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31. 发明申请

WO2007106318A3 BIOCOMPATIBLE BONDING METHOD AND ELECTRONICS PACKAGE SUITABLE FOR IMPLANTATION 审中-公开
标题翻译：生物相容性粘结方法和适用于植入的电子装置
公开(公告)号：WO2007106318A3
公开(公告)日：2007-12-21
申请号：PCT/US2007004741
申请日：2007-02-22
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , OK JERRY
发明人： GREENBERG ROBERT J , OK JERRY
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/3752 , H01L23/057 , H01L23/10 , H01L23/4985 , H01L2224/05573 , H01L2224/16225 , H01L2224/73204 , H01L2224/92125 , H01L2924/01079 , H01L2924/1461 , H05K1/0306 , H05K3/321 , H05K3/328 , H05K3/361 , H05K3/4015 , H05K3/423 , H05K3/4652 , H05K3/4691 , H05K2201/09127 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/0733 , H05K2203/1446 , H01L2924/00
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子器件封装结合到电极或柔性电路的方法，以及适合于植入活体组织（例如用于视网膜或皮层电极阵列）的所得电子封装，以使视线恢复某些不具视力的个人。通过电镀铂或金等生物相容性材料，将密封的电子组件直接接合到柔性电路或电极上，从而有效地形成电镀铆钉形连接，其将柔性电路结合到电子组件。由此产生的电子器件是生物相容性的，适用于长期植入活体组织。

32. 发明申请

WO2007118527A1 VERFAHREN ZUR HERSTELLUNG VON IMPLANTATSTRUKTUREN ZUR KONTAKTIERUNG ODER ELEKTROSTIMULATION VON LEBENDEN GEWEBEZELLEN ODER NERVEN 审中-公开
标题翻译：用于生产植入结构，用于接触或活的组织细胞或神经的电刺激
公开(公告)号：WO2007118527A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/000686
申请日：2007-01-26
申请人： IMI INTELLIGENT MEDICAL IMPLANTS AG , TIEDTKE, Hans-Jürgen
发明人： TIEDTKE, Hans-Jürgen
IPC分类号： A61N1/05 , B81B3/00
CPC分类号： A61N1/05 , A61N1/0543 , A61N1/0551 , B81C99/008 , B81C2201/0107 , B81C2201/0181 , Y10T428/12493
摘要： Die Aufgabe, ein Verfahren zur Herstellung von Multilayern bzw. Mehrschichtsystemen zu schaffen, bei dem die auf einem Substrat erzeugten Strukturen gemeinsam vom Substrat leicht gelöst werden können und im Verbund erhalten bleiben, wird nach der vorliegenden Erfindung gelöst durch ein Verfahren zum Herstellen von Implantatstrukturen umfassend das Erzeugen einer ersten Metallschicht auf einem Substrat, Erzeugen einer zweiten Metallschicht über der ersten Metallschicht, das Herstellen einer Anzahl von mehrlagigen Implantatstrukturen über der zweiten Metallschicht, Entfernen der ersten Metallschicht zwischen dem Substrat und der zweiten Metallschicht und Ablösen der Implantatstrukturen in einem zusammenhängenden Verbund von dem Substrat. Bei dem erfindungsgemäßen Verfahren wird zwischen den Implantatstrukturen und dem Substrat eine Ablöseschicht bestehend aus zwei oder drei Metallschichten erzeugt, die beim Ablösen der fertig prozessierten Multilayer durch einen Unterätzungsprozess als Opferschicht dienen. Dadurch wird eine gleichmäßige und zuverlässige Trennung der fertigen Multilayer im Verbund vom Substrat erzielt, was die nachfolgende Aufbau- und Verbindungstechnik der Implantatstrukturen erleichtert.
摘要翻译：的目的是提供用于生产多层或多层系统，其中在衬底上产生的结构可以从基板容易脱落在一起，并且被保持在复合材料的制造，其包括植入物结构提供的方法，根据本发明的方法在衬底上产生一第一金属层，形成在所述第一金属层的第二金属层，在第二金属层中形成多个多层植入物的结构，在一个有凝聚力的复合去除植入物结构的衬底和所述第二金属层和分离之间的第一金属层所述衬底。在本发明方法，其中包括从所述植入物的结构和衬底，其分离由Unterätzungsprozess成品加工多层作为牺牲层时使用之间的两个或三个金属层所产生的剥离层。在复合材料中的成品多层的均匀和可靠的分离，从衬底上，这有利于该植入物结构的随后的组装和互连得到的。

