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    • 2. 发明申请
    • PROCESS FOR THE PREPARATION OF AMINES
    • 胺的制备方法
    • WO2007068417A2
    • 2007-06-21
    • PCT/EP2006/011885
    • 2006-12-11
    • SYNGENTA PARTICIPATIONS AGTOBLER, HansWALTER, HaraldCORSI, CamillaEHRENFREUND, JosefGIORDANO, FannyZELLER, Martin
    • TOBLER, HansWALTER, HaraldCORSI, CamillaEHRENFREUND, JosefGIORDANO, FannyZELLER, Martin
    • C07C209/28A01N45/02C07C211/31
    • C07C209/62C07B2200/09C07C17/23C07C17/30C07C17/354C07C25/22C07C25/24C07C209/10C07C209/70C07C211/61C07C2603/66C07C23/10
    • The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R 1 and R 2 are independently H or C 1-6 alkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein R 1 and R 2 have the meanings given for the compound of the formula (I), R 3 is H or C 1-4 alkyl and Ph is phenyl, or a compound of the general formula (III), wherein R 1 , R 2 , R 3 and Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R 3 )- from the benzylamino moiety PhCH(R 3 )NH- in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2,3-double bond and the double bond joining the R 1 R 2 C- moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides.
    • 本发明涉及一种制备通式(I)的化合物的方法,其中R 1和R 2如上所述, 该方法包括用还原剂处理通式(II)的化合物,其中R 1和R 1不是氢原子或C 1-6烷基, (I)化合物给出含义,R 3为H或C 1-4烷基且Ph为苯基或 通式(III)的化合物,其中R 1,R 2,R 3和Ph具有以下化合物给出的含义:其中R 1,R 2, 式(II)的还原剂可有效地从苄基氨基部分PhCH(R 3)NH-中裂解苄基部分Ph-CH(R 3) 式(II)化合物或在式(III)化合物中留下氨基,另外,在式(III)化合物的情况下,还原2,3-双 债券和双键joini 将R 1 2 R 2 C-部分转移至苯并降冰片烯环的9-位成为单键。 它还涉及制备化合物(II)和(III)及其前体和化合物(II)和(III)本身及其某些前体(它们是新化合物)的方法。 化合物(I)可用于制备各种杀真菌的杂环基 - 羧酸苯并降冰片烷-5-基 - 酰胺。
    • 3. 发明申请
    • N-SULPHONYL AND N-SULPHINYL AMINO ACID DERIVATIVES AS MICROBICIDES
    • 作为微生物的N-磺酰基和N-磺酰氨基酸衍生物
    • WO1997014677A1
    • 1997-04-24
    • PCT/EP1996004349
    • 1996-10-07
    • NOVARTIS AGZELLER, Martin
    • NOVARTIS AG
    • C07C311/06
    • C07C311/06A01N41/06C07C307/06
    • alpha -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 is C3-C8cycloalkyl; a C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl group substituted by one or more halogen atoms; or a group (a) wherein p and q are identical or different and are each independently of the other the number zero or one; and R13, R14, R15 and R16 are identical or different and are each independently of the others hydrogen or C1-C4alkyl; and X is hydrogen, in which case p and q must have the value zero; phenyl unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, carboxy, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C3-C6alkenyloxy, C3-C6alkynyloxy, C3-C7cycloalkyl, C1-C6haloalcoxy, C1-C6alkylthio, C1-C6alcoxycarbonyl, C3-C6alkenyloxycarbonyl, C3-C6alkynyloxycarbonyl, C1-C6alkyl or by C1-C6alkoxy; cyano; -COOR17; -COR18 or a group (b) wherein R17 and R21 are each independently of the other hydrogen, C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl, and R18 is hydrogen; C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl or phenyl, unsubstituted or substituted by halogen, nitro, cyano, C1-C4alkyl or by C1-C4alkoxy, and R19 and R20 are identical or different and are each independently of the other hydrogen or C1-C4alkyl, are valuable microbicides. They can be used in plant protection in the form of suitable compositions, for example in the control of fungal diseases.
