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41. 发明申请

WO2004029336A3 MECHANICAL STABILITY ENHANCEMENT BY PORE SIZE AND CONNECTIVITY CONTROL IN COLLOIDAL CRYSTALS BY LAYER-BY-LAYER GROWTH OF OXIDE 审中-公开
标题翻译：逐层生长的氧化物在胶体晶体中的孔径和连接性控制机械稳定性的提高
公开(公告)号：WO2004029336A3
公开(公告)日：2004-06-03
申请号：PCT/CA0301413
申请日：2003-09-26
申请人： UNIV TORONTO
发明人： MIGUEZ HERNAN , OZIN GEOFFREY ALAN , YANG SAN MING , TETREAULT NICOLAS
IPC分类号： C30B5/00 , G02B6/122 , G02B6/12 , C30B29/60 , H01L21/00
CPC分类号： G02B6/1225 , B82Y20/00 , C30B5/00 , C30B29/60 , G02B6/122
摘要： The present invention provides a method to control the degree of connectivity of the colloidal particles making up a colloidal crystal and, consequently, the pore size, filling fraction, mechanical stability and optical properties of the colloidal lattice, without disrupting its long range order and without the deleterious effects of lattice contraction induced cracking observed in conventional necking methods based on thermal sintering. The colloidal particles are connected to adjacent colloidal particles in the lattice by a homogeneous layer of uniform and controllable thickness of a metal oxide. This metal oxide layer is grown in a layer-by-layer process and is chemically bonded to the colloidal particle surface and serves to enhance the mechanical stability of the colloidal crystal in addition to acting to control the pore size or void volume between the colloidal particles in the lattice.
摘要翻译：本发明提供了一种控制构成胶体晶体的胶体粒子的连接程度，并且因此控制胶体晶格的孔径，填充分数，机械稳定性和光学性质的方法，而不破坏其长程有序且没有在基于热烧结的常规颈缩方法中观察到的晶格收缩诱导裂纹的有害影响。胶体颗粒通过金属氧化物的均匀和可控厚度的均匀层连接到晶格中的相邻胶体颗粒。该金属氧化物层以逐层工艺生长并且化学结合到胶体颗粒表面并用于增强胶体晶体的机械稳定性，此外还起到控制胶体颗粒之间的孔径或空隙体积的作用在格子里。

42. 发明申请

WO02079394A3 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO02079394A3
公开(公告)日：2003-07-10
申请号：PCT/US0210903
申请日：2002-04-02
申请人： GENENCOR INT , UNIV TORONTO , DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R
发明人： DAVIS BENJAMIN G , JONES JOHN BRYAN , BOTT RICHARD R
IPC分类号： A61K47/48 , C07H5/10 , C07K14/36 , C12N1/21 , C07H1/00 , A61K31/70 , A61K38/16 , C07H17/00
CPC分类号： B82Y5/00 , A61K47/51 , A61K47/665 , A61K47/6898 , C07H5/10 , C07K14/36
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及一种化学修饰的突变蛋白，其包含半胱氨酸残基，其取代了半胱氨酸以外的残基而不是前体蛋白，随后通过半胱氨酸残基与糖基化硫代磺酸酯反应来修饰取代的半胱氨酸残基。还提供了一种生产化学修饰的突变蛋白的方法。本发明还涉及糖基化甲磺酸盐。本发明的另一方面是一种改变蛋白质的功能特征的方法，包括提供蛋白质并使蛋白质与糖基化甲磺酸盐试剂在与蛋白质相比产生具有改变的功能特征的糖蛋白的条件下反应。此外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于制备硫代糖糖，如此制备的硫代糖糖的合成方法，以及制备糖苷配基体试剂的方法。

43. 发明申请

WO0050563A9 G PROTEIN-COUPLED RECEPTOR RESEMBLING GALANIN RECEPTORS 审中-公开
标题翻译： G蛋白偶联受体阻断GALANIN受体
公开(公告)号：WO0050563A9
公开(公告)日：2001-08-30
申请号：PCT/US0004416
申请日：2000-02-22
申请人： MERCK & CO INC , MERCK FROSST CANADA INC , UNIV TORONTO , HOWARD ANDREW D , NEILL GARY P O , DOWD BRIAN O , GEORGE SUSAN
发明人： HOWARD ANDREW D , O'NEILL GARY P , O'DOWD BRIAN , GEORGE SUSAN
IPC分类号： C07K14/72 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/63
CPC分类号： C07K14/723
摘要： Human and rat DNAs encoding a novel G-protein coupled receptor, GPR54, as well as proteins encoded by the DNAs, are provided. Methods of identifying agonists and antagonists of GPR54 are also provided.
摘要翻译：提供了编码新型G蛋白偶联受体GPR54的人和大鼠DNA，以及由DNA编码的蛋白质。还提供了鉴定GPR54的激动剂和拮抗剂的方法。

