专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016149232A1 FREEZE STABLE TETRAKIS(HYDROXYMETHYL) PHOSPHONIUM SULFATE FORMULATIONS 审中-公开
标题翻译：冻结稳定的四氯化钛（羟甲基）硫酸磷酸盐配方
公开(公告)号：WO2016149232A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022408
申请日：2016-03-15
申请人： ROHM AND HAAS COMPANY
发明人： STEPHENS, Randall W. , WARWICK, Eileen F.
IPC分类号： A01N57/34 , A01N25/02 , A01P1/00
CPC分类号： A01N25/02 , A01N57/34
摘要： A composition comprising: (a) tetrakis(hydroxymethyl)phosphonium sulfate (THPS); (b) water; and (c) 1,2-propanediol; wherein the weight percentages of (a), (b) and (c) are within the area on a ternary phase diagram for (a), (b) and (c) bounded by five points: (A) 20% THPS/40% water/40% 1,2-propanediol; (B) 20% THPS/20% water/60% 1,2-propanediol; (C) 65% THPS/22% water/13% 1,2-propanediol; (D) 65% THPS/25% water/10% 1,2-propanediol; and (E) 40% THPS/28% water/32% 1,2-propanediol.
摘要翻译：一种组合物，其包含：（a）四（羟甲基）硫酸鏻（THPS）; （b）水; 和（c）1,2-丙二醇; （a），（b）和（c）的重量百分比在（a），（b）和（c）的三元相图上的区域内，以五点为界：（A）20％THPS / 40 ％水/ 40％1,2-丙二醇; （B）20％THPS / 20％水/ 60％1,2-丙二醇; （C）65％THPS / 22％水/ 13％1,2-丙二醇; （D）65％THPS / 25％水/ 10％1,2-丙二醇; 和（E）40％THPS / 28％水/ 32％1,2-丙二醇。

2. 发明申请

WO2010105872A3 STABILIZED BIOCIDAL COMPOSITION 审中-公开
标题翻译：稳定的生物组合物
公开(公告)号：WO2010105872A3
公开(公告)日：2011-11-24
申请号：PCT/EP2010051194
申请日：2010-02-01
申请人： RHODIA OPERATIONS , JONES CHRIS , EDMUNDS STEPHANIE , FELLOWS ALAN
发明人： JONES CHRIS , EDMUNDS STEPHANIE , FELLOWS ALAN
IPC分类号： A01P1/00 , A01N25/22 , A01N33/12 , A01N37/44 , A01N37/46 , A01N57/34 , C02F1/50
CPC分类号： C02F1/50 , A01N57/20 , A01N57/34 , C02F5/10 , C02F2103/365 , C02F2303/04 , A01N25/22 , A01N2300/00
摘要： The current invention relates to a process for stabilising a phosphorus-containing compound aqueous composition, comprising the step of adding to said composition an efficient arsenic stabilizing amount of a compound selected from the group consisting of ammonia, ammonium salt, organic amino acid, peptide and polypeptide; application of the stabilized composition for treating an aqueous system optionally containing or in contact with metal sulphide scale, which method comprises adding to said system, separately or together, an efficient anti-scale amount of a stabilized aqueous composition or for treating a water system to kill or inhibit the growth of micro organisms comprising applying thereto or forming in situ an efficient inhibiting amount of the stabilized aqueous composition.
摘要翻译：本发明涉及稳定含磷化合物水性组合物的方法，其包括向所述组合物中加入有效的砷稳定量的选自氨，铵盐，有机氨基酸，肽和多肽; 用于处理任选地含有或与金属硫化物垢接触的水性体系的稳定化组合物的应用，该方法包括向所述体系中分别或一起加入稳定的水性组合物的有效抗垢量或用于将水系统处理杀死或抑制微生物的生长，包括施用于其上或在原位形成有效抑制量的稳定的水性组合物。

3. 发明申请

WO2010100470A2 IMPROVEMENTS IN AND RELATING TO BIOCIDAL COMPOSITIONS 审中-公开
标题翻译：对生物组合物的改善和相关
公开(公告)号：WO2010100470A2
公开(公告)日：2010-09-10
申请号：PCT/GB2010/050342
申请日：2010-02-26
申请人： BWA WATER ADDITIVES UK LIMITED , KRAMER, Jeffrey , PATEL, Suresh , GASCOIGNE, Sylvie
发明人： KRAMER, Jeffrey , PATEL, Suresh , GASCOIGNE, Sylvie
IPC分类号： A01N57/34
CPC分类号： D21C9/08 , A01N57/34 , C02F1/50 , D21H21/36 , F28F2265/20 , A01N25/10 , A01N33/12 , A01N2300/00
摘要： Embodiments of the present subject matter provide a biocidal composition comprising an aqueous mixture of (a) a phosphonium compound and (b) a polymeric ammonium compound, wherein the weight ratio of compound (a) to compound (b) is from 0.2:1 to 20:1, and wherein the phosphonium compound (a) has a given formula and the polymeric ammonium compound (b) comprises a given repeat unit.
摘要翻译：本发明的实施方案提供了包含（a）鏻化合物和（b）聚合铵化合物的水性混合物的杀生物组合物，其中化合物（a）与化合物（b）的重量比为0.2:1至 20：1，其中鏻化合物（a）具有给定的式，并且聚合铵化合物（b）包含给定的重复单元。