33. 发明申请

WO2007035774A1 RETINAL PROSTHESIS WITH A NEW CONFIGURATION 审中-公开
标题翻译：用新的配置进行RETINAL PROSTHISIS
公开(公告)号：WO2007035774A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/036549
申请日：2006-09-19
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , MCMAHON, Matthew, J. , LITTLE, James, Singleton , MCCLURE, Kelly, H. , MECH, Brian, V. , TALBOT, Neil, Hamiton , NEYSMITH, Jordan, M.
发明人： GREENBERG, Robert, J. , MCMAHON, Matthew, J. , LITTLE, James, Singleton , MCCLURE, Kelly, H. , MECH, Brian, V. , TALBOT, Neil, Hamiton , NEYSMITH, Jordan, M.
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/025 , A61N1/36046 , A61N1/37229 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09909 , H05K2203/1105 , H05K2203/1476 , H05K2203/302
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别适用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

34. 发明申请

WO2007035361A2 TRANS-RETINAL FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：变压器柔性电路电极阵列
公开(公告)号：WO2007035361A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/035674
申请日：2006-09-13
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , HUMAYUN, Mark, S.
发明人： GREENBERG, Robert, J. , HUMAYUN, Mark, S.
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally. The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.
摘要翻译：申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜的方法。本发明是用于视网膜下刺激的改进的电极阵列。诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。

35. 发明申请

WO2006123248A3 IMPROVED METHODS AND DEVICES FOR DELIVERING A THERAPEUTIC PRODUCT TO THE OCULAR SPHERE OF A SUBJECT 审中-公开
标题翻译：改进的方法和装置，用于将治疗产品递送到受试者的OCULAR SPHERE
公开(公告)号：WO2006123248A3
公开(公告)日：2007-01-18
申请号：PCT/IB2006001667
申请日：2006-04-18
申请人： INST NAT SANTE RECH MED , BEHAR-COHEN FRANCINE , BENEZRA DAVID , BIGEY PASCAL , BLOQUEL CAROLE , SCHERMAN DANIEL
发明人： BEHAR-COHEN FRANCINE , BENEZRA DAVID , BIGEY PASCAL , BLOQUEL CAROLE , SCHERMAN DANIEL
IPC分类号： A61K31/70 , A61K48/00 , C12M1/42 , C12N15/87
CPC分类号： C12N15/87 , A61K9/0048 , A61K38/00 , A61K48/00 , A61N1/0543 , A61N1/306 , A61N1/327 , A61N1/36046
摘要： The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and/or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and/or extra-ocular muscle or cells administration, their preparation and uses.
摘要翻译：本发明通常涉及将生物活性剂特别是治疗性或预防性核酸递送至受试者的眼球的改进方法，所述方法包括将所述药物施用于睫状体的组织或细胞和/或到眼外肌肉组织或细胞。更具体地，本发明涉及装置，其用途，特别是基因治疗，以及用于通过特定的睫状体组织或细胞和/或眼外肌或细胞给予治疗的眼球的病理学的方法产品并将其转移到待治疗的眼组织中。本发明还涉及药物组合物，其包含适合于睫状体组织或细胞和/或眼外肌或细胞给药，其制备和用途的形式的产品。

36. 发明申请

WO2005070495A3 NEURAL STIMULATION ARRAY PROVIDING PROXIMITY OF ELECTRODES TO CELLS VIA CELLULAR MIGRATION 审中-公开
标题翻译：神经刺激阵列通过细胞迁移提供电极对细胞的接近
公开(公告)号：WO2005070495A3
公开(公告)日：2006-11-23
申请号：PCT/US2005002212
申请日：2005-01-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL , HUIE PHILIP JR , VANKOV ALEXANDER , FISHMAN HARVEY A
IPC分类号： A61N1/36 , A61N1/00 , A61N1/04 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An interface for selective excitation or sensing of neural cells in a biological neural network is provided. The interface includes a membrane with a number of channels passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell(s) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel. An alternative interface provides cell excitation via an array of electrically conductive pillars on a substrate. The pillars have electrically insulated sides and exposed top surfaces, to provide selective cell excitation.
摘要翻译：提供了一种生物神经网络中选择性激发或感应神经细胞的界面。界面包括具有穿过膜的多个通道的膜。每个通道内至少有一个电极。生物神经网络中的神经细胞生长或迁移到通道中，从而紧密接近电极。一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞。然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。另一种界面通过衬底上的导电柱阵列提供电池激发。支柱具有电绝缘的侧面和暴露的顶表面，以提供选择性的电池激发。

