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31. 发明申请

WO0244746A2 PREPARATORY PULSE SEQUENCE FOR SUPPRESSION OF ARTIFACTS IN MR IMAGES 审中-公开
标题翻译：用于抑制MR图像中的伪影的准备脉冲序列
公开(公告)号：WO0244746A2
公开(公告)日：2002-06-06
申请号：PCT/US0150928
申请日：2001-10-22
申请人： GE MED SYS GLOBAL TECH CO LLC
发明人： MA JINGFEI
IPC分类号： G01R33/48 , A61B5/055 , G01R33/483 , G01R33/54 , G01R33/44
CPC分类号： G01R33/4838 , G01R33/4828
摘要： Image artifacts produced by NMR signals emanating from outside the designed spherical volume (10) in an MRI system are suppressed by interleaving preparatory pulse sequences with image pulse sequences performed during a scan. Each preparatory pulse sequence includes a pair of RF pulses (200, 204) having equal, but opposite flip angles. Spins in the image field of view are tipped and then restored by the pair of RF pulses (200, 204) and spins outside the designed spherical volume (10) are saturated.
摘要翻译：通过在扫描期间将预备脉冲序列与图像脉冲序列交错来抑制由MRI系统中设计的球形体积（10）外部发出的NMR信号产生的图像伪影。每个预备脉冲序列包括具有相等但相反翻转角的一对RF脉冲（200,204）。图像视场中的自旋被倾斜，然后被一对RF脉冲（200,204）恢复，并且设计的球形体积（10）外部的自旋被饱和。

32. 发明申请

WO1989011822A1 SEPARATIVE IMAGING METHOD FOR WATER AND FAT BY MRI 审中-公开
标题翻译：用于水和脂肪的分离成像方法
公开(公告)号：WO1989011822A1
公开(公告)日：1989-12-14
申请号：PCT/JP1989000542
申请日：1989-05-31
申请人： YOKOGAWA MEDICAL SYSTEMS, LTD. , INOUE, Yuji
发明人： YOKOGAWA MEDICAL SYSTEMS, LTD.
IPC分类号： A61B05/05
CPC分类号： G01R33/4828 , G01R33/485
摘要： A separative imaging is provided to obtain separate images of water and fat using quantitative MRI while eliminating separation error caused by non-uniform magnetic field. When a spin echo signal is received, there are carried out the S0 scanning in which the phases of magnetization vectors of water and fat are in agreement with each other, the S1 scanning in which the phases of magnetization vectors are different by 180° and the S2 scanning in which the phases of magnetization vectors are different by 90°. A quantitative difference between water and fat is calculated from the image data of the S1 and S2 scannings, and a separation image of water and fat is obtained from the absolute value images of the S0 and S1 scannings. According to the invention which uses absolute value images of the S0 and S1 scannings, there does not develop any separation error caused by deviation in the phase that stems from non-uniform magnetic field. Further, the phase term due to non-uniform static magnetic field is removed and a quantitative difference between water and fat is calculated based on the image data of the S1 and S2 scannings. Water and fat component are identified for the separation images found from the absolute value data.

33. 发明申请

WO2018166844A1 MRI INVOLVING REGULARIZING THE PHASE OF MRI DATA AND/OR WATER/FAT-DECOMPOSITION 审中-公开
公开(公告)号：WO2018166844A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/055486
申请日：2018-03-06
申请人： UNIVERSITÄTSSPITAL BASEL , KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITÄT MÜNCHEN
发明人： BIERI, Oliver , GANTER, Carl
IPC分类号： G01R33/48 , G01R33/565
CPC分类号： G01R33/4828 , G01R33/56545
摘要： A post-processing method for regularizing the phase information of magnetic resonance (MR) related imaging data is provided. According to this method the values of a first phase information map obtained from at least one MR image are used for the calculation of a regularized second phase information map. In doing so, the values of the second phase information map are represented by a truncated Fourier expansion with coefficients that are determined from the first phase information map by means of a least squared minimization. In a further aspect, the invention provides a method for water/fat- decomposition of multi-echo MRI data, wherein a maximum likelihood estimation is made by means of minimizing a function chi square for determining the complex water and fat signal amplitudes a and b of the water and the fat signal, respectively, wherein the estimation is simplified by minimizing chi square separately with respect to the derivatives of a and b.

