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31. 发明申请

WO0001668A3 NAALADASE INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS 审中-公开
标题翻译： NAALADASE抑制剂可用作药物化合物和组合物
公开(公告)号：WO0001668A3
公开(公告)日：2000-09-21
申请号：PCT/US9915128
申请日：1999-07-02
申请人： GUILFORD PHARM INC
发明人： JACKSON PAUL F , MACLIN KEITH M , WANG ERIC , SLUSHER BARBARA S , LAPIDUS RENA S , MAJER PAVEL
IPC分类号： C07D213/55 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61P9/00 , A61P13/08 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07C309/17 , C07C309/24 , C07C317/44 , C07C323/12 , C07C323/52 , C07C323/56 , C07C327/06 , C07C327/12 , C07C327/18 , C07C327/22 , C07C327/36 , C07C329/12 , C07C333/04 , C07C333/14 , C07C333/20 , A61K31/27 , A61K31/44
CPC分类号： C07C309/17 , C07C309/24 , C07C317/44 , C07C323/12 , C07C323/52 , C07C323/56 , C07C327/18 , C07C327/36 , C07C329/12 , C07C333/14 , C07C333/20 , C07D213/55
摘要： The present invention relates to N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
摘要翻译：本发明涉及N-乙酰化α-链接酸性二肽酶（NAALADase）抑制剂酶活性，包含此类抑制剂的药物组合物及其用于抑制NAALADase酶活性从而实现神经元活性，抑制血管生成和治疗谷氨酸异常的方法，强迫症，前列腺疾病，疼痛和糖尿病性神经病。

32. 发明申请

WO00050431A1 PLATINUM (II) COMPOUNDS 审中-公开
标题翻译：铂（II）化合物
公开(公告)号：WO00050431A1
公开(公告)日：2000-08-31
申请号：PCT/GB2000/000686
申请日：2000-02-25
IPC分类号： C07D233/84 , A61K31/28 , A61K31/7135 , A61P29/00 , A61P33/00 , A61P35/00 , C07C323/12 , C07D213/22 , C07D235/28 , C07D239/38 , C07D473/38 , C07F15/00 , C07H23/00
CPC分类号： A61K31/28 , A61K31/7135 , C07C323/12 , C07D213/22 , C07D233/84 , C07D235/28 , C07D239/38 , C07D473/38 , C07F15/00 , C07H23/00 , Y02A50/409 , Y02A50/414
摘要： A compound which is a complex of formula (I) wherein each X, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, aralkyl, alkaryl, acyl, halogen, haloalkyl, haloaryl, hydroxyalkyl, hydroxyaryl, aminoalkyl, aminoaryl, primary, secondary or tertiary amine, hydrazine, alkylhydrazine, alkoxyl, alkylthio, aralkoxyl, nitrile, ester, amide, nitro, azide or aziridino, or is a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species, or a covalently linked moiety which provides recognition for a target receptor; and Y is alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aralkyl, heterocyclyl, an inorganic oxyacid or inorganic oxyacid derivative, or a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species; or a pharmaceutically acceptable salt thereof, for use in a method of treatment of the human or animal body by therapy.
摘要翻译：作为式（I）的络合物的化合物，其中每个X可以相同或不同，为氢，烷基，环烷基，烯基，环烯基，炔基，芳基，杂环基，芳烷基，烷芳基，酰基，卤素，卤代烷基，卤代芳基，羟基烷基，羟基芳基，氨基烷基，氨基芳基，伯，仲或叔胺，肼，烷基肼，烷氧基，烷硫基，芳烷氧基，腈，酯，酰胺，硝基，叠氮或氮丙啶基，或是共价连接的链，至少一种其它式（I）的络合物，以形成二聚体或低聚物种，或共价连接的部分，其为靶受体提供识别; 和Y是烷基，环烷基，烯基，环烯基，炔基，芳烷基，杂环基，无机含氧酸或无机含氧酸衍生物，或共价连接的链，其与至少一个式（I）的其它络合物连接以形成二聚体或低聚物种; 或其药学上可接受的盐，用于通过治疗治疗人或动物体的方法。

