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41. 发明申请

WO2010075115A3 BODY-ASSOCIATED RECEIVER AND METHOD 审中-公开
标题翻译：身体关联接收机和方法
公开(公告)号：WO2010075115A3
公开(公告)日：2010-09-23
申请号：PCT/US2009068128
申请日：2009-12-15
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
发明人： ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
IPC分类号： A61B5/05 , A61B5/048 , H04B13/00
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/145 , A61B5/14532 , A61B5/4094 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , A61M5/1452 , A61M5/172 , G06F19/34 , G06F19/3418 , H04B13/005
摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.
摘要翻译：提供接收器，可能是外置的或可植入的。本发明的接收器的方面包括以下中的一个或多个的存在：高功率低功率模块; 中介模块; 电源模块，被配置为激活和去激活到高功率处理块的一个或多个电源; 一个连接主和从块的串行外设接口总线; 和一个多用途连接器。本发明的接收器可以被配置为接收传导传输的信号。还提供了包括接收器的系统以及使用它们的方法。另外公开了使用接收器与剂量递送系统协调的系统和方法。

42. 发明申请

WO2010057063A2 PACING AND STIMULATION SYSTEM, DEVICE AND METHOD 审中-公开
标题翻译：起搏和刺激系统，装置和方法
公开(公告)号：WO2010057063A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064487
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61N1/36 , A61N1/02 , A61N1/04
CPC分类号： A61N1/36146 , A61N1/056 , A61N1/36185 , A61N1/3686
摘要： System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.
摘要翻译：提供了可变起搏和刺激的系统，装置和方法。在一个示例设备中，一个或多个引导集成电路可以可编程地控制一个或多个可变性参数。一个或多个电极可以提供电刺激。每个电极可以由至少一个引线集成电路单独寻址并且由至少一个可变性参数控制。在刺激时间之间的时间间隔期间，电极可以有意地短接在一起，以消散可能会持续并导致电极退化的电位。

43. 发明申请

WO2010057046A2 MULTIPLEXED MULTI-ELECTRODE NEUROSTIMULATION DEVICES 审中-公开
标题翻译：多重复合多电极神经调节装置
公开(公告)号：WO2010057046A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064468
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , THOMPSON TODD , JENSEN MARC , COLLIOU OLIVIER , STRAND ANGELA
发明人： ZDEBLICK MARK , THOMPSON TODD , JENSEN MARC , COLLIOU OLIVIER , STRAND ANGELA
IPC分类号： A61N1/36 , A61N1/02 , A61N1/05
CPC分类号： A61N1/375 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36185
摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.
摘要翻译：提供植入式刺激装置。器件的各个方面包括配置用于神经刺激的多路复用多电极部件。多路复用的多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。卫星结构包括可操作地耦合到一个或多个电极的密封集成电路控制器。还提供了包括本发明的设备的系统以及在各种不同的应用中使用该系统和设备的方法。

44. 发明申请

WO2010056438A2 SHIELDED STIMULATION AND SENSING SYSTEM AND METHOD 审中-公开
标题翻译：屏蔽刺激和感测系统及方法
公开(公告)号：WO2010056438A2
公开(公告)日：2010-05-20
申请号：PCT/US2009059704
申请日：2009-10-06
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36185 , A61N1/05 , A61N1/0534 , A61N1/0553
摘要： Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.
摘要翻译：提供电极的空间阵列，每个阵列在组织的区域中。连接阵列的电极，使得一些电极相对于用于脉冲刺激或感测电活动的一对电极或两者都用作屏蔽电极。屏蔽电极连接在一起，限定电节点，该节点以与电源电平或用于感测电路的参考电压限定稳定的电位。可以采用复用技术，使得在几个电极位置中的每一个处的感测活动可以传送到电极位置外部的电子装置。

45. 发明申请

WO2009140291A3 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：连续的田间计量系统及其使用方法
公开(公告)号：WO2009140291A3
公开(公告)日：2010-02-25
申请号：PCT/US2009043653
申请日：2009-05-12
申请人： PROTEUS BIOMEDICAL INC , ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
发明人： ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.
摘要翻译：提供连续场断层摄影系统。系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

46. 发明申请

WO2008008281A3 SMART PARENTERAL ADMINISTRATION SYSTEM 审中-公开
标题翻译：智能会议管理系统
公开(公告)号：WO2008008281A3
公开(公告)日：2008-12-04
申请号：PCT/US2007015547
申请日：2007-07-06
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61M31/00 , G06Q10/00
CPC分类号： A61M15/0068 , A61B5/117 , A61B5/411 , A61M1/16 , A61M1/1656 , A61M1/1668 , A61M1/167 , A61M1/28 , A61M5/14 , A61M5/1782 , A61M15/00 , A61M15/008 , A61M2016/0021 , A61M2016/0027 , A61M2205/13 , A61M2205/3523 , A61M2205/3538 , A61M2205/3553 , A61M2205/3561 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/6018 , A61M2205/6081 , A61M2230/06 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/63 , H04B13/005
摘要： The invention provides methods and systems for evaluating a fluid transfer event between a parenteral fluid delivery and a patient. The evaluation of the fluid transfer event can be prospective, real-time and/or historic, as desired, and take a variety of different formats.
摘要翻译：本发明提供了用于评估肠胃外流体递送和患者之间的流体转移事件的方法和系统。流体转移事件的评估可以根据需要是预期的，实时的和/或历史的，并且采取各种不同的格式。