34. 发明申请

WO2017007663A1 FIELD-INVARIANT QUANTITATIVE MAGNETIC-RESONANCE SIGNATURES 审中-公开
标题翻译：场不变量子磁共振信号
公开(公告)号：WO2017007663A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/040215
申请日：2016-06-29
申请人： TESLA HEALTH, INC , STEVENS, Andrew G.
发明人： STEVENS, Andrew G. , KADITZ, Jeffrey H.
IPC分类号： G01R33/54 , G01R33/46 , G01R33/465 , G01R33/483
CPC分类号： G01R33/54 , G01R33/445 , G01R33/4828 , G01R33/56
摘要： A system that determines an invariant magnetic-resonance ( MR ) signature of a biological sample is disclosed. During operation, the system determines a magnetic-resonance ( MR ) model of voxels in a biological sample based on differences between MR signals associated with the voxels in multiple scans and simulated MR signals. The MR signals are measured or captured by an MR scanner in the system during multiple MR scans, and based on scanning instructions, and the simulated MR signals for the biological sample are generated using the MR model and the scanning instructions. Moreover, the system iteratively modifies the scanning instructions (including a magnetic-field strength and/or a pulse sequence) in the MR scans based on the differences until a convergence criterion is achieved. Then, the system stores, in memory, an identifier of the biological sample and a magnetic-field-strength-invariant MR signature of the biological sample that is associated with the MR model.
摘要翻译：公开了一种确定生物样品的不变磁共振（MR）签名的系统。在操作期间，系统基于与多个扫描中的体素相关联的MR信号与模拟的MR信号之间的差异来确定生物样本中的体素的磁共振（MR）模型。在多次MR扫描期间，并且基于扫描指令，由系统中的MR扫描仪测量或捕获MR信号，并且使用MR模型和扫描指令生成生物样品的模拟MR信号。此外，系统基于差异迭代地修改MR扫描中的扫描指令（包括磁场强度和/或脉冲序列），直到达到收敛标准。然后，系统在存储器中存储生物样品的标识符和与MR模型相关联的生物样品的磁场强度不变的MR特征。

35. 发明申请

WO2016198415A1 MAGNETIC RESONANCE FINGERPRINTING DICTIONARY GENERATION USING A SUPPLEMENTARY MAGNETIC FIELD COIL 审中-公开
标题翻译：使用辅助磁场线圈指向词汇生成的磁共振
公开(公告)号：WO2016198415A1
公开(公告)日：2016-12-15
申请号：PCT/EP2016/062927
申请日：2016-06-08
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas Erik , BOERNERT, Peter , DONEVA, Mariya Ivanova , CROOIJMANS, Wim
IPC分类号： G01R33/30 , G01R33/3875 , G01R33/46 , G01R33/465 , G01R33/48 , G01R33/31 , G01R33/389
CPC分类号： G01R33/4625 , G01R33/30 , G01R33/31 , G01R33/36 , G01R33/3875 , G01R33/389 , G01R33/465 , G01R33/4828
摘要： The invention provides for a method of operating an instrument (100). The instrument comprises a magnetic resonance system (102) for measuring dictionary magnetic resonance data (154) from a measurement zone (108). The magnetic resonance system comprises a magnet (104) for generating a main magnetic field within the measurement zone. The magnetic resonance system comprises a test fixture (124) for holding a test sample (132) within the measurement zone. The test fixture comprises a supplementary magnetic field coil (126) and a magnetic resonance antenna (128). The method comprises the steps of repeatedly: choosing (200) an electrical current; supplying (202) the electrical current to the supplementary magnetic field coil to adjust the main magnetic field within the measurement zone; acquiring (204) the dictionary magnetic resonance data from the test sample with the magnetic resonance antenna by controlling the magnetic resonance system according to a magnetic resonance fingerprinting technique; and appending (206) the dictionary magnetic resonance data to a magnetic resonance fingerprinting dictionary (156).
摘要翻译：本发明提供了一种操作仪器（100）的方法。仪器包括用于从测量区域（108）测量字典磁共振数据（154）的磁共振系统（102）。磁共振系统包括用于在测量区域内产生主磁场的磁体（104）。磁共振系统包括用于将测试样品（132）保持在测量区域内的测试夹具（124）。测试夹具包括辅助磁场线圈（126）和磁共振天线（128）。该方法包括重复：选择（200）电流; 向辅助磁场线圈提供（202）电流以调整测量区内的主磁场; 通过根据磁共振指纹技术控制磁共振系统，利用磁共振天线从测试样本获取（204）字典磁共振数据; 并将磁盘磁共振数据附加（206）到磁共振指纹词典（156）。