33. 发明申请

WO0032568A2 alpha -SULFIN- AND alpha -SULFONAMINO ACID AMIDES 审中-公开
标题翻译： α-磺基和α-磺酰氨基酸酰胺
公开(公告)号：WO0032568A2
公开(公告)日：2000-06-08
申请号：PCT/EP9909350
申请日：1999-12-01
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , ZELLER MARTIN , JEANGUENAT ANDRE , LAMBERTH CLEMENS
发明人： ZELLER MARTIN , JEANGUENAT ANDRE , LAMBERTH CLEMENS
IPC分类号： A01N41/06 , C07B61/00 , C07C303/34 , C07C303/38 , C07C303/40 , C07C307/06 , C07C311/06 , C07C311/11 , C07C323/12 , C07C311/00
CPC分类号： C07C323/12 , C07C307/06 , C07C311/06
摘要： (57) Abstract The invention relates to alpha -sulfin- and alpha -sulfonamino acid amides of general formula (I), including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 and R10 are each independently hydrogen or C1-C4alkyl; and R11 is either (1) or (2), wherein R14, R15, R16 and R17 are each independently hydrogen or C1-C4alkyl, X is oxygen, sulfur or -NR18-, wherein R18 is hydrogen or C1-C4alkyl, and A is optionally substituted mono- or polycylic aryl or heteroaryl, and to the preparation of those substances and to agrochemical compositions comprising at least one of those compounds as active ingredient. The invention relates also to the preparation of compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.
摘要翻译：（57）摘要本发明涉及通式（I）的α-亚磺酰基和α-磺酰氨基酰胺，包括其旋光异构体和这些异构体的混合物，其中n为0或1; R8是C1-C6烷基，C3-C6链烯基或C3-C6炔基; R9和R10各自独立地为氢或C1-C4烷基; 和R 11是（1）或（2），其中R 14，R 15，R 16和R 17各自独立地是氢或C 1 -C 4烷基，X是氧，硫或-NR 18 - ，其中R 18是氢或C 1 -C 4烷基，是任选取代的单或多环芳基或杂芳基，以及这些物质的制备以及包含这些化合物中的至少一种作为活性成分的农药组合物。本发明还涉及组合物的制备以及化合物或组合物在通过植物病原微生物，特别是真菌控制或防止植物感染的用途。

34. 发明申请

WO00026184A1 BISPHENYL THIOCOMPOUNDS 审中-公开
标题翻译： BISPHENYLTHIO CONNECTIONS
公开(公告)号：WO00026184A1
公开(公告)日：2000-05-11
申请号：PCT/DE1999/003096
申请日：1999-09-22
IPC分类号： C07C321/28 , C07C323/09 , C07C323/12 , C07C323/20 , C10M105/72 , C10M135/28 , C10N30/02 , C10N30/06 , C10N30/08 , C10N40/02 , C10N40/04 , C07C323/18 , C10M135/30
CPC分类号： C10M135/28 , C07C321/28 , C07C323/09 , C07C323/12 , C07C2601/14 , C10M105/72 , C10M2219/086
摘要： The invention relates to bisphenyl thiocompounds of formula (I), wherein X1 to X5 independently represent H, Cl, F, OH, SH, R, -OR and -SR, wherein R is an organic radical with 1 to 18 C atoms, which can be an alkyl or alkenyl radical that can also contain -O-, -S- instead of a one to four non-adjacent CH2 groups and that can be substituted once or multiple times by -OH, -SH or halogen, an unsubstituted phenyl, cyclohexyl or cyclohexylmethyl radical or substituted by one or up to three alkyl groups with a total of 1 to 9 C atoms in which a CH2 group may be substituted by, provided that at least 3 of the radicals X1 to X5 arer; Y1 to Y5 independently have the meaning cited for X1 to X5 and Z represents an alpha , omega -alkylene group with 2 to 18 C atoms in which one to three CH2 groups may be substituted by -O- or -S- and 1,4-cyclohexandimethyl group or a simple bond. The invention also relates to the use of said compounds as lubricants.
摘要翻译：本发明涉及式（I）其中X 1至X 5各自独立地表示H，氯，氟，OH，SH，R-CR的Bisphenylthio化合物，和-SR，其中R是一个有机基团的碳原子数1〜18的是是一个烷基或链烯基团，其还可以含有一个或最多四个非相邻CH 2基团，而不是-O - ， - S-，并且也可以是单 - 或多取代-OH，-SH，或卤素能，是未取代的或者被一个或至多3个烷基基团与总共1至9个碳原子的，在其每一个中的一个CH 2基团可以被-O - 取代，取代的苯基，环己基或环己基甲基，其条件是X 1至X 5的至少3是-SR; Y1到Y5各自独立地是如对于X 1至X 5的含义所定义; 和Z是α，ω-亚烷基碳原子数为2〜18，在其中也可以被替换到3 CH 2个基团可以被-O-或-S-取代，1,4-亚cyclohexanedimethyl-式的基团（基团 II）或单键，以及它们作为润滑剂的用途。

