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41. 发明申请

WO2003106655A3 FIBROUS PROTEIN-IMMOBILIZATION SYSTEMS 审中-公开
公开(公告)号：WO2003106655A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/019197
申请日：2003-06-18
申请人： THE UNIVERSITY OF AKRON , WANG, Ping , RENEKER, Darrell , JIA, Hongfei , ZHU, Guangyu
发明人： WANG, Ping , RENEKER, Darrell , JIA, Hongfei , ZHU, Guangyu
IPC分类号： C12N11/02 , C12N11/06 , G01N33/544 , G01N33/549 , C07K17/02 , C07K17/06
摘要： The present invention provides a fibrous protein-immobilization system composition comprising a fiber comprising fiber-forming material, and a protein attached to the fiber-forming material.

42. 发明申请

WO2003004538A1 METHODS FOR PRODUCING MICRO- AND NANO-SCALE DISPERSED-PHASE MORPHOLOGIES IN POLYMERIC SYSTEMS COMPRISING AT LEAST TWO COMPONENTS 审中-公开
标题翻译：在包含最少两个组分的聚合体系中生产微量和纳米尺度分散相形态的方法
公开(公告)号：WO2003004538A1
公开(公告)日：2003-01-16
申请号：PCT/US2002/021060
申请日：2002-07-03
申请人： THE UNIVERSITY OF AKRON , JANA, Sadhan , SILVI, Norberto
发明人： JANA, Sadhan , SILVI, Norberto
IPC分类号： C08F8/00
CPC分类号： C08J3/005 , B29C47/0004 , B29C47/0021 , C08L23/10 , C08L25/06 , C08L2205/22 , C08L2666/04
摘要： A polymeric system is disclosed wherein at least one minor polymeric component is dispersed into a major polymeric component such that the minor polymeric component is dispersed with less than micro-scale dispersed-phase morphologies.
摘要翻译：公开了一种聚合物体系，其中至少一种次要聚合物组分分散在主要聚合物组分中，使得次要聚合物组分以小于微尺度分散相形态分散。

43. 发明申请

WO2002083765A1 MULTI-COMPONENT POLYMERIC NETWORKS CONTAINING POLY(ETHYLENE GLYCOL) 审中-公开
标题翻译：含有聚（乙二醇）的多组分聚合物网络
公开(公告)号：WO2002083765A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011220
申请日：2002-04-08
申请人： THE UNIVERSITY OF AKRON
发明人： KENNEDY, Joseph , KURIAN, Pious
IPC分类号： C08G77/46
CPC分类号： C08G65/336 , C08G77/42 , C08G77/442
摘要： Multicomponent networks or membranes of the present invention have good mechanical properties that are permeable to water, hydrocarbons, and oxygen. The networks contain at least two and preferably at least three covalently combined domains, i.e., a hydrophilic, lipophilic and an oxyphilic polymer segment, that give rise to a multicontinuous domain microstructure. At least one of these domains includes poly(ethylene glycol).
摘要翻译：本发明的多组分网络或膜具有对水，烃和氧可渗透的良好机械性能。网络包含至少两个并且优选至少三个共价结合的结构域，即亲水性，亲脂性和亲氧聚合物链段，其产生多连续结构域微结构。这些领域中的至少一个包括聚（乙二醇）。