37. 发明申请

WO2006116625A2 BATCH-FABRICATED FLEXIBLE INTRAOCULAR RETINAL PROSTHESIS SYSTEMS AND METHODS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：批量制作柔性肌内放射治疗系统及其制造方法
公开(公告)号：WO2006116625A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016070
申请日：2006-04-28
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , TAI, Yu-Chong , RODGER, Damien C. , LI, Wen , HUMAYUN, Mark , WEILAND, James D. , AMERI, Hossein
发明人： TAI, Yu-Chong , RODGER, Damien C. , LI, Wen , HUMAYUN, Mark , WEILAND, James D. , AMERI, Hossein
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046 , Y10T29/49002 , Y10T29/49128 , Y10T29/4913 , Y10T29/49156 , Y10T29/49224
摘要： Intraocular retinal prosthesis systems and methods for fabricating the same are provided. In one aspect, fabrication of all or multiple components of a prosthesis device or system are combined into a single monolithic fabrication process. Also, many such entire systems can be fabricated simultaneously in a single microfabrication processing run. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.
摘要翻译：提供了眼内视网膜假体系统及其制造方法。在一个方面，假体装置或系统的全部或多个部件的制造被组合成单个整体制造工艺。此外，许多这样的整个系统可以在单个微细加工处理运行中同时制造。假体装置包括将电极阵列区域与功率和数据管理区域连接的电缆区域。电极阵列区域包括一个或多个暴露电极阵列，功率和数据管理区域包括各种功率和控制元件。功率和数据管理元件在一个方面包括RF线圈或线圈以及经配置以通过电缆向电极提供驱动信号并且从RF线圈或线圈接收功率和信号的电路布置和/或芯片。每个区域包括在同一制造过程中在单个聚合物层上或其中制造的元件。

38. 发明申请

WO2006107702A2 NEURAL ELECTRODE ARRAY 审中-公开
标题翻译：神经电极阵列
公开(公告)号：WO2006107702A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/011643
申请日：2006-03-30
申请人： NEURAL SIGNALS, INC. , KENNEDY, Philip
发明人： KENNEDY, Philip
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046
摘要： A neural electrode array (100) includes an electrode support member (110), a conductor (114) and at least one anchor structure (130). The electrode support member (110) is substantially rigid and non-conductive and defines a plurality of spaced-apart holes (120) passing therethrough. An electrically conductive contact (112) is disposed adjacently to each hole. The conductor (114) uniquely connects each contact (112) to a bus (140). The anchor structure (130) includes a portion for engagement with tissue that is capable of maintaining the support member in a substantially fixed relationship with a neural region.
摘要翻译：神经电极阵列（100）包括电极支撑构件（110），导体（114）和至少一个锚结构（130）。电极支撑构件（110）基本上是刚性的且不导电的并且限定了穿过其中的多个间隔开的孔（120）。导电触点（112）设置成与每个孔相邻。导体（114）将每个触点（112）唯一地连接到总线（140）。锚结构（130）包括用于与组织接合的部分，其能够将支撑构件保持在与神经区域基本上固定的关系。

39. 发明申请

WO2006100677A2 DEVICE AND METHOD FOR PUPIL SIZE MODULATION 审中-公开
标题翻译：用于PULIL SIZE调制的装置和方法
公开(公告)号：WO2006100677A2
公开(公告)日：2006-09-28
申请号：PCT/IL2006/000362
申请日：2006-03-21
申请人： A.T.I. - ADVANCED MEDICAL TECHNOLOGIES LTD. , LIVNE, Abraham , RON, Ilan
发明人： LIVNE, Abraham , RON, Ilan
IPC分类号： A61B3/10
CPC分类号： A61N1/36046 , A61N1/0543 , A61N2/006
摘要： A device and method are presented for drug-free, non-invasive, modulation of a size of a patient's pupil. The invention utilizes application of an external electric and/or magnetic field of desired properties to the patient's iris to thereby effect stimulation or neutralization of synapses and thus temporarily inducing mydriasis or miosis effect.
摘要翻译：提出了一种用于无药物，非侵入性调节患者瞳孔大小的装置和方法。本发明利用对患者虹膜的期望特性的外部电场和/或磁场的应用，从而实现突触的刺激或中和，从而暂时引起散瞳或瞳孔缩小效应。

40. 发明申请

WO2005123183A3 ELECTROPORATION DEVICE AND METHOD FOR DELIVERY TO OCULAR TISSUE 审中-公开
标题翻译：电动装置和用于输送至组织的方法
公开(公告)号：WO2005123183A3
公开(公告)日：2006-06-08
申请号：PCT/US2005020677
申请日：2005-06-13
申请人： UNIV SOUTH FLORIDA , HELLER RICHARD , JAROSZESKI MARK J , GILBERT RICHARD A , HAUSWIRTH WILLIAM H
发明人： HELLER RICHARD , JAROSZESKI MARK J , GILBERT RICHARD A , HAUSWIRTH WILLIAM H
IPC分类号： A61N1/30 , A61N1/05 , A61N1/32
CPC分类号： A61N1/0543 , A61N1/0412 , A61N1/0476 , A61N1/327
摘要： In accordance with the present invention is provided a device and method for delivering DNA for the purpose of gene therapy to specific regions within and around the eye.
摘要翻译：根据本发明提供了用于将基因治疗目的的DNA递送到眼睛内和眼睛周围的特定区域的装置和方法。

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