35. 发明申请

WO9964054A9 MULTIBINDING INHIBITORS OF TOPOISOMERASE 审中-公开
标题翻译：多重抑制剂的多重抑制剂
公开(公告)号：WO9964054A9
公开(公告)日：2000-03-02
申请号：PCT/US9912908
申请日：1999-06-08
申请人： ADVANCED MEDICINE INC , LINSELL MARTIN S , MEIER DAVIS SUSAN , GRIFFIN JOHN H
发明人： LINSELL MARTIN S , MEIER-DAVIS SUSAN , GRIFFIN JOHN H
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00 , C07G11/00
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y10S530/807
摘要： Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligant is capable of binding to a topoisomerase and the distance between ligands is between about 2-50 ANGSTROM . The multibinding compounds of this invention are useful in the treatment and prevention of cancer, microbial infections and the like.
摘要翻译：公开了抑制作为DNA复制和修复的较高密码子中必需酶的拓扑异构酶的多结合化合物。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每个结合物能够结合拓扑异构酶，并且配体之间的距离在约2-50埃之间。本发明的多重联结化合物可用于治疗和预防癌症，微生物感染等。

36. 发明申请

WO99064037A1 NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES 审中-公开
标题翻译：调节酶工艺的新型治疗剂
公开(公告)号：WO99064037A1
公开(公告)日：1999-12-16
申请号：PCT/US1999/012620
申请日：1999-06-08
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y02A50/401 , Y02A50/57 , Y10S530/807
摘要： Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate or enzyme cofactor thereby modulating the biological processes/functions thereof.
摘要翻译：公开了调节酶过程的新型多结合化合物。本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合酶，酶底物或酶辅因子，从而调节其生物学过程/功能。

37. 发明申请

WO9963937A2 MULTIVALENT MACROLIDE ANTIBIOTICS 审中-公开
标题翻译：多功能抗体抗体
公开(公告)号：WO9963937A2
公开(公告)日：1999-12-16
申请号：PCT/US9912771
申请日：1999-06-08
申请人： ADVANCED MEDICINE INC , GRIFFIN JOHN H , PACE JOHN L
发明人： GRIFFIN JOHN H , PACE JOHN L
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00 , A61K
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y10S530/807
摘要： Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.
摘要翻译：公开了包括大肠杆菌素抗生素，氨基糖苷类，林可素，恶唑烷酮，链霉素，四环素和/或其它结合细菌核糖体RNA的化合物和/或涉及细菌中的核糖体蛋白质合成的一种或多种蛋白质的多结合化合物，其可用于治疗细菌感染。这些化合物对蛋白质表达有不利影响，具有抗菌作用。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每种配体是大环内酯类抗生素，氨基糖苷，林可素，恶唑烷酮，链霉素，四环素或与细菌核糖体RNA结合的其他化合物和/或参与细菌中核糖体蛋白质合成的一种或多种蛋白质。