    • 式(I)的α-氨基酰胺,其中取代基定义如下:n是数字0或1; R1至R7如本文所定义; R8是C1-C6烷基,C3-C6链烯基或C3-C6炔基; R9为C3-C8环烷基; 被一个或多个卤素原子取代的C 1 -C 6烷基,C 3 -C 6烯基或C 3 -C 6炔基; 或其中p和q相同或不同并且各自独立于数字零或一个的基团(a); R 13,R 14,R 15和R 16相同或不同,各自独立地为氢或C 1 -C 4烷基; 并且X是氢,在这种情况下,p和q必须具有零值; 未被取代或被卤素,硝基,氰基,羧基,C 2 -C 6烯基,C 2 -C 6炔基,C 1 -C 6卤代烷基,C 3 -C 6烯氧基,C 3 -C 6炔氧基,C 3 -C 7环烷基,C 1 -C 6卤代烷氧基,C 1 -C 6烷硫基, C 1 -C 6烷氧基羰基,C 3 -C 6烯氧基羰基,C 3 -C 6炔氧基羰基,C 1 -C 6烷基或C 1 -C 6烷氧基; 氰基; -COOR17; -COR 18或其中R 17和R 21各自独立地为其它氢,C 1 -C 6烷基,C 3 -C 6烯基或C 3 -C 6炔基的基团(b),R 18为氢; C 1 -C 6烷基,C 2 -C 6烯基,C 2 -C 6炔基或苯基,未被取代或被卤素,硝基,氰基,C 1 -C 4烷基或C 1 -C 4烷氧基取代,R 19和R 20相同或不同,各自独立地为氢或 C1-C4烷基是有价值的杀菌剂。 它们可以以合适的组合物的形式用于植物保护,例如用于控制真菌疾病。
    • 6. 发明申请
    • PROCESS
    • 处理
    • WO2007020381A2
    • 2007-02-22
    • PCT/GB2006/002946
    • 2006-08-08
    • SYNGENTA PARTICIPATIONS AGBOWDEN, Martin, CharlesCLARK, Thomas, AitchesonGIORDANO, Fanny, Delphine, BrigtteJAU, BeatSCHNEIDER, Hans-DieterSEIFERT, GottfriedWISS, JuergZELLER, MartinFABER, Dominik
    • BOWDEN, Martin, CharlesCLARK, Thomas, AitchesonGIORDANO, Fanny, Delphine, BrigtteJAU, BeatSCHNEIDER, Hans-DieterSEIFERT, GottfriedWISS, JuergZELLER, MartinFABER, Dominik
    • C07C231/02C07C235/34C07C59/70C07C43/174C07C43/313
    • C07C231/12C07C33/46C07C59/70C07C69/734C07C213/02C07C235/34C07C251/16C07C255/37C07C315/04C07C319/20C07C317/46C07C323/62
    • A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R 1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R 1 and n are as hereinbefore defined; m and m' are independently 0 or 1; when m and m' are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C 1-4 dialkylamino or cyano; when one of m and m' is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C 1-4 dialkylamino or cyano; when m and m' are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C 1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R 1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with , wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.