36. 发明申请

WO2016198363A1 BONE MRI USING A B0 INHOMOGENITY MAP AND A SUBJECT MAGNETIC SUSCEPTIBILITY MAP 审中-公开
标题翻译：使用B0不均匀性图和主要磁性可靠性图
公开(公告)号：WO2016198363A1
公开(公告)日：2016-12-15
申请号：PCT/EP2016/062820
申请日：2016-06-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOERNERT, Peter , NEHRKE, Kay , EGGERS, Holger
IPC分类号： G01R33/44 , G01R33/48 , G01R33/56 , G01R33/565 , A61B5/055
CPC分类号： G01R33/4816 , A61B5/055 , A61N5/1039 , A61N5/1049 , A61N2005/1055 , G01R33/443 , G01R33/481 , G01R33/4812 , G01R33/4828 , G01R33/56 , G01R33/56536 , G01R33/56563
摘要： The invention provides for a medical instrument (100, 500) comprising a magnetic resonance imaging system (102) for acquiring magnetic resonance data (142) from a subject (118) within an imaging zone (108). The magnetic resonance imaging system comprises: a main magnet (104) for generating a B0 magnetic field within the imaging zone; a memory (134, 136) containing machine executable instructions (160, 162, 164, 166) and pulse sequence commands (140); a processor (130) for controlling the medical instrument. Execution of the machine executable instructions causes the processor to: acquire (200) the magnetic resonance data by controlling the magnetic resonance imaging system with the pulse sequence commands; receive (202) a subject magnetic susceptibility map (144) of the subject; calculate (204) a B0 inhomogeneity map (146) from the magnetic resonance data; calculate (206) a subject B0 magnetic field perturbation (148) from the subject magnetic susceptibility map; calculate (208) a residual B0 magnetic field perturbation (150) by subtracting the subject B0 magnetic field perturbation from the B0 inhomogeneity map; and calculate (210) a bone map (152) from the residual B0 magnetic field perturbation.
摘要翻译：本发明提供一种包括用于从成像区域（108）内的受检者（118）获取磁共振数据（142）的磁共振成像系统（102）的医疗器械（100,500）。磁共振成像系统包括：主磁体（104），用于在成像区内产生B0磁场; 包含机器可执行指令（160,162,164,166）和脉冲序列命令（140）的存储器（134,136）; 用于控制医疗器械的处理器（130）。执行机器可执行指令使得处理器通过用脉冲序列命令控制磁共振成像系统来获取（200）磁共振数据; 接收（202）所述对象的对象磁化率图（144）; 从磁共振数据计算（204）B0不均匀性图（146）; 从对象磁化率图计算（206）受试者B0磁场扰动（148）; 通过从B0不均匀性图中减去对象B0磁场扰动来计算（208）残留B0磁场扰动（150）; 并根据剩余B0磁场扰动计算（210）骨骼图（152）。

37. 发明申请

WO2016196176A1 METHODS AND APPARATUS FOR BONE SEGMENTATION IN MAGNETIC RESONANCE IMAGES 审中-公开
标题翻译：磁共振成像中骨分离的方法和装置
公开(公告)号：WO2016196176A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034279
申请日：2016-05-26
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： MULKERN, Robert, V. , JARRETT, Delma , BALASUBRAMANIAN, Mukund
IPC分类号： G01R33/48 , G01R33/56 , G01R33/561 , G01R33/50 , G01R33/565 , G06T7/00 , A61B5/055
CPC分类号： G06T7/0014 , B33Y50/00 , G01R33/4828 , G01R33/50 , G01R33/5608 , G01R33/5618 , G01R33/56527 , G06T5/50 , G06T7/11 , G06T7/136 , G06T7/194 , G06T2200/08 , G06T2207/10088 , G06T2207/20224 , G06T2207/30008
摘要： Methods and apparatus for processing magnetic resonance imaging (MRI) data to perform bone segmentation. MRI data comprising a set of gradient-echo images acquired throughout a spin echo is processed to generate a bone segmentation image. The bone segmentation image is generated based, at least in part, on at least two images in the set of gradient-echo images, wherein the at least two images include a first image corresponding to a beginning portion of the spin echo and a second image corresponding to a central portion of the spin echo.
摘要翻译：用于处理磁共振成像（MRI）数据以执行骨分割的方法和装置。包括在整个自旋回波中获取的一组梯度回波图像的MRI数据被处理以产生骨分割图像。骨分割图像至少部分地基于所述梯度 - 回波图像集合中的至少两个图像生成，其中所述至少两个图像包括对应于所述自旋回波的开始部分的第一图像和第二图像对应于自旋回波的中心部分。

