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    • 31. 发明申请
    • SELECTIVE HYDROXYLATION OF PHENOL OR PHENOLIC ETHERS
    • 苯酚或酚醛的选择性羟化
    • WO1992018449A1
    • 1992-10-29
    • PCT/GB1992000639
    • 1992-04-09
    • SOLVAY INTEROX LIMITEDWASSON, Robert, CraigJOHNSTONE, AlexanderSANDERSON, William, Ronald
    • SOLVAY INTEROX LIMITED
    • C07C37/60
    • C01B25/372B01J27/16C07C37/60C07C41/26C07C39/08C07C43/23
    • Phenols, and related aromatic compounds, phenolic ethers, can be hydroxylated selectively using hydrogen peroxide in the presence of an amorphous or microcrystalline zirconium phosphate catalyst in a solvent containing an aliphatic carboxylic acid. The process is particularly suitable for phenol itself, and advantageously employs a partially dehydrated microcrystalline catalyst obtained by heating an hydrated microcrystalline zirconium phosphate for example at about 100 DEG C. A convenient reaction temperature is 50 to 90 DEG C, and convenient solvent is acetic acid. In an improved method of producing the catalyst, zirconium phosphate is precipitated from an aqueous phosphoric acid solution of zirconium oxychloride in the presence of a cationic phase transfer agent such as an alkylpyridinium salt or tetraalkylquaternary ammonium salt or a nonionic surfactant such as an alcohol ethoxylate.
    • 在含有脂族羧酸的溶剂中,在无定形或微晶磷酸锆催化剂存在下,可以使用过氧化氢选择性地使苯酚和相关芳香族化合物酚醛醚羟基化。 该方法特别适用于苯酚本身,并且有利地使用通过例如在约100℃下加热水合微晶磷酸锆获得的部分脱水的微晶催化剂。方便的反应温度为50-90℃,方便的溶剂为乙酸 。 在制备催化剂的改进方法中,在阳离子相转移剂如烷基吡啶鎓盐或四烷基季铵盐或非离子表面活性剂如醇乙氧基化物的存在下,从磷酸锆水溶液中沉淀出磷酸锆。