    • 一种制备式(I)化合物的方法,其中:R是炔基; R 1是烷基,烯基,炔基,环烷基,环烷基 - 烷基,苯基和苯基烷基,所有后退基团依次可以携带一个或多个相同或不同的卤素原子; 烷氧基; 烯; 炔; 烷氧基; 卤代烷氧基; 烷; 卤代烷; alkysulfonyl; 甲酰基; 烷; 羟基; 卤素; 氰基; 硝基; 氨基; 烷基; 二烷基; 羧基; 烷; 链烯基氧基; 或炔氧基羰基; 并且n为0至3的整数,所述方法包括:(i)其中R,R 1和N 2如上定义的式(III)化合物的反应; m和m'独立地为0或1; 当m和m'均为0时,A为任选被一个或多个独立地选自卤素,羟基,烷氧基,C 1 -C 6烷氧基的烷基,烯基或炔基(适宜地具有至多8个碳原子) 4个二烷基氨基或氰基; 当m和m'中的一个是0而另一个是1时,A是含有至少两个碳原子(并且合适地具有至多8个碳原子)的烷二基,亚烯基或炔二基,任选被一个或多个独立选择的基团取代 卤素,羟基,烷氧基,C 1-4烷基氨基或氰基; 当m和m'均为1时,A是含有至少三个碳原子(并且合适地具有至多8个碳原子)的烷三基,亚烷基三炔或炔三基,任选地被一个或多个独立地选自卤素,羟基,烷氧基 C 1-4烷基氨基或氰基; 并且其中如果基团A含有三个或更多个碳原子,一个或多个碳原子可以各自任选被氧原子替代,条件是分子中任何两个氧原子之间至少有一个碳原子, 得到式(II)化合物,其中R,R 1和n如上所定义,和(ii)式(II)化合物与式 其中L是离去基团,得到如上文所定义的式(I)化合物。
    • 7. 发明申请
    • GLASBAUELEMENT MIT EINER TRÄGERPLATTE AUS GLAS
    • 与载体平板玻璃玻璃成分
    • WO2004033198A1
    • 2004-04-22
    • PCT/EP2003/050696
    • 2003-10-06
    • NEW DESIGN PRODUCT DEVELOPMENT "DPD" ZELLER & STEINDL OEGZELLER, MartinSTEINDL, Roman
    • ZELLER, MartinSTEINDL, Roman
    • B32B17/06
    • B32B17/10247B32B17/10311E06B3/6604F24S10/40F24S20/66F24S23/00F24S80/52Y02B10/22Y02E10/44
    • Ein Glasbauelement (1, 1') umfasst eine Trägerplatte (2), einen um die Trägerplatte (2) rundumlaufenden Distanzsteg (3) und mindestens eine Deckplatte (7). Auf der Trägerplatte (2) ist eine Beschichtung (6) aus Glasbruchstücken (4), die durch ein Fixiermittel (5) gebunden sind, aufgetragen. Die Beschichtung (6) bildet einen glasklaren Überzug über die Glasbruchstücke (4), trägt einerseits zum Lichtbrechungseffekt bei und bewirkt eine meist punktuelle Verbindung der Glasbruchstücke (4), die den Zwischenraum zwischen der Trägerplatte (2) und der Deckplatte (7) weitgehend ausfüllen. Zum Zwecke der Brandschutzausrüstung kann das Fixiermittel (5) ein Wasserglas, insbesondere eine wässerige Natrium-, Kalium- oder Lithiumsilikatlösung sein. Ergänzend können noch Rohroder Schlauchleitungen (11) zwischen Trägerplatte (2) und Deckplatte (7), vorzugsweise eingebettet in der Beschichtung (6), vorgesehen sein. Diese Leitungen sind in ein Heiz- und bzw. oder Kühlsystem als Wärmetauscher allenfalls auch zur Energiegewinnung eingebunden.