4. 发明申请

WO2004035666A3 ANTIMICROBIAL ELASTOMERS 审中-公开
标题翻译：抗微生物弹性体
公开(公告)号：WO2004035666A3
公开(公告)日：2004-05-27
申请号：PCT/EP0309421
申请日：2003-08-26
申请人： CREAVIS TECH & INNOVATION GMBH , OTTERSBACH PETER
发明人： OTTERSBACH PETER
IPC分类号： A01N25/10 , A01N25/34 , A01N33/04 , A01N37/12 , A01N37/20 , C08F291/00 , C08F293/00 , C08F297/00 , C08J7/04 , C08L21/00 , C08L33/00 , C08L53/00 , C08L53/02 , C08L101/00 , C09D153/00 , C09D153/02 , A01N33/12 , A01N57/34 , C08F220/02 , C09D133/00
CPC分类号： C09D153/00 , A01N25/10 , A01N25/34 , A01N33/04 , A01N37/12 , A01N37/20 , C08F291/00 , C08F293/005 , C08F297/00 , C08J7/047 , C08L21/00 , C08L33/00 , C08L53/00 , C08L53/02 , C08L101/00 , C09D153/02 , A01N2300/00 , C08L2666/04 , C08L2666/02
摘要： The invention relates to antimicrobial rubber-like systems, in particular those for coming into contact with fresh or feed water.
摘要翻译：本发明涉及抗菌橡胶体系，特别是与新鲜或服务用水接触的那些。

5. 发明申请

WO02080939A3 IONENE POLYMERS AND THEIR USE AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：离子聚合物及其作为抗微生物剂
公开(公告)号：WO02080939A3
公开(公告)日：2003-10-09
申请号：PCT/US0201450
申请日：2002-01-17
申请人： GENZYME CORP
发明人： FITZPATRICK RICHARD , KLINGER JEFFREY D , SHACKETT KEITH K
IPC分类号： A01N25/10 , A01N33/12 , A01N47/44 , A01N57/34 , A61K31/74 , A61K31/785 , A61K31/787 , A61K31/80 , A61P1/00 , A61P1/02 , A61P31/04 , C08G61/12 , C08G73/00 , C08G73/02 , C08G73/06 , C08G79/06 , C08G79/00 , C08L79/00 , C08L85/00
CPC分类号： C08G73/0627 , A61K31/74 , A61K31/785 , A61K31/787 , A61K31/80 , C08G61/12 , C08G73/00 , C08G73/0226
摘要： Disclosed are ionene polymers having antimicrobial activity. "Ionene polymers" as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting suchsurface with a composition of the invention.
摘要翻译：公开了具有抗微生物活性的紫罗烯聚合物。本发明中使用的“紫罗烯聚合物”是阳离子聚合物，其中提供正电荷的大部分原子是位于聚合物的主聚合物链或骨架中而不是侧基的季铵化氮。还公开了包含紫罗烯聚合物和用于治疗哺乳动物微生物感染的方法的抗微生物组合物，其包括向哺乳动物施用治疗有效量的本发明的至少一种抗微生物组合物的步骤。还公开了包含至少一种紫罗烯聚合物的抗微生物组合物和用于预防，抑制或消除微生物在易感表面上的生长，扩散和/或积累的方法（包括但不限于在易感的表面上形成生物膜包括使这种表面与本发明的组合物接触的步骤。

6. 发明申请

WO02030198A1 SEED DISINFECTANTS 审中-公开
标题翻译：种子消毒剂
公开(公告)号：WO02030198A1
公开(公告)日：2002-04-18
申请号：PCT/JP2000/006991
申请日：2000-10-06
IPC分类号： A01N57/34 , A01N43/36 , A01N43/50 , A01N43/653 , A01N47/38 , A01N57/20
CPC分类号： A01N57/34 , A01N47/38 , A01N43/653 , A01N43/50 , A01N43/36 , A01N2300/00
摘要： Seed disinfectants with which seed-infectious mould diseases and bacterial diseases can be controlled at the same time. These seed disinfectants contain as the active ingredients at least one member selected from the group consisting of 2-(4-chlorobenzyl)-5-isopropyl-1-(1H-1,2,4-tiazol-1-ylmethyl)-1-cyclopentanol, (E)-4-chloro- alpha , alpha , alpha -trifluoro-N-(1-imidazol-1-yl-2-propoxyethylidene)-o-toluidine, penta-4-enyl-N-furfuryl-N-imidazol-1-ylcarbonyl-DL-homoalaninate, N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazol-1-carboxamide, 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile, etc. and a tetrakis(hydroxymethyl)phosphonium salt.
摘要翻译：可同时控制种子感染性霉菌病和细菌性疾病的种子消毒剂。这些种子消毒剂含有作为活性成分的至少一种选自2-（4-氯苄基）-5-异丙基-1-（1H-1,2,4-噻唑-1-基甲基）-1- 环戊醇，（E）-4-氯-α，α，α-三氟-N-（1-咪唑-1-基-2-丙氧基亚乙基） - 对甲苯胺，五-4-烯基-N-糠基-N- 咪唑-1-基羰基-DL-高丙氨酸盐，N-丙基-N- [2-（2,4,6-三氯苯氧基）乙基]咪唑-1-甲酰胺，4-（2,2-二氟-1,3-苯并间 -4-基）吡咯-3-腈等，和四（羟甲基）鏻盐。