44. 发明申请

WO0050563A3 G PROTEIN-COUPLED RECEPTOR RESEMBLING GALANIN RECEPTORS 审中-公开
标题翻译： G蛋白偶联受体阻断GALANIN受体
公开(公告)号：WO0050563A3
公开(公告)日：2000-12-21
申请号：PCT/US0004416
申请日：2000-02-22
申请人： MERCK & CO INC , MERCK FROSST CANADA INC , UNIV TORONTO , HOWARD ANDREW D , NEILL GARY P O , DOWD BRIAN O , GEORGE SUSAN
发明人： HOWARD ANDREW D , O'NEILL GARY P , O'DOWD BRIAN , GEORGE SUSAN
IPC分类号： C07K14/72
CPC分类号： C07K14/723
摘要： Human and rat DNAs encoding a novel G-protein coupled receptor, GPR54, as well as proteins encoded by the DNAs, are provided. Methods of identifying agonists and antagonists of GPR54 are also provided.
摘要翻译：提供了编码新型G蛋白偶联受体GPR54的人和大鼠DNA，以及由DNA编码的蛋白质。还提供了鉴定GPR54的激动剂和拮抗剂的方法。

45. 发明申请

WO9420530A3 NEUROPEPTIDES AND THEIR USE AS INSECTICIDES 审中-公开
标题翻译：神经病毒及其作为杀虫剂使用
公开(公告)号：WO9420530A3
公开(公告)日：1994-10-13
申请号：PCT/GB9400507
申请日：1994-03-14
申请人： QUEEN MARY & WESTFIELD COLLEGE , NAT UNIVERSITY HOSPITAL , UNIV TORONTO , THORPE ALAN , DUVE HANNE , JOHNSON ANDERS , TOBE STEPHEN
发明人： THORPE ALAN , DUVE HANNE , JOHNSON ANDERS , TOBE STEPHEN
IPC分类号： A01N25/06 , A01N25/08 , A01N63/02 , C07K7/06 , C07K7/08 , C07K14/435
CPC分类号： C07K7/06 , A01N63/02 , C07K7/08
摘要： This invention relates to novel neuropeptides isolated from Calliphora vomitoria, which are suitable for use in insecticidal formulations for controlling insects.

46. 发明申请

WO2016028503A8 THERAPY FOR FILOVIRUS INFECTION 审中-公开
标题翻译：治疗感染FILOVIRUS的疾病
公开(公告)号：WO2016028503A8
公开(公告)日：2016-09-15
申请号：PCT/US2015043927
申请日：2015-08-06
申请人： ALBERT EINSTEIN COLLEGE MEDICINE INC , GOVERNING COUNCIL UNIV TORONTO , U S ARMY MEDICAL RES AND MAT COMMAND
发明人： LAI JONATHAN R , KOELLHOFFER JAYNE F , FREI JULIA , CHANDRAN KARTIK , SIDHU SACHDEV , CHEN GANG , DYE JOHN M JR , ZAK SAMANTHA
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.
摘要翻译：本发明致力于改善对丝状病毒感染的治疗。本发明提供了分离的人源化抗 - 病毒糖蛋白融合前核心抗体，其包含具有与人抗体构架区95％或更高同一性的序列的构架区。还提供了治疗和/或抑制受试者中的丝状病毒感染的方法，包括向受试者施用一定量的本文所述的任何抗体或其量的抗原结合片段。还提供了包含本文所述的任何抗体或其一定量的抗原结合片段的组合物。在一个实施方案中，组合物包含药学上可接受的载体。

47. 发明申请

WO2014153495A9 NOVEL STAT3 INHIBITORS 审中-公开
标题翻译：新型STAT3抑制剂
公开(公告)号：WO2014153495A9
公开(公告)日：2015-04-23
申请号：PCT/US2014031412
申请日：2014-03-21
申请人： UNIV HAWAII , UNIV TORONTO
发明人： TURKSON JAMES , GUNNING PATRICK , HAFTCHENARY SINA
IPC分类号： A01N37/12 , A01N37/44 , A61K31/19 , C07C311/37
CPC分类号： C07C311/18 , C07C311/19 , C07C2601/14
摘要： The present disclosure provides pharmaceutical compositions comprising Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of use.
摘要翻译：本公开提供包含Stat3抑制剂及其某些药学上可接受的盐的药物组合物和使用方法。