38. 发明申请

WO98057612A1 COMPOSITE MATERIALS AND ADHESION PROMOTERS FOR DENTAL APPLICATIONS 审中-公开
标题翻译：用于牙科应用的复合材料和粘合促进剂
公开(公告)号：WO98057612A1
公开(公告)日：1998-12-23
申请号：PCT/US1998/012715
申请日：1998-06-18
IPC分类号： A61K6/00 , A61K6/04 , A61K6/08 , A61K6/083 , C07C321/18 , C07C323/12 , C08K3/08 , C08K3/22 , C08K9/00 , C08L101/00 , C08K3/10 , C08K5/37
CPC分类号： C08K3/22 , A61K6/0073 , A61K6/046 , A61K6/083 , C07C321/18 , C07C323/12 , C08K3/08 , C08L43/02 , C08L33/00
摘要： Composite materials particularly suitable in the dental art as a tooth filling material including a polymer matrix, a metal, metal alloy, metal oxide particulate, or combinations thereof, in the presence or obsence of colloidal silica, and a coupling agent to adhere the particulate to the polymer matrix. Adhesion can also be facilitated by cleaning and/or coating the particulates prior to incorporation into the polymer matrix. One or two paste systems of the composition with suitable initiators, accelerators, etc. can be formulated.
摘要翻译：在胶体二氧化硅的存在或有意义下，特别适合作为牙齿填充材料的复合材料，包括聚合物基质，金属，金属合金，金属氧化物颗粒或其组合，以及将颗粒粘附到聚合物基质。通过在掺入聚合物基质之前清洁和/或涂覆颗粒也可以促进粘附。可以配制具有合适的引发剂，促进剂等的组合物的一种或两种糊状体系。

39. 发明申请

WO98042661A1 AROMATIC AND HETEROCYCLIC NITRATO DERIVATIVES 审中-公开
标题翻译：芳香和杂环NITRATO衍生物
公开(公告)号：WO98042661A1
公开(公告)日：1998-10-01
申请号：PCT/IL1998/000144
申请日：1998-03-26
IPC分类号： A61K31/21 , A61K31/222 , A61K31/385 , A61K31/426 , A61K31/4365 , A61K31/44 , A61P9/08 , A61P9/10 , C07C321/10 , C07C321/28 , C07C323/12 , C07C323/19 , C07C323/20 , C07C323/56 , C07C323/62 , C07C327/32 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/82 , C07D277/14 , C07D277/20 , C07D277/56 , C07D339/04 , C07D339/08 , C07D495/04 , C07C323/42 , C07D213/62 , C07D213/78 , C07D277/06 , C07D327/06 , C07D339/02 , C07D401/12 , C07D471/04 , C07D487/04
CPC分类号： C07D213/70 , C07C323/12 , C07C323/19 , C07C323/56 , C07C323/62 , C07C327/32 , C07D213/80 , C07D213/82 , C07D277/14 , C07D339/04 , C07D339/08 , C07D495/04
摘要： An organic compound is provided which contains at least one nitric oxide donor group and at least one group being, or being adapted to be converted in vivo to a free sulfhydryl group. A preferred compound contains at least one sulfhydryl group, either in the reduced -SH form or in the oxidized -S-S-disulfide form.
摘要翻译：提供了一种有机化合物，其含有至少一个一氧化氮供体基团和至少一个基团，或适于在体内转化为游离巯基。优选的化合物含有至少一个以还原-SH形式或氧化的-S-S-二硫化物形式的巯基。

40. 发明申请

WO8809804A3 ANTI-OXIDANT COMPOSITIONS 审中-公开
标题翻译：抗氧化剂组合物
公开(公告)号：WO8809804A3
公开(公告)日：1989-03-09
申请号：PCT/US8801905
申请日：1988-06-01
申请人： LUBRIZOL CORP
发明人： SALOMON MARY F
IPC分类号： C07D277/72 , C07C321/14 , C07C321/28 , C07C323/12 , C10M135/22 , C10M135/24 , C10M135/28 , C10M135/30 , C10M135/36 , C10M151/04 , C10M159/12 , C10M173/02 , C10N30/10 , C10N40/04 , C10N40/08 , C07C149/18 , C10M135/00 , C10M135/20
CPC分类号： C10M135/30 , C10M135/24 , C10M135/36 , C10M151/04 , C10M173/02 , C10M2201/02 , C10M2215/064 , C10M2219/084 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2219/108 , C10M2221/02 , C10M2221/04 , C10M2221/041 , C10M2221/043 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/046 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106 , C10N2250/02
摘要： The present invention deals with compositions containing sulfur and oxygen which are useful in lubricants and automatic transmission fluids.

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