/164 , A61K38/39 , A61K39/00 , A61K2039/505 , C07K14/78 , C07K16/18 , G01N33/5026
摘要： The disclosure provides a method of inhibiting neovascularization in a subject. The method comprises administering to the subject an agent that interferes with fibronectin (Fn) matrix assembly in an amount effective to inhibit neovascularization. The disclosure also provides a method of identifying an agent that inhibits neovascularization. The method comprises detecting fibronectin (Fn) matrix assembly by stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A decrease in Fn matrix assembly in the presence of the agent compared to Fn matrix assembly in the absence of the agent is indicative of an agent that inhibits neovascularization. Alternatively, the method of identifying an agent that inhibits neovascularization comprises detecting changes in nuclear architecture in stimulated endothelial cells cultured in three-dimensional culture gel in the presence and absence of an agent. A reduction in nuclear architecture organization identifies an agent that inhibits neovascularization.
摘要翻译：本公开提供了抑制受试者中新生血管形成的方法。该方法包括以有效抑制新血管形成的量向受试者施用干扰纤连蛋白（Fn）基质组合物的药剂。本公开还提供了鉴定抑制新血管形成的药剂的方法。该方法包括在存在和不存在药剂的情况下，通过在三维培养凝胶中培养的受激内皮细胞检测纤连蛋白（Fn）基质装配体。在不存在药物的情况下，与Fn基质组装相比，在药剂存在下Fn基质组装的减少指示抑制新生血管形成的药剂。或者，识别抑制新血管形成的药剂的方法包括检测在存在和不存在药剂的情况下在三维培养凝胶中培养的受刺激的内皮细胞中的核结构的变化。核建筑组织的减少确定了抑制新血管形成的药物。

48. 发明申请

WO2006119406A3 COMPOSITIONS AND METHODS FOR INCREASING OSTEOBLAST CELL DIFFERENTIATION AND BONE GENERATION 审中-公开
标题翻译：用于增加OSTEOBLAST细胞分化和骨生成的组合物和方法
公开(公告)号：WO2006119406A3
公开(公告)日：2009-04-23
申请号：PCT/US2006017104
申请日：2006-05-03
申请人： UAB RESEARCH FOUNDATION , ZAYZAFOON MAJD , MCDONALD JAY M , YEO HYEONJU
发明人： ZAYZAFOON MAJD , MCDONALD JAY M , YEO HYEONJU
IPC分类号： G01N33/567
CPC分类号： G01N33/5026
摘要： The present invention relates to the discovery of a novel pathway for the induction of osteoblast cellular differentiation and bone generation. Specifically, the present invention envisions a novel screening tool for the determination of compounds capable of promoting osteoblast cellular differentiation that could be used in the treatment of various bone-loss or bone density decreasing disorders. The method of screening of the present invention enables one to determine whether a compound affects certain pathways that promote via direct induction, or the downregulation of inhibiting activity, the differentiation of progenitor cells into osteoblasts. This promotion of osteoblasts could provide for treatments for bone-loss or bone density disorders. The invention further encompasses methods of increasing bone density using the compounds, the compounds, and pharmaceutical compositions comprising the compounds.
摘要翻译：本发明涉及用于诱导成骨细胞分化和骨产生的新途径的发现。具体地，本发明设想了一种用于测定能够促进成骨细胞分化的化合物的新型筛选工具，其可用于治疗各种骨丢失或骨密度降低障碍。本发明的筛选方法能够确定化合物是否影响通过直接诱导促进的某些途径，或抑制活性的下调，将祖细胞分化成成骨细胞。成骨细胞的这种促进可以提供骨丢失或骨密度紊乱的治疗。本发明还包括使用化合物，化合物和包含该化合物的药物组合物来增加骨密度的方法。

49. 发明申请

WO2008088758A1 METHODS TO IDENTIFY INHIBITORS OF CELL SICKLING 审中-公开
标题翻译：识别细胞Y Y的抑制剂的方法
公开(公告)号：WO2008088758A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/000427
申请日：2008-01-11
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , SMITH, Jeffrey, F. , EATON, William, A. , HOFRICHTER, H., James
发明人： SMITH, Jeffrey, F. , EATON, William, A. , HOFRICHTER, H., James
IPC分类号： G01N33/50
CPC分类号： G01N33/5005 , G01N33/5026
摘要： The invention relates to methods of screening for inhibitors of diseases or biological processes that involve peptide or protein polymerization. Included in the methods of the invention are methods to identify inhibitors of deoxyhemoglobin S polymerization. Also included in the invention are diagnostic and therapeutic methods.
摘要翻译：本发明涉及筛选涉及肽或蛋白质聚合的疾病或生物过程抑制剂的方法。包括在本发明方法中的方法是鉴定脱氧血红蛋白S聚合抑制剂的方法。本发明还包括诊断和治疗方法。

50. 发明申请

WO2008035309A2 METHOD FOR IDENTIFYING COMPOUNDS THAT ACT AS INSULIN-SENSITIZERS 审中-公开
标题翻译：识别作为胰岛素敏感剂的化合物的方法
公开(公告)号：WO2008035309A2
公开(公告)日：2008-03-27
申请号：PCT/IB2007053817
申请日：2007-09-20
申请人： NICHOLAS PIRAMAL INDIA LTD , MARITA ROSALIND ADAIKALASAMY , SHARMA SOMESH , ANTHONY JESSY , KELKAR ADITYA , BHUMRA SUJIT KAUR , GHATE ADITEE , NEMMANI KUMAR VENKATA SUBRAHMA , DEKA NABAJYOTI , GANGOPADHYAY ASHOK KUMAR
发明人： MARITA ROSALIND ADAIKALASAMY , SHARMA SOMESH , ANTHONY JESSY , KELKAR ADITYA , BHUMRA SUJIT KAUR , GHATE ADITEE , NEMMANI KUMAR VENKATA SUBRAHMA , DEKA NABAJYOTI , GANGOPADHYAY ASHOK KUMAR
IPC分类号： G01N33/50
CPC分类号： G01N33/502 , G01N33/5026
摘要： The present invention relates to a method for identifying compounds that act as insulin-sensitizers. The method can include screening of test compounds in two assays of insulin sensitivity. This method can identify lead compounds for the treatment of disorders caused by insulin resistance to glucose uptake. This invention also includes methods for treating insulin resistance and related disorders.
摘要翻译：本发明涉及用于鉴定作为胰岛素敏化剂的化合物的方法。该方法可以包括在胰岛素敏感性的两种测定中筛选测试化合物。该方法可以鉴定铅化合物用于治疗由胰岛素抵抗葡萄糖摄取引起的疾病。本发明还包括治疗胰岛素抵抗和相关疾病的方法。

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