8. 发明申请

WO9964054A9 MULTIBINDING INHIBITORS OF TOPOISOMERASE 审中-公开
标题翻译：多重抑制剂的多重抑制剂
公开(公告)号：WO9964054A9
公开(公告)日：2000-03-02
申请号：PCT/US9912908
申请日：1999-06-08
申请人： ADVANCED MEDICINE INC , LINSELL MARTIN S , MEIER DAVIS SUSAN , GRIFFIN JOHN H
发明人： LINSELL MARTIN S , MEIER-DAVIS SUSAN , GRIFFIN JOHN H
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00 , C07G11/00
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y10S530/807
摘要： Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligant is capable of binding to a topoisomerase and the distance between ligands is between about 2-50 ANGSTROM . The multibinding compounds of this invention are useful in the treatment and prevention of cancer, microbial infections and the like.
摘要翻译：公开了抑制作为DNA复制和修复的较高密码子中必需酶的拓扑异构酶的多结合化合物。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每个结合物能够结合拓扑异构酶，并且配体之间的距离在约2-50埃之间。本发明的多重联结化合物可用于治疗和预防癌症，微生物感染等。

9. 发明申请

WO99064037A1 NOVEL THERAPEUTIC AGENTS THAT MODULATE ENZYMATIC PROCESSES 审中-公开
标题翻译：调节酶工艺的新型治疗剂
公开(公告)号：WO99064037A1
公开(公告)日：1999-12-16
申请号：PCT/US1999/012620
申请日：1999-06-08
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y02A50/401 , Y02A50/57 , Y10S530/807
摘要： Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate or enzyme cofactor thereby modulating the biological processes/functions thereof.
摘要翻译：公开了调节酶过程的新型多结合化合物。本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合酶，酶底物或酶辅因子，从而调节其生物学过程/功能。

10. 发明申请

WO9963937A2 MULTIVALENT MACROLIDE ANTIBIOTICS 审中-公开
标题翻译：多功能抗体抗体
公开(公告)号：WO9963937A2
公开(公告)日：1999-12-16
申请号：PCT/US9912771
申请日：1999-06-08
申请人： ADVANCED MEDICINE INC , GRIFFIN JOHN H , PACE JOHN L
发明人： GRIFFIN JOHN H , PACE JOHN L
IPC分类号： C07D499/44 , A01N57/34 , A61K31/00 , A61K31/357 , A61K31/397 , A61K31/407 , A61K31/421 , A61K31/424 , A61K31/431 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/522 , A61K31/536 , A61K31/5377 , A61K31/546 , A61K31/551 , A61K31/65 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61K51/00 , A61P31/04 , A61P31/18 , A61P43/00 , C07B61/00 , C07C233/36 , C07C233/78 , C07C237/24 , C07C237/26 , C07C271/20 , C07C275/42 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07D207/32 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D263/28 , C07D265/18 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D453/02 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D477/00 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D498/18 , C07D501/20 , C07D519/00 , C07H15/236 , C07H15/238 , C07H15/26 , C07H17/08 , C07H19/06 , C07H19/20 , C07K2/00 , C07K4/00 , C12N9/99 , C12P19/38 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B30/04 , C40B40/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/573 , G01N33/68 , G01N33/92 , G01N37/00 , A61K
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y10S530/807
摘要： Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.
摘要翻译：公开了包括大肠杆菌素抗生素，氨基糖苷类，林可素，恶唑烷酮，链霉素，四环素和/或其它结合细菌核糖体RNA的化合物和/或涉及细菌中的核糖体蛋白质合成的一种或多种蛋白质的多结合化合物，其可用于治疗细菌感染。这些化合物对蛋白质表达有不利影响，具有抗菌作用。含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。每种配体是大环内酯类抗生素，氨基糖苷，林可素，恶唑烷酮，链霉素，四环素或与细菌核糖体RNA结合的其他化合物和/或参与细菌中核糖体蛋白质合成的一种或多种蛋白质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式