44. 发明申请

WO1998019996A1 NITRIC OXIDE DONOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PULMONARY HYPERTENSION AND OTHER INDICATIONS 审中-公开
标题翻译：硝酸氧化合物和药物组合物用于肺动脉高压和其他适应症
公开(公告)号：WO1998019996A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020104
申请日：1997-11-05
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , THE UNIVERSITY OF AKRON
发明人： CHILDREN'S HOSPITAL MEDICAL CENTER , THE UNIVERSITY OF AKRON , SALZMAN, Andrew, L. , SZABO, Csaba , ROSELLE, Dominick, C. , BRILLI, Richard, J. , KRAFTE-JACOBS, Brian , SMITH, Daniel, J.
IPC分类号： C07C291/04
CPC分类号： C07C291/04 , A61K31/131 , C08F8/30 , C08G73/0213 , Y10S514/929 , Y10S514/944 , Y10S514/946 , Y10S514/947
摘要： The invention is directed to nitric oxide (NO) donor compounds (such as those of formulae 1-4) and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.
摘要翻译：本发明涉及一氧化氮（NO）供体化合物（如式1-4的化合物）和含有这种一氧化氮（NO）供体化合物的药物组合物，用于将NO输送到粘膜的顶端表面，其中硝酸释放氧化物以通过粘膜的上皮单层。 NO供体化合物包括聚亚烷基亚胺NO供体以及叔氨基脂族NO供体化合物。本发明的化合物和组合物可用于期望通过粘膜表面递送NO的任何情况。例如，本发明的化合物和组合物特别可用于治疗肺动脉高压，男性阳ence以及其他几种特定病症。

45. 发明申请

WO1998005701A1 MULTI-ARM STAR POLYMERS HAVING A WELL-DEFINED CORE AND METHODS FOR THE SYNTHESIS THEREOF 审中-公开
标题翻译：具有良好定义核心的多臂星形聚合物及其合成方法
公开(公告)号：WO1998005701A1
公开(公告)日：1998-02-12
申请号：PCT/US1997014016
申请日：1997-08-07
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , KENNEDY, Joseph, P. , MAJOROS, Istvan, J. , MARSALKO, Timea, M.
IPC分类号： C08G77/38
CPC分类号： C07C43/215 , C07C69/712 , C07C2603/92 , C08G77/38 , C08G77/52 , C08G81/024
摘要： The synthesis of star polymers having well-defined arms emanating from well-defined and readily controllable calix[n]arene (n=4 to 16) cores are described. The synthesis is particularly suitable for polyisobutylene and/or polysiloxane star polymers. The synthesis has been achieved using carbocationic and/or anionic ring opening polymerization techniques to form polymer arms of desired molecular weights, then separately preparing the calixarene derivative core, and finally, linking the arms to the core by transesterification or hydrosilation. The star polymers are usable as viscosity modifiers and oil additives since they are less sensitive to oxidative reactions and shear stable.
摘要翻译：描述了从明确定义且容易控制的杯[n]芳烃（n = 4至16）核发出具有明确定义的臂的星形聚合物的合成。该合成特别适用于聚异丁烯和/或聚硅氧烷星形聚合物。已经使用碳阳离子和/或阴离子开环聚合技术来合成以形成所需分子量的聚合物臂，然后分别制备杯芳烃衍生物核心，最后通过酯交换或硅氢化将臂连接到核心。星形聚合物可用作粘度调节剂和油添加剂，因为它们对氧化反应和剪切稳定性较不敏感。