38. 发明申请

WO2016170170A1 FAT CHARACTERIZATION METHOD USING MRI IMAGES ACQUIRED WITH A MULTIPLE-GRADIENT ECHO SEQUENCE 审中-公开
标题翻译：使用获得多级梯级顺序的MRI图像的FAT特征化方法
公开(公告)号：WO2016170170A1
公开(公告)日：2016-10-27
申请号：PCT/EP2016/059102
申请日：2016-04-22
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ PARIS DIDEROT - PARIS 7
发明人： LEPORQ, Benjamin , LAMBERT, Simon , VAN BEERS, Bernard
IPC分类号： G01R33/24 , A61B5/055 , G01R33/48 , G01R33/50 , G01R33/561
CPC分类号： A61B5/4872 , A61B5/055 , A61B5/748 , A61B2576/00 , G01R33/243 , G01R33/4828 , G01R33/50 , G01R33/5608 , G01R33/5615 , G01R33/5616 , G01R33/5618
摘要： A method for post-processing images of a region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of: unwrapping the phase of each image, extracting a real signal over echo time for at least one pixel of the unwrapped images, and calculating fat characterization parameters by using a fitting technique applied on a model, the model being a function which associates to a plurality of parameters each extracted real signal, the plurality of parameters comprising at least two fat characterization parameters and at least one parameter obtained by a measurement, the fitting technique being a non-linear least-square fitting technique using pseudo-random initial conditions.
摘要翻译：一种用于后处理受试者感兴趣区域的图像的方法，所述图像是用磁共振成像技术获取的，所述后处理方法至少包括以下步骤：展开每个图像的相位，提取真实的信号通过回波时间对于展开图像的至少一个像素，并且通过使用应用于模型的拟合技术来计算脂肪表征参数，所述模型是与每个提取的实际信号的多个参数相关联的函数，所述多个参数包括至少两个脂肪表征参数和通过测量获得的至少一个参数，拟合技术是使用伪随机初始条件的非线性最小二乘拟合技术。

39. 发明申请

WO2016166119A1 MAGNETIC RESONANCE FINGERPRINTING WITH REDUCED SENSITIVITY TO INHOMOGENEITIES IN THE MAIN MAGNETIC FIELD 审中-公开
标题翻译：磁性共振指示性降低对主磁场中的不均匀性的敏感性
公开(公告)号：WO2016166119A1
公开(公告)日：2016-10-20
申请号：PCT/EP2016/058048
申请日：2016-04-13
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NIELSEN, Tim , BOERNERT, Peter , NEHRKE, Kay , AMTHOR, Thomas Erik , DONEVA, Mariya Ivanova
IPC分类号： G01R33/565 , G01R33/48 , G01R33/54 , G01R33/56
CPC分类号： G01R33/445 , G01R33/4828 , G01R33/50 , G01R33/54 , G01R33/543 , G01R33/546 , G01R33/56 , G01R33/5612 , G01R33/5617 , G01R33/56563
摘要： The invention provides for a magnetic resonance system (100) comprising a magnet (104) for generating a main magnetic field within the measurement zone and a magnetic field gradient system (110, 112) for generating a gradient magnetic field within the measurement zone in at least one direction by supplying current to a set of magnetic gradient coils (112) for each of the at least one direction. Instructions cause a a processor (130) controlling the magnetic resonance system, wherein execution of the machine executable instructions causes the processor to acquire (200) the magnetic resonance data by controlling the magnetic resonance system with pulse sequence commands. The pulse sequence commands (140) cause the magnetic resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence commands specify a train (500) of pulse sequence repetitions (502, 504), each with a fixed repetition time (302). Each repetition comprises either a radio frequency pulse (310) chosen from a distribution of radio frequency pulses or a sampling event (404) occurring at a fixed delay (316) from the start of the pulse sequence repetition. The pulse sequence commands specify the application of gradient (308) magnetic fields in the at least one direction by controlling the supplied current to the set of gradient coils. Each of the set of magnetic gradient coils the integral of current supplied is a constant for each fixed repetition time. The instructions further cause the processor to calculate (202) the abundance of each of a set of predetermined substances by comparing the magnetic resonance data with a magnetic resonance fingerprinting dictionary (144).
摘要翻译：本发明提供一种磁共振系统（100），其包括用于在测量区域内产生主磁场的磁体（104）和用于在测量区域内产生梯度磁场的磁场梯度系统（110,112）至少一个方向，通过向至少一个方向中的每一个的一组磁梯度线圈（112）提供电流。指令使处理器（130）控制磁共振系统，其中机器可执行指令的执行使得处理器通过用脉冲序列命令控制磁共振系统来获取（200）磁共振数据。脉冲序列命令（140）使得磁共振系统根据磁共振指纹技术获取磁共振数据。脉冲序列命令指定脉冲序列重复（502,504）的列（500），每一个具有固定的重复时间（302）。每个重复包括从脉冲序列重复开始起的从射频脉冲的分布中选择的射频脉冲（310）或以固定延迟（316）发生的采样事件（404）。脉冲序列命令通过控制提供给该组梯度线圈的电流来指定在至少一个方向上应用梯度（308）的磁场。磁性梯度线圈组中的每一个，电流的积分是每个固定的重复时间的常数。指令还使处理器通过将磁共振数据与磁共振指纹词典（144）进行比较来计算（202）一组预定物质中的每一个的丰度。