47. 发明申请

WO2007028035A3 IMPLANTABLE ZERO-WIRE COMMUNICATIONS SYSTEM 审中-公开
标题翻译：可插拔的ZERO-WIRE通信系统
公开(公告)号：WO2007028035A3
公开(公告)日：2007-06-07
申请号：PCT/US2006034258
申请日：2006-09-01
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , ROBERTSON TIMOTHY
发明人： ZDEBLICK MARK , ROBERTSON TIMOTHY
IPC分类号： G08C17/00 , A61N1/00
CPC分类号： A61B5/0022 , A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/026 , A61B5/0265 , A61B5/145 , A61B5/14535 , A61B5/415 , A61B5/418 , A61B5/6862 , A61B5/6876 , A61M5/172 , A61N1/37217 , A61N1/37223 , H02J50/20 , Y02A90/26
摘要： The present invention shows an implantable system that communicates wirelessly with each other using a unique format that enables device configurations and applications heretofore not possible. Sensors (205, 206, 208,204) are located on a body (200) communicate with each other and with a data collector (106) by exchanging information using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium
摘要翻译：本发明示出了使用能够使得以前不可能实现的设备配置和应用的唯一格式彼此无线通信的可植入系统。传感器（205,206,208,204）位于主体（200）上，通过使用长波长/低频电磁波段中的准静电信号传输来交换信息，并与数据采集器（106）进行通信，患者的身体作为导电介质

48. 发明申请

WO2006069322A2 IMPLANTABLE ADDRESSABLE SEGMENTED ELECTRODES 审中-公开
标题翻译：可植入地线的电极
公开(公告)号：WO2006069322A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046811
申请日：2005-12-22
申请人： PROTEUS BIOMEDICAL INC , JENSEN MARC , COSTELLO BENEDICT J , THOMPSON TODD , ZDEBLICK MARK , FRANK JEREMY , LEI DINO , ADDIS BRUCE , COLLIOU OLIVIER
发明人： JENSEN MARC , COSTELLO BENEDICT J , THOMPSON TODD , ZDEBLICK MARK , FRANK JEREMY , LEI DINO , ADDIS BRUCE , COLLIOU OLIVIER
CPC分类号： A61N1/05 , A61N1/375
摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.
摘要翻译：提供了可植入可寻址的分段电极装置，以及制造和使用它们的方法。主题装置包括由电耦合到两个或更多个电极的集成电路组成的分段电极结构，其中每个电极可以被单独激活。还提供了可植入装置和系统，以及包含这种装置和系统或其组件的试剂盒，其包括分段的电极结构。

49. 发明申请

WO2004067081A2 METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING 审中-公开
标题翻译：用于增强心脏肥大的方法和装置
公开(公告)号：WO2004067081A2
公开(公告)日：2004-08-12
申请号：PCT/US2004001806
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , RUGGIO JOSEPH M
发明人： ZDEBLICK MARK , RUGGIO JOSEPH M
IPC分类号： A61N20060101 , A61N1/18 , A61N1/362 , A61N1/365 , A61N1/368 , A61N
CPC分类号： A61N1/365 , A61B5/02028 , A61B5/02055 , A61B5/0215 , A61B5/02158 , A61B5/026 , A61B5/14535 , A61B5/14539 , A61B5/1459 , A61B5/6883 , A61N1/3627 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.
摘要翻译：用于增强心脏起搏的方法，装置和系统通常提供测量至少一个心脏特征，基于所测量的特征来计算至少一个心脏性能参数，以及调整心脏起搏装置的至少一个功能参数。装置可以包括至少一个导管（例如具有一个或多个传感器和/或致动器的多路导管），至少一个植入物（例如可植入心脏壁的传感器）或两者的组合。可以对各种心脏性能参数和/或起搏装置性能参数进行加权，并且可以使用参数及其各自的权重来确定对起搏装置进行的一项或多项调整。在某些情况下，会自动进行调整。

50. 发明申请

WO2004052182A3 MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：监测和治疗HEMODYNAMIC参数
公开(公告)号：WO2004052182A3
公开(公告)日：2005-07-14
申请号：PCT/US0339524
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL INC
发明人： ZDEBLICK MARK , SAVAGE GEORGE M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/03 , A61B5/042 , A61B5/05 , A61B17/00 , A61B18/00 , A61B18/14 , A61B18/22 , A61N1/00 , A61N1/05
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier (100) provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors (106). The carrier (100) includes a body (102) and at least two electrical conductors (104) coupled with at least two effectors (106). Effectors (106) may be any combination of sensors (206), actuators (206) or both. Sensors (206) may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators (206) may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors (106) residing on parallel conductors in the patient, including addressing a first addressable sensor (106) in the network to obtain data and addressing a second addressable sensor (106) in the network to obtain data.
摘要翻译：复用的医疗载体（100）提供用于感测一个或多个患者参数和/或通过单独识别的效应器（106）递送能量。载体（100）包括主体（102）和与至少两个效应器（106）耦合的至少两个电导体（104）。效应器（106）可以是传感器（206），致动器（206）或两者的任何组合。传感器（206）可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。致动器（206）可用于例如调节心脏，刺激肌肉或神经组织，广播超声波能量，发光，加热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者中的并行导体上的复用传感器（106）的网络，包括寻址网络中的第一可寻址传感器（106）以获得数据并寻址第二可寻址传感器（106 ）在网络中获取数据。

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