    • 的玻璃元件(1,1“)包括支撑板(2),围绕所述支撑板围绕旋转(2)间隔件横档(3)和至少一个盖板(7)。 在支承板(2)是通过固定装置(5)连接,施加的玻璃碎片(4)的涂层(6)。 该涂层(6)形成在所述的玻璃碎片(4)上,一方面担负着在光折射效果的清澈的涂层并引起碎片玻璃的最有选择性的连接(4),其基本上填充承载板之间的中间空间(2)和盖板(7) , 用于消防设备的目的,该固定装置(5)可以是水玻璃,特别是水性钠,钾或硅酸锂溶液。 承载板(2)和盖板之间的互补仍然管道或软管(11)(7),优选地嵌入在(6),来提供该涂层。 这些行是在加热和冷却系统,或作为一个热交换器或可能还包括用于能量。
    • 9. 发明申请
    • NOVEL N-BISARYL- AND N-ARYL-CYCLOALKYLIDENYL-$G(a)-SULFIN- AND $G(a)-SULFONAMINO ACID AMIDES
    • 新型N-双 - 和N-芳基 - 环己基-L-甘氨酸G(a)-SULFIN-和DOLLAR G(a) - 磺酰氨基酸
    • WO2003002525A1
    • 2003-01-09
    • PCT/EP2002/007027
    • 2002-06-25
    • SYNGENTA PARTICIPATIONS AGJEANGUENAT, AndréLAMBERTH, ClemensZELLER, Martin
    • JEANGUENAT, AndréLAMBERTH, ClemensZELLER, Martin
    • C07C311/06
    • A01N41/06A01N55/00C07C307/06C07C311/06C07C2601/14C07F7/1852
    • The invention relates to novel pesticidally active N-bisaryl- and N-aryl-cycloalkylidenyl-α-sulfin- and α-sulfonamino acid amides of the general formula I, including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R 1 is C 1 -C 12 alkyl; C 1 -C 12 alkyl substituted with C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfonyl, C 3 -C 8 cycloalkyl, cyano, C 1 -C 6 alkoxycarbonyl, C 3 -C 6 alkoxycarbonyl, C 3 -C 6 alkenyloxycarbonyl or C 3 -C 6 alkynyloxycarbonyl; C 2 -C 12 alkenyl; C 2 -C 12 alkynyl; C 1 -C 12 haloalkyl; or a group NR 11 R 12 wherein R 11 and R 12 are each independently of the other C 1 -C 6 alkyl, or together are tetra- or penta-methylene; R 2 and R 3 ae each independently hydrogen; C 1 -C 8 alkyl; C 1 -C 8 alkyl substituted with hydroxy, mercapto, C 1 -C 4 alkoxy or C 1 -C 4 alkylthio; C 3 -C 8 alkenyl; C 3 -C 8 alkynyl; C 3 -C 8 cycloalkyl; C 3 -C 8 cycloalkyl-C 1 -C 4 alkyl; optionally substituted aryl; optionally substituted heteroaryl; or the two groups R 2 and R 3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; A is an optionally substituted saturated or unsaturated C 3 -C 8 -cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R 4 and R 5 are each independently hydrogen or an organic radicak, and R 6 is hydrogen; tri-C 1 -C 4 alkyl-silyl; di-C 1 -C 4 alkyl-phenysilyl; C 1 -C 4 alkyl-diphenylsilyl; tri-phenylsilyl; optionally subsituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl. The novel compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytophathogenic microorganisms.
    • 本发明涉及通式I的新型农药活性N-二芳基 - 和N-芳基 - 环丙烯基-α-亚磺酰基和α-磺酰氨基酸酰胺,包括其旋光异构体和这些异构体的混合物,其中n是数 零或一; R1是C1-C12烷基; 被C 1 -C 4烷氧基,C 1 -C 4烷硫基,C 1 -C 4烷基磺酰基,C 3 -C 8环烷基,氰基,C 1 -C 6烷氧基羰基,C 3 -C 6烷氧基羰基,C 3 -C 6烯氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C2--C 12烯; C2-C12alkynyl; C1-C12haloalkyl; 或NR 11 R 12基团,其中R 11和R 12各自独立地为C 1 -C 6烷基,或一起为四或五亚甲基; R2和R3各自独立地为氢; C1-C8烷基; 被羟基,巯基,C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8烯基; C3-C8炔; C3-C8环烷基; C3-C8环烷基-C1-C4烷基; 任选取代的芳基; 任选取代的杂芳基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; A是任选取代的饱和或不饱和的C 3 -C 8 - 亚环烷基,任选取代的亚苯基或任选取代的饱和或不饱和杂环亚烷基桥,R 4和R 5各自独立地为氢或有机基,R 6为氢; 三C1-C4烷基甲硅烷基; 二C1-C4烷基,phenysilyl; C1-C4烷基 - 二苯基甲硅烷; 三苯基甲硅烷基; 任选取代的烷基; 任选取代的烯基或任选取代的炔基。 新化合物具有植物保护性质,适用于保护植物免受植物致病性微生物的侵袭。