46. 发明申请

WO1997048091A1 ROTARY VALVE FOR BRASS INSTRUMENTS 审中-公开
标题翻译：黄铜仪器旋转阀
公开(公告)号：WO1997048091A1
公开(公告)日：1997-12-18
申请号：PCT/US1997009597
申请日：1997-05-30
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , LEONARD, Brian, Phillip
IPC分类号： G10D09/04
CPC分类号： G10D9/04
摘要： A rotary valve (10) for a brass wind instrument includes a rotor (12) rotatably disposed in a casing (30). Four tube connectors (50) are connected to the casing in fluid-tight connections. Each tube connector (50) has a passageway (52) therethrough having a constant, circular cross section. The rotor (12) has two ducts (14, 16) therethrough, each having a constant, circular cross section with a diameter (18) equal to the diameter of the passageways (52) through the tube connectors (50). The rotor (12) is selectively rotatable between an unactuated position and an actuated position. When the rotor (12) is in the unactuated position, a single soundpath (70) is formed through the valve. The single soundpath (70) has limited curvature and has a constant diameter. When the rotor (12) is in the actuated position, two soundpaths (72, 74) are formed through the valve (10). The first of the two soundpaths (72) subjects the sound to only a single 45 degree turn through the valve.
摘要翻译：一种用于黄铜管乐器的旋转阀（10）包括可旋转地设置在壳体（30）中的转子（12）。四个管连接器（50）以流体密封的连接连接到壳体。每个管连接器（50）具有穿过其中具有恒定的圆形横截面的通道（52）。转子（12）具有穿过其中的两个管道（14,16），每个具有恒定的圆形横截面，其直径（18）等于通过管连接器（50）的通道直径（52）。转子（12）可选择性地在未致动位置和致动位置之间旋转。当转子（12）处于未致动位置时，通过该阀形成单个声音路径（70）。单个声音路径（70）具有有限的曲率并且具有恒定的直径。当转子（12）处于致动位置时，通过阀（10）形成两个声音路径（72,74）。两个声音路径（72）中的第一个使声音仅通过阀门转过45度。

47. 发明申请

WO1997001583A1 PROCESS TO IMPROVE CHEMICAL AND OXIDATIVE STABILITY OF HYDROGENATED POLYMERS 审中-公开
标题翻译：提高氢化聚合物的化学和氧化稳定性的方法
公开(公告)号：WO1997001583A1
公开(公告)日：1997-01-16
申请号：PCT/US1996010839
申请日：1996-06-27
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , HARWOOD, H., James , JOLLY, Steven, W.
IPC分类号： C08F08/00
CPC分类号： C08F8/04 , C08F8/00 , C08F297/00
摘要： This invention describes chemical modifications of hydrogenated polymers, particularly thermoplastic elastomers, e.g., Kraton3 G, to increase the chemical resistance thereof. The number of residual reactive unsaturated diene-based midblocks were reduced through a post-hydrogenation reaction with an alkyl phenyl ether, e.g., anisole. The anisolated thermoplastic elastomer was then further reacted with benzenesulfonylation and nitration reactions to produce even more useful derivatives thereof.
摘要翻译：本发明描述了氢化聚合物，特别是热塑性弹性体如Kraton3G的化学改性，以增加其耐化学性。通过与烷基苯基醚如苯甲醚进行后氢化反应，还原残余的反应性不饱和二烯基中间嵌段的数目。然后将各向异性热塑性弹性体与苯磺酰化反应和硝化反应进一步反应，产生更有用的衍生物。

48. 发明申请

WO1996025148A1 A TIME-RELEASE DELIVERY MATRIX COMPOSITION AND CORRESPONDING CONTROLLED-RELEASE COMPOSITIONS 审中-公开
标题翻译：时间释放交付矩阵组合物和相应的控制释放组合物
公开(公告)号：WO1996025148A1
公开(公告)日：1996-08-22
申请号：PCT/US1996002106
申请日：1996-02-16
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , GALIATSATOS, Vassillios , ALABAKOVSKA, Lubica
IPC分类号： A61K09/14
CPC分类号： A61K9/2027 , A61K9/2031
摘要： A composition is provided for use as a matrix for controlled-release compositions. Such compositions utilize an active ingredient dispersed in a matrix. Active ingredients include, for example, pharmaceuticals and agricultural agents. The matrix is a blend of a poly(hydroxyethyl) methacrylate, polyethylene glycol and a time-release extending agent which is a low molecular weight polymer having hydrophilic and hydrophobic side groups, such as diblock or triblock poly(ethylene oxide propyleneoxide).
摘要翻译：提供组合物用作控释组合物的基质。这样的组合物利用分散在基质中的活性成分。活性成分包括例如药物和农药。基质是聚（羟乙基）甲基丙烯酸酯，聚乙二醇和时间延长剂的混合物，其是具有亲水和疏水侧基的低分子量聚合物，例如二嵌段或三嵌段聚（环氧乙烷环氧丙烷）。