40. 发明申请

WO2016116545A1 MRI METHOD FOR CALCULATING DERIVED VALUES FROM B0 AND B1 MAPS 审中-公开
标题翻译：从B0和B1 MAPS计算衍生值的MRI方法
公开(公告)号：WO2016116545A1
公开(公告)日：2016-07-28
申请号：PCT/EP2016/051199
申请日：2016-01-21
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KATSCHER, Ulrich , MEINEKE, Jan Jakob , EGGERS, Holger , BOERNERT, Peter
IPC分类号： G01R33/24 , G01R33/48 , G01R33/56 , G01R33/565 , A61B5/055 , G01R33/28
CPC分类号： G01R33/443 , A61B5/055 , G01R33/243 , G01R33/246 , G01R33/288 , G01R33/4816 , G01R33/4824 , G01R33/4828 , G01R33/54 , G01R33/5608 , G01R33/56563
摘要： The invention provides for a magnetic resonance imaging system (100, 300, 100) for acquiring magnetic resonance data (110, 1104) from a subject (118) within an imaging zone (108). The magnetic resonance imaging system comprises a memory (136) for storing machine executable instructions (160, 162, 164, 166, 316) and pulse sequence data (140, 1102). The pulse sequence data comprises instructions for controlling the magnetic resonance imaging system to acquire magnetic resonance data according to a magnetic resonance imaging method. The magnetic resonance imaging system further comprises a processor (130) for controlling the magnetic resonance imaging system. Execution of the machine executable instructions causes the processor to: acquire (1200) the magnetic resonance data by controlling the magnetic resonance imaging system with the pulse sequence data;calculate(1202) a B0 inhomogeneity map (148) by analyzing the magnetic resonance data according to the magnetic resonance imaging method, calculate (1204) a B1 phase map (150) and/or a B1 amplitude map (1106) by analyzing the magnetic resonance data according to the magnetic resonance imaging method;and calculate (1206) a second derivative (1110) of the B1 phase map and/or a second derivative of the B1 magnitude map 1 and/or a second derivative of the B0 in homogeneity map in at least one predetermined direction. The second derivative is calculated using a corrected voxel size in the at least one predetermined direction, wherein the corrected voxel size is calculated using a correction factor calculated from the derivative of the B0 inhomogeneity map.
摘要翻译：本发明提供一种用于从成像区域（108）内的对象（118）获取磁共振数据（110,1104）的磁共振成像系统（100,300,100）。磁共振成像系统包括用于存储机器可执行指令（160,162,164,166,316）和脉冲序列数据（140,1102）的存储器（136）。脉冲序列数据包括用于根据磁共振成像方法控制磁共振成像系统获取磁共振数据的指令。磁共振成像系统还包括用于控制磁共振成像系统的处理器（130）。执行机器可执行指令使得处理器通过用脉冲序列数据控制磁共振成像系统来获取（1200）磁共振数据;通过分析磁共振数据来计算（1202）B0不均匀性图（148）对于磁共振成像方法，通过根据磁共振成像方法分析磁共振数据来计算（1204）B1相位图（150）和/或B1振幅图（1106）;并计算（1206）二次导数（1110）和/或B1幅度图1的二阶导数和/或均匀性图中的B0的二次导数在至少一个预定方向上。使用在至少一个预定方向上的校正体素大小来计算二阶导数，其中使用由B0不均匀性图的导数计算的校正因子来计算校正的体素大小。

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