48. 发明申请

WO2013075248A9 DEVICES AND METHODS FOR PRODUCING PLANAR POLYMERIC MATERIALS USING MICROFLUIDICS 审中-公开
标题翻译：用微生物制造平面聚合材料的装置和方法
公开(公告)号：WO2013075248A9
公开(公告)日：2014-12-18
申请号：PCT/CA2012050847
申请日：2012-11-23
申请人： UNIV TORONTO
发明人： GUENTHER AXEL , LENG LIAN , WOLLARD ANDREW , MCALLISTER ARIANNA , RADISIC MILICA , ZHANG BOYANG
IPC分类号： B81B1/00 , A23G3/00 , A61K8/72 , A61K35/12 , C08J5/18 , C12M1/34 , C12M3/00 , C12N11/02 , C40B60/00
CPC分类号： B29C47/0021 , A23G3/0002 , B01L3/5027 , C12M23/16
摘要： Methods and devices are disclosed for providing the controlled formation of planar homogeneous or heterogeneous materials using microfluidic devices. In one embodiment, a planar array of microfluidic channels is employed to produce a flowing liquid sheet having heterogeneous structure by spatially and temporally controlling dispensing of polymer liquid from selected microchannels. The resulting liquid sheet is solidified to produce a planar heterogeneous material that may be continuously drawn and/or fed from the plurality of microfluidic channels. The polymer liquid may include a payload that may be selectively incorporated into the heterogeneous structure. In some embodiments, the local material composition is controllable, thereby allowing control over local and bulk material properties, such as the permeability and the elasticity, and of creating materials with directionally dependent properties.
摘要翻译：公开了用于使用微流体装置提供平面均质或异质材料的受控形成的方法和装置。在一个实施例中，使用微流体通道的平面阵列来通过空间和时间控制从选定的微通道分配聚合物液体来产生具有不均匀结构的流动液体片。所得液体片材被固化以产生可以从多个微流体通道连续拉伸和/或进料的平面非均质材料。聚合物液体可以包括可以选择性地结合到异质结构中的有效载荷。在一些实施方案中，局部材料组成是可控的，从而允许控制局部和体积材料性质，例如渗透性和弹性，以及产生具有定向依赖性质的材料。

49. 发明申请

WO2012109157A3 BIOPROBES AND METHODS OF USE THEREOF 审中-公开
标题翻译：生物学及其使用方法
公开(公告)号：WO2012109157A3
公开(公告)日：2013-11-14
申请号：PCT/US2012024015
申请日：2012-02-06
申请人： UNIV TORONTO , KELLEY SHANA O , FANG ZHICHAO , VASILYEVA ELIZAVETA
发明人： KELLEY SHANA O , FANG ZHICHAO , VASILYEVA ELIZAVETA
IPC分类号： C12Q1/68 , C07H21/04 , G01N33/50
CPC分类号： C12Q1/6816 , C12N2310/3181 , C12Q1/6837 , C12Q1/6886 , G01N27/26 , G01N27/3276 , G01N27/3277 , C12Q2523/31
摘要： Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.
摘要翻译：公开了基于生物分子的生物探针，其表现出改善的水溶性和单层形成性质，其基本上很少或没有聚集，其可以明显地干扰生物探针与靶核苷酸的结合。生物探针可以与合适的报道系统结合使用以检测非常少量的生物标志物。生物探针包含能与靶核苷酸杂交的核碱基序列; 和至少一个连接到所述核碱基序列的带电官能团。还公开了生物传感器和包括生物探针的感测装置。进一步公开的是用于生物探针的合适的电化学报告体系。还包括使用这些装置和探针的方法，包括用于检测靶标生物标志物，包括癌细胞或病原体的生物标志物。

50. 发明申请

WO2012078313A3 GB1 PEPTIDIC LIBRARIES AND COMPOUNDS, AND METHODS OF SCREENING THE SAME 审中-公开
标题翻译： GB1PEPTIDIC LIBRARIES AND COMPOUNDS，及其筛选方法
公开(公告)号：WO2012078313A3
公开(公告)日：2012-08-23
申请号：PCT/US2011060276
申请日：2011-11-10
申请人： REFLEXION PHARMACEUTICALS INC , UNIV TORONTO , SIDHU SACHDEV S , UPPALAPATI MARUTI , AULT-RICHE DANA
发明人： SIDHU SACHDEV S , UPPALAPATI MARUTI , AULT-RICHE DANA
IPC分类号： C07K14/71 , C07K14/435 , C40B40/10 , G01N33/68
CPC分类号： G01N33/6845 , C07K1/00 , C07K14/315 , C40B30/04
摘要： GB 1 peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Aspects of the methods include screening GB 1 peptidic libraries for specific binding to 40 residue or more D-target proteins. Once a L-peptidic compound has been identified that specifically binds to the D-target protein, the D-enantiomer of that compound may be produced. GB 1 peptidic compounds that specifically bind to a target molecule are also provided. These libraries, compounds and methods find use in a variety of applications in which specific binding to target molecules, e.g., target proteins is desired.
摘要翻译：提供GB 1肽图书馆和筛选相同的特异性结合靶蛋白的方法。方法的方面包括筛选GB 1肽文库以特异性结合40个残基或更多个D靶蛋白。一旦确定了特异性结合D靶蛋白的L-肽化合物，就可以生产该化合物的D-对映异构体。还提供了特异性结合靶分子的GB 1肽化合物。这些文库，化合物和方法可用于其中期望与靶分子（例如靶蛋白）的特异性结合的多种应用。

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