49. 发明申请

WO1995008587A1 POLYMERIC NETWORKS OF POLYSILOXANE WITH INCREASED MODULUS 审中-公开
标题翻译：具有增加模量的聚硅氧烷的聚合物网络
公开(公告)号：WO1995008587A1
公开(公告)日：1995-03-30
申请号：PCT/US1994010602
申请日：1994-09-20
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , GALIATSATOS, Vassilios , SUBRAMANIAN, Pazam, Raman
IPC分类号： C08G77/06
CPC分类号： C08J3/24 , C08G77/16 , C08G77/18 , C08G77/70 , C08J2383/04 , C08L83/04 , C08L2666/44 , C08L83/00
摘要： Disclosed is a method for making polyorganosiloxane networks (preferably polydimethylsiloxane) with controlled heterogeneity of the molecular weight between cross-links. Low molecular weight functionally terminated polyorganosiloxanes are reacted with a polyfunctional cross-linking agent to form a product of molecular weight from about 1.33 to 15 times that of the starting materials. These partially cross-linked chains are then reacted with more cross-linking agents and functionally terminated polyorganosiloxanes of 20-40 times higher molecular weight. The molecular weight achieved in the first reaction has an effect on properties such as modulus, birefringence, and stress optical coefficient. The low molecular weight chains in this form serve to increase modulus and durability while keeping optical clarity of the inherently soft networks.
摘要翻译：公开了一种制备交联剂之间分子量控制异质性的聚有机硅氧烷网络（优选聚二甲基硅氧烷）的方法。将低分子量官能封端的聚有机硅氧烷与多官能交联剂反应以形成分子量为起始原料的约1.33至15倍的产物。然后将这些部分交联的链与更多的分子量为20-40倍的交联剂和官能封端的聚有机硅氧烷反应。在第一反应中获得的分子量对诸如模量，双折射和应力光学系数的性质具有影响。这种形式的低分子量链用于增加模量和耐久性，同时保持固有软网络的光学透明度。

50. 发明申请

WO1994024191A1 NEGATIVE BIREFRINGENT POLYIMIDE FILMS 审中-公开
标题翻译：负性双重聚酰亚胺薄膜
公开(公告)号：WO1994024191A1
公开(公告)日：1994-10-27
申请号：PCT/US1994004445
申请日：1994-04-21
申请人： THE UNIVERSITY OF AKRON
发明人： THE UNIVERSITY OF AKRON , HARRIS, Frank, W. , CHENG, Stephen, Z., D.
IPC分类号： C08G69/26
CPC分类号： G02F1/13363 , C08G69/26 , C08G69/265 , C08G69/32 , C08G69/44 , C08G73/10 , C08G73/1039 , C08G73/106 , C08G73/1064 , C08G73/1067 , C08G73/1071 , C08G73/14 , C08G73/16 , G02F1/133634 , G02F2413/02 , G02F2413/07 , Y10T428/31721
摘要： A negative birefringent film, useful in liquid crystal displays (2), and a method for controlling the negative birefringence of a polyimide film is disclosed which allows the matching of an application to a targeted amount of birefringence by controlling the degree of in-plane orientation of the polyimide by the selection of functional groups within both the diamine and dianhydride segments of the polyimide which affect the polyimide backbone chain rigidity, linearity, and symmetry. The higher the rigidity, linearity and symmetry of the polyimide backbone, the larger the value of the negative birefringence of the polyimide film.
摘要翻译：公开了一种在液晶显示器（2）中有用的负双折射膜和用于控制聚酰亚胺薄膜的负双折射的方法，其允许通过控制面内取向度来将应用与目标量的双折射匹配通过选择影响聚酰亚胺主链刚性，线性和对称性的聚酰亚胺的二胺和二酐链段内的官能团。聚酰亚胺主链的刚性，线性和对称性越高，聚酰亚胺薄膜的负双